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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43675

FusionGeneSummary for ZNF746_SMIM3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF746_SMIM3
Fusion gene ID: 43675
HgeneTgene
Gene symbol

ZNF746

SMIM3

Gene ID

155061

85027

Gene namezinc finger protein 746small integral membrane protein 3
SynonymsPARISC5orf62|MST150|NID67
Cytomap

7q36.1

5q33.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 746parkin-interacting substrateparkin-interacting sustratesmall integral membrane protein 3NGF-induced differentiation clone 67 proteinUncharacterized protein C5orf62small membrane protein NID67
Modification date2018052520180519
UniProtAcc

Q6NUN9

Q9BZL3

Ensembl transtripts involved in fusion geneENST00000340622, ENST00000458143, 
ENST00000461958, 
ENST00000526627, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: ZNF746 [Title/Abstract] AND SMIM3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF746

GO:0000122

negative regulation of transcription by RNA polymerase II

21376232

HgeneZNF746

GO:0045892

negative regulation of transcription, DNA-templated

21376232

HgeneZNF746

GO:0045944

positive regulation of transcription by RNA polymerase II

21376232

HgeneZNF746

GO:1901216

positive regulation of neuron death

21376232


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU655959ZNF746chr7

149194604

-SMIM3chr5

150174991

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000340622ENST00000526627ZNF746chr7

149194604

-SMIM3chr5

150174991

+
5CDS-5UTRENST00000458143ENST00000526627ZNF746chr7

149194604

-SMIM3chr5

150174991

+
5CDS-5UTRENST00000461958ENST00000526627ZNF746chr7

149194604

-SMIM3chr5

150174991

+

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FusionProtFeatures for ZNF746_SMIM3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF746

Q6NUN9

SMIM3

Q9BZL3

Transcription repressor that specifically binds to the5'-TATTTT[T/G]-3' consensus sequence on promoters and represstranscription of PGC-1-alpha (PPARGC1A), thereby playing a role inregulation of neuron death. {ECO:0000269|PubMed:21376232}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF746_SMIM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF746_SMIM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF746PARK2, HMOX2, GSK3B, EPHA8, ILK, FAM118B, MAP3K7, FES, DUSP23, PRKRA, RPS6KA6, DIABLO, ZAK, ELAVL1, PPP2R2C, RPL23AP5, MYO1C, POLRMT, IGF2BP3, NOP56, DDX3X, IRS4, EIF3D, DHX15, PSMD3, HNRNPR, TIMM44, AP1G1, MYO1B, SYNCRIP, CPNE3, DNAJB6, NDUFS3, SNRNP200, SLC25A12, SRP72, MYO1D, PRPF6, UBR5, PGM3, AHSA1, AP2A1, AIFM1, LDHA, GLUD1, COX2, PGK1, RPN1, RPN2, ATP1A1, SLC25A5, PCCA, PCCB, RPLP2, RPLP0, CDK1, ATP5B, NPM1, LDHB, PFKM, HSP90AB1, CYC1, RPS17, RPSA, TPM1, PARP1, PDHB, PC, MTHFD1, SLC25A4, ACTN1, XRCC5, EEF2, PKM, HSP90B1, RPS2, HIST1H1C, ATP2A2, YBX3, PFKL, TCP1, RPL7, MYL12A, NCL, FBL, RPS4Y1, UQCRC2, SFPQ, MCM3, RPS12, ATP5A1, RPL13, RPL10, CAD, ABCD3, POLD1, ALDH1B1, HIST1H2BB, RFC4, COPB2, MYH11, ATP5C1, RPL4, SRP14, RBMX, RPL3, CCT6A, RPL13A, RFC5, HADHA, IARS, SKIV2L2, LRPPRC, RPL35, MSH2, NOP2, RPL27A, RPL5, RPL21, RPL28, RPS9, ATP5O, IDH2, RPL34, FASN, CCT3, TUFM, RANBP2, RPL14, CCT4, DAP3, GALK1, HNRNPM, HNRNPF, MSH6, SLC25A1, ACLY, COPA, HADHB, NPEPPS, EIF3B, MARS, NUP107, EIF3E, PSMC1, RPS15A, RPS23, RPL7A, RPS6, RPL23, RPS24, PRKDC, MRPS34, MRPS9, SRSF3, SLC25A3, CLTC, U2AF1, HIST1H1A, RPL6, SLC25A11, CEBPZ, UBE3A, RPL18, SRSF1, DHX9, NUP160, ILF2, ILF3, TARDBP, PSMD2, TRIM28, PABPC4, EIF3I, MOGS, BYSL, EIF3A, DYNC1H1, TRIM25, RBM39, SART3, EFTUD2, NONO, PWP2, SF3B3, SKIV2L, DDB1, SMN1, HIST3H3, RPL10A, TIMM50, RPS11, PHB, GNB2L1, RPL8, PTCD3, PPP6R3, RRP12, TUBB2A, RPS16, ZNF746, MRPL14, PRPF8, SFXN4, TTC37, ZNF783, CYFIP1, RPS27L, DHX30, MYH14, ACACA, CAND1, DHX37, FTSJ3, ABI1, LRRC47, ADCK3, RPS4Y2, DDX54, NOC3L, PRPF31, DNAJC9, H1FX, MRPS27, WASF1, GCN1L1, MRPS31, USP9X, TBL3, AP2M1, OTUB1, DDX27, PGAM5, RPL10L, IPO9, MCCC1, CDC5L, PHB2, MYBBP1A, NTPCR, TUBGCP2, GNL3, NAA15, POLDIP3, OSBPL8, PABPC3, UNC45A, SENP3, NOL6, C14orf169, SFXN1, MOV10, DDX21, FAM207A, ATAD3A, RBM28, LYAR, NSUN2, FAM120A, IGF2BP1, RAI14, RPS15, ZNF212, ZNF282, SRP68, PUF60, SLC25A13, MRTO4, AKAP8L, MAGED2, DIMT1, RPL26L1, WDR3, EIF3L, FARSA, NCKAP1, MRPS28, MRPS17, WBP11, NOP58, MRPS2, MRPL11, MRPS23, NOC2L, RPL36, LAS1L, IGF2BP2, KLHL40, ZNF398, ZNF324BSMIM3BSCL2, ATP6V0C, EMP1, MAL, PMP22, PNMA1, CLEC7A, LZTS2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF746_SMIM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF746_SMIM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource