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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43664

FusionGeneSummary for ZNF721_YAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF721_YAP1
Fusion gene ID: 43664
HgeneTgene
Gene symbol

ZNF721

YAP1

Gene ID

170960

10413

Gene namezinc finger protein 721Yes associated protein 1
Synonyms-COB1|YAP|YAP2|YAP65|YKI
Cytomap

4p16.3

11q22.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 721transcriptional coactivator YAP165 kDa Yes-associated proteinprotein yorkie homologyes-associated protein 1yes-associated protein 2yes-associated protein YAP65 homologyorkie homolog
Modification date2018051920180527
UniProtAcc

Q8TF20

P46937

Ensembl transtripts involved in fusion geneENST00000506646, ENST00000507078, 
ENST00000338977, ENST00000511833, 
ENST00000526343, ENST00000282441, 
ENST00000537274, ENST00000345877, 
ENST00000531439, ENST00000524575, 
ENST00000528834, 
Fusion gene scores* DoF score5 X 3 X 4=6013 X 7 X 11=1001
# samples 513
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1001*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF721 [Title/Abstract] AND YAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneYAP1

GO:0006974

cellular response to DNA damage stimulus

18280240

TgeneYAP1

GO:0008283

cell proliferation

17974916

TgeneYAP1

GO:0032570

response to progesterone

16772533

TgeneYAP1

GO:0033148

positive regulation of intracellular estrogen receptor signaling pathway

16772533

TgeneYAP1

GO:0045893

positive regulation of transcription, DNA-templated

20368466

TgeneYAP1

GO:0045944

positive regulation of transcription by RNA polymerase II

25796446

TgeneYAP1

GO:0050767

regulation of neurogenesis

25433207

TgeneYAP1

GO:0050847

progesterone receptor signaling pathway

16772533

TgeneYAP1

GO:0060242

contact inhibition

17974916

TgeneYAP1

GO:0065003

protein-containing complex assembly

20368466

TgeneYAP1

GO:0071480

cellular response to gamma radiation

18280240

TgeneYAP1

GO:0072091

regulation of stem cell proliferation

25433207


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-36-1578-01AZNF721chr4

492845

-YAP1chr11

102056749

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000506646ENST00000526343ZNF721chr4

492845

-YAP1chr11

102056749

+
intron-intronENST00000506646ENST00000282441ZNF721chr4

492845

-YAP1chr11

102056749

+
intron-intronENST00000506646ENST00000537274ZNF721chr4

492845

-YAP1chr11

102056749

+
intron-intronENST00000506646ENST00000345877ZNF721chr4

492845

-YAP1chr11

102056749

+
intron-intronENST00000506646ENST00000531439ZNF721chr4

492845

-YAP1chr11

102056749

+
intron-intronENST00000506646ENST00000524575ZNF721chr4

492845

-YAP1chr11

102056749

+
intron-intronENST00000506646ENST00000528834ZNF721chr4

492845

-YAP1chr11

102056749

+
intron-intronENST00000507078ENST00000526343ZNF721chr4

492845

-YAP1chr11

102056749

+
intron-intronENST00000507078ENST00000282441ZNF721chr4

492845

-YAP1chr11

102056749

+
intron-intronENST00000507078ENST00000537274ZNF721chr4

492845

-YAP1chr11

102056749

+
intron-intronENST00000507078ENST00000345877ZNF721chr4

492845

-YAP1chr11

102056749

+
intron-intronENST00000507078ENST00000531439ZNF721chr4

492845

-YAP1chr11

102056749

+
intron-intronENST00000507078ENST00000524575ZNF721chr4

492845

-YAP1chr11

102056749

+
intron-intronENST00000507078ENST00000528834ZNF721chr4

492845

-YAP1chr11

102056749

+
5UTR-intronENST00000338977ENST00000526343ZNF721chr4

492845

-YAP1chr11

102056749

+
5UTR-intronENST00000338977ENST00000282441ZNF721chr4

492845

-YAP1chr11

102056749

+
5UTR-intronENST00000338977ENST00000537274ZNF721chr4

492845

-YAP1chr11

102056749

+
5UTR-intronENST00000338977ENST00000345877ZNF721chr4

492845

-YAP1chr11

102056749

+
5UTR-intronENST00000338977ENST00000531439ZNF721chr4

492845

-YAP1chr11

102056749

+
5UTR-intronENST00000338977ENST00000524575ZNF721chr4

492845

-YAP1chr11

102056749

+
5UTR-intronENST00000338977ENST00000528834ZNF721chr4

492845

-YAP1chr11

102056749

+
5UTR-intronENST00000511833ENST00000526343ZNF721chr4

492845

-YAP1chr11

102056749

+
5UTR-intronENST00000511833ENST00000282441ZNF721chr4

492845

-YAP1chr11

102056749

+
5UTR-intronENST00000511833ENST00000537274ZNF721chr4

492845

-YAP1chr11

102056749

+
5UTR-intronENST00000511833ENST00000345877ZNF721chr4

492845

-YAP1chr11

102056749

+
5UTR-intronENST00000511833ENST00000531439ZNF721chr4

492845

-YAP1chr11

102056749

+
5UTR-intronENST00000511833ENST00000524575ZNF721chr4

492845

-YAP1chr11

102056749

+
5UTR-intronENST00000511833ENST00000528834ZNF721chr4

492845

-YAP1chr11

102056749

+

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FusionProtFeatures for ZNF721_YAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF721

Q8TF20

YAP1

P46937

May be involved in transcriptional regulation.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF721_YAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF721_YAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF721TRIM28YAP1ERBB4, TP53BP2, KIF5A, SLC9A3R1, YWHAQ, RUNX3, RUNX2, RUNX1, TP73, TP63, WBP1, SMAD7, SMAD6, SCAMP3, AMOT, ITCH, EP300, BTRC, YWHAG, FBXW11, SMAD1, SMAD5, SMAD3, EGFR, ELAVL1, KLF5, LATS2, LATS1, PML, SUMO1, PTPN14, NFE2, POLR2A, AMOTL2, SRSF2, AHCYL1, UBQLN2, SULT1A1, UNK, UBA2, ZFYVE19, VPS4B, PRDX1, IGBP1, THUMPD1, ZPR1, NUBP2, UBE2L3, PIN1, USP9X, TTC9C, UCHL3, UBE2D1, UFM1, UBE2C, UBXN7, VPS25, TEAD1, CREB1, PPP1CA, AMOTL1, ARID1A, ARID1B, ATPIF1, BCL9L, CCDC85C, DPF2, INADL, LIN7C, MPDZ, MPP5, NF2, PARD3, PDLIM7, RAE1, RAPGEF2, RASSF8, SLC9A3R2, SMARCD1, TEAD3, TJP2, WBP2, YWHAB, YWHAE, YWHAH, YWHAZ, MAP2K1, ARFIP1, PAPOLA, PRMT3, RTF1, STAT1, TSNAX, TOM1, FBXW7, ABL1, ENO1, MOV10, NXF1, FAM189B, PRRG4, CYYR1, TEAD4, ARRDC1, LDLRAD4, STUB1, CPVL, ERP44, FASN, HSPH1, HSPA4L, HSPA4, HYOU1, MCMBP, RAPGEF6, PTCH1, PRRG2, NEDD8, TEAD2, XPO1, SMAD2, ENAH, CDH1, PTPN21, DEFA6, BAG4, CTNNB1, NUDT5, PRKD1, XRCC5, XRCC6, AHNAK, EPRS, THBS1, EEF1A1, EEF1A1P5, WWC3, TUBB, HRNR, PFKP, RPL6, COPA, VCP, EIF3B, CAD, RBM10, SUN2, SLC25A5, PSMD2, ACTN1, RRBP1, DDX3X, RPS4X, FAM120A, NCL, CSTF1, TMPO, MAP4, USP15, RPL7A, SNRPB, RPL18, SF3B3, FLG2, HSPB1, CCT2, SND1, PRPF8, EIF4B, HSP90B1, NPM1, PPP2R1A, CYFIP1, MATR3, TUBB6, HNRNPA2B1, RPS6, PSMC2, EIF3L, HNRNPR, IMMT, PHB2, RPS8, PTRF, RPL10A, PARP1, HIST1H1E, LMNB1, PA2G4, HNRNPF, ITGB1, NUMA1, SRSF6, TGM2, OGDH, PDIA3, RPL24, PHGDH, IPO5, TSR1, TRIP6, YBX1, SMARCA4, ATAD3A, RPL19, CCT5, PGAM5, SEC16A, AJUBA, PSMC5, UPF1, RPL15, XRN2, RPL13A, PSMC6, CNN2, HDAC1, HDAC2, SFN, SUPT16H, RBBP7, PRDX6, SEPT2, UQCRC2, MVD, MYH10, PLOD2, PSMD6, ADSS, PAICS, FUBP1, CIAPIN1, SFXN1, PSMA5, RPL9, DNAJC10, PTBP1, ANXA5, KPNA2, WDR1, C11orf84, H2AFY, JUN, RTN4, RPL14, H1FX, IGFBP7, ACTL6A, RPL17, ZYX, PSMB4, TWF1, HIST1H1B, TK1, CDC20, RAN, RPL21, SV2B, HN1L


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF721_YAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF721_YAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneYAP1C0027819Neuroblastoma1CTD_human
TgeneYAP1C0919267ovarian neoplasm1CTD_human
TgeneYAP1C1168401Squamous cell carcinoma of the head and neck1CTD_human