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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43667

FusionGeneSummary for ZNF730_CEP89

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF730_CEP89
Fusion gene ID: 43667
HgeneTgene
Gene symbol

ZNF730

CEP89

Gene ID

100129543

84902

Gene namezinc finger protein 730centrosomal protein 89
Synonyms-CCDC123|CEP123
Cytomap

19p12

19q13.11

Type of geneprotein-codingprotein-coding
Descriptionputative zinc finger protein 730centrosomal protein of 89 kDacentrosomal protein 123centrosomal protein 89kDacoiled-coil domain containing 123coiled-coil domain-containing protein 123, mitochondrial
Modification date2018040320180519
UniProtAcc

Q6ZMV8

Q96ST8

Ensembl transtripts involved in fusion geneENST00000593635, ENST00000597761, 
ENST00000305768, ENST00000590597, 
ENST00000591863, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 3 X 3=36
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF730 [Title/Abstract] AND CEP89 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-QC-A6FX-01AZNF730chr19

23299978

+CEP89chr19

33392318

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000593635ENST00000305768ZNF730chr19

23299978

+CEP89chr19

33392318

-
intron-intronENST00000593635ENST00000590597ZNF730chr19

23299978

+CEP89chr19

33392318

-
intron-intronENST00000593635ENST00000591863ZNF730chr19

23299978

+CEP89chr19

33392318

-
Frame-shiftENST00000597761ENST00000305768ZNF730chr19

23299978

+CEP89chr19

33392318

-
5CDS-intronENST00000597761ENST00000590597ZNF730chr19

23299978

+CEP89chr19

33392318

-
5CDS-intronENST00000597761ENST00000591863ZNF730chr19

23299978

+CEP89chr19

33392318

-

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FusionProtFeatures for ZNF730_CEP89


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF730

Q6ZMV8

CEP89

Q96ST8

May be involved in transcriptional regulation.{ECO:0000250}. Required for ciliogenesis. Also plays a role inmitochondrial metabolism where it may modulate complex IVactivity. {ECO:0000269|PubMed:23348840,ECO:0000269|PubMed:23575228}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF730_CEP89


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF730_CEP89


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF730CEP89LATS2, PICK1, PCM1, CEP162, CEP128, ABLIM1, ANKRD26, ANXA1, ATG2B, CEP131, C3orf14, CC2D1A, CCDC138, CCDC14, CCDC66, CCDC77, CCDC85C, CEP170, CEP192, CEP55, CRK, CSPP1, DHX35, DLG5, FGFR1OP, FLII, GPATCH1, HAUS2, HAUS3, HAUS4, HAUS5, HAUS6, HAUS7, HAUS8, KIAA0753, KIF7, LUZP1, MB21D2, MED4, MPHOSPH9, NCS1, NME7, NMT1, OFD1, PIBF1, PLEKHG1, RNF219, SAMD4B, SIRT2, SRBD1, SSX2IP, TCHP, TP53BP2, TXLNG, UNC45A, WDR83, WRAP73, XRN1, YWHAG, YWHAH, ADSL, C2CD3, CEP164, CEP350, CEP72, ERC1, KIAA1671, KIF14, MAP7D3, MARK2, MOB2, MOB4, NAV1, NPHP4, SDCCAG3, SLC25A12, TBC1D2B, TRIM37, TTK, TXLNA, WDR45, TBC1D31, CNTRL, NINL, MYH9, GAR1, CTDSPL, PTPRG, PMF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF730_CEP89


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF730_CEP89


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource