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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43639

FusionGeneSummary for ZNF708_UBD

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF708_UBD
Fusion gene ID: 43639
HgeneTgene
Gene symbol

ZNF708

UBD

Gene ID

7562

10537

Gene namezinc finger protein 708ubiquitin D
SynonymsKOX8|ZNF15|ZNF15L1FAT10|GABBR1|UBD-3
Cytomap

19p12

6p22.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 708ZNF15, ZNF15L1zinc finger protein 15-like 1 (KOX 8)ubiquitin Ddiubiquitinubiquitin-like protein FAT10
Modification date2018051920180523
UniProtAcc

P17019

O15205

Ensembl transtripts involved in fusion geneENST00000356929, ENST00000377050, 
ENST00000414436, ENST00000432676, 
ENST00000421519, ENST00000383547, 
ENST00000383641, ENST00000429935, 
Fusion gene scores* DoF score4 X 5 X 1=202 X 2 X 1=4
# samples 52
** MAII scorelog2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: ZNF708 [Title/Abstract] AND UBD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBD

GO:0006511

ubiquitin-dependent protein catabolic process

17889673

TgeneUBD

GO:0016567

protein ubiquitination

15831455|17889673

TgeneUBD

GO:0070842

aggresome assembly

19033385


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG055615ZNF708chr19

21474095

-UBDchr6

826777

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000356929ENST00000377050ZNF708chr19

21474095

-UBDchr6

826777

-
intron-intronENST00000356929ENST00000414436ZNF708chr19

21474095

-UBDchr6

826777

-
intron-intronENST00000356929ENST00000432676ZNF708chr19

21474095

-UBDchr6

826777

-
intron-3UTRENST00000356929ENST00000421519ZNF708chr19

21474095

-UBDchr6

826777

-
intron-3UTRENST00000356929ENST00000383547ZNF708chr19

21474095

-UBDchr6

826777

-
intron-3UTRENST00000356929ENST00000383641ZNF708chr19

21474095

-UBDchr6

826777

-
intron-3UTRENST00000356929ENST00000429935ZNF708chr19

21474095

-UBDchr6

826777

-

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FusionProtFeatures for ZNF708_UBD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF708

P17019

UBD

O15205

May be involved in transcriptional regulation. Ubiquitin-like protein modifier which can be covalentlyattached to target protein and subsequently leads to theirdegradation by the 26S proteasome, in a NUB1-dependent manner.Probably functions as a survival factor. Conjugation abilityactivated by UBA6. Promotes the expression of the proteasomesubunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced andLPS-mediated activation of the central mediator of innate immunityNF-kappa-B by promoting TNF-alpha-mediated proteasomal degradationof ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-inducedp65 nuclear translocation in renal tubular epithelial cells(RTECs). May be involved in dendritic cell (DC) maturation, theprocess by which immature dendritic cells differentiate into fullycompetent antigen-presenting cells that initiate T-cell responses.Mediates mitotic non-disjunction and chromosome instability, inlong-term in vitro culture and cancers, by abbreviating mitoticphase and impairing the kinetochore localization of MAD2L1 duringthe prometaphase stage of the cell cycle. May be involved in theformation of aggresomes when proteasome is saturated or impaired.Mediates apoptosis in a caspase-dependent manner, especially inrenal epithelium and tubular cells during renal diseases such aspolycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN). {ECO:0000269|PubMed:15831455,ECO:0000269|PubMed:16495226, ECO:0000269|PubMed:16495380,ECO:0000269|PubMed:17889673, ECO:0000269|PubMed:18574467,ECO:0000269|PubMed:19028597, ECO:0000269|PubMed:19033385,ECO:0000269|PubMed:19166848, ECO:0000269|PubMed:19726511,ECO:0000269|PubMed:19959714}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF708_UBD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF708_UBD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF708_UBD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF708_UBD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneUBDC0019188Hepatitis, Animal1CTD_human
TgeneUBDC0023892Biliary cirrhosis1CTD_human
TgeneUBDC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneUBDC2239176Liver carcinoma1CTD_human