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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43686

FusionGeneSummary for ZNF76_ANKS1A

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF76_ANKS1A
Fusion gene ID: 43686
HgeneTgene
Gene symbol

ZNF76

ANKS1A

Gene ID

7629

23294

Gene namezinc finger protein 76ankyrin repeat and sterile alpha motif domain containing 1A
SynonymsD6S229E|ZNF523|Zfp523ANKS1
Cytomap

6p21.31

6p21.31

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 76zinc finger protein 523zinc finger protein 76 (expressed in testis)ankyrin repeat and SAM domain-containing protein 1AOdinankyrin repeat and SAM domain containing 1
Modification date2018051920180522
UniProtAcc

P36508

Q92625

Ensembl transtripts involved in fusion geneENST00000373953, ENST00000440666, 
ENST00000339411, ENST00000482946, 
ENST00000360359, ENST00000535627, 
ENST00000470698, 
Fusion gene scores* DoF score1 X 2 X 1=226 X 6 X 14=2184
# samples 128
** MAII scorelog2(1/2*10)=2.32192809488736log2(28/2184*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF76 [Title/Abstract] AND ANKS1A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF76

GO:0045944

positive regulation of transcription by RNA polymerase II

10893243


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-BA-6871-01AZNF76chr6

35263760

+ANKS1Achr6

34977682

+
TCGALDHNSCTCGA-BA-6871-01AZNF76chr6

35227504

+ANKS1Achr6

34985250

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000373953ENST00000360359ZNF76chr6

35263760

+ANKS1Achr6

34977682

+
5CDS-intronENST00000373953ENST00000535627ZNF76chr6

35263760

+ANKS1Achr6

34977682

+
5CDS-intronENST00000373953ENST00000470698ZNF76chr6

35263760

+ANKS1Achr6

34977682

+
5CDS-intronENST00000440666ENST00000360359ZNF76chr6

35263760

+ANKS1Achr6

34977682

+
5CDS-intronENST00000440666ENST00000535627ZNF76chr6

35263760

+ANKS1Achr6

34977682

+
5CDS-intronENST00000440666ENST00000470698ZNF76chr6

35263760

+ANKS1Achr6

34977682

+
5CDS-intronENST00000339411ENST00000360359ZNF76chr6

35263760

+ANKS1Achr6

34977682

+
5CDS-intronENST00000339411ENST00000535627ZNF76chr6

35263760

+ANKS1Achr6

34977682

+
5CDS-intronENST00000339411ENST00000470698ZNF76chr6

35263760

+ANKS1Achr6

34977682

+
intron-intronENST00000482946ENST00000360359ZNF76chr6

35263760

+ANKS1Achr6

34977682

+
intron-intronENST00000482946ENST00000535627ZNF76chr6

35263760

+ANKS1Achr6

34977682

+
intron-intronENST00000482946ENST00000470698ZNF76chr6

35263760

+ANKS1Achr6

34977682

+
5UTR-3CDSENST00000373953ENST00000360359ZNF76chr6

35227504

+ANKS1Achr6

34985250

+
5UTR-intronENST00000373953ENST00000535627ZNF76chr6

35227504

+ANKS1Achr6

34985250

+
5UTR-intronENST00000373953ENST00000470698ZNF76chr6

35227504

+ANKS1Achr6

34985250

+
intron-3CDSENST00000440666ENST00000360359ZNF76chr6

35227504

+ANKS1Achr6

34985250

+
intron-intronENST00000440666ENST00000535627ZNF76chr6

35227504

+ANKS1Achr6

34985250

+
intron-intronENST00000440666ENST00000470698ZNF76chr6

35227504

+ANKS1Achr6

34985250

+
intron-3CDSENST00000339411ENST00000360359ZNF76chr6

35227504

+ANKS1Achr6

34985250

+
intron-intronENST00000339411ENST00000535627ZNF76chr6

35227504

+ANKS1Achr6

34985250

+
intron-intronENST00000339411ENST00000470698ZNF76chr6

35227504

+ANKS1Achr6

34985250

+
intron-3CDSENST00000482946ENST00000360359ZNF76chr6

35227504

+ANKS1Achr6

34985250

+
intron-intronENST00000482946ENST00000535627ZNF76chr6

35227504

+ANKS1Achr6

34985250

+
intron-intronENST00000482946ENST00000470698ZNF76chr6

35227504

+ANKS1Achr6

34985250

+

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FusionProtFeatures for ZNF76_ANKS1A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF76

P36508

ANKS1A

Q92625

May be involved in transcriptional regulation. Regulator of different signaling pathways. RegulatesEPHA8 receptor tyrosine kinase signaling to control cell migrationand neurite retraction (By similarity). {ECO:0000250,ECO:0000269|PubMed:17875921}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF76_ANKS1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF76_ANKS1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF76TBP, PIAS1, ELAVL1, CAND1, EP300, HDAC1, SMAD1, SHMT2, MOV10, NXF1, GRHL1, ZBTB1ANKS1AYWHAG, SFN, UBC, EPHA8, EGFR, ERBB2, ERBB4, BAG3, YWHAB, DNPEP, PACSIN2, PTPN12, TRIM47, DEF6, PIK3R3, ARHGAP10, DOK3, KLF15, NHLRC2, TRIT1, RANBP3, RB1, SMARCD1, RIN1, DAB2IP, HIF1AN, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF76_ANKS1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF76_ANKS1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneANKS1AC1956346Coronary Artery Disease1CTD_human