![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 43593 |
FusionGeneSummary for ZNF675_IGSF23 |
![]() |
Fusion gene information | Fusion gene name: ZNF675_IGSF23 | Fusion gene ID: 43593 | Hgene | Tgene | Gene symbol | ZNF675 | IGSF23 | Gene ID | 171392 | 147710 |
Gene name | zinc finger protein 675 | immunoglobulin superfamily member 23 | |
Synonyms | TBZF|TIZ | - | |
Cytomap | 19p12 | 19q13.31 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 675TRAF6 inhibitory zinc fingerTRAF6-binding zinc finger proteinTRAF6-inhibitory zinc finger protein | immunoglobulin superfamily member 23 | |
Modification date | 20180519 | 20180329 | |
UniProtAcc | Q8TD23 | A1L1A6 | |
Ensembl transtripts involved in fusion gene | ENST00000601935, ENST00000600313, ENST00000596211, ENST00000359788, ENST00000601010, ENST00000599168, | ENST00000402988, | |
Fusion gene scores | * DoF score | 4 X 1 X 4=16 | 5 X 4 X 4=80 |
# samples | 4 | 5 | |
** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF675 [Title/Abstract] AND IGSF23 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ZNF675 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 11751921 |
Hgene | ZNF675 | GO:0007249 | I-kappaB kinase/NF-kappaB signaling | 11751921 |
Hgene | ZNF675 | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | 11751921 |
Hgene | ZNF675 | GO:0019221 | cytokine-mediated signaling pathway | 11751921 |
Hgene | ZNF675 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 11751921 |
Hgene | ZNF675 | GO:0043508 | negative regulation of JUN kinase activity | 11751921 |
Hgene | ZNF675 | GO:0045671 | negative regulation of osteoclast differentiation | 11751921|11851921 |
Hgene | ZNF675 | GO:0046329 | negative regulation of JNK cascade | 11751921 |
Hgene | ZNF675 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway | 11751921 |
Hgene | ZNF675 | GO:2000678 | negative regulation of transcription regulatory region DNA binding | 11751921 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A8-A08I-01A | ZNF675 | chr19 | 23869833 | - | IGSF23 | chr19 | 45121426 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000601935 | ENST00000402988 | ZNF675 | chr19 | 23869833 | - | IGSF23 | chr19 | 45121426 | + |
5CDS-intron | ENST00000600313 | ENST00000402988 | ZNF675 | chr19 | 23869833 | - | IGSF23 | chr19 | 45121426 | + |
5CDS-intron | ENST00000596211 | ENST00000402988 | ZNF675 | chr19 | 23869833 | - | IGSF23 | chr19 | 45121426 | + |
5CDS-intron | ENST00000359788 | ENST00000402988 | ZNF675 | chr19 | 23869833 | - | IGSF23 | chr19 | 45121426 | + |
5CDS-intron | ENST00000601010 | ENST00000402988 | ZNF675 | chr19 | 23869833 | - | IGSF23 | chr19 | 45121426 | + |
5CDS-intron | ENST00000599168 | ENST00000402988 | ZNF675 | chr19 | 23869833 | - | IGSF23 | chr19 | 45121426 | + |
Top |
FusionProtFeatures for ZNF675_IGSF23 |
![]() |
Hgene | Tgene |
ZNF675 | IGSF23 |
May be involved in transcriptional regulation. May playa role during osteoclast differentiation by modulating TRAF6signaling activity. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ZNF675_IGSF23 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ZNF675_IGSF23 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF675 | TRAF6, TNFSF11, IL1B, LMO4 | IGSF23 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ZNF675_IGSF23 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ZNF675_IGSF23 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |