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Fusion gene ID: 43668 |
FusionGeneSummary for ZNF732_DAB1 |
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Fusion gene information | Fusion gene name: ZNF732_DAB1 | Fusion gene ID: 43668 | Hgene | Tgene | Gene symbol | ZNF732 | DAB1 | Gene ID | 654254 | 115209 |
Gene name | zinc finger protein 732 | OMA1 zinc metallopeptidase | |
Synonyms | - | 2010001O09Rik|DAB1|MPRP-1|MPRP1|YKR087C|ZMPOMA1|peptidase | |
Cytomap | 4p16.3 | 1p32.2-p32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 732zinc finger protein LOC654254 | metalloendopeptidase OMA1, mitochondrialOMA1 homolog, zinc metallopeptidaseOMA1 zinc metallopeptidase homologmetalloprotease-related protein 1overlapping activity with M-AAA proteaseoverlapping with the m-AAA protease 1 homologzinc metallopeptidase | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | B4DXR9 | O75553 | |
Ensembl transtripts involved in fusion gene | ENST00000419098, | ENST00000485760, ENST00000371236, ENST00000371234, ENST00000420954, ENST00000439789, ENST00000414851, ENST00000371231, ENST00000371230, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 10 X 7 X 7=490 |
# samples | 1 | 10 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(10/490*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF732 [Title/Abstract] AND DAB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-A2-A3Y0-01A | ZNF732 | chr4 | 289227 | - | DAB1 | chr1 | 57611102 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000419098 | ENST00000485760 | ZNF732 | chr4 | 289227 | - | DAB1 | chr1 | 57611102 | - |
5CDS-5UTR | ENST00000419098 | ENST00000371236 | ZNF732 | chr4 | 289227 | - | DAB1 | chr1 | 57611102 | - |
5CDS-5UTR | ENST00000419098 | ENST00000371234 | ZNF732 | chr4 | 289227 | - | DAB1 | chr1 | 57611102 | - |
5CDS-5UTR | ENST00000419098 | ENST00000420954 | ZNF732 | chr4 | 289227 | - | DAB1 | chr1 | 57611102 | - |
5CDS-5UTR | ENST00000419098 | ENST00000439789 | ZNF732 | chr4 | 289227 | - | DAB1 | chr1 | 57611102 | - |
5CDS-5UTR | ENST00000419098 | ENST00000414851 | ZNF732 | chr4 | 289227 | - | DAB1 | chr1 | 57611102 | - |
5CDS-5UTR | ENST00000419098 | ENST00000371231 | ZNF732 | chr4 | 289227 | - | DAB1 | chr1 | 57611102 | - |
5CDS-5UTR | ENST00000419098 | ENST00000371230 | ZNF732 | chr4 | 289227 | - | DAB1 | chr1 | 57611102 | - |
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FusionProtFeatures for ZNF732_DAB1 |
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Hgene | Tgene |
ZNF732 | DAB1 |
May be involved in transcriptional regulation.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF732_DAB1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF732_DAB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF732 | TRIM28 | DAB1 | APLP1, SIAH1, LRP2, LRP1, LDLR, VLDLR, LRP8, MYO6, APP, APLP2, CDK5, SH3KBP1, SOCS1, SOCS3, ERBB2, ERBB3, INPP5D, RBFOX1, CDK6, MBNL1, ROR2, PIN1, SNRPB, TCEA2, HYAL3, BHLHE40, PPIG, MAGED1, DAZAP2, SERF2, SIRPB1, ARID5A, CLASRP, POGZ, FAM168A, RBFOX2, ZBTB32, VENTX, TOLLIP, USP53, ZCCHC10, WDYHV1, STRBP, MBNL3, SMAP2, HMBOX1, FAM103A1, RHOXF2, LNX1, ZC3H10, C1orf94, NAF1, HNRNPLL, ZNF488, PRR20A, CIART, TMTC3, TCEANC, LGALS9B, KRTAP8-1, KRTAP19-5, KRTAP19-7, LGALS9C, SOCS6, SOCS7 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF732_DAB1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF732_DAB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | DAB1 | C0004352 | Autistic Disorder | 1 | CTD_human |