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Fusion gene ID: 43636 |
FusionGeneSummary for ZNF708_CYP46A1 |
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Fusion gene information | Fusion gene name: ZNF708_CYP46A1 | Fusion gene ID: 43636 | Hgene | Tgene | Gene symbol | ZNF708 | CYP46A1 | Gene ID | 7562 | 10858 |
Gene name | zinc finger protein 708 | cytochrome P450 family 46 subfamily A member 1 | |
Synonyms | KOX8|ZNF15|ZNF15L1 | CP46|CYP46 | |
Cytomap | 19p12 | 14q32.2 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 708ZNF15, ZNF15L1zinc finger protein 15-like 1 (KOX 8) | cholesterol 24-hydroxylaseCH24Hcytochrome P450 46A1cytochrome P450, family 46, subfamily A, polypeptide 1cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase) | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P17019 | Q9Y6A2 | |
Ensembl transtripts involved in fusion gene | ENST00000356929, | ENST00000261835, ENST00000423126, ENST00000554176, | |
Fusion gene scores | * DoF score | 4 X 5 X 1=20 | 2 X 2 X 2=8 |
# samples | 5 | 2 | |
** MAII score | log2(5/20*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: ZNF708 [Title/Abstract] AND CYP46A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CYP46A1 | GO:0006707 | cholesterol catabolic process | 18621681 |
Tgene | CYP46A1 | GO:0006805 | xenobiotic metabolic process | 20667828 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AK095062 | ZNF708 | chr19 | 21475896 | - | CYP46A1 | chr14 | 100192913 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000356929 | ENST00000261835 | ZNF708 | chr19 | 21475896 | - | CYP46A1 | chr14 | 100192913 | + |
intron-3CDS | ENST00000356929 | ENST00000423126 | ZNF708 | chr19 | 21475896 | - | CYP46A1 | chr14 | 100192913 | + |
intron-3CDS | ENST00000356929 | ENST00000554176 | ZNF708 | chr19 | 21475896 | - | CYP46A1 | chr14 | 100192913 | + |
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FusionProtFeatures for ZNF708_CYP46A1 |
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Hgene | Tgene |
ZNF708 | CYP46A1 |
May be involved in transcriptional regulation. | Involved in the turnover of cholesterol. It convertscholesterol into 24S-hydroxycholesterol and, to a lesser extent,25-hydroxycholesterol. Has also activity with xenobioticcompounds, such as clotrimazole. {ECO:0000269|PubMed:18621681,ECO:0000269|PubMed:20667828}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF708_CYP46A1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF708_CYP46A1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF708_CYP46A1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF708_CYP46A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CYP46A1 | C0002395 | Alzheimer's Disease | 1 | CTD_human |