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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 4369

FusionGeneSummary for BRAF_TRIM24

check button Fusion gene summary
Fusion gene informationFusion gene name: BRAF_TRIM24
Fusion gene ID: 4369
HgeneTgene
Gene symbol

BRAF

TRIM24

Gene ID

673

8805

Gene nameB-Raf proto-oncogene, serine/threonine kinasetripartite motif containing 24
SynonymsB-RAF1|B-raf|BRAF1|NS7|RAFB1PTC6|RNF82|TF1A|TIF1|TIF1A|TIF1ALPHA|hTIF1
Cytomap

7q34

7q33-q34

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene transcription intermediary factor 1-alphaE3 ubiquitin-protein ligase TRIM24RING finger protein 82RING-type E3 ubiquitin transferase TIF1-alphaTIF1-alphatranscriptional intermediary factor 1
Modification date2018052720180519
UniProtAcc

P15056

O15164

Ensembl transtripts involved in fusion geneENST00000288602, ENST00000343526, 
ENST00000415680, ENST00000497516, 
Fusion gene scores* DoF score18 X 12 X 10=21604 X 4 X 4=64
# samples 224
** MAII scorelog2(22/2160*10)=-3.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRAF [Title/Abstract] AND TRIM24 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRAF

GO:0006468

protein phosphorylation

17563371

HgeneBRAF

GO:0010828

positive regulation of glucose transmembrane transport

23010278

HgeneBRAF

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

HgeneBRAF

GO:0043066

negative regulation of apoptotic process

19667065

HgeneBRAF

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22065586

HgeneBRAF

GO:0071277

cellular response to calcium ion

18567582

HgeneBRAF

GO:0090150

establishment of protein localization to membrane

23010278

TgeneTRIM24

GO:0016567

protein ubiquitination

19556538

TgeneTRIM24

GO:0071391

cellular response to estrogen stimulus

21164480


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVREADTCGA-F5-6464-01ABRAFchr7

140624366

-TRIM24chr7

138258252

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000288602ENST00000343526BRAFchr7

140624366

-TRIM24chr7

138258252

+
In-frameENST00000288602ENST00000415680BRAFchr7

140624366

-TRIM24chr7

138258252

+
5CDS-intronENST00000288602ENST00000497516BRAFchr7

140624366

-TRIM24chr7

138258252

+

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FusionProtFeatures for BRAF_TRIM24


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRAF

P15056

TRIM24

O15164

Transcriptional coactivator that interacts with numerousnuclear receptors and coactivators and modulates the transcriptionof target genes. Interacts with chromatin depending on histone H3modifications, having the highest affinity for histone H3 that isboth unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23'(H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotesubiquitination and proteasomal degradation of p53/TP53. Plays arole in the regulation of cell proliferation and apoptosis, atleast in part via its effects on p53/TP53 levels. Up-regulatesligand-dependent transcription activation by AR, GCR/NR3C1,thyroid hormone receptor (TR) and ESR1. Modulates transcriptionactivation by retinoic acid (RA) receptors, including RARA. Playsa role in regulating retinoic acid-dependent proliferation ofhepatocytes (By similarity). {ECO:0000250,ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538,ECO:0000269|PubMed:21164480}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRAFchr7:140624366chr7:138258252ENST00000288602-1186_1146767Compositional biasNote=Poly-Gly
TgeneTRIM24chr7:140624366chr7:138258252ENST00000343526+1019932_9876261051DomainBromo
TgeneTRIM24chr7:140624366chr7:138258252ENST00000415680+1019932_9875921017DomainBromo
TgeneTRIM24chr7:140624366chr7:138258252ENST00000343526+1019891_9076261051MotifNuclear localization signal
TgeneTRIM24chr7:140624366chr7:138258252ENST00000415680+1019891_9075921017MotifNuclear localization signal
TgeneTRIM24chr7:140624366chr7:138258252ENST00000343526+1019754_7796261051RegionNote=Nuclear receptor binding site (NRBS)
TgeneTRIM24chr7:140624366chr7:138258252ENST00000415680+1019754_7795921017RegionNote=Nuclear receptor binding site (NRBS)
TgeneTRIM24chr7:140624366chr7:138258252ENST00000343526+1019826_8736261051Zinc fingerPHD-type
TgeneTRIM24chr7:140624366chr7:138258252ENST00000415680+1019826_8735921017Zinc fingerPHD-type

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRAFchr7:140624366chr7:138258252ENST00000288602-118122_12946767Compositional biasNote=Poly-Ser
HgeneBRAFchr7:140624366chr7:138258252ENST00000288602-118428_43246767Compositional biasNote=Poly-Ser
HgeneBRAFchr7:140624366chr7:138258252ENST00000288602-118155_22746767DomainRBD
HgeneBRAFchr7:140624366chr7:138258252ENST00000288602-118457_71746767DomainProtein kinase
HgeneBRAFchr7:140624366chr7:138258252ENST00000288602-118463_47146767Nucleotide bindingATP
HgeneBRAFchr7:140624366chr7:138258252ENST00000288602-118234_28046767Zinc fingerPhorbol-ester/DAG-type
TgeneTRIM24chr7:140624366chr7:138258252ENST00000343526+1019289_3596261051Coiled coilOntology_term=ECO:0000255
TgeneTRIM24chr7:140624366chr7:138258252ENST00000415680+1019289_3595921017Coiled coilOntology_term=ECO:0000255
TgeneTRIM24chr7:140624366chr7:138258252ENST00000343526+1019344_3476261051Compositional biasNote=Poly-Gln
TgeneTRIM24chr7:140624366chr7:138258252ENST00000343526+10199_156261051Compositional biasNote=Poly-Ala
TgeneTRIM24chr7:140624366chr7:138258252ENST00000415680+1019344_3475921017Compositional biasNote=Poly-Gln
TgeneTRIM24chr7:140624366chr7:138258252ENST00000415680+10199_155921017Compositional biasNote=Poly-Ala
TgeneTRIM24chr7:140624366chr7:138258252ENST00000343526+1019158_2116261051Zinc fingerB box-type 1
TgeneTRIM24chr7:140624366chr7:138258252ENST00000343526+1019218_2596261051Zinc fingerB box-type 2
TgeneTRIM24chr7:140624366chr7:138258252ENST00000343526+101956_826261051Zinc fingerRING-type
TgeneTRIM24chr7:140624366chr7:138258252ENST00000415680+1019158_2115921017Zinc fingerB box-type 1
TgeneTRIM24chr7:140624366chr7:138258252ENST00000415680+1019218_2595921017Zinc fingerB box-type 2
TgeneTRIM24chr7:140624366chr7:138258252ENST00000415680+101956_825921017Zinc fingerRING-type


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FusionGeneSequence for BRAF_TRIM24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_BRAF_ENST00000288602_chr7_140624366_-_TRIM24_ENST00000343526_chr7_138258252_+_471aa
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSSVPSPGL
AGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNANYPRSIL
TSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHL
SCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIK
NPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEFRNESEDNKFSDDSDD

>In-frame_BRAF_ENST00000288602_chr7_140624366_-_TRIM24_ENST00000415680_chr7_138258252_+_471aa
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSSVPSPGL
AGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNANYPRSIL
TSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHL
SCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIK
NPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEFRNESEDNKFSDDSDD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_BRAF_ENST00000288602_chr7_140624366_-_TRIM24_ENST00000343526_chr7_138258252_+_1413nt
ATGGCGGCGCTGAGCGGTGGCGGTGGTGGCGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGC
GCCGGCGCCGCGGCCTCTTCGGCTGCGGACCCTGCCATTCCGGAGGAGATTGACTGTTCAAGTACTATTATGCTGGACAATATTGTGAGG
AAAGATACTAATATAGATCATGGCCAGCCAAGACCACCCTCAAACAGAACGGTCCAGTCACCAAATTCATCAGTGCCATCTCCAGGCCTT
GCAGGACCTGTTACTATGACTAGTGTACACCCCCCAATACGTTCACCTAGTGCCTCCAGCGTTGGAAGCCGAGGAAGCTCTGGCTCTTCC
AGCAAACCAGCAGGAGCTGACTCTACACACAAAGTCCCAGTGGTCATGCTGGAGCCAATTCGAATAAAACAAGAAAACAGTGGACCACCG
GAAAATTATGATTTCCCTGTTGTTATAGTGAAGCAAGAATCAGATGAAGAATCTAGGCCTCAAAATGCCAATTATCCAAGAAGCATACTC
ACCTCCCTGCTCTTAAATAGCAGTCAGAGCTCTACTTCTGAGGAGACTGTGCTAAGATCAGATGCCCCTGATAGTACAGGAGATCAACCT
GGACTTCACCAGGACAATTCCTCAAATGGAAAGTCTGAATGGTTGGATCCTTCCCAGAAGTCACCTCTTCATGTTGGAGAGACAAGGAAA
GAGGATGACCCCAATGAGGACTGGTGTGCAGTTTGTCAAAACGGAGGGGAACTCCTCTGCTGTGAAAAGTGCCCCAAAGTATTCCATCTT
TCTTGTCATGTGCCCACATTGACAAATTTTCCAAGTGGAGAGTGGATTTGCACTTTCTGCCGAGACTTATCTAAACCAGAAGTTGAATAT
GATTGTGATGCTCCCAGTCACAACTCAGAAAAAAAGAAAACTGAAGGCCTTGTTAAGTTAACACCTATAGATAAAAGGAAGTGTGAGCGC
CTACTTTTATTTCTTTACTGCCATGAAATGAGCCTGGCTTTTCAAGACCCTGTTCCTCTAACTGTGCCTGATTATTACAAAATAATTAAA
AATCCAATGGATTTGTCAACCATCAAGAAAAGACTACAAGAAGATTATTCCATGTACTCAAAACCTGAAGATTTTGTAGCTGATTTTAGA
TTGATCTTTCAAAACTGTGCTGAATTCAATGAGCCTGATTCAGAAGTAGCCAATGCTGGTATAAAACTTGAAAATTATTTTGAAGAACTT
CTAAAGAACCTCTATCCAGAAAAAAGGTTTCCCAAACCAGAATTCAGGAATGAATCAGAAGATAATAAATTTAGTGATGATTCAGATGAT

>In-frame_BRAF_ENST00000288602_chr7_140624366_-_TRIM24_ENST00000415680_chr7_138258252_+_1413nt
ATGGCGGCGCTGAGCGGTGGCGGTGGTGGCGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGC
GCCGGCGCCGCGGCCTCTTCGGCTGCGGACCCTGCCATTCCGGAGGAGATTGACTGTTCAAGTACTATTATGCTGGACAATATTGTGAGG
AAAGATACTAATATAGATCATGGCCAGCCAAGACCACCCTCAAACAGAACGGTCCAGTCACCAAATTCATCAGTGCCATCTCCAGGCCTT
GCAGGACCTGTTACTATGACTAGTGTACACCCCCCAATACGTTCACCTAGTGCCTCCAGCGTTGGAAGCCGAGGAAGCTCTGGCTCTTCC
AGCAAACCAGCAGGAGCTGACTCTACACACAAAGTCCCAGTGGTCATGCTGGAGCCAATTCGAATAAAACAAGAAAACAGTGGACCACCG
GAAAATTATGATTTCCCTGTTGTTATAGTGAAGCAAGAATCAGATGAAGAATCTAGGCCTCAAAATGCCAATTATCCAAGAAGCATACTC
ACCTCCCTGCTCTTAAATAGCAGTCAGAGCTCTACTTCTGAGGAGACTGTGCTAAGATCAGATGCCCCTGATAGTACAGGAGATCAACCT
GGACTTCACCAGGACAATTCCTCAAATGGAAAGTCTGAATGGTTGGATCCTTCCCAGAAGTCACCTCTTCATGTTGGAGAGACAAGGAAA
GAGGATGACCCCAATGAGGACTGGTGTGCAGTTTGTCAAAACGGAGGGGAACTCCTCTGCTGTGAAAAGTGCCCCAAAGTATTCCATCTT
TCTTGTCATGTGCCCACATTGACAAATTTTCCAAGTGGAGAGTGGATTTGCACTTTCTGCCGAGACTTATCTAAACCAGAAGTTGAATAT
GATTGTGATGCTCCCAGTCACAACTCAGAAAAAAAGAAAACTGAAGGCCTTGTTAAGTTAACACCTATAGATAAAAGGAAGTGTGAGCGC
CTACTTTTATTTCTTTACTGCCATGAAATGAGCCTGGCTTTTCAAGACCCTGTTCCTCTAACTGTGCCTGATTATTACAAAATAATTAAA
AATCCAATGGATTTGTCAACCATCAAGAAAAGACTACAAGAAGATTATTCCATGTACTCAAAACCTGAAGATTTTGTAGCTGATTTTAGA
TTGATCTTTCAAAACTGTGCTGAATTCAATGAGCCTGATTCAGAAGTAGCCAATGCTGGTATAAAACTTGAAAATTATTTTGAAGAACTT
CTAAAGAACCTCTATCCAGAAAAAAGGTTTCCCAAACCAGAATTCAGGAATGAATCAGAAGATAATAAATTTAGTGATGATTCAGATGAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_BRAF_ENST00000288602_chr7_140624366_-_TRIM24_ENST00000343526_chr7_138258252_+_6516nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGATTGACTGTTCAAGTACTATTATGCTGGACAATATTGTGAGGAAAGATACTAATATAGATCATGGCCAGCC
AAGACCACCCTCAAACAGAACGGTCCAGTCACCAAATTCATCAGTGCCATCTCCAGGCCTTGCAGGACCTGTTACTATGACTAGTGTACA
CCCCCCAATACGTTCACCTAGTGCCTCCAGCGTTGGAAGCCGAGGAAGCTCTGGCTCTTCCAGCAAACCAGCAGGAGCTGACTCTACACA
CAAAGTCCCAGTGGTCATGCTGGAGCCAATTCGAATAAAACAAGAAAACAGTGGACCACCGGAAAATTATGATTTCCCTGTTGTTATAGT
GAAGCAAGAATCAGATGAAGAATCTAGGCCTCAAAATGCCAATTATCCAAGAAGCATACTCACCTCCCTGCTCTTAAATAGCAGTCAGAG
CTCTACTTCTGAGGAGACTGTGCTAAGATCAGATGCCCCTGATAGTACAGGAGATCAACCTGGACTTCACCAGGACAATTCCTCAAATGG
AAAGTCTGAATGGTTGGATCCTTCCCAGAAGTCACCTCTTCATGTTGGAGAGACAAGGAAAGAGGATGACCCCAATGAGGACTGGTGTGC
AGTTTGTCAAAACGGAGGGGAACTCCTCTGCTGTGAAAAGTGCCCCAAAGTATTCCATCTTTCTTGTCATGTGCCCACATTGACAAATTT
TCCAAGTGGAGAGTGGATTTGCACTTTCTGCCGAGACTTATCTAAACCAGAAGTTGAATATGATTGTGATGCTCCCAGTCACAACTCAGA
AAAAAAGAAAACTGAAGGCCTTGTTAAGTTAACACCTATAGATAAAAGGAAGTGTGAGCGCCTACTTTTATTTCTTTACTGCCATGAAAT
GAGCCTGGCTTTTCAAGACCCTGTTCCTCTAACTGTGCCTGATTATTACAAAATAATTAAAAATCCAATGGATTTGTCAACCATCAAGAA
AAGACTACAAGAAGATTATTCCATGTACTCAAAACCTGAAGATTTTGTAGCTGATTTTAGATTGATCTTTCAAAACTGTGCTGAATTCAA
TGAGCCTGATTCAGAAGTAGCCAATGCTGGTATAAAACTTGAAAATTATTTTGAAGAACTTCTAAAGAACCTCTATCCAGAAAAAAGGTT
TCCCAAACCAGAATTCAGGAATGAATCAGAAGATAATAAATTTAGTGATGATTCAGATGATGACTTTGTACAGCCCCGGAAGAAACGCCT
CAAAAGCATTGAAGAACGCCAGTTGCTTAAATAATATGCAGCACCACTAGCTTGTGCTGGTTTTTAGATTTTTTTGTTTTCAAAAAAACA
TTTGTCAGTAATTTAACATCACTACAAAAAGAAGAGTTTGTGACTATTCTCATCTCTGTTTTGGACGTTTACTAGACTTTGATTTCCTTA
ATAGCCCATTTCTGTTAACCTCTTATCACTAAGAAAGAAAGGAAAGAAGGAGATGAATAGAAGAAAGAAAATGGAAAGAAGGAAAAAAGG
AGGATAGAAAAAGGATGGAAGAAAGAAGCATTGAAAACAAAGACATTCTTCCCACTTCTTGGATTTTTAAACCACAGTCTGGAGTGATAG
CTACTGTAGAAAGGAAATAGACTTTGTATGAACTCTTTAAGTTGAAAAGTAAAAAATATATGTGGTTTGGATGTGTGCTTTAATTCAGCT
TTAGAAATTAATACCACTACCCGTGAATTATATGGCCTGACAATATGAATTAGGTGTACTGTACTGAAGAACAGTACTCCACAAACATGG
GTGGTAACAAGAGTTCCATCCCAGGAGGCCAAACGGTGCAACAGAAGGGTAGGTTAGATGCTATTAAGAAGGCACTTAATAGTACATCAT
GTAAGATGGCAACTGTATTAAAGAAAAATCCGGAAAACAAATGTTTGATTTTTGTTTTTGTTTTTATCTTGTCTGTAGAGGTATTTTGGT
ATAGCAGGTTTTCAAGGCCATTTTTTATACATTTCTAGATCTAGATTTTCAACTTCTTCCACTGAGGGAAGTATATACATTTGGGTTTGC
TGTGTGTCTATGTGAGGTTTAATTGTACAGGTGATCCTTTTACAACAAGCCTCATTGTTTGCAGTATAGCTTTTAGTGGAACTACCCAAA
ATATAAATACAGCAGCGTGCACTGTATTTGATGTGAGGGTTCTTCATCATATACCCTACTGGGCATTAAATATAAGTTCCTCTGAAAGGG
ACTCGTTTTTGTGGTTTTCATCTGTCTATAATTTGGAATGAAAATGTGTTGTAGGATTTTGGGAGCAGGCAGCTGGGGGGAATTAATAGT
GATTTTTTTTTTTTCCTGAAGCATCTATCTCATGTTTTTCTTTTGAGAGTCAGAACATCAAACTTAATCTTTGATCTGACTTCTGATTTT
ATTCTTCTGATTGATTGATAGAGGTACAAAAGACTTATCTTCTGAGGACAAGCATATTCTTAATGTGCCAGACCTACCCGGTTCAGCTGA
TATAGATAGATAGATAGATAGAAGAAAATTGCTGTGCCATACATTAATCCAGCATTTGACACAATATCTAAATGGTTTGCCGAAGTTAAT
CTGTATTTATAAAACATTAACTGGAGTAAATTTTTCTCCTTAGGATGATAGAATAAAAAGAGCTCACTTGAAAGAAGGCTATTATTTGCA
TTATATCACCTGCCATAAATTTAACATAGAAGACTTGGTTTTATCTACATGGCTTTACTTCTTAAAGTGGAAAATATCCTGTGGCTAATT
CATTGGGTTTTCAGGTACTGCTAAAGATAAAATACAGGGAGAAAATAACTTGTTAGCAATAGATCCCCATTGTTTATATATATAGGTCTT
GTTCATAATATGTCAATTATGTATTGTTAAAAAGTCCTACTCACTTTTCAAATATGTGTTACATGGTAATGTTTGTCATTGTTGTTTTAA
AGTTGCATTTGACATTTGTTCTCCAAAGAGTGTTTGAACAGATTTTGATAACAGTGCATACACCTTTTGTCTTTTTTTGCTCCAGCATTT
TATTTTTAGCACAGCAGCTGTGGAGCTTTTGCTGATAATTTTATTGTTGGTATCTTAGAATACTGTTCGTCTGACAGTTTATTCTTCCAT
ACTTGTCTCCCAAGTTAAAACAGAGCAAAACAGATAAATTATTTTGAGAATCATCACAAAAGGGAGTTAGAACTTGTGAGACTAAAACTA
TAATTTCCTAAATGTGACTAATGAACCCCAAACTGTCACTATTACATTCAGTGCCATATTTATCTTTCAAAACAGTATTTGTTTCACCCT
AACCATCTTTGGCTGAATGAAAGGCAGTTGAGAACCATCTTTTGGTCATACATAATATAATTATATTAAAAGTAAAGATCGGGGCTGGGC
GCAGTGGCTCACACCTGCAATCCCACCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACAAAGTCAAGAGTTCGAGATCAGCCTGGCCAA
CATTGTGAAACCCCGCCTCTACAAAAAATACAAAAATTAGCCGGACATGGTGGCGTGCAACTGTAATCCCAACTACTCAGGAGGCTGAGA
CAGGAGAATCACTTGAACGCAGGAGGCAGAAGTTGCAGTGAGCCAAGATCTCACCATTGCACTCCAGCCTGAGTGACAGAGACTCAGTCT
CAAAAACAAAAAGTAAAGGTCTTGGGTTTCTCTCTGTAAATAGCCTTTGTGTAATGGTCTTTAGATTAATATCCTTTGACTTTATTAATA
AGTACCTGTGTGCCCAGGTGGATCTCAGCTAAGTCATCCTTAAATTCTGTTCAAATAGAAATAAACCATAAAATGAGCCTAACTATAACC
CACACTCACTTATCAAGCATTCCCCCAAAAGTTCAGTGCGATTCAGGTAACCTTGACCTAAACTTGTACACTCCGGTGTACATCTTTGAC
CATAAACTCTGGGAGATTTCCCTCTGGATTTGGGATCAGGAGCCCAGTAGGGCCCCATTGCTGAATGTTTATCACACTTCTGGCTAGGGC
TTATGGATGAGCAGACCACGTAGGAGCTAGGATTTACTCAGTTCCACCTCACTGACAGCTTTTCTAGGTGCCAAGCAACTGACTTTTCCT
GTGTAAGGAAGCCCAAGTACTTGACCAGTGATATATATGGCCATGGCAAAAGTATAAATGGATGGATGTAGACCATATTCAACGCAGAAT
ACATTTTAGATCGGTATCTGGCATTGTAATCATTTTGTCTTTTGAATTAACATGCCCTGCTTGTCTTTTCTGAATGGAAGGGTAGGAAAG
TGGAAGGTACTAAAAAGGAAAATGTAGTTTTAGTTTCTTTTCTAAGCTAAAGAACTGGCTTTACTACTGCTATATTTTACTACCACATAG
TAGTGTAGATGTAGTATAACTTGCTTAGGAATGCTTTCAAAAAGGTTACCTCCATAGTCAAAAAAAGGGGGAGTATACAGCTGATTGTTG
CATTTATGAAACTGCATTTCAATATGCTATGCTGTTACTGTGCTTAGACACTTCCTTACGTTTGAGTTCCAAGGAGAGAGAGTGAGAAGA
GGAACTCCTTTTGCTGAGCTCTGGTCCAAATTAATGTGAATCCCCAAAGTAAATTGCTGCATATGAACAACAGGTTTTAGGTTTAAATTG
AAGATACATTCATTTTATATGTATTTGTTGTGAATGAGAGAAATTGAGTGATCTGATTGGCCATTAAAATTATGGTGAATGGGTCGGGCG
CAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTAGATACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACAT
GGTGAAACCCCATCTCTACTAAAAATACCAAAATCACCAGGGTGTGGTGGCCCATGCCTGTAATCCTAGCTACTCGGGAGGCTGAGGCAG
GAGAATCGGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGTAGTCCAGCCTGGGTGTCAGAGCAAGACTCTGT
CACAAAAAGAAAAATTATGGGGAATGGCCGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACC
TGAAGTCAGGAGCTCAAGACCAGCCTGGCCAACATGGTGAAACCCCACCTCAACAGAATATACAAAAAAATTAGCTGGGTGTGGTGGCGG
GTGCCTGTAATCTCAGCTACTTTGGGATGCTGAGGCAGGAGAATAGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGTCGAGATTGCACC
ATTGCACTCCAGCCTGGGCAACAAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAAATGGTGACCATGCGTTCAACCATATAATTTCTTAC
TGAAATTGAGCTCCTCCTTTTGAATAACCATGTACATATTTTTAAAAGTATTTTATAGCCCTATGTAAATTAATAGTTGATGTCTTTTTA
TAAATGTTTATTGCATATTCATCTTGAATGTGAATTTACTGTTGTAATTCACATACTGGTGTCATGTTTCTGAGTGAGAATAATGCTAGT
CAGTCAGATCACAGATTTTTCTCCATGAAGGTTTTACTTATTGAGAGGGACATCTGAGGCAGTAGTCTTCGTCTTTAATTTTTGGGGGCA
GATTGGTGCTTTGGTTTTAATAAAAACTAACTTTGATGGATTTTTACTGTCAATATTTTACCACAAGGATTTTTTAATAGAAAAATTACT
GAATGTTACTTCAGCAGAGTTCTATCTACTTTGAGTCTCCATTACTACTACTGTTGTTCCCCTAGCTGTAACATTGATCCATATAGGGGC
AAGCTACTAGTCCATAAATAGCTGTAATAGGAAAACAGTTTTTTAAAATTCTAACACGTGTATTTCACCAGCCTTAAAAGATTTAAAAAA
AAATCTGACAGGAAGGAAAGCGGGTGGTAAGTATCTTGGATTATTCTGCCTCATACCAGCCACTCCCAAAGTAGGAGGACCAAAGATGCC
ATGAAGACTTCTAGTTGTCTGGAAGTTATTTGGGGAAGGGGGGAAAGACACAGAGTGGGGACCTTTGGAAGTCATTTTAAAAATTTAGCT
ATGTTAATTCCACTTGTAAAGTTTGAAAGGTTTTGATTCTTGTAATTTCTGAGAATTACTATGTTTTAAATTTACTATTGGATATTTAAC
AGATCTTTCATGGGGCCAACCTATTTGCTTCCTTAATTTTCAAATTAAGTCCTAATTTGAGTCCTAAAAAAATCTTTCCTTGTTAGTTGC

>In-frame_BRAF_ENST00000288602_chr7_140624366_-_TRIM24_ENST00000415680_chr7_138258252_+_2108nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGATTGACTGTTCAAGTACTATTATGCTGGACAATATTGTGAGGAAAGATACTAATATAGATCATGGCCAGCC
AAGACCACCCTCAAACAGAACGGTCCAGTCACCAAATTCATCAGTGCCATCTCCAGGCCTTGCAGGACCTGTTACTATGACTAGTGTACA
CCCCCCAATACGTTCACCTAGTGCCTCCAGCGTTGGAAGCCGAGGAAGCTCTGGCTCTTCCAGCAAACCAGCAGGAGCTGACTCTACACA
CAAAGTCCCAGTGGTCATGCTGGAGCCAATTCGAATAAAACAAGAAAACAGTGGACCACCGGAAAATTATGATTTCCCTGTTGTTATAGT
GAAGCAAGAATCAGATGAAGAATCTAGGCCTCAAAATGCCAATTATCCAAGAAGCATACTCACCTCCCTGCTCTTAAATAGCAGTCAGAG
CTCTACTTCTGAGGAGACTGTGCTAAGATCAGATGCCCCTGATAGTACAGGAGATCAACCTGGACTTCACCAGGACAATTCCTCAAATGG
AAAGTCTGAATGGTTGGATCCTTCCCAGAAGTCACCTCTTCATGTTGGAGAGACAAGGAAAGAGGATGACCCCAATGAGGACTGGTGTGC
AGTTTGTCAAAACGGAGGGGAACTCCTCTGCTGTGAAAAGTGCCCCAAAGTATTCCATCTTTCTTGTCATGTGCCCACATTGACAAATTT
TCCAAGTGGAGAGTGGATTTGCACTTTCTGCCGAGACTTATCTAAACCAGAAGTTGAATATGATTGTGATGCTCCCAGTCACAACTCAGA
AAAAAAGAAAACTGAAGGCCTTGTTAAGTTAACACCTATAGATAAAAGGAAGTGTGAGCGCCTACTTTTATTTCTTTACTGCCATGAAAT
GAGCCTGGCTTTTCAAGACCCTGTTCCTCTAACTGTGCCTGATTATTACAAAATAATTAAAAATCCAATGGATTTGTCAACCATCAAGAA
AAGACTACAAGAAGATTATTCCATGTACTCAAAACCTGAAGATTTTGTAGCTGATTTTAGATTGATCTTTCAAAACTGTGCTGAATTCAA
TGAGCCTGATTCAGAAGTAGCCAATGCTGGTATAAAACTTGAAAATTATTTTGAAGAACTTCTAAAGAACCTCTATCCAGAAAAAAGGTT
TCCCAAACCAGAATTCAGGAATGAATCAGAAGATAATAAATTTAGTGATGATTCAGATGATGACTTTGTACAGCCCCGGAAGAAACGCCT
CAAAAGCATTGAAGAACGCCAGTTGCTTAAATAATATGCAGCACCACTAGCTTGTGCTGGTTTTTAGATTTTTTTGTTTTCAAAAAAACA
TTTGTCAGTAATTTAACATCACTACAAAAAGAAGAGTTTGTGACTATTCTCATCTCTGTTTTGGACGTTTACTAGACTTTGATTTCCTTA
ATAGCCCATTTCTGTTAACCTCTTATCACTAAGAAAGAAAGGAAAGAAGGAGATGAATAGAAGAAAGAAAATGGAAAGAAGGAAAAAAGG
AGGATAGAAAAAGGATGGAAGAAAGAAGCATTGAAAACAAAGACATTCTTCCCACTTCTTGGATTTTTAAACCACAGTCTGGAGTGATAG
CTACTGTAGAAAGGAAATAGACTTTGTATGAACTCTTTAAGTTGAAAAGTAAAAAATATATGTGGTTTGGATGTGTGCTTTAATTCAGCT
TTAGAAATTAATACCACTACCCGTGAATTATATGGCCTGACAATATGAATTAGGTGTACTGTACTGAAGAACAGTACTCCACAAACATGG
GTGGTAACAAGAGTTCCATCCCAGGAGGCCAAACGGTGCAACAGAAGGGTAGGTTAGATGCTATTAAGAAGGCACTTAATAGTACATCAT


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FusionGenePPI for BRAF_TRIM24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BRAFYWHAB, YWHAG, YWHAQ, YWHAZ, SFN, HRAS, AKT1, MAPK3, RAP1GAP, RAF1, MRAS, RAP1A, PAK2, TERF1, CCDC88A, NEDD4L, MAP2K1, RNF149, KSR1, BRAP, PRKCE, RPS6KB2, HSP90AA1, BRAF, YWHAE, HSPA5, MAP2K2, HSPA1A, HSPA8, YWHAH, HSPA9, ARAF, CDC37, HSP90AB1, PHKB, LIMK1, IQGAP1, MAPK1, BAD, LIPF, MUS81, FBXW7, FGFR2, BRCA2, VHL, FNTA, HDAC2, PIK3CA, EGFR, PTEN, FNIP1, FNIP2, RAB3GAP1, KRAS, KIAA0141, FKBPL, ARMCX3, KCNC4, RPTOR, CYLD, NRASTRIM24ZNF10, TRIM28, TRIM24, PML, NR3C2, ESR1, THRA, RARA, RXRA, NR3C1, AR, TRIM33, GTF2E1, TAF7, TAF11, UBE2U, ATF4, NFE2L2, STAT6, FOSL1, ESR2, PPARG, TP53, BRD7, HIST1H3A, HIST1H3D, HIST1H3C, HIST1H3E, HIST1H3I, HIST1H3G, HIST1H3J, HIST1H3H, HIST1H3B, HIST1H3F, HIST2H4B, HIST1H4I, HIST1H4A, HIST1H4D, HIST1H4F, HIST1H4K, HIST1H4C, HIST1H4H, HIST1H4B, HIST1H4E, HIST1H4L, HIST2H4A, HIST1H4J, HIST4H4, NCOA1, NONO, CDK12, SNRPA, SF3B2, SF3B1, RNF141, RNF181, TRIM8, BRCA1, RNF2, MAGEA10, RFPL4B, QPRT, HSPB1, NTRK1, MUS81, PTEN, TCF4, FOXI1, USP37, NANOG, ZNF264, ZNF483, ZNF324B, WDYHV1, ZNF695, ZIM2, SYCE3, ZNF764, ZNF785, ZNF331, ZNF133, ZNF254, ZNF550, CDC16, CNKSR1, MTNR1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneTRIM24chr7:140624366chr7:138258252ENST00000343526+1019834_8406261051histone H3 that is not methylated at 'Lys-4' (H3K4me0)
TgeneTRIM24chr7:140624366chr7:138258252ENST00000415680+1019834_8405921017histone H3 that is not methylated at 'Lys-4' (H3K4me0)


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BRAF_TRIM24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneBRAFP15056DB08881VemurafenibSerine/threonine-protein kinase B-rafsmall moleculeapproved
HgeneBRAFP15056DB08896RegorafenibSerine/threonine-protein kinase B-rafsmall moleculeapproved
HgeneBRAFP15056DB00398SorafenibSerine/threonine-protein kinase B-rafsmall moleculeapproved|investigational
HgeneBRAFP15056DB08912DabrafenibSerine/threonine-protein kinase B-rafsmall moleculeapproved|investigational

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RelatedDiseases for BRAF_TRIM24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRAFC0025202melanoma21CTD_human
HgeneBRAFC1527249Colorectal Cancer8UNIPROT
HgeneBRAFC1275081Cardio-facio-cutaneous syndrome6CTD_human;ORPHANET;UNIPROT
HgeneBRAFC0009404Colorectal Neoplasms4CTD_human
HgeneBRAFC0040136Thyroid Neoplasm4CTD_human
HgeneBRAFC0024305Lymphoma, Non-Hodgkin3UNIPROT
HgeneBRAFC0684249Carcinoma of lung3UNIPROT
HgeneBRAFC3150970NOONAN SYNDROME 73CTD_human;UNIPROT
HgeneBRAFC0152013Adenocarcinoma of lung (disorder)2CTD_human
HgeneBRAFC0002448Ameloblastoma1CTD_human
HgeneBRAFC0004114Astrocytoma1CTD_human
HgeneBRAFC0010276Craniopharyngioma1CTD_human;ORPHANET
HgeneBRAFC0017638Glioma1CTD_human
HgeneBRAFC0022665Kidney Neoplasm1CTD_human
HgeneBRAFC0023903Liver neoplasms1CTD_human
HgeneBRAFC0024694Mandibular Neoplasms1CTD_human
HgeneBRAFC0028326Noonan Syndrome1CTD_human;ORPHANET
HgeneBRAFC0033578Prostatic Neoplasms1CTD_human
HgeneBRAFC0036920Sezary Syndrome1CTD_human
HgeneBRAFC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
HgeneBRAFC0206686Adrenocortical carcinoma1CTD_human
HgeneBRAFC0206754Neuroendocrine Tumors1CTD_human
HgeneBRAFC0238463Papillary thyroid carcinoma1CTD_human;ORPHANET
HgeneBRAFC0587248Costello syndrome (disorder)1CTD_human
HgeneBRAFC0596263Carcinogenesis1CTD_human
HgeneBRAFC0920269Microsatellite Instability1CTD_human
HgeneBRAFC2239176Liver carcinoma1CTD_human
TgeneTRIM24C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTRIM24C2239176Liver carcinoma1CTD_human