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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43595

FusionGeneSummary for ZNF676_KANK3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF676_KANK3
Fusion gene ID: 43595
HgeneTgene
Gene symbol

ZNF676

KANK3

Gene ID

163223

256949

Gene namezinc finger protein 676KN motif and ankyrin repeat domains 3
Synonyms-ANKRD47
Cytomap

19p12

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 676KN motif and ankyrin repeat domain-containing protein 3ankyrin repeat domain 47ankyrin repeat domain-containing protein 47kidney ankyrin repeat-containing protein 3
Modification date2018051920180523
UniProtAcc

Q8N7Q3

Q6NY19

Ensembl transtripts involved in fusion geneENST00000397121, ENST00000330915, 
ENST00000593649, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 1 X 2=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: ZNF676 [Title/Abstract] AND KANK3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-P5-A77X-01AZNF676chr19

22375818

-KANK3chr19

8389980

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000397121ENST00000330915ZNF676chr19

22375818

-KANK3chr19

8389980

-
In-frameENST00000397121ENST00000593649ZNF676chr19

22375818

-KANK3chr19

8389980

-

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FusionProtFeatures for ZNF676_KANK3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF676

Q8N7Q3

KANK3

Q6NY19

May be involved in transcriptional regulation. May be involved in the control of cytoskeleton formationby regulating actin polymerization.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF676chr19:22375818chr19:8389980ENST00000397121-231_4343589DomainKRAB
TgeneKANK3chr19:22375818chr19:8389980ENST00000330915-611807_810645822Compositional biasNote=Poly-Pro
TgeneKANK3chr19:22375818chr19:8389980ENST00000593649-611807_810645841Compositional biasNote=Poly-Pro
TgeneKANK3chr19:22375818chr19:8389980ENST00000330915-611656_690645822RepeatNote=ANK 2
TgeneKANK3chr19:22375818chr19:8389980ENST00000330915-611695_724645822RepeatNote=ANK 3
TgeneKANK3chr19:22375818chr19:8389980ENST00000330915-611728_758645822RepeatNote=ANK 4
TgeneKANK3chr19:22375818chr19:8389980ENST00000330915-611762_795645822RepeatNote=ANK 5
TgeneKANK3chr19:22375818chr19:8389980ENST00000593649-611656_690645841RepeatNote=ANK 2
TgeneKANK3chr19:22375818chr19:8389980ENST00000593649-611695_724645841RepeatNote=ANK 3
TgeneKANK3chr19:22375818chr19:8389980ENST00000593649-611728_758645841RepeatNote=ANK 4
TgeneKANK3chr19:22375818chr19:8389980ENST00000593649-611762_795645841RepeatNote=ANK 5

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF676chr19:22375818chr19:8389980ENST00000397121-23169_19143589Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF676chr19:22375818chr19:8389980ENST00000397121-23197_21943589Zinc fingerC2H2-type 2
HgeneZNF676chr19:22375818chr19:8389980ENST00000397121-23225_24743589Zinc fingerC2H2-type 3
HgeneZNF676chr19:22375818chr19:8389980ENST00000397121-23253_27543589Zinc fingerC2H2-type 4
HgeneZNF676chr19:22375818chr19:8389980ENST00000397121-23281_30343589Zinc fingerC2H2-type 5
HgeneZNF676chr19:22375818chr19:8389980ENST00000397121-23309_33143589Zinc fingerC2H2-type 6
HgeneZNF676chr19:22375818chr19:8389980ENST00000397121-23337_35943589Zinc fingerC2H2-type 7
HgeneZNF676chr19:22375818chr19:8389980ENST00000397121-23365_38743589Zinc fingerC2H2-type 8
HgeneZNF676chr19:22375818chr19:8389980ENST00000397121-23393_41543589Zinc fingerC2H2-type 9
HgeneZNF676chr19:22375818chr19:8389980ENST00000397121-23421_44343589Zinc fingerC2H2-type 10
HgeneZNF676chr19:22375818chr19:8389980ENST00000397121-23449_47143589Zinc fingerC2H2-type 11
HgeneZNF676chr19:22375818chr19:8389980ENST00000397121-23477_49943589Zinc fingerC2H2-type 12
HgeneZNF676chr19:22375818chr19:8389980ENST00000397121-23505_52743589Zinc fingerC2H2-type 13
HgeneZNF676chr19:22375818chr19:8389980ENST00000397121-23533_55543589Zinc fingerC2H2-type 14
HgeneZNF676chr19:22375818chr19:8389980ENST00000397121-23561_58343589Zinc fingerC2H2-type 15
TgeneKANK3chr19:22375818chr19:8389980ENST00000330915-611181_230645822Coiled coilOntology_term=ECO:0000255
TgeneKANK3chr19:22375818chr19:8389980ENST00000330915-611367_404645822Coiled coilOntology_term=ECO:0000255
TgeneKANK3chr19:22375818chr19:8389980ENST00000593649-611181_230645841Coiled coilOntology_term=ECO:0000255
TgeneKANK3chr19:22375818chr19:8389980ENST00000593649-611367_404645841Coiled coilOntology_term=ECO:0000255
TgeneKANK3chr19:22375818chr19:8389980ENST00000330915-611479_482645822Compositional biasNote=Poly-Ser
TgeneKANK3chr19:22375818chr19:8389980ENST00000593649-611479_482645841Compositional biasNote=Poly-Ser
TgeneKANK3chr19:22375818chr19:8389980ENST00000330915-611622_652645822RepeatNote=ANK 1
TgeneKANK3chr19:22375818chr19:8389980ENST00000593649-611622_652645841RepeatNote=ANK 1


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FusionGeneSequence for ZNF676_KANK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZNF676_ENST00000397121_chr19_22375818_-_KANK3_ENST00000330915_chr19_8389980_-_220aa
MLENYRNLVFLGIAAFKPDLIIFLEQGKEPWNMKRHEMVEEPPGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKA
SQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALL

>In-frame_ZNF676_ENST00000397121_chr19_22375818_-_KANK3_ENST00000593649_chr19_8389980_-_239aa
MLENYRNLVFLGIAAFKPDLIIFLEQGKEPWNMKRHEMVEEPPGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKA
SQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZNF676_ENST00000397121_chr19_22375818_-_KANK3_ENST00000330915_chr19_8389980_-_660nt
ATGTTAGAGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGCCTTTAAGCCAGACCTGATCATTTTTCTGGAGCAAGGAAAAGAGCCC
TGGAATATGAAGAGACATGAGATGGTGGAAGAACCCCCAGGGGCCTGCGAGGTCAACCGCCAGAACCGAGCCGGCTACTCGGCCCTCATG
CTGGCTGCACTCACCTCTGTGAGGCAGGAAGAGGAGGACATGGCTGTGGTCCAGAGACTCTTCTGCATGGGTGATGTCAATGCCAAGGCC
AGTCAGACGGGGCAGACAGCCCTCATGCTGGCCATCAGCCATGGCCGACAGGACATGGTGGCAACCCTACTGGCGTGTGGGGCTGATGTG
AATGCGCAGGATGCGGATGGGGCCACAGCGCTGATGTGTGCCAGTGAGTATGGGCGCCTGGACACCGTGCGGCTGCTGCTCACCCAGCCA
GGCTGTGACCCTGCCATCCTGGACAATGAGGGCACCAGTGCCCTGGCCATCGCCCTGGAGGCTGAGCAGGATGAGGTGGCCGCTCTGCTA
CATGCCCACCTGAGCTCGGGCCAGCCCGACACCCAGAGCGAGTCACCCCCTGGCTCCCAGACAGCCACACCTGGTGAAGGAGAATGCGGT

>In-frame_ZNF676_ENST00000397121_chr19_22375818_-_KANK3_ENST00000593649_chr19_8389980_-_717nt
ATGTTAGAGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGCCTTTAAGCCAGACCTGATCATTTTTCTGGAGCAAGGAAAAGAGCCC
TGGAATATGAAGAGACATGAGATGGTGGAAGAACCCCCAGGGGCCTGCGAGGTCAACCGCCAGAACCGAGCCGGCTACTCGGCCCTCATG
CTGGCTGCACTCACCTCTGTGAGGCAGGAAGAGGAGGACATGGCTGTGGTCCAGAGACTCTTCTGCATGGGTGATGTCAATGCCAAGGCC
AGTCAGACGGGGCAGACAGCCCTCATGCTGGCCATCAGCCATGGCCGACAGGACATGGTGGCAACCCTACTGGCGTGTGGGGCTGATGTG
AATGCGCAGGATGCGGATGGGGCCACAGCGCTGATGTGTGCCAGTGAGTATGGGCGCCTGGACACCGTGCGGCTGCTGCTCACCCAGCCA
GGCTGTGACCCTGCCATCCTGGACAATGAGGGCACCAGTGCCCTGGCCATCGCCCTGGAGGCTGAGCAGGATGAGGTGGCCGCTCTGCTA
CATGCCCACCTGAGCTCGGGCCAGCCCGACACCCAGGCTGGAGTGCAGCGGCACAATCTCAGTTCACTGCAACCTCCACCTCCCAGGTTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNF676_ENST00000397121_chr19_22375818_-_KANK3_ENST00000330915_chr19_8389980_-_1233nt
ATTACATATACACAGATGTTATGGATCTTATACCACTTTCTTTTCTCAGAGTTAGAGAATACATTAGTGAACATTTCTGTGTTGAAAACT
ATTTTATTGAATAATTTCAGTCATTCATATAAGTCAGAACCAGCTCTCTCTACTCTCTCCATTTTACCTTGAGTCACATTAAAAGTTCTG
CCCATGACCAATTGGTAAATATATGTGTTTGTGTGTGTTTTCCAGGGAGCATTGACATTTAGGGATGTGGCCATAGAATTCTCTCTGGAG
GAGTGGCAATGCCTGGATTCTACACAGCAGAATTTATATAGGAATGTGATGTTAGAGAACTACAGAAACCTGGTCTTCCTGGGTATTGCT
GCCTTTAAGCCAGACCTGATCATTTTTCTGGAGCAAGGAAAAGAGCCCTGGAATATGAAGAGACATGAGATGGTGGAAGAACCCCCAGGG
GCCTGCGAGGTCAACCGCCAGAACCGAGCCGGCTACTCGGCCCTCATGCTGGCTGCACTCACCTCTGTGAGGCAGGAAGAGGAGGACATG
GCTGTGGTCCAGAGACTCTTCTGCATGGGTGATGTCAATGCCAAGGCCAGTCAGACGGGGCAGACAGCCCTCATGCTGGCCATCAGCCAT
GGCCGACAGGACATGGTGGCAACCCTACTGGCGTGTGGGGCTGATGTGAATGCGCAGGATGCGGATGGGGCCACAGCGCTGATGTGTGCC
AGTGAGTATGGGCGCCTGGACACCGTGCGGCTGCTGCTCACCCAGCCAGGCTGTGACCCTGCCATCCTGGACAATGAGGGCACCAGTGCC
CTGGCCATCGCCCTGGAGGCTGAGCAGGATGAGGTGGCCGCTCTGCTACATGCCCACCTGAGCTCGGGCCAGCCCGACACCCAGAGCGAG
TCACCCCCTGGCTCCCAGACAGCCACACCTGGTGAAGGAGAATGCGGTGACAATGGAGAGAACCCCCAGGTTCAGTAAGCTGCCTCGTCT
GGCTCACTACACCTAGCTGTGGGGAGATCTCCTCGTCAGTCACCTCAGCCTTTGGCGCACAGAAGGGTCCAGGGTCCCCTGCTCAGAGGC
TAACACTGGCCGAAGAGAAAGGCAATTTCAGTTGGGGTGACTGTGGCAGGAAGGGGCTCACTCTGGCCCCACCAAGGTGAGGTGGGGACC

>In-frame_ZNF676_ENST00000397121_chr19_22375818_-_KANK3_ENST00000593649_chr19_8389980_-_1118nt
ATTACATATACACAGATGTTATGGATCTTATACCACTTTCTTTTCTCAGAGTTAGAGAATACATTAGTGAACATTTCTGTGTTGAAAACT
ATTTTATTGAATAATTTCAGTCATTCATATAAGTCAGAACCAGCTCTCTCTACTCTCTCCATTTTACCTTGAGTCACATTAAAAGTTCTG
CCCATGACCAATTGGTAAATATATGTGTTTGTGTGTGTTTTCCAGGGAGCATTGACATTTAGGGATGTGGCCATAGAATTCTCTCTGGAG
GAGTGGCAATGCCTGGATTCTACACAGCAGAATTTATATAGGAATGTGATGTTAGAGAACTACAGAAACCTGGTCTTCCTGGGTATTGCT
GCCTTTAAGCCAGACCTGATCATTTTTCTGGAGCAAGGAAAAGAGCCCTGGAATATGAAGAGACATGAGATGGTGGAAGAACCCCCAGGG
GCCTGCGAGGTCAACCGCCAGAACCGAGCCGGCTACTCGGCCCTCATGCTGGCTGCACTCACCTCTGTGAGGCAGGAAGAGGAGGACATG
GCTGTGGTCCAGAGACTCTTCTGCATGGGTGATGTCAATGCCAAGGCCAGTCAGACGGGGCAGACAGCCCTCATGCTGGCCATCAGCCAT
GGCCGACAGGACATGGTGGCAACCCTACTGGCGTGTGGGGCTGATGTGAATGCGCAGGATGCGGATGGGGCCACAGCGCTGATGTGTGCC
AGTGAGTATGGGCGCCTGGACACCGTGCGGCTGCTGCTCACCCAGCCAGGCTGTGACCCTGCCATCCTGGACAATGAGGGCACCAGTGCC
CTGGCCATCGCCCTGGAGGCTGAGCAGGATGAGGTGGCCGCTCTGCTACATGCCCACCTGAGCTCGGGCCAGCCCGACACCCAGGCTGGA
GTGCAGCGGCACAATCTCAGTTCACTGCAACCTCCACCTCCCAGGTTCAAGAAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTAC
AACAGCTGTGAGCCATCGCGCCTGGCACAACTTACAATTTTTTGACTTCATGATAGCATAAAAGCAATGTGTGCTTAGTAAAAACCACAC


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FusionGenePPI for ZNF676_KANK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF676TP63KANK3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF676_KANK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF676_KANK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZNF676C0040128Thyroid Diseases1CTD_human