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Fusion gene ID: 43666 |
FusionGeneSummary for ZNF727_STRIP2 |
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Fusion gene information | Fusion gene name: ZNF727_STRIP2 | Fusion gene ID: 43666 | Hgene | Tgene | Gene symbol | ZNF727 | STRIP2 | Gene ID | 442319 | 57464 |
Gene name | zinc finger protein 727 | striatin interacting protein 2 | |
Synonyms | ZNF727P | FAM40B|FAR11B | |
Cytomap | 7q11.21 | 7q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | putative zinc finger protein 727zinc finger protein 727 pseudogene | striatin-interacting protein 2FAR11 factor arrest 11 homolog Bfamily with sequence similarity 40, member Bhomolog of yeast FAR11 protein 2protein FAM40B | |
Modification date | 20180403 | 20180519 | |
UniProtAcc | A8MUV8 | Q9ULQ0 | |
Ensembl transtripts involved in fusion gene | ENST00000550760, | ENST00000249344, ENST00000435494, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 3=27 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZNF727 [Title/Abstract] AND STRIP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-09-2054-01A | ZNF727 | chr7 | 63529987 | + | STRIP2 | chr7 | 129079863 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000550760 | ENST00000249344 | ZNF727 | chr7 | 63529987 | + | STRIP2 | chr7 | 129079863 | + |
Frame-shift | ENST00000550760 | ENST00000435494 | ZNF727 | chr7 | 63529987 | + | STRIP2 | chr7 | 129079863 | + |
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FusionProtFeatures for ZNF727_STRIP2 |
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Hgene | Tgene |
ZNF727 | STRIP2 |
May be involved in transcriptional regulation.{ECO:0000250}. | Plays a role in the regulation of cell morphology andcytoskeletal organization. Required in the control of cell shape.{ECO:0000269|PubMed:21834987}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF727_STRIP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF727_STRIP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF727 | STRIP2 | CTTNBP2, CTTNBP2NL, STRIP1, MOB4, STK26, SIKE1, STK24, STK25, STRN, STRN3, TRAF3IP3, ZRANB1, APP, PPP2CB, SLMAP, PPP2CA, FGFR1OP2, PRDM14 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF727_STRIP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF727_STRIP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |