|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 43639 |
FusionGeneSummary for ZNF708_UBD |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF708_UBD | Fusion gene ID: 43639 | Hgene | Tgene | Gene symbol | ZNF708 | UBD | Gene ID | 7562 | 10537 |
| Gene name | zinc finger protein 708 | ubiquitin D | |
| Synonyms | KOX8|ZNF15|ZNF15L1 | FAT10|GABBR1|UBD-3 | |
| Cytomap | 19p12 | 6p22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 708ZNF15, ZNF15L1zinc finger protein 15-like 1 (KOX 8) | ubiquitin Ddiubiquitinubiquitin-like protein FAT10 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P17019 | O15205 | |
| Ensembl transtripts involved in fusion gene | ENST00000356929, | ENST00000377050, ENST00000414436, ENST00000432676, ENST00000421519, ENST00000383547, ENST00000383641, ENST00000429935, | |
| Fusion gene scores | * DoF score | 4 X 5 X 1=20 | 2 X 2 X 1=4 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/20*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: ZNF708 [Title/Abstract] AND UBD [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | UBD | GO:0006511 | ubiquitin-dependent protein catabolic process | 17889673 |
| Tgene | UBD | GO:0016567 | protein ubiquitination | 15831455|17889673 |
| Tgene | UBD | GO:0070842 | aggresome assembly | 19033385 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG055615 | ZNF708 | chr19 | 21474095 | - | UBD | chr6 | 826777 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000356929 | ENST00000377050 | ZNF708 | chr19 | 21474095 | - | UBD | chr6 | 826777 | - |
| intron-intron | ENST00000356929 | ENST00000414436 | ZNF708 | chr19 | 21474095 | - | UBD | chr6 | 826777 | - |
| intron-intron | ENST00000356929 | ENST00000432676 | ZNF708 | chr19 | 21474095 | - | UBD | chr6 | 826777 | - |
| intron-3UTR | ENST00000356929 | ENST00000421519 | ZNF708 | chr19 | 21474095 | - | UBD | chr6 | 826777 | - |
| intron-3UTR | ENST00000356929 | ENST00000383547 | ZNF708 | chr19 | 21474095 | - | UBD | chr6 | 826777 | - |
| intron-3UTR | ENST00000356929 | ENST00000383641 | ZNF708 | chr19 | 21474095 | - | UBD | chr6 | 826777 | - |
| intron-3UTR | ENST00000356929 | ENST00000429935 | ZNF708 | chr19 | 21474095 | - | UBD | chr6 | 826777 | - |
Top |
FusionProtFeatures for ZNF708_UBD |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF708 | UBD |
| May be involved in transcriptional regulation. | Ubiquitin-like protein modifier which can be covalentlyattached to target protein and subsequently leads to theirdegradation by the 26S proteasome, in a NUB1-dependent manner.Probably functions as a survival factor. Conjugation abilityactivated by UBA6. Promotes the expression of the proteasomesubunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced andLPS-mediated activation of the central mediator of innate immunityNF-kappa-B by promoting TNF-alpha-mediated proteasomal degradationof ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-inducedp65 nuclear translocation in renal tubular epithelial cells(RTECs). May be involved in dendritic cell (DC) maturation, theprocess by which immature dendritic cells differentiate into fullycompetent antigen-presenting cells that initiate T-cell responses.Mediates mitotic non-disjunction and chromosome instability, inlong-term in vitro culture and cancers, by abbreviating mitoticphase and impairing the kinetochore localization of MAD2L1 duringthe prometaphase stage of the cell cycle. May be involved in theformation of aggresomes when proteasome is saturated or impaired.Mediates apoptosis in a caspase-dependent manner, especially inrenal epithelium and tubular cells during renal diseases such aspolycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN). {ECO:0000269|PubMed:15831455,ECO:0000269|PubMed:16495226, ECO:0000269|PubMed:16495380,ECO:0000269|PubMed:17889673, ECO:0000269|PubMed:18574467,ECO:0000269|PubMed:19028597, ECO:0000269|PubMed:19033385,ECO:0000269|PubMed:19166848, ECO:0000269|PubMed:19726511,ECO:0000269|PubMed:19959714}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ZNF708_UBD |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ZNF708_UBD |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ZNF708_UBD |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ZNF708_UBD |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | UBD | C0019188 | Hepatitis, Animal | 1 | CTD_human |
| Tgene | UBD | C0023892 | Biliary cirrhosis | 1 | CTD_human |
| Tgene | UBD | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | UBD | C2239176 | Liver carcinoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|