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Fusion gene ID: 43601 |
FusionGeneSummary for ZNF681_IMMP2L |
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Fusion gene information | Fusion gene name: ZNF681_IMMP2L | Fusion gene ID: 43601 | Hgene | Tgene | Gene symbol | ZNF681 | IMMP2L | Gene ID | 148213 | 83943 |
Gene name | zinc finger protein 681 | inner mitochondrial membrane peptidase subunit 2 | |
Synonyms | - | IMMP2L-IT1|IMP2|IMP2-LIKE | |
Cytomap | 19p12 | 7q31.1 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 681 | mitochondrial inner membrane protease subunit 2IMP2 inner mitochondrial membrane peptidase-likeIMP2 inner mitochondrial membrane protease-likeinner mitochondrial membrane peptidase 2 like | |
Modification date | 20180522 | 20180526 | |
UniProtAcc | Q96N22 | Q96T52 | |
Ensembl transtripts involved in fusion gene | ENST00000402377, ENST00000395385, | ENST00000405709, ENST00000331762, ENST00000452895, ENST00000415362, ENST00000447215, ENST00000437687, ENST00000489381, ENST00000450877, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 15 X 7 X 10=1050 |
# samples | 1 | 15 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(15/1050*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF681 [Title/Abstract] AND IMMP2L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | STAD | TCGA-BR-8289-01A | ZNF681 | chr19 | 23941549 | - | IMMP2L | chr7 | 110603621 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000402377 | ENST00000405709 | ZNF681 | chr19 | 23941549 | - | IMMP2L | chr7 | 110603621 | - |
Frame-shift | ENST00000402377 | ENST00000331762 | ZNF681 | chr19 | 23941549 | - | IMMP2L | chr7 | 110603621 | - |
Frame-shift | ENST00000402377 | ENST00000452895 | ZNF681 | chr19 | 23941549 | - | IMMP2L | chr7 | 110603621 | - |
Frame-shift | ENST00000402377 | ENST00000415362 | ZNF681 | chr19 | 23941549 | - | IMMP2L | chr7 | 110603621 | - |
Frame-shift | ENST00000402377 | ENST00000447215 | ZNF681 | chr19 | 23941549 | - | IMMP2L | chr7 | 110603621 | - |
Frame-shift | ENST00000402377 | ENST00000437687 | ZNF681 | chr19 | 23941549 | - | IMMP2L | chr7 | 110603621 | - |
5CDS-5UTR | ENST00000402377 | ENST00000489381 | ZNF681 | chr19 | 23941549 | - | IMMP2L | chr7 | 110603621 | - |
5CDS-5UTR | ENST00000402377 | ENST00000450877 | ZNF681 | chr19 | 23941549 | - | IMMP2L | chr7 | 110603621 | - |
5UTR-3CDS | ENST00000395385 | ENST00000405709 | ZNF681 | chr19 | 23941549 | - | IMMP2L | chr7 | 110603621 | - |
5UTR-3CDS | ENST00000395385 | ENST00000331762 | ZNF681 | chr19 | 23941549 | - | IMMP2L | chr7 | 110603621 | - |
5UTR-3CDS | ENST00000395385 | ENST00000452895 | ZNF681 | chr19 | 23941549 | - | IMMP2L | chr7 | 110603621 | - |
5UTR-3CDS | ENST00000395385 | ENST00000415362 | ZNF681 | chr19 | 23941549 | - | IMMP2L | chr7 | 110603621 | - |
5UTR-3CDS | ENST00000395385 | ENST00000447215 | ZNF681 | chr19 | 23941549 | - | IMMP2L | chr7 | 110603621 | - |
5UTR-3CDS | ENST00000395385 | ENST00000437687 | ZNF681 | chr19 | 23941549 | - | IMMP2L | chr7 | 110603621 | - |
5UTR-5UTR | ENST00000395385 | ENST00000489381 | ZNF681 | chr19 | 23941549 | - | IMMP2L | chr7 | 110603621 | - |
5UTR-5UTR | ENST00000395385 | ENST00000450877 | ZNF681 | chr19 | 23941549 | - | IMMP2L | chr7 | 110603621 | - |
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FusionProtFeatures for ZNF681_IMMP2L |
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Hgene | Tgene |
ZNF681 | IMMP2L |
May be involved in transcriptional regulation.{ECO:0000250}. | Catalyzes the removal of transit peptides required forthe targeting of proteins from the mitochondrial matrix, acrossthe inner membrane, into the inter-membrane space. Known toprocess the nuclear encoded protein DIABLO.{ECO:0000269|PubMed:15814844}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF681_IMMP2L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF681_IMMP2L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF681 | IMMP2L | HNRNPD |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF681_IMMP2L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF681_IMMP2L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IMMP2L | C0004352 | Autistic Disorder | 1 | CTD_human |