![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 43594 |
FusionGeneSummary for ZNF675_SLC27A1 |
![]() |
Fusion gene information | Fusion gene name: ZNF675_SLC27A1 | Fusion gene ID: 43594 | Hgene | Tgene | Gene symbol | ZNF675 | SLC27A1 | Gene ID | 171392 | 376497 |
Gene name | zinc finger protein 675 | solute carrier family 27 member 1 | |
Synonyms | TBZF|TIZ | ACSVL5|FATP|FATP-1|FATP1 | |
Cytomap | 19p12 | 19p13.11 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 675TRAF6 inhibitory zinc fingerTRAF6-binding zinc finger proteinTRAF6-inhibitory zinc finger protein | long-chain fatty acid transport protein 1fatty acid transport protein 1solute carrier family 27 (fatty acid transporter), member 1 | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q8TD23 | Q6PCB7 | |
Ensembl transtripts involved in fusion gene | ENST00000601935, ENST00000600313, ENST00000596211, ENST00000359788, ENST00000601010, ENST00000599168, | ENST00000442725, ENST00000252595, ENST00000598424, ENST00000598848, | |
Fusion gene scores | * DoF score | 4 X 1 X 4=16 | 4 X 4 X 4=64 |
# samples | 4 | 4 | |
** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF675 [Title/Abstract] AND SLC27A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ZNF675 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 11751921 |
Hgene | ZNF675 | GO:0007249 | I-kappaB kinase/NF-kappaB signaling | 11751921 |
Hgene | ZNF675 | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | 11751921 |
Hgene | ZNF675 | GO:0019221 | cytokine-mediated signaling pathway | 11751921 |
Hgene | ZNF675 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 11751921 |
Hgene | ZNF675 | GO:0043508 | negative regulation of JUN kinase activity | 11751921 |
Hgene | ZNF675 | GO:0045671 | negative regulation of osteoclast differentiation | 11751921|11851921 |
Hgene | ZNF675 | GO:0046329 | negative regulation of JNK cascade | 11751921 |
Hgene | ZNF675 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway | 11751921 |
Hgene | ZNF675 | GO:2000678 | negative regulation of transcription regulatory region DNA binding | 11751921 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCS | TCGA-N8-A4PL-01A | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000601935 | ENST00000442725 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-5UTR | ENST00000601935 | ENST00000252595 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-5UTR | ENST00000601935 | ENST00000598424 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-intron | ENST00000601935 | ENST00000598848 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-5UTR | ENST00000600313 | ENST00000442725 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-5UTR | ENST00000600313 | ENST00000252595 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-5UTR | ENST00000600313 | ENST00000598424 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-intron | ENST00000600313 | ENST00000598848 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-5UTR | ENST00000596211 | ENST00000442725 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-5UTR | ENST00000596211 | ENST00000252595 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-5UTR | ENST00000596211 | ENST00000598424 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-intron | ENST00000596211 | ENST00000598848 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-5UTR | ENST00000359788 | ENST00000442725 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-5UTR | ENST00000359788 | ENST00000252595 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-5UTR | ENST00000359788 | ENST00000598424 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-intron | ENST00000359788 | ENST00000598848 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-5UTR | ENST00000601010 | ENST00000442725 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-5UTR | ENST00000601010 | ENST00000252595 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-5UTR | ENST00000601010 | ENST00000598424 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-intron | ENST00000601010 | ENST00000598848 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-5UTR | ENST00000599168 | ENST00000442725 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-5UTR | ENST00000599168 | ENST00000252595 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-5UTR | ENST00000599168 | ENST00000598424 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
5CDS-intron | ENST00000599168 | ENST00000598848 | ZNF675 | chr19 | 23869833 | - | SLC27A1 | chr19 | 17581349 | + |
Top |
FusionProtFeatures for ZNF675_SLC27A1 |
![]() |
Hgene | Tgene |
ZNF675 | SLC27A1 |
May be involved in transcriptional regulation. May playa role during osteoclast differentiation by modulating TRAF6signaling activity. | Mediates the ATP-dependent import of long-chain fattyacids (LCFA) into the cell by mediating their translocation at theplasma membrane (PubMed:28178239). Has also an acyl-CoA ligaseactivity for long-chain and very-long-chain fatty acids. May actdirectly as a bona fide transporter, or alternatively, in acytoplasmic or membrane-associated multimeric protein complex totrap and draw fatty acids towards accumulation. Plays a pivotalrole in regulating available LCFA substrates from exogenoussources in tissues undergoing high levels of beta-oxidation ortriglyceride synthesis. May be involved in regulation ofcholesterol metabolism (By similarity).{ECO:0000250|UniProtKB:Q60714, ECO:0000269|PubMed:28178239}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ZNF675_SLC27A1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ZNF675_SLC27A1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF675 | TRAF6, TNFSF11, IL1B, LMO4 | SLC27A1 | RPE65 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ZNF675_SLC27A1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ZNF675_SLC27A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |