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Fusion gene ID: 43663 |
FusionGeneSummary for ZNF721_RFPL3S |
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Fusion gene information | Fusion gene name: ZNF721_RFPL3S | Fusion gene ID: 43663 | Hgene | Tgene | Gene symbol | ZNF721 | RFPL3S | Gene ID | 170960 | 10737 |
Gene name | zinc finger protein 721 | RFPL3 antisense | |
Synonyms | - | NCRNA00005|RFPL3-AS|RFPL3-AS1|RFPL3ANT|RFPL3AS | |
Cytomap | 4p16.3 | 22q12.3 | |
Type of gene | protein-coding | ncRNA | |
Description | zinc finger protein 721 | RFPL3 antisense RNA 1 (non-protein coding)non-protein coding RNA 5ret finger protein-like 3 antisense | |
Modification date | 20180519 | 20180329 | |
UniProtAcc | Q8TF20 | P0C7P2 | |
Ensembl transtripts involved in fusion gene | ENST00000506646, ENST00000507078, ENST00000338977, ENST00000511833, | ENST00000382084, ENST00000400234, ENST00000461833, ENST00000382086, | |
Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 2 X 2 X 2=8 |
# samples | 5 | 2 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: ZNF721 [Title/Abstract] AND RFPL3S [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-69-7979-01A | ZNF721 | chr4 | 429559 | - | RFPL3S | chr22 | 32764554 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000506646 | ENST00000382084 | ZNF721 | chr4 | 429559 | - | RFPL3S | chr22 | 32764554 | - |
3UTR-3CDS | ENST00000506646 | ENST00000400234 | ZNF721 | chr4 | 429559 | - | RFPL3S | chr22 | 32764554 | - |
3UTR-intron | ENST00000506646 | ENST00000461833 | ZNF721 | chr4 | 429559 | - | RFPL3S | chr22 | 32764554 | - |
3UTR-intron | ENST00000506646 | ENST00000382086 | ZNF721 | chr4 | 429559 | - | RFPL3S | chr22 | 32764554 | - |
Frame-shift | ENST00000507078 | ENST00000382084 | ZNF721 | chr4 | 429559 | - | RFPL3S | chr22 | 32764554 | - |
Frame-shift | ENST00000507078 | ENST00000400234 | ZNF721 | chr4 | 429559 | - | RFPL3S | chr22 | 32764554 | - |
5CDS-intron | ENST00000507078 | ENST00000461833 | ZNF721 | chr4 | 429559 | - | RFPL3S | chr22 | 32764554 | - |
5CDS-intron | ENST00000507078 | ENST00000382086 | ZNF721 | chr4 | 429559 | - | RFPL3S | chr22 | 32764554 | - |
intron-3CDS | ENST00000338977 | ENST00000382084 | ZNF721 | chr4 | 429559 | - | RFPL3S | chr22 | 32764554 | - |
intron-3CDS | ENST00000338977 | ENST00000400234 | ZNF721 | chr4 | 429559 | - | RFPL3S | chr22 | 32764554 | - |
intron-intron | ENST00000338977 | ENST00000461833 | ZNF721 | chr4 | 429559 | - | RFPL3S | chr22 | 32764554 | - |
intron-intron | ENST00000338977 | ENST00000382086 | ZNF721 | chr4 | 429559 | - | RFPL3S | chr22 | 32764554 | - |
intron-3CDS | ENST00000511833 | ENST00000382084 | ZNF721 | chr4 | 429559 | - | RFPL3S | chr22 | 32764554 | - |
intron-3CDS | ENST00000511833 | ENST00000400234 | ZNF721 | chr4 | 429559 | - | RFPL3S | chr22 | 32764554 | - |
intron-intron | ENST00000511833 | ENST00000461833 | ZNF721 | chr4 | 429559 | - | RFPL3S | chr22 | 32764554 | - |
intron-intron | ENST00000511833 | ENST00000382086 | ZNF721 | chr4 | 429559 | - | RFPL3S | chr22 | 32764554 | - |
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FusionProtFeatures for ZNF721_RFPL3S |
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Hgene | Tgene |
ZNF721 | RFPL3S |
May be involved in transcriptional regulation.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF721_RFPL3S |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF721_RFPL3S |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF721 | TRIM28 | RFPL3S |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF721_RFPL3S |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF721_RFPL3S |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |