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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43642

FusionGeneSummary for ZNF709_MAN2B1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF709_MAN2B1
Fusion gene ID: 43642
HgeneTgene
Gene symbol

ZNF709

MAN2B1

Gene ID

163051

4125

Gene namezinc finger protein 709mannosidase alpha class 2B member 1
Synonyms-LAMAN|MANB
Cytomap

19p13.2

19p13.13

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 709lysosomal alpha-mannosidaselysosomal acid alpha-mannosidasemannosidase alpha-Bmannosidase, alpha B, lysosomal
Modification date2018040320180523
UniProtAcc

Q8N972

O00754

Ensembl transtripts involved in fusion geneENST00000397732, ENST00000428311, 
ENST00000493776, 		ENST00000456935, 
ENST00000221363, ENST00000495617, 
Fusion gene scores* DoF score3 X 2 X 3=184 X 4 X 4=64
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF709 [Title/Abstract] AND MAN2B1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAN2B1

GO:0006464

cellular protein modification process

8910458


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-IR-A3LI-01AZNF709chr19

12595469

-MAN2B1chr19

12758412

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000397732ENST00000456935ZNF709chr19

12595469

-MAN2B1chr19

12758412

-
In-frameENST00000397732ENST00000221363ZNF709chr19

12595469

-MAN2B1chr19

12758412

-
5CDS-intronENST00000397732ENST00000495617ZNF709chr19

12595469

-MAN2B1chr19

12758412

-
intron-3CDSENST00000428311ENST00000456935ZNF709chr19

12595469

-MAN2B1chr19

12758412

-
intron-3CDSENST00000428311ENST00000221363ZNF709chr19

12595469

-MAN2B1chr19

12758412

-
intron-intronENST00000428311ENST00000495617ZNF709chr19

12595469

-MAN2B1chr19

12758412

-
intron-3CDSENST00000493776ENST00000456935ZNF709chr19

12595469

-MAN2B1chr19

12758412

-
intron-3CDSENST00000493776ENST00000221363ZNF709chr19

12595469

-MAN2B1chr19

12758412

-
intron-intronENST00000493776ENST00000495617ZNF709chr19

12595469

-MAN2B1chr19

12758412

-

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FusionProtFeatures for ZNF709_MAN2B1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF709

Q8N972

MAN2B1

O00754

May be involved in transcriptional regulation. Necessary for the catabolism of N-linked carbohydratesreleased during glycoprotein turnover. Cleaves all known types ofalpha-mannosidic linkages.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-144_751642DomainKRAB
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14102_1241642Zinc fingerC2H2-type 1
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14140_1621642Zinc fingerC2H2-type 2
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14168_1901642Zinc fingerC2H2-type 3
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14196_2181642Zinc fingerC2H2-type 4
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14224_2461642Zinc fingerC2H2-type 5
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14252_2741642Zinc fingerC2H2-type 6
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14280_3021642Zinc fingerC2H2-type 7
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14308_3301642Zinc fingerC2H2-type 8
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14336_3581642Zinc fingerC2H2-type 9
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14364_3861642Zinc fingerC2H2-type 10
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14392_4141642Zinc fingerC2H2-type 11
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14420_4421642Zinc fingerC2H2-type 12
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14448_4701642Zinc fingerC2H2-type 13
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14476_4981642Zinc fingerC2H2-type 14
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14504_5261642Zinc fingerC2H2-type 15
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14532_5541642Zinc fingerC2H2-type 16
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14560_5821642Zinc fingerC2H2-type 17
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14588_6101642Zinc fingerC2H2-type 18
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14616_6381642Zinc fingerC2H2-type 19


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FusionGeneSequence for ZNF709_MAN2B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZNF709_ENST00000397732_chr19_12595469_-_MAN2B1_ENST00000456935_chr19_12758412_-_125aa
MFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNTGPT

>In-frame_ZNF709_ENST00000397732_chr19_12595469_-_MAN2B1_ENST00000221363_chr19_12758412_-_125aa
MFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNTGPT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZNF709_ENST00000397732_chr19_12595469_-_MAN2B1_ENST00000456935_chr19_12758412_-_375nt
ATGTTCTCAGGGCTGCGCAGGGACCTGCCGCCCTCGGTGCACCTGCTCACGCTGGCCAGCTGGGGCCCCGAAATGGTGCTGCTGCGCTTG
GAGCACCAGTTTGCCGTAGGAGAGGATTCCGGACGTAACCTGAGCGCCCCCGTTACCTTGAACTTGAGGGACCTGTTCTCCACCTTCACC
ATCACCCGCCTGCAGGAGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGGCTCAAGTGGACAACAAACACAGGCCCCACA
CCCCACCAAACTCCGTACCAGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATCCGCACTTTCCTGGCCTCAGTTCAATGGAAG

>In-frame_ZNF709_ENST00000397732_chr19_12595469_-_MAN2B1_ENST00000221363_chr19_12758412_-_375nt
ATGTTCTCAGGGCTGCGCAGGGACCTGCCGCCCTCGGTGCACCTGCTCACGCTGGCCAGCTGGGGCCCCGAAATGGTGCTGCTGCGCTTG
GAGCACCAGTTTGCCGTAGGAGAGGATTCCGGACGTAACCTGAGCGCCCCCGTTACCTTGAACTTGAGGGACCTGTTCTCCACCTTCACC
ATCACCCGCCTGCAGGAGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGGCTCAAGTGGACAACAAACACAGGCCCCACA
CCCCACCAAACTCCGTACCAGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATCCGCACTTTCCTGGCCTCAGTTCAATGGAAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNF709_ENST00000397732_chr19_12595469_-_MAN2B1_ENST00000456935_chr19_12758412_-_654nt
GGAGGGGCGCTGCGCAAACGGCGAGGGCGTGGCTACCAGCCGCTGCGCTCCGCTCTGGGGTCTCCTCACCCCAGAAGGCCCTCAGGTGGA
GGAAGGGCCTCAGGTGGAGGTAGGACCTGTGCTGGCCGCGGGAGAGGTAAACAGAACACCAGGACATCCCAGAGTCTGGGAAATGTTCTC
AGGGCTGCGCAGGGACCTGCCGCCCTCGGTGCACCTGCTCACGCTGGCCAGCTGGGGCCCCGAAATGGTGCTGCTGCGCTTGGAGCACCA
GTTTGCCGTAGGAGAGGATTCCGGACGTAACCTGAGCGCCCCCGTTACCTTGAACTTGAGGGACCTGTTCTCCACCTTCACCATCACCCG
CCTGCAGGAGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGGCTCAAGTGGACAACAAACACAGGCCCCACACCCCACCA
AACTCCGTACCAGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATCCGCACTTTCCTGGCCTCAGTTCAATGGAAGGAGGTGGA
TGGTTAGGTCTGCTGGGATGGGCCCTCCAAGCCCAAGCCTCCTGCTCCGGGGGCAGACCAGACTCTGACTCTCCTCTTGGGGCTGCTGCC

>In-frame_ZNF709_ENST00000397732_chr19_12595469_-_MAN2B1_ENST00000221363_chr19_12758412_-_651nt
GGAGGGGCGCTGCGCAAACGGCGAGGGCGTGGCTACCAGCCGCTGCGCTCCGCTCTGGGGTCTCCTCACCCCAGAAGGCCCTCAGGTGGA
GGAAGGGCCTCAGGTGGAGGTAGGACCTGTGCTGGCCGCGGGAGAGGTAAACAGAACACCAGGACATCCCAGAGTCTGGGAAATGTTCTC
AGGGCTGCGCAGGGACCTGCCGCCCTCGGTGCACCTGCTCACGCTGGCCAGCTGGGGCCCCGAAATGGTGCTGCTGCGCTTGGAGCACCA
GTTTGCCGTAGGAGAGGATTCCGGACGTAACCTGAGCGCCCCCGTTACCTTGAACTTGAGGGACCTGTTCTCCACCTTCACCATCACCCG
CCTGCAGGAGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGGCTCAAGTGGACAACAAACACAGGCCCCACACCCCACCA
AACTCCGTACCAGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATCCGCACTTTCCTGGCCTCAGTTCAATGGAAGGAGGTGGA
TGGTTAGGTCTGCTGGGATGGGCCCTCCAAGCCCAAGCCTCCTGCTCCGGGGGCAGACCAGACTCTGACTCTCCTCTTGGGGCTGCTGCC


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FusionGenePPI for ZNF709_MAN2B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF709MAN2B1DNAJB11, NKX3-1, FBXO6, ATG7, LUC7L2, SEC24A, MOV10, NXF1, LGALS9, AGL, DTD1, LRRC47, CHID1, KIAA0368, NAGA, SNX2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF709_MAN2B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF709_MAN2B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMAN2B1C0024748alpha-Mannosidosis4CTD_human;UNIPROT
TgeneMAN2B1C0017661IGA Glomerulonephritis1CTD_human