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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43661

FusionGeneSummary for ZNF721_CPLX1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF721_CPLX1
Fusion gene ID: 43661
HgeneTgene
Gene symbol

ZNF721

CPLX1

Gene ID

170960

10815

Gene namezinc finger protein 721complexin 1
Synonyms-CPX-I|CPX1|EIEE63
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 721complexin-1CPX Icomplexin Isynaphin 2
Modification date2018051920180525
UniProtAcc

Q8TF20

O14810

Ensembl transtripts involved in fusion geneENST00000506646, ENST00000507078, 
ENST00000338977, ENST00000511833, 
ENST00000304062, ENST00000505203, 
Fusion gene scores* DoF score5 X 3 X 4=604 X 3 X 4=48
# samples 55
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF721 [Title/Abstract] AND CPLX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-0901-01BZNF721chr4

492845

-CPLX1chr4

818389

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000506646ENST00000304062ZNF721chr4

492845

-CPLX1chr4

818389

-
intron-5UTRENST00000506646ENST00000505203ZNF721chr4

492845

-CPLX1chr4

818389

-
intron-5UTRENST00000507078ENST00000304062ZNF721chr4

492845

-CPLX1chr4

818389

-
intron-5UTRENST00000507078ENST00000505203ZNF721chr4

492845

-CPLX1chr4

818389

-
5UTR-5UTRENST00000338977ENST00000304062ZNF721chr4

492845

-CPLX1chr4

818389

-
5UTR-5UTRENST00000338977ENST00000505203ZNF721chr4

492845

-CPLX1chr4

818389

-
5UTR-5UTRENST00000511833ENST00000304062ZNF721chr4

492845

-CPLX1chr4

818389

-
5UTR-5UTRENST00000511833ENST00000505203ZNF721chr4

492845

-CPLX1chr4

818389

-

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FusionProtFeatures for ZNF721_CPLX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF721

Q8TF20

CPLX1

O14810

May be involved in transcriptional regulation.{ECO:0000250}. Positively regulates a late step in exocytosis ofvarious cytoplasmic vesicles, such as synaptic vesicles and othersecretory vesicles (PubMed:21785414). Organizes the SNAREs into across-linked zigzag topology that, when interposed between thevesicle and plasma membranes, is incompatible with fusion, therebypreventing SNAREs from releasing neurotransmitters until an actionpotential arrives at the synapse (PubMed:21785414). Also involvedin glucose-induced secretion of insulin by pancreatic beta-cells.Essential for motor behavior. {ECO:0000250|UniProtKB:P63040,ECO:0000269|PubMed:21785414}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF721_CPLX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF721_CPLX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF721TRIM28CPLX1STX1A, SNAP25, VAMP2, FLNA, KHSRP, PPIA, SEC24C, STAM, GGA2, TACC3, DPY30, GLO1, NDRG3, PFDN5, S100A9, SGTA, UBE2V2, UBE2B, PSMD9, SNRPA, PSMD2, POMP, TAGLN2, RNF114, TRIP6, HBS1L, HN1, NEDD8, NENF, NUBP2, GINS3, IQCB1, AGTRAP, CMTM5, CPLX2, VAMP3, GYPB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF721_CPLX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF721_CPLX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCPLX1C0005586Bipolar Disorder1CTD_human
TgeneCPLX1C0011570Mental Depression1PSYGENET
TgeneCPLX1C0011581Depressive disorder1PSYGENET
TgeneCPLX1C0033975Psychotic Disorders1CTD_human
TgeneCPLX1C0036341Schizophrenia1CTD_human