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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43637

FusionGeneSummary for ZNF708_ILF3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF708_ILF3
Fusion gene ID: 43637
HgeneTgene
Gene symbol

ZNF708

ILF3

Gene ID

7562

3609

Gene namezinc finger protein 708interleukin enhancer binding factor 3
SynonymsKOX8|ZNF15|ZNF15L1CBTF|DRBF|DRBP76|MMP4|MPHOSPH4|MPP4|NF-AT-90|NF110|NF110b|NF90|NF90a|NF90b|NFAR|NFAR-1|NFAR2|TCP110|TCP80
Cytomap

19p12

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 708ZNF15, ZNF15L1zinc finger protein 15-like 1 (KOX 8)interleukin enhancer-binding factor 3M-phase phosphoprotein 4double-stranded RNA-binding protein, 76 kDdsRNA binding protein NFAR-2/MPP4interleukin enhancer binding factor 3, 90kDinterleukin enhancer binding factor 3, 90kDanuclear factor associated
Modification date2018051920180523
UniProtAcc

P17019

Q12906

Ensembl transtripts involved in fusion geneENST00000356929, ENST00000420083, 
ENST00000449870, ENST00000318511, 
ENST00000407004, ENST00000589998, 
ENST00000250241, ENST00000592763, 
ENST00000588657, ENST00000590261, 
ENST00000586544, 
Fusion gene scores* DoF score4 X 5 X 1=209 X 11 X 2=198
# samples 513
** MAII scorelog2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(13/198*10)=-0.606988807051155
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF708 [Title/Abstract] AND ILF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneILF3

GO:0006468

protein phosphorylation

21123651

TgeneILF3

GO:0045892

negative regulation of transcription, DNA-templated

11739746

TgeneILF3

GO:0045893

positive regulation of transcription, DNA-templated

11739746


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI036811ZNF708chr19

21479526

-ILF3chr19

10801555

+
ChiTaRS3.1BI037746ZNF708chr19

21479517

-ILF3chr19

10801555

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000356929ENST00000420083ZNF708chr19

21479526

-ILF3chr19

10801555

+
intron-3UTRENST00000356929ENST00000449870ZNF708chr19

21479526

-ILF3chr19

10801555

+
intron-3UTRENST00000356929ENST00000318511ZNF708chr19

21479526

-ILF3chr19

10801555

+
intron-intronENST00000356929ENST00000407004ZNF708chr19

21479526

-ILF3chr19

10801555

+
intron-intronENST00000356929ENST00000589998ZNF708chr19

21479526

-ILF3chr19

10801555

+
intron-intronENST00000356929ENST00000250241ZNF708chr19

21479526

-ILF3chr19

10801555

+
intron-intronENST00000356929ENST00000592763ZNF708chr19

21479526

-ILF3chr19

10801555

+
intron-intronENST00000356929ENST00000588657ZNF708chr19

21479526

-ILF3chr19

10801555

+
intron-intronENST00000356929ENST00000590261ZNF708chr19

21479526

-ILF3chr19

10801555

+
intron-3UTRENST00000356929ENST00000586544ZNF708chr19

21479526

-ILF3chr19

10801555

+
intron-intronENST00000356929ENST00000420083ZNF708chr19

21479517

-ILF3chr19

10801555

+
intron-3UTRENST00000356929ENST00000449870ZNF708chr19

21479517

-ILF3chr19

10801555

+
intron-3UTRENST00000356929ENST00000318511ZNF708chr19

21479517

-ILF3chr19

10801555

+
intron-intronENST00000356929ENST00000407004ZNF708chr19

21479517

-ILF3chr19

10801555

+
intron-intronENST00000356929ENST00000589998ZNF708chr19

21479517

-ILF3chr19

10801555

+
intron-intronENST00000356929ENST00000250241ZNF708chr19

21479517

-ILF3chr19

10801555

+
intron-intronENST00000356929ENST00000592763ZNF708chr19

21479517

-ILF3chr19

10801555

+
intron-intronENST00000356929ENST00000588657ZNF708chr19

21479517

-ILF3chr19

10801555

+
intron-intronENST00000356929ENST00000590261ZNF708chr19

21479517

-ILF3chr19

10801555

+
intron-3UTRENST00000356929ENST00000586544ZNF708chr19

21479517

-ILF3chr19

10801555

+

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FusionProtFeatures for ZNF708_ILF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF708

P17019

ILF3

Q12906

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF708_ILF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF708_ILF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF708_ILF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF708_ILF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource