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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43638

FusionGeneSummary for ZNF708_PTPRZ1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF708_PTPRZ1
Fusion gene ID: 43638
HgeneTgene
Gene symbol

ZNF708

PTPRZ1

Gene ID

7562

5803

Gene namezinc finger protein 708protein tyrosine phosphatase, receptor type Z1
SynonymsKOX8|ZNF15|ZNF15L1HPTPZ|HPTPzeta|PTP-ZETA|PTP18|PTPRZ|PTPZ|R-PTP-zeta-2|RPTPB|RPTPbeta|phosphacan
Cytomap

19p12

7q31.32

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 708ZNF15, ZNF15L1zinc finger protein 15-like 1 (KOX 8)receptor-type tyrosine-protein phosphatase zetaprotein tyrosine phosphatase, receptor-type, Z polypeptide 1protein tyrosine phosphatase, receptor-type, zeta polypeptide 1protein-tyrosine phosphatase receptor type Z polypeptide 2receptor-type tyrosine
Modification date2018051920180519
UniProtAcc

P17019

P23471

Ensembl transtripts involved in fusion geneENST00000356929, ENST00000393386, 
ENST00000449182, ENST00000483028, 
Fusion gene scores* DoF score4 X 5 X 1=205 X 6 X 3=90
# samples 56
** MAII scorelog2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF708 [Title/Abstract] AND PTPRZ1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE765133ZNF708chr19

21506506

+PTPRZ1chr7

121652002

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000356929ENST00000393386ZNF708chr19

21506506

+PTPRZ1chr7

121652002

+
intron-intronENST00000356929ENST00000449182ZNF708chr19

21506506

+PTPRZ1chr7

121652002

+
intron-intronENST00000356929ENST00000483028ZNF708chr19

21506506

+PTPRZ1chr7

121652002

+

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FusionProtFeatures for ZNF708_PTPRZ1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF708

P17019

PTPRZ1

P23471

May be involved in transcriptional regulation. Protein tyrosine phosphatase that negatively regulatesoligodendrocyte precursor proliferation in the embryonic spinalcord. Required for normal differentiation of the precursor cellsinto mature, fully myelinating oligodendrocytes. May play a rolein protecting oligondendrocytes against apoptosis. May play a rolein the establishment of contextual memory, probably via thedephosphorylation of proteins that are part of important signalingcascades (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF708_PTPRZ1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF708_PTPRZ1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF708_PTPRZ1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF708_PTPRZ1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTPRZ1C0036341Schizophrenia3PSYGENET
TgenePTPRZ1C0032273Pneumoconiosis1CTD_human
TgenePTPRZ1C0079487Helicobacter Infections1CTD_human