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Fusion gene ID: 43680 |
FusionGeneSummary for ZNF761_TBC1D4 |
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Fusion gene information | Fusion gene name: ZNF761_TBC1D4 | Fusion gene ID: 43680 | Hgene | Tgene | Gene symbol | ZNF761 | TBC1D4 | Gene ID | 388561 | 9882 |
Gene name | zinc finger protein 761 | TBC1 domain family member 4 | |
Synonyms | ZNF468 | AS160|NIDDM5 | |
Cytomap | 19q13.42 | 13q22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 761zinc finger protein 468 | TBC1 domain family member 4TBC (Tre-2, BUB2, CDC16) domain-containing proteinakt substrate of 160 kDa | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O60343 | ||
Ensembl transtripts involved in fusion gene | ENST00000454407, | ENST00000377636, ENST00000431480, ENST00000425511, ENST00000377625, ENST00000478591, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 2=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZNF761 [Title/Abstract] AND TBC1D4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CB218472 | ZNF761 | chr19 | 53948691 | + | TBC1D4 | chr13 | 75866240 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000454407 | ENST00000377636 | ZNF761 | chr19 | 53948691 | + | TBC1D4 | chr13 | 75866240 | - |
intron-intron | ENST00000454407 | ENST00000431480 | ZNF761 | chr19 | 53948691 | + | TBC1D4 | chr13 | 75866240 | - |
intron-intron | ENST00000454407 | ENST00000425511 | ZNF761 | chr19 | 53948691 | + | TBC1D4 | chr13 | 75866240 | - |
intron-intron | ENST00000454407 | ENST00000377625 | ZNF761 | chr19 | 53948691 | + | TBC1D4 | chr13 | 75866240 | - |
intron-intron | ENST00000454407 | ENST00000478591 | ZNF761 | chr19 | 53948691 | + | TBC1D4 | chr13 | 75866240 | - |
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FusionProtFeatures for ZNF761_TBC1D4 |
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Hgene | Tgene |
ZNF761 | TBC1D4 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | May act as a GTPase-activating protein for RAB2A, RAB8A,RAB10 and RAB14. Isoform 2 promotes insulin-induced glucosetransporter SLC2A4/GLUT4 translocation at the plasma membrane,thus increasing glucose uptake. {ECO:0000269|PubMed:15971998,ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF761_TBC1D4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF761_TBC1D4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF761_TBC1D4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF761_TBC1D4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |