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Fusion gene ID: 43662 |
FusionGeneSummary for ZNF721_FASN |
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Fusion gene information | Fusion gene name: ZNF721_FASN | Fusion gene ID: 43662 | Hgene | Tgene | Gene symbol | ZNF721 | FASN | Gene ID | 170960 | 2194 |
Gene name | zinc finger protein 721 | fatty acid synthase | |
Synonyms | - | FAS|OA-519|SDR27X1 | |
Cytomap | 4p16.3 | 17q25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 721 | fatty acid synthaseshort chain dehydrogenase/reductase family 27X, member 1 | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q8TF20 | P49327 | |
Ensembl transtripts involved in fusion gene | ENST00000506646, ENST00000507078, ENST00000338977, ENST00000511833, | ENST00000306749, ENST00000579758, | |
Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 7 X 7 X 5=245 |
# samples | 5 | 8 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/245*10)=-1.61470984411521 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF721 [Title/Abstract] AND FASN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-C8-A12Y-01A | ZNF721 | chr4 | 467770 | - | FASN | chr17 | 80039719 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000506646 | ENST00000306749 | ZNF721 | chr4 | 467770 | - | FASN | chr17 | 80039719 | - |
5CDS-intron | ENST00000506646 | ENST00000579758 | ZNF721 | chr4 | 467770 | - | FASN | chr17 | 80039719 | - |
5UTR-3CDS | ENST00000507078 | ENST00000306749 | ZNF721 | chr4 | 467770 | - | FASN | chr17 | 80039719 | - |
5UTR-intron | ENST00000507078 | ENST00000579758 | ZNF721 | chr4 | 467770 | - | FASN | chr17 | 80039719 | - |
intron-3CDS | ENST00000338977 | ENST00000306749 | ZNF721 | chr4 | 467770 | - | FASN | chr17 | 80039719 | - |
intron-intron | ENST00000338977 | ENST00000579758 | ZNF721 | chr4 | 467770 | - | FASN | chr17 | 80039719 | - |
intron-3CDS | ENST00000511833 | ENST00000306749 | ZNF721 | chr4 | 467770 | - | FASN | chr17 | 80039719 | - |
intron-intron | ENST00000511833 | ENST00000579758 | ZNF721 | chr4 | 467770 | - | FASN | chr17 | 80039719 | - |
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FusionProtFeatures for ZNF721_FASN |
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Hgene | Tgene |
ZNF721 | FASN |
May be involved in transcriptional regulation.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF721_FASN |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF721_FASN |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF721 | TRIM28 | FASN | FASN, EWSR1, USP2, HDAC5, PCK1, RAD21, NDRG1, MAPK3, ARRB1, ARRB2, SIRT7, TSG101, ISG15, CUL3, CDK2, DCUN1D1, SHC1, AP2M1, EMD, TP53BP1, EIF4A3, MAGOH, PTPN11, SMURF1, HSP90AB1, HSP90AA1, FN1, VCAM1, NOS2, NPM1, LMNA, PRR12, YWHAQ, FBXO6, CAP1, KIAA1598, SIRT1, TPM3, TPM4, LGR4, PHKG2, ILK, STAU1, HUWE1, FUS, CUL7, OBSL1, CCDC8, EED, PTGR2, KIF3A, IMPDH1, HAUS4, TEAD3, YAP1, ABCC1, AHSA1, ASNS, CARM1, CCT6A, CCT6B, CYP27A1, HSD17B12, PC, PEF1, PIK3C2B, GFPT1, GFPT2, HSPBP1, MTCH1, TARBP1, NTRK1, AKT1, PTEN, HSPA5, KIF11, DNAJC7, IRF3, FOXI1, FOXI2, CRY1, CRY2, FOXL1, MCM2, SNW1, CDC5L, ZNF746, CDH1, USP22, CYLD, COX15, DLD, DLST, DNM1L, HSD17B10, PDHA1, SDHA, VHL, CAD, HIF1A, BRCA1, HDAC6 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF721_FASN |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | FASN | P49327 | DB01083 | Orlistat | Fatty acid synthase | small molecule | approved|investigational |
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RelatedDiseases for ZNF721_FASN |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | FASN | C0025202 | melanoma | 3 | CTD_human |
Tgene | FASN | C2239176 | Liver carcinoma | 3 | CTD_human |
Tgene | FASN | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Tgene | FASN | C0007193 | Cardiomyopathy, Dilated | 1 | CTD_human |
Tgene | FASN | C0007194 | Hypertrophic Cardiomyopathy | 1 | CTD_human |
Tgene | FASN | C0018801 | Heart failure | 1 | CTD_human |
Tgene | FASN | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
Tgene | FASN | C0023827 | liposarcoma | 1 | CTD_human |
Tgene | FASN | C0028754 | Obesity | 1 | CTD_human |
Tgene | FASN | C0086132 | Depressive Symptoms | 1 | PSYGENET |
Tgene | FASN | C0919267 | ovarian neoplasm | 1 | CTD_human |
Tgene | FASN | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
Tgene | FASN | C3714756 | Intellectual Disability | 1 | CTD_human |
Tgene | FASN | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |