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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43672

FusionGeneSummary for ZNF738_KIF1B

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF738_KIF1B
Fusion gene ID: 43672
HgeneTgene
Gene symbol

ZNF738

KIF1B

Gene ID

148203

23095

Gene namezinc finger protein 738kinesin family member 1B
Synonyms-CMT2|CMT2A|CMT2A1|HMSNII|KLP|NBLST1
Cytomap

19p12

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionprotein ZNF738kinesin-like protein KIF1Bkinesin superfamily protein KIF1B
Modification date2018052220180523
UniProtAcc

Q8NE65

O60333

Ensembl transtripts involved in fusion geneENST00000311015, ENST00000380870, 
ENST00000597810, ENST00000594245, 
ENST00000377093, ENST00000263934, 
ENST00000377086, ENST00000377083, 
ENST00000377081, ENST00000465635, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 7 X 6=294
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/294*10)=-1.877744249949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF738 [Title/Abstract] AND KIF1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA666479ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000311015ENST00000377093ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
5CDS-5UTRENST00000311015ENST00000263934ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
5CDS-5UTRENST00000311015ENST00000377086ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
5CDS-5UTRENST00000311015ENST00000377083ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
5CDS-5UTRENST00000311015ENST00000377081ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
5CDS-intronENST00000311015ENST00000465635ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
5CDS-5UTRENST00000380870ENST00000377093ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
5CDS-5UTRENST00000380870ENST00000263934ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
5CDS-5UTRENST00000380870ENST00000377086ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
5CDS-5UTRENST00000380870ENST00000377083ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
5CDS-5UTRENST00000380870ENST00000377081ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
5CDS-intronENST00000380870ENST00000465635ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
5CDS-5UTRENST00000597810ENST00000377093ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
5CDS-5UTRENST00000597810ENST00000263934ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
5CDS-5UTRENST00000597810ENST00000377086ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
5CDS-5UTRENST00000597810ENST00000377083ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
5CDS-5UTRENST00000597810ENST00000377081ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
5CDS-intronENST00000597810ENST00000465635ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
intron-5UTRENST00000594245ENST00000377093ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
intron-5UTRENST00000594245ENST00000263934ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
intron-5UTRENST00000594245ENST00000377086ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
intron-5UTRENST00000594245ENST00000377083ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
intron-5UTRENST00000594245ENST00000377081ZNF738chr19

21558767

+KIF1Bchr1

10292306

+
intron-intronENST00000594245ENST00000465635ZNF738chr19

21558767

+KIF1Bchr1

10292306

+

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FusionProtFeatures for ZNF738_KIF1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF738

Q8NE65

KIF1B

O60333

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF738_KIF1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF738_KIF1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF738TRIM28KIF1BBRCA1, STARD13, EEF1A1, GIPC1, YWHAG, CALM1, ELAVL1, KIAA0368, YWHAE, APP, PIK3C3, YWHAB, C18orf25, SEC24A, SIAH1, TRAK2, PSMC3, NINL, CSNK2A2, MAGEA1, UBE2I, YWHAH, RBM7, PARD6A, THOC2, SMC6, VPS26B, ZSCAN26, KIF1A, BIN2, CETN1, KIAA1279, VPS33B, VIPAS39, GOPC, PLOD1, PDF, PPP4R1, CAV3, TULP2, EIF4A1, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, CGN, DENND1A, SH3PXD2A, SRGAP2, RTKN, MAST3, EIF4E2, CBY1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF738_KIF1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF738_KIF1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKIF1BC0026769Multiple Sclerosis1CTD_human
TgeneKIF1BC1861678Charcot-Marie-Tooth Disease, Axonal, Type 2a11CTD_human;ORPHANET;UNIPROT