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Fusion gene ID: 43660 |
FusionGeneSummary for ZNF721_CHL1 |
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Fusion gene information | Fusion gene name: ZNF721_CHL1 | Fusion gene ID: 43660 | Hgene | Tgene | Gene symbol | ZNF721 | CHL1 | Gene ID | 170960 | 10752 |
Gene name | zinc finger protein 721 | cell adhesion molecule L1 like | |
Synonyms | - | CALL|L1CAM2 | |
Cytomap | 4p16.3 | 3p26.3 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 721 | neural cell adhesion molecule L1-like proteinL1 cell adhesion molecule 2cell adhesion molecule with homology to L1CAM (close homolog of L1)cell adhesion molecule with homology to L1CAM (close homologue of L1)close homolog of L1 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8TF20 | O00533 | |
Ensembl transtripts involved in fusion gene | ENST00000506646, ENST00000507078, ENST00000338977, ENST00000511833, | ENST00000256509, ENST00000397491, ENST00000489224, | |
Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 4 X 4 X 4=64 |
# samples | 5 | 4 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF721 [Title/Abstract] AND CHL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-VT-A80G-01A | ZNF721 | chr4 | 429559 | - | CHL1 | chr3 | 286296 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-5UTR | ENST00000506646 | ENST00000256509 | ZNF721 | chr4 | 429559 | - | CHL1 | chr3 | 286296 | + |
3UTR-5UTR | ENST00000506646 | ENST00000397491 | ZNF721 | chr4 | 429559 | - | CHL1 | chr3 | 286296 | + |
3UTR-3UTR | ENST00000506646 | ENST00000489224 | ZNF721 | chr4 | 429559 | - | CHL1 | chr3 | 286296 | + |
5CDS-5UTR | ENST00000507078 | ENST00000256509 | ZNF721 | chr4 | 429559 | - | CHL1 | chr3 | 286296 | + |
5CDS-5UTR | ENST00000507078 | ENST00000397491 | ZNF721 | chr4 | 429559 | - | CHL1 | chr3 | 286296 | + |
5CDS-3UTR | ENST00000507078 | ENST00000489224 | ZNF721 | chr4 | 429559 | - | CHL1 | chr3 | 286296 | + |
intron-5UTR | ENST00000338977 | ENST00000256509 | ZNF721 | chr4 | 429559 | - | CHL1 | chr3 | 286296 | + |
intron-5UTR | ENST00000338977 | ENST00000397491 | ZNF721 | chr4 | 429559 | - | CHL1 | chr3 | 286296 | + |
intron-3UTR | ENST00000338977 | ENST00000489224 | ZNF721 | chr4 | 429559 | - | CHL1 | chr3 | 286296 | + |
intron-5UTR | ENST00000511833 | ENST00000256509 | ZNF721 | chr4 | 429559 | - | CHL1 | chr3 | 286296 | + |
intron-5UTR | ENST00000511833 | ENST00000397491 | ZNF721 | chr4 | 429559 | - | CHL1 | chr3 | 286296 | + |
intron-3UTR | ENST00000511833 | ENST00000489224 | ZNF721 | chr4 | 429559 | - | CHL1 | chr3 | 286296 | + |
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FusionProtFeatures for ZNF721_CHL1 |
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Hgene | Tgene |
ZNF721 | CHL1 |
May be involved in transcriptional regulation.{ECO:0000250}. | Extracellular matrix and cell adhesion protein thatplays a role in nervous system development and in synapticplasticity. Both soluble and membranous forms promote neuriteoutgrowth of cerebellar and hippocampal neurons and suppressneuronal cell death. Plays a role in neuronal positioning ofpyramidal neurons and in regulation of both the number ofinterneurons and the efficacy of GABAergic synapses. May play arole in regulating cell migration in nerve regeneration andcortical development. Potentiates integrin-dependent cellmigration towards extracellular matrix proteins. Recruits ANK3 tothe plasma membrane (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF721_CHL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF721_CHL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF721 | TRIM28 | CHL1 | ANK1, ANK3, ANK2, LGALS1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF721_CHL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF721_CHL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CHL1 | C0036341 | Schizophrenia | 2 | CTD_human |
Tgene | CHL1 | C0015923 | Fetal Alcohol Syndrome | 1 | PSYGENET |
Tgene | CHL1 | C2985290 | Fetal Alcohol Spectrum Disorders | 1 | PSYGENET |
Tgene | CHL1 | C3714756 | Intellectual Disability | 1 | CTD_human |