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Fusion gene ID: 43602 |
FusionGeneSummary for ZNF682_CRLF1 |
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Fusion gene information | Fusion gene name: ZNF682_CRLF1 | Fusion gene ID: 43602 | Hgene | Tgene | Gene symbol | ZNF682 | CRLF1 | Gene ID | 91120 | 9244 |
Gene name | zinc finger protein 682 | cytokine receptor like factor 1 | |
Synonyms | BC39498_3 | CISS|CISS1|CLF|CLF-1|NR6|zcytor5 | |
Cytomap | 19p12 | 19p13.11 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 682 | cytokine receptor-like factor 1class I cytokine receptorcytokine type 1 receptor CRLP-1cytokine-like factor 1 | |
Modification date | 20180403 | 20180523 | |
UniProtAcc | O95780 | O75462 | |
Ensembl transtripts involved in fusion gene | ENST00000596019, ENST00000397162, ENST00000397165, ENST00000358523, ENST00000595736, ENST00000597972, ENST00000593468, ENST00000599240, | ENST00000594325, ENST00000392386, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 2 X 4=32 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZNF682 [Title/Abstract] AND CRLF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CRLF1 | GO:0008284 | positive regulation of cell proliferation | 10966616 |
Tgene | CRLF1 | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein | 10966616 |
Tgene | CRLF1 | GO:0043524 | negative regulation of neuron apoptotic process | 10966616 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-DA-A95V-06A | ZNF682 | chr19 | 20150152 | - | CRLF1 | chr19 | 18710656 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000596019 | ENST00000594325 | ZNF682 | chr19 | 20150152 | - | CRLF1 | chr19 | 18710656 | - |
5CDS-intron | ENST00000596019 | ENST00000392386 | ZNF682 | chr19 | 20150152 | - | CRLF1 | chr19 | 18710656 | - |
intron-intron | ENST00000397162 | ENST00000594325 | ZNF682 | chr19 | 20150152 | - | CRLF1 | chr19 | 18710656 | - |
intron-intron | ENST00000397162 | ENST00000392386 | ZNF682 | chr19 | 20150152 | - | CRLF1 | chr19 | 18710656 | - |
5CDS-intron | ENST00000397165 | ENST00000594325 | ZNF682 | chr19 | 20150152 | - | CRLF1 | chr19 | 18710656 | - |
5CDS-intron | ENST00000397165 | ENST00000392386 | ZNF682 | chr19 | 20150152 | - | CRLF1 | chr19 | 18710656 | - |
intron-intron | ENST00000358523 | ENST00000594325 | ZNF682 | chr19 | 20150152 | - | CRLF1 | chr19 | 18710656 | - |
intron-intron | ENST00000358523 | ENST00000392386 | ZNF682 | chr19 | 20150152 | - | CRLF1 | chr19 | 18710656 | - |
5UTR-intron | ENST00000595736 | ENST00000594325 | ZNF682 | chr19 | 20150152 | - | CRLF1 | chr19 | 18710656 | - |
5UTR-intron | ENST00000595736 | ENST00000392386 | ZNF682 | chr19 | 20150152 | - | CRLF1 | chr19 | 18710656 | - |
intron-intron | ENST00000597972 | ENST00000594325 | ZNF682 | chr19 | 20150152 | - | CRLF1 | chr19 | 18710656 | - |
intron-intron | ENST00000597972 | ENST00000392386 | ZNF682 | chr19 | 20150152 | - | CRLF1 | chr19 | 18710656 | - |
5CDS-intron | ENST00000593468 | ENST00000594325 | ZNF682 | chr19 | 20150152 | - | CRLF1 | chr19 | 18710656 | - |
5CDS-intron | ENST00000593468 | ENST00000392386 | ZNF682 | chr19 | 20150152 | - | CRLF1 | chr19 | 18710656 | - |
5UTR-intron | ENST00000599240 | ENST00000594325 | ZNF682 | chr19 | 20150152 | - | CRLF1 | chr19 | 18710656 | - |
5UTR-intron | ENST00000599240 | ENST00000392386 | ZNF682 | chr19 | 20150152 | - | CRLF1 | chr19 | 18710656 | - |
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FusionProtFeatures for ZNF682_CRLF1 |
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Hgene | Tgene |
ZNF682 | CRLF1 |
May be involved in transcriptional regulation. | Cytokine receptor subunit, possibly playing a regulatoryrole in the immune system and during fetal development. May beinvolved in nervous system development. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF682_CRLF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF682_CRLF1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF682 | CRLF1 | CLCF1, ENO1, SHMT2, MOV10, SCGB2A2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF682_CRLF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF682_CRLF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CRLF1 | C1848947 | COLD-INDUCED SWEATING SYNDROME 1 | 6 | ORPHANET;UNIPROT |