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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43601

FusionGeneSummary for ZNF681_IMMP2L

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF681_IMMP2L
Fusion gene ID: 43601
HgeneTgene
Gene symbol

ZNF681

IMMP2L

Gene ID

148213

83943

Gene namezinc finger protein 681inner mitochondrial membrane peptidase subunit 2
Synonyms-IMMP2L-IT1|IMP2|IMP2-LIKE
Cytomap

19p12

7q31.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 681mitochondrial inner membrane protease subunit 2IMP2 inner mitochondrial membrane peptidase-likeIMP2 inner mitochondrial membrane protease-likeinner mitochondrial membrane peptidase 2 like
Modification date2018052220180526
UniProtAcc

Q96N22

Q96T52

Ensembl transtripts involved in fusion geneENST00000402377, ENST00000395385, 
ENST00000405709, ENST00000331762, 
ENST00000452895, ENST00000415362, 
ENST00000447215, ENST00000437687, 
ENST00000489381, ENST00000450877, 
Fusion gene scores* DoF score1 X 1 X 1=115 X 7 X 10=1050
# samples 115
** MAII scorelog2(1/1*10)=3.32192809488736log2(15/1050*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF681 [Title/Abstract] AND IMMP2L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-8289-01AZNF681chr19

23941549

-IMMP2Lchr7

110603621

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000402377ENST00000405709ZNF681chr19

23941549

-IMMP2Lchr7

110603621

-
Frame-shiftENST00000402377ENST00000331762ZNF681chr19

23941549

-IMMP2Lchr7

110603621

-
Frame-shiftENST00000402377ENST00000452895ZNF681chr19

23941549

-IMMP2Lchr7

110603621

-
Frame-shiftENST00000402377ENST00000415362ZNF681chr19

23941549

-IMMP2Lchr7

110603621

-
Frame-shiftENST00000402377ENST00000447215ZNF681chr19

23941549

-IMMP2Lchr7

110603621

-
Frame-shiftENST00000402377ENST00000437687ZNF681chr19

23941549

-IMMP2Lchr7

110603621

-
5CDS-5UTRENST00000402377ENST00000489381ZNF681chr19

23941549

-IMMP2Lchr7

110603621

-
5CDS-5UTRENST00000402377ENST00000450877ZNF681chr19

23941549

-IMMP2Lchr7

110603621

-
5UTR-3CDSENST00000395385ENST00000405709ZNF681chr19

23941549

-IMMP2Lchr7

110603621

-
5UTR-3CDSENST00000395385ENST00000331762ZNF681chr19

23941549

-IMMP2Lchr7

110603621

-
5UTR-3CDSENST00000395385ENST00000452895ZNF681chr19

23941549

-IMMP2Lchr7

110603621

-
5UTR-3CDSENST00000395385ENST00000415362ZNF681chr19

23941549

-IMMP2Lchr7

110603621

-
5UTR-3CDSENST00000395385ENST00000447215ZNF681chr19

23941549

-IMMP2Lchr7

110603621

-
5UTR-3CDSENST00000395385ENST00000437687ZNF681chr19

23941549

-IMMP2Lchr7

110603621

-
5UTR-5UTRENST00000395385ENST00000489381ZNF681chr19

23941549

-IMMP2Lchr7

110603621

-
5UTR-5UTRENST00000395385ENST00000450877ZNF681chr19

23941549

-IMMP2Lchr7

110603621

-

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FusionProtFeatures for ZNF681_IMMP2L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF681

Q96N22

IMMP2L

Q96T52

May be involved in transcriptional regulation.{ECO:0000250}. Catalyzes the removal of transit peptides required forthe targeting of proteins from the mitochondrial matrix, acrossthe inner membrane, into the inter-membrane space. Known toprocess the nuclear encoded protein DIABLO.{ECO:0000269|PubMed:15814844}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF681_IMMP2L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF681_IMMP2L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF681IMMP2LHNRNPD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF681_IMMP2L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF681_IMMP2L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIMMP2LC0004352Autistic Disorder1CTD_human