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Fusion gene ID: 43650 |
FusionGeneSummary for ZNF714_STAP2 |
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Fusion gene information | Fusion gene name: ZNF714_STAP2 | Fusion gene ID: 43650 | Hgene | Tgene | Gene symbol | ZNF714 | STAP2 | Gene ID | 148206 | 55620 |
Gene name | zinc finger protein 714 | signal transducing adaptor family member 2 | |
Synonyms | - | BKS | |
Cytomap | 19p12 | 19p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 714 | signal-transducing adaptor protein 2BRK substratebreast tumor kinase substratebrk kinase substrate | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q96N38 | Q9UGK3 | |
Ensembl transtripts involved in fusion gene | ENST00000596053, ENST00000596143, ENST00000601416, ENST00000291770, ENST00000600535, | ENST00000600324, ENST00000594605, ENST00000597593, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 4 X 5=120 |
# samples | 1 | 6 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF714 [Title/Abstract] AND STAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | READ | TCGA-DY-A1DF-01A | ZNF714 | chr19 | 21266875 | + | STAP2 | chr19 | 4338941 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-intron | ENST00000596053 | ENST00000600324 | ZNF714 | chr19 | 21266875 | + | STAP2 | chr19 | 4338941 | - |
5UTR-intron | ENST00000596053 | ENST00000594605 | ZNF714 | chr19 | 21266875 | + | STAP2 | chr19 | 4338941 | - |
5UTR-intron | ENST00000596053 | ENST00000597593 | ZNF714 | chr19 | 21266875 | + | STAP2 | chr19 | 4338941 | - |
5UTR-intron | ENST00000596143 | ENST00000600324 | ZNF714 | chr19 | 21266875 | + | STAP2 | chr19 | 4338941 | - |
5UTR-intron | ENST00000596143 | ENST00000594605 | ZNF714 | chr19 | 21266875 | + | STAP2 | chr19 | 4338941 | - |
5UTR-intron | ENST00000596143 | ENST00000597593 | ZNF714 | chr19 | 21266875 | + | STAP2 | chr19 | 4338941 | - |
5UTR-intron | ENST00000601416 | ENST00000600324 | ZNF714 | chr19 | 21266875 | + | STAP2 | chr19 | 4338941 | - |
5UTR-intron | ENST00000601416 | ENST00000594605 | ZNF714 | chr19 | 21266875 | + | STAP2 | chr19 | 4338941 | - |
5UTR-intron | ENST00000601416 | ENST00000597593 | ZNF714 | chr19 | 21266875 | + | STAP2 | chr19 | 4338941 | - |
5UTR-intron | ENST00000291770 | ENST00000600324 | ZNF714 | chr19 | 21266875 | + | STAP2 | chr19 | 4338941 | - |
5UTR-intron | ENST00000291770 | ENST00000594605 | ZNF714 | chr19 | 21266875 | + | STAP2 | chr19 | 4338941 | - |
5UTR-intron | ENST00000291770 | ENST00000597593 | ZNF714 | chr19 | 21266875 | + | STAP2 | chr19 | 4338941 | - |
3UTR-intron | ENST00000600535 | ENST00000600324 | ZNF714 | chr19 | 21266875 | + | STAP2 | chr19 | 4338941 | - |
3UTR-intron | ENST00000600535 | ENST00000594605 | ZNF714 | chr19 | 21266875 | + | STAP2 | chr19 | 4338941 | - |
3UTR-intron | ENST00000600535 | ENST00000597593 | ZNF714 | chr19 | 21266875 | + | STAP2 | chr19 | 4338941 | - |
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FusionProtFeatures for ZNF714_STAP2 |
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Hgene | Tgene |
ZNF714 | STAP2 |
May be involved in transcriptional regulation. | Substrate of protein kinase PTK6. May play a regulatoryrole in the acute-phase response in systemic inflammation and maymodulate STAT3 activity. {ECO:0000269|PubMed:10980601}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF714_STAP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF714_STAP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF714 | PCBD1, LZTR1, ELAVL1, ZNF550, ZNF223 | STAP2 | PTK6, CBL, PTK2, CSF1R, MYD88, IKBKB, CHUK, MLH1, EGFR, PADI1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF714_STAP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF714_STAP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |