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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43663

FusionGeneSummary for ZNF721_RFPL3S

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF721_RFPL3S
Fusion gene ID: 43663
HgeneTgene
Gene symbol

ZNF721

RFPL3S

Gene ID

170960

10737

Gene namezinc finger protein 721RFPL3 antisense
Synonyms-NCRNA00005|RFPL3-AS|RFPL3-AS1|RFPL3ANT|RFPL3AS
Cytomap

4p16.3

22q12.3

Type of geneprotein-codingncRNA
Descriptionzinc finger protein 721RFPL3 antisense RNA 1 (non-protein coding)non-protein coding RNA 5ret finger protein-like 3 antisense
Modification date2018051920180329
UniProtAcc

Q8TF20

P0C7P2

Ensembl transtripts involved in fusion geneENST00000506646, ENST00000507078, 
ENST00000338977, ENST00000511833, 
ENST00000382084, ENST00000400234, 
ENST00000461833, ENST00000382086, 
Fusion gene scores* DoF score5 X 3 X 4=602 X 2 X 2=8
# samples 52
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: ZNF721 [Title/Abstract] AND RFPL3S [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-69-7979-01AZNF721chr4

429559

-RFPL3Schr22

32764554

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000506646ENST00000382084ZNF721chr4

429559

-RFPL3Schr22

32764554

-
3UTR-3CDSENST00000506646ENST00000400234ZNF721chr4

429559

-RFPL3Schr22

32764554

-
3UTR-intronENST00000506646ENST00000461833ZNF721chr4

429559

-RFPL3Schr22

32764554

-
3UTR-intronENST00000506646ENST00000382086ZNF721chr4

429559

-RFPL3Schr22

32764554

-
Frame-shiftENST00000507078ENST00000382084ZNF721chr4

429559

-RFPL3Schr22

32764554

-
Frame-shiftENST00000507078ENST00000400234ZNF721chr4

429559

-RFPL3Schr22

32764554

-
5CDS-intronENST00000507078ENST00000461833ZNF721chr4

429559

-RFPL3Schr22

32764554

-
5CDS-intronENST00000507078ENST00000382086ZNF721chr4

429559

-RFPL3Schr22

32764554

-
intron-3CDSENST00000338977ENST00000382084ZNF721chr4

429559

-RFPL3Schr22

32764554

-
intron-3CDSENST00000338977ENST00000400234ZNF721chr4

429559

-RFPL3Schr22

32764554

-
intron-intronENST00000338977ENST00000461833ZNF721chr4

429559

-RFPL3Schr22

32764554

-
intron-intronENST00000338977ENST00000382086ZNF721chr4

429559

-RFPL3Schr22

32764554

-
intron-3CDSENST00000511833ENST00000382084ZNF721chr4

429559

-RFPL3Schr22

32764554

-
intron-3CDSENST00000511833ENST00000400234ZNF721chr4

429559

-RFPL3Schr22

32764554

-
intron-intronENST00000511833ENST00000461833ZNF721chr4

429559

-RFPL3Schr22

32764554

-
intron-intronENST00000511833ENST00000382086ZNF721chr4

429559

-RFPL3Schr22

32764554

-

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FusionProtFeatures for ZNF721_RFPL3S


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF721

Q8TF20

RFPL3S

P0C7P2

May be involved in transcriptional regulation.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF721_RFPL3S


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF721_RFPL3S


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF721TRIM28RFPL3S


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF721_RFPL3S


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF721_RFPL3S


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource