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Fusion gene ID: 43667 |
FusionGeneSummary for ZNF730_CEP89 |
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Fusion gene information | Fusion gene name: ZNF730_CEP89 | Fusion gene ID: 43667 | Hgene | Tgene | Gene symbol | ZNF730 | CEP89 | Gene ID | 100129543 | 84902 |
Gene name | zinc finger protein 730 | centrosomal protein 89 | |
Synonyms | - | CCDC123|CEP123 | |
Cytomap | 19p12 | 19q13.11 | |
Type of gene | protein-coding | protein-coding | |
Description | putative zinc finger protein 730 | centrosomal protein of 89 kDacentrosomal protein 123centrosomal protein 89kDacoiled-coil domain containing 123coiled-coil domain-containing protein 123, mitochondrial | |
Modification date | 20180403 | 20180519 | |
UniProtAcc | Q6ZMV8 | Q96ST8 | |
Ensembl transtripts involved in fusion gene | ENST00000593635, ENST00000597761, | ENST00000305768, ENST00000590597, ENST00000591863, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 3 X 3=36 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZNF730 [Title/Abstract] AND CEP89 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-QC-A6FX-01A | ZNF730 | chr19 | 23299978 | + | CEP89 | chr19 | 33392318 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000593635 | ENST00000305768 | ZNF730 | chr19 | 23299978 | + | CEP89 | chr19 | 33392318 | - |
intron-intron | ENST00000593635 | ENST00000590597 | ZNF730 | chr19 | 23299978 | + | CEP89 | chr19 | 33392318 | - |
intron-intron | ENST00000593635 | ENST00000591863 | ZNF730 | chr19 | 23299978 | + | CEP89 | chr19 | 33392318 | - |
Frame-shift | ENST00000597761 | ENST00000305768 | ZNF730 | chr19 | 23299978 | + | CEP89 | chr19 | 33392318 | - |
5CDS-intron | ENST00000597761 | ENST00000590597 | ZNF730 | chr19 | 23299978 | + | CEP89 | chr19 | 33392318 | - |
5CDS-intron | ENST00000597761 | ENST00000591863 | ZNF730 | chr19 | 23299978 | + | CEP89 | chr19 | 33392318 | - |
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FusionProtFeatures for ZNF730_CEP89 |
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Hgene | Tgene |
ZNF730 | CEP89 |
May be involved in transcriptional regulation.{ECO:0000250}. | Required for ciliogenesis. Also plays a role inmitochondrial metabolism where it may modulate complex IVactivity. {ECO:0000269|PubMed:23348840,ECO:0000269|PubMed:23575228}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF730_CEP89 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF730_CEP89 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF730 | CEP89 | LATS2, PICK1, PCM1, CEP162, CEP128, ABLIM1, ANKRD26, ANXA1, ATG2B, CEP131, C3orf14, CC2D1A, CCDC138, CCDC14, CCDC66, CCDC77, CCDC85C, CEP170, CEP192, CEP55, CRK, CSPP1, DHX35, DLG5, FGFR1OP, FLII, GPATCH1, HAUS2, HAUS3, HAUS4, HAUS5, HAUS6, HAUS7, HAUS8, KIAA0753, KIF7, LUZP1, MB21D2, MED4, MPHOSPH9, NCS1, NME7, NMT1, OFD1, PIBF1, PLEKHG1, RNF219, SAMD4B, SIRT2, SRBD1, SSX2IP, TCHP, TP53BP2, TXLNG, UNC45A, WDR83, WRAP73, XRN1, YWHAG, YWHAH, ADSL, C2CD3, CEP164, CEP350, CEP72, ERC1, KIAA1671, KIF14, MAP7D3, MARK2, MOB2, MOB4, NAV1, NPHP4, SDCCAG3, SLC25A12, TBC1D2B, TRIM37, TTK, TXLNA, WDR45, TBC1D31, CNTRL, NINL, MYH9, GAR1, CTDSPL, PTPRG, PMF1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF730_CEP89 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF730_CEP89 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |