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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 43585

FusionGeneSummary for ZNF66_MLLT3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF66_MLLT3
Fusion gene ID: 43585
HgeneTgene
Gene symbol

ZNF66

MLLT3

Gene ID

7617

4300

Gene namezinc finger protein 66MLLT3, super elongation complex subunit
SynonymsZNF66PAF9|YEATS3
Cytomap

19p12

9p21.3

Type of geneprotein-codingprotein-coding
Descriptionputative zinc finger protein 66protein AF-9ALL1-fused gene from chromosome 9 proteinYEATS domain-containing protein 3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translo
Modification date2018052420180519
UniProtAcc

Q6ZN08

P42568

Ensembl transtripts involved in fusion geneENST00000360204, ENST00000594534, 
ENST00000344519, ENST00000425625, 
ENST00000380338, ENST00000355930, 
ENST00000429426, ENST00000475957, 
ENST00000380321, 
Fusion gene scores* DoF score1 X 1 X 1=19 X 18 X 8=1296
# samples 122
** MAII scorelog2(1/1*10)=3.32192809488736log2(22/1296*10)=-2.55849028935997
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF66 [Title/Abstract] AND MLLT3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMLLT3

GO:0045893

positive regulation of transcription, DNA-templated

25417107|27105114

TgeneMLLT3

GO:0090090

negative regulation of canonical Wnt signaling pathway

19591803


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-69-7980-01AZNF66chr19

20976684

+MLLT3chr9

20448264

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000360204ENST00000380338ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-5UTRENST00000360204ENST00000355930ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-5UTRENST00000360204ENST00000429426ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-intronENST00000360204ENST00000475957ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-intronENST00000360204ENST00000380321ZNF66chr19

20976684

+MLLT3chr9

20448264

-
Frame-shiftENST00000594534ENST00000380338ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-5UTRENST00000594534ENST00000355930ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-5UTRENST00000594534ENST00000429426ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-intronENST00000594534ENST00000475957ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-intronENST00000594534ENST00000380321ZNF66chr19

20976684

+MLLT3chr9

20448264

-
Frame-shiftENST00000344519ENST00000380338ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-5UTRENST00000344519ENST00000355930ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-5UTRENST00000344519ENST00000429426ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-intronENST00000344519ENST00000475957ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-intronENST00000344519ENST00000380321ZNF66chr19

20976684

+MLLT3chr9

20448264

-
Frame-shiftENST00000425625ENST00000380338ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-5UTRENST00000425625ENST00000355930ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-5UTRENST00000425625ENST00000429426ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-intronENST00000425625ENST00000475957ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-intronENST00000425625ENST00000380321ZNF66chr19

20976684

+MLLT3chr9

20448264

-

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FusionProtFeatures for ZNF66_MLLT3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF66

Q6ZN08

MLLT3

P42568

May be involved in transcriptional regulation.{ECO:0000250}. Chromatin reader component of the super elongationcomplex (SEC), a complex required to increase the catalytic rateof RNA polymerase II transcription by suppressing transientpausing by the polymerase at multiple sites along the DNA(PubMed:20159561, PubMed:20471948, PubMed:25417107,PubMed:27105114, PubMed:27545619). Specifically recognizes andbinds acylated histone H3, with a marked preference for histone H3that is crotonylated (PubMed:25417107, PubMed:27105114,PubMed:27545619). Crotonylation marks active promoters andenhancers and confers resistance to transcriptional repressors(PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizesand binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and withslightly lower affinity histone H3 crotonylated at 'Lys-18'(H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3acetylated at 'Lys-9' (H3K9ac), but with lower affinity thancrotonylated histone H3 (PubMed:25417107, PubMed:27105114). In theSEC complex, MLLT3 is required to recruit the complex tocrotonylated histones (PubMed:27105114, PubMed:27545619).{ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948,ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114,ECO:0000269|PubMed:27545619}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+344_7575574DomainKRAB
TgeneMLLT3chr19:20976684chr9:20448264ENST00000380338-211149_19492569Compositional biasNote=Poly-Ser
TgeneMLLT3chr19:20976684chr9:20448264ENST00000380338-211383_39192569Compositional biasNote=Poly-Ser
TgeneMLLT3chr19:20976684chr9:20448264ENST00000380338-211466_46992569Compositional biasNote=Poly-Pro
TgeneMLLT3chr19:20976684chr9:20448264ENST00000380338-211295_30092569MotifNuclear localization signal
TgeneMLLT3chr19:20976684chr9:20448264ENST00000380338-211106_10892569RegionHistone H3K9cr binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34145_16775574Zinc fingerC2H2-type 1%3B atypical
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34171_19575574Zinc fingerC2H2-type 2
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34201_22375574Zinc fingerC2H2-type 3
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34229_25175574Zinc fingerC2H2-type 4
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34257_27975574Zinc fingerC2H2-type 5
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34285_30775574Zinc fingerC2H2-type 6
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34313_33575574Zinc fingerC2H2-type 7
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34341_36375574Zinc fingerC2H2-type 8
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34369_39175574Zinc fingerC2H2-type 9
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34397_41975574Zinc fingerC2H2-type 10
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34425_44775574Zinc fingerC2H2-type 11
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34453_47575574Zinc fingerC2H2-type 12
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34481_50375574Zinc fingerC2H2-type 13
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34509_53175574Zinc fingerC2H2-type 14
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34537_55975574Zinc fingerC2H2-type 15
TgeneMLLT3chr19:20976684chr9:20448264ENST00000380338-2118_11292569DomainYEATS
TgeneMLLT3chr19:20976684chr9:20448264ENST00000380338-21178_8092569RegionHistone H3K9cr binding


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FusionGeneSequence for ZNF66_MLLT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZNF66_ENST00000360204_chr19_20976684_+_MLLT3_ENST00000380338_chr9_20448264_-_770aa
MAQRNLYRDVMLENYRNLVFLGIVVSKPDLITHLEQGKKPSTMQRHEMVANPSGRCEXKXIQQTTQXEVQGQKESQSLRCDSGSCVPKEL
LGSCFFCFLFLFLLFXILLSQRGILSYASKFSKNSTFLSVSFLHIHSESQSPLHDIXETAQSSCFFIVLGTHKYLPNFEKLKLFFSFLFV
SGLKFVRVVVSVAFFFVHFCAQSILFLLLYSLEIXFEIVSTIFCFLLFPQDCFGYSKFILVSCKFXNCIFHYCKKKHCNFNRKIIESVNH
FGXYDSLIIFILLIHXHKIFXNXEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSS
SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVP
KMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVK
IESETSEKKKSTLPPFDDIVDPNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDS
EMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZNF66_ENST00000360204_chr19_20976684_+_MLLT3_ENST00000380338_chr9_20448264_-_2310nt
ATGGCACAGCGGAATTTATATAGGGATGTGATGTTAGAGAACTACAGAAACCTGGTCTTTCTTGGTATTGTTGTCTCAAAGCCAGACCTC
ATCACCCATCTGGAGCAAGGAAAAAAACCTTCGACTATGCAGAGACATGAGATGGTAGCCAACCCCTCAGGTAGGTGTGAGTGAAAATGA
ATACAACAGACAACACAGTAAGAAGTCCAAGGTCAAAAAGAAAGCCAGTCCTTAAGGTGTGATTCTGGAAGCTGTGTTCCAAAGGAACTT
CTGGGCAGCTGTTTTTTTTGTTTTTTGTTTTTGTTTTTGTTGTTTTAAATTTTGCTGTCACAAAGGGGCATATTGTCTTATGCTTCTAAA
TTCTCTAAAAATTCTACTTTTCTCTCAGTGAGCTTCCTTCACATTCACAGTGAGAGCCAAAGTCCTCTTCATGACATATAAGAGACAGCA
CAATCCAGCTGCTTTTTCATTGTTTTGGGGACACACAAATATCTTCCTAATTTTGAGAAACTGAAACTATTTTTTAGTTTTCTTTTTGTA
TCCGGTCTGAAATTTGTGAGAGTAGTAGTTTCTGTTGCATTTTTTTTTGTTCATTTTTGTGCACAGTCCATTCTATTTTTATTACTATAT
AGTCTTGAAATATAGTTTGAAATTGTAAGTACGATATTCTGTTTTCTTCTTTTTCCTCAAGATTGCTTTGGCTATTCAAAGTTTATTTTA
GTTTCATGTAAATTTTAGAATTGTATTTTCCATTATTGTAAAAAAAAACACTGCAATTTTAATAGGAAGATTATTGAGTCTGTAAATCAC
TTTGGATAATATGATTCTTTAATAATATTTATTCTTTTAATTCATTGACATAAAATATTTTAAAATTAAGAAGAACCTAGGAAAGTCCGC
TTTGATTATGACTTATTCCTGCATCTTGAAGGCCATCCACCAGTGAATCACCTCCGCTGTGAAAAGCTAACTTTCAACAACCCCACAGAG
GACTTTAGGAGAAAGTTGCTGAAGGCAGGAGGGGACCCTAATAGGAGTATTCATACCAGCAGCAGCAGCAGCAGCAGCAGTAGCAGCAGC
AGCAGCAGCAGCAGCAGCAGCAGTAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGTAGCAGCAGCAGTAGCAGCAGCAGCAGCAGCAGT
AGTACCAGTTTTTCAAAGCCTCACAAATTAATGAAGGAGCACAAGGAAAAACCTTCTAAAGACTCCAGAGAACATAAAAGTGCCTTCAAA
GAACCTTCCAGGGATCACAACAAATCTTCCAAAGAATCCTCTAAGAAACCCAAAGAAAATAAACCACTGAAAGAAGAGAAAATAGTTCCT
AAGATGGCCTTCAAGGAACCTAAACCCATGTCAAAAGAGCCAAAACCAGATAGTAACTTACTCACCATCACCAGTGGACAAGATAAGAAG
GCTCCTAGTAAAAGGCCGCCCATTTCAGATTCTGAAGAACTCTCAGCCAAAAAAAGGAAAAAGAGTAGCTCAGAGGCTTTATTTAAAAGT
TTTTCTAGCGCACCACCACTGATACTCACTTGTTCTGCTGACAAAAAACAGATAAAAGATAAATCTCATGTCAAGATGGGAAAGGTCAAA
ATTGAAAGTGAGACATCAGAGAAGAAGAAATCAACGTTACCGCCATTTGATGATATTGTGGATCCCAATGATTCAGATGTGGAGGAGAAT
ATATCCTCTAAATCTGATTCTGAACAACCCAGTCCTGCCAGCTCCAGCTCCAGCTCCAGCTCCAGCTTCACACCATCCCAGACCAGGCAA
CAAGGTCCTTTGAGGTCTATAATGAAAGATCTGCATTCTGATGACAATGAGGAGGAATCAGATGAAGTGGAGGATAACGACAATGACTCT
GAAATGGAGAGGCCTGTAAATAGAGGAGGCAGCCGAAGTCGCAGAGTTAGCTTAAGTGATGGCAGCGATAGTGAAAGCAGTTCTGCTTCT
TCACCCCTACATCACGAACCTCCACCACCCTTACTAAAAACCAACAACAACCAGATTCTTGAAGTGAAAAGTCCAATAAAGCAAAGCAAA
TCAGATAAGCAAATAAAGAATGGTGAATGTGACAAGGCATACCTAGATGAACTGGTAGAGCTTCACAGAAGGTTAATGACATTGAGAGAA
AGACACATTCTGCAGCAGATCGTGAACCTTATAGAAGAAACTGGACACTTTCATATCACAAACACAACATTTGATTTTGATCTTTGCTCG


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNF66_ENST00000360204_chr19_20976684_+_MLLT3_ENST00000380338_chr9_20448264_-_7227nt
GCTTTCTTGGGAAGATGGCGGCTGTGTCGGTGTATGCTCCACCAGTTGGAGGCTTCTCTTTTGATAACTGCCGCAGGGGCCATTGCAATT
TAGAGATGTGGCCATAGAATTCTCTCTGGAGGAGTGGCATTGCCTGGACATGGCACAGCGGAATTTATATAGGGATGTGATGTTAGAGAA
CTACAGAAACCTGGTCTTTCTTGGTATTGTTGTCTCAAAGCCAGACCTCATCACCCATCTGGAGCAAGGAAAAAAACCTTCGACTATGCA
GAGACATGAGATGGTAGCCAACCCCTCAGGTAGGTGTGAGTGAAAATGAATACAACAGACAACACAGTAAGAAGTCCAAGGTCAAAAAGA
AAGCCAGTCCTTAAGGTGTGATTCTGGAAGCTGTGTTCCAAAGGAACTTCTGGGCAGCTGTTTTTTTTGTTTTTTGTTTTTGTTTTTGTT
GTTTTAAATTTTGCTGTCACAAAGGGGCATATTGTCTTATGCTTCTAAATTCTCTAAAAATTCTACTTTTCTCTCAGTGAGCTTCCTTCA
CATTCACAGTGAGAGCCAAAGTCCTCTTCATGACATATAAGAGACAGCACAATCCAGCTGCTTTTTCATTGTTTTGGGGACACACAAATA
TCTTCCTAATTTTGAGAAACTGAAACTATTTTTTAGTTTTCTTTTTGTATCCGGTCTGAAATTTGTGAGAGTAGTAGTTTCTGTTGCATT
TTTTTTTGTTCATTTTTGTGCACAGTCCATTCTATTTTTATTACTATATAGTCTTGAAATATAGTTTGAAATTGTAAGTACGATATTCTG
TTTTCTTCTTTTTCCTCAAGATTGCTTTGGCTATTCAAAGTTTATTTTAGTTTCATGTAAATTTTAGAATTGTATTTTCCATTATTGTAA
AAAAAAACACTGCAATTTTAATAGGAAGATTATTGAGTCTGTAAATCACTTTGGATAATATGATTCTTTAATAATATTTATTCTTTTAAT
TCATTGACATAAAATATTTTAAAATTAAGAAGAACCTAGGAAAGTCCGCTTTGATTATGACTTATTCCTGCATCTTGAAGGCCATCCACC
AGTGAATCACCTCCGCTGTGAAAAGCTAACTTTCAACAACCCCACAGAGGACTTTAGGAGAAAGTTGCTGAAGGCAGGAGGGGACCCTAA
TAGGAGTATTCATACCAGCAGCAGCAGCAGCAGCAGCAGTAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGTAGCAGCAGCAGCAGCAG
CAGCAGCAGCAGCAGTAGCAGCAGCAGTAGCAGCAGCAGCAGCAGCAGTAGTACCAGTTTTTCAAAGCCTCACAAATTAATGAAGGAGCA
CAAGGAAAAACCTTCTAAAGACTCCAGAGAACATAAAAGTGCCTTCAAAGAACCTTCCAGGGATCACAACAAATCTTCCAAAGAATCCTC
TAAGAAACCCAAAGAAAATAAACCACTGAAAGAAGAGAAAATAGTTCCTAAGATGGCCTTCAAGGAACCTAAACCCATGTCAAAAGAGCC
AAAACCAGATAGTAACTTACTCACCATCACCAGTGGACAAGATAAGAAGGCTCCTAGTAAAAGGCCGCCCATTTCAGATTCTGAAGAACT
CTCAGCCAAAAAAAGGAAAAAGAGTAGCTCAGAGGCTTTATTTAAAAGTTTTTCTAGCGCACCACCACTGATACTCACTTGTTCTGCTGA
CAAAAAACAGATAAAAGATAAATCTCATGTCAAGATGGGAAAGGTCAAAATTGAAAGTGAGACATCAGAGAAGAAGAAATCAACGTTACC
GCCATTTGATGATATTGTGGATCCCAATGATTCAGATGTGGAGGAGAATATATCCTCTAAATCTGATTCTGAACAACCCAGTCCTGCCAG
CTCCAGCTCCAGCTCCAGCTCCAGCTTCACACCATCCCAGACCAGGCAACAAGGTCCTTTGAGGTCTATAATGAAAGATCTGCATTCTGA
TGACAATGAGGAGGAATCAGATGAAGTGGAGGATAACGACAATGACTCTGAAATGGAGAGGCCTGTAAATAGAGGAGGCAGCCGAAGTCG
CAGAGTTAGCTTAAGTGATGGCAGCGATAGTGAAAGCAGTTCTGCTTCTTCACCCCTACATCACGAACCTCCACCACCCTTACTAAAAAC
CAACAACAACCAGATTCTTGAAGTGAAAAGTCCAATAAAGCAAAGCAAATCAGATAAGCAAATAAAGAATGGTGAATGTGACAAGGCATA
CCTAGATGAACTGGTAGAGCTTCACAGAAGGTTAATGACATTGAGAGAAAGACACATTCTGCAGCAGATCGTGAACCTTATAGAAGAAAC
TGGACACTTTCATATCACAAACACAACATTTGATTTTGATCTTTGCTCGCTGGACAAAACCACAGTCCGTAAACTACAGAGTTACCTGGA
AACATCTGGAACATCCTGAGGATATAACAACTGGATGCATCAAGAACTATTGTGTTTTTTTTTTTTGGTTTTTTTTTTTTTTGGTTGTGA
TTTTTTGTTCTTGTTGTTTATATGAAAACACTCAAAATGATGCAACCAAAAGGGAAAAAATAAAAATCAAACAACCTTCAGCTTTATTTT
TCTTTAAAGCCAGTCATCATCTCTTGATAAAGGAGAGGTTAAAGCAAACCAGCCTCAGCGGACCACTCTTCTCTCCAAGGAAATCCCCGG
GAAGAGTTAGCCTGGATAGCCTTGAAAACAAACAAATCAAACACAACACAAGAAAACTCAAAGAATGTGTATGGTATCATGTATCTCTCT
GTGGTGGTTCATTCCACAGGACGAATGCATATTCAACACACTGCCTTATTACATAACTGATCTATTTATTATCGCATACAGATATTCTAA
GTCGTTGAGGGAATGACACCATCAGACATTATAAGTACTTGGTCCCGTGGATGCTCTTTCAATGCAGCACCCTTGCCATCCCAAGCCCAG
TGACCTTACTCGTATACCGTGCCACTTTCCACCAACTTTTTCCAAGTCCTTTAACTCGTTGCAGTCTGTATTTTCCACCTTTTGTTTTTC
CAGTTCCAGGACACAGATTATCAACTGGGGGGACCAAATAGCCACCTTGATTTTCTTCTTTGTGGTCTTTTTCCTGAAAGTTGGGGCCCA
GTCCTTGGCTGTATCCATGTAATGATCTTGGACCATGGTAGAAAATGCACCAAATAGGATCATATGAATTGCTGTCTAGCCTTAGTCAAT
AAACTTGTAGGACTTTTAAACAAAAGTGTACCTGTAAATGTCCTGAATCCAGCATTGTTGAGCTGTCATCAACATTCTTGTGTCTGTTTT
ACTGTTACAATATTAGGTGAATATGGAAGTAAAGGCATTCCACAGGATCATCATTTAAAAAAAAAGAATTCTGGTCCTGTTTTCTAAAAA
AAAAAACTGTTGTAGAAATTCTTAATTTGGATCTATTTATTAGTCAGAGTTTCAGCTTTCTTCAGCTGCCAGTGTGTTACTCATCTTTAT
CCTAAAAATCTGGAATCAGAGATTTTTGTTTGTTCACATATGATTCTCTTAGACACTTTTATATTTGAAAAAATTAAAATCTTTCTTTGG
GGAAAAATTCTTGGTTATTCTGCCATAACAGATTATGTATTAACTTGTAGATTCAGTGGTTCAATACCTGTTTAGTTGCTTGCTAATATT
TCCAGAAGGATTTCTTGTATTGGTGAAAGACGGTTGGGGATGGGGGGATTTTTTTGTTCTTGTTGTACCCTTGTTTTGAAACTAGAAATC
TGTCCTGTGGCATGCAAAAGAAAGCAAATTATTTTTAAAAGAAAAAAACCAAAGTACTTTTGGTGTCATTATTCCATCTTCTCCATAAGT
GGAGAAATGAAAAGTAAGAACAGCTCATCTTCAAAGTTTTTACTAGAAATTCAGCCGAAAAGAAGAGAAATGAAGAAATACTTCTGGATC
CAAAGGTTCGTCACTGGATCAGCCTTAAGAAAGTCTCTATGTGTGCTAATAGACCAGTATCTCCCTTGTTTGTTCCCATGCCAGATGCTG
TCTTTTCATACAGAGATTAACTAGTGTCTGTACAGAAAATGGTCTTTCCAGACCCATTCTTTTGGGCAGTTATATAAATGCAGATTGATA
ATGGAGTTATTTCTGCATTTTAAAAAGGGGATTTTTTACACTGTTTCTTTCTATCCAAAGAAACTATTTTTCCTTTAAAAAATTATAATA
CAGCCATGCTCCTTGTAAATTATTTCTCTGAAGCGTCCTCCCAGAGGACAAGTGTACTTTCTCAATAATGTTATGATTCTTAATGACGAT
TGGCATGAACCGTACTTGAAGCATTTGTTGTATTGTCCACTTCTTGATGTGCAGAGAAACTTTGAGTCATTTTGGACATTAGGTGATTGA
TGAATTGTGTGGTTTCAGTTGCGTTTTGTTTTTAACTTTATAGCTGGAAGGGGAGGGTAATGTTTATATGGAAATGTTGCAAATTTTTAA
AATATTTTAAAATTTCTAACTGCTAACACATATTCTGATCAAGCCAGAAGTTTATGTGATTTAATATATCTGTGTAGTTTAACTAGAAAC
GTATATATGTAGTTTGGGCCATTTTTATTTCTGTAACTAAATTGTGGGGCAAAAAATATGATTTGCCAATGTAAAAATTTTTTCCTTTAA
GTTACTAACCAAGAAGCTAGGTAAGATAAGAAATGACCAAACAAAAATAATGATAAGAAGGACAGCTATTATATGATAAACTTTAGACTT
GAAAATTAGGTAATAAAGTTAATTTCTTCAGAATATCCTAAAATGTAAGTTTGTAAATTGATAAAGTTCAGAAAAACTTATCCATCTTCT
ACTCATCAAGATAGCAAAGTAAGTTTTTCACAAAATTAAGACTGAGAGTTACGTTATTTTTTTTGAAGTGGTAATCTTGCTCTCATCTAA
TTTTTAAATACAGAAATAAAAAGATCCCTTTGAATTAATTTCAAGTAGTTTTAATACCTCTCTTAAAGTAACCCCTTCAGTTCTGTCACA
TTTATATACACCCAACTTTGAAGCCTATTAAGAATATCTTTGACATGTGAGTACCCTAACAGTGGCTCTGGTTTCTTAAGCACAAAGGGA
AAATGGCAGGGTTTAATTTCTTTGGTGTACATATATAAATAGATGTTTCAAATAAAATTAATTGGGTAAATGTGAATATGGTTTGAACCA
GCCAGAGTATGATAAACTTTTAAAAAATTTTTCCTCAGTGATCAGCCAGGGGAAAAAATATATGTACAGAGCTCCTGCCCCTCTGCCCCC
TTATAACTTAGCTTTTGCCTCTGGTTTTGCAGCAGGATGTGTGTTGGTGGGTTTGGGGTTCCTTCTGTCTTCGGATGTAACAGTCATGTT
AGCAACAATATTTTGCAGTTACTTCACCATCCTCAGCATAATCTGCCTCTCTCTCAATCTTAATACAGACAAATAGGTATGTCTATAAAT
GCGTTCATATAGTGTCAAGGTAGGGAAGACTATAAAAACTTCAGATCAGGAAAAAAATATCTCTTAAGAGAGTGTCTTAAACATTTTAAA
TTGCTAGGCAATTTAAATCTCTCTAATCTGAATATTCACCTTTTGGTGGAAAGAGCCAGTAATATTGGTTTTCTTCCACTAAAAAGTTTC
TTCAAAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGCCGATATCTTTTACAGGCCCACCTAATCTTTAAAAAAAAGAGAAGAAACAA
TTTTAGGCCTGTATAACATCCTATTTACTACTTCAAGCTCCACAAATGTAGTTAATATATTTGTTTAAGAGAGACTTTACTCTTAAATGT
TTTAACTTTGCCTACTTAATGGAGTTGGATGTCCAGTGTTGGAAACAGTCAGTGTCTGTTTGGTGGCTCGTGTTTATTTTTGTCACTGTA
GAAGTGATCTGCTCTGGAGTAATTTGCTGTATGCTTATTACTTTCCACCTTTAGCGTTTTGTGTACTAATGCTATGTACTGCTCCTATAT
TTATATATACATATATATATATATATACACATATATATTATCAGAGTAATCTTGCTTTGGACTGTTGCTCTAAAACTATGAATATGATGT
AGAGACTACTACAGCTGCAGTGAATGTTAAGGAGTCAATTCCCATGGTTTAGTTTAGTCTCGGGCTGGAAGTCTACATCTTTTGACCTCT
TTTGTTTTATATGATGCTTTTTATTATGTAGGCACTGCCATCCCTGAATATTCCTTGTAAAGATGCAGTGAAGAAGTCAATTTAAAAGGA
AGACAAAGCCACCGCTGTCTGTAAACTGTAAATGTGTATTTTGGCACTTGTACTCCAGTATTCTGAAAATAGAGTTATGATGGAAATGCT
GACAGATCCTTAATGGTGGCCAGAGCTACCATGCAGTGCAAAAATAAATTAAGTGAAAATGTATTATTGAGATTAACAGTGCAAGGCCAA
TACATTTTATAAATCTGTCAGTATCTTTTTAATGGACTGTGTATGTGTAGTTATGTTGAAAGATACATTGTGTATGTGTACATGCTTTTG
TGTGAATTCAAGGCACACTGTAAGATGTATTTCCCTTCTCTAAAATCCATGTTGAAATGTAAGTACAGATTGATAGAAATAGGTGTTTTA
CTTAAACTCATATAATCTGTTTCAGCACCTTTTTTAAAATGTATAATTGTACTGATTTGCTGAGAGTCATTTGACCAAAGTTTGGCTTTA
TTTTGCATACAGGAAAAATTAGCCCCTAGCCTTTTCTCAAGAAGTGATGCTGTTTCTAAAGAAGAATAGATGGGGAGATCTGAGACATCC
AGAGAGAGGACAATGTGTCCAAAACCAGCTGAAGGCAGAGAGTCCATGCCTCATTCATTTTAGGAGTCCCTCATGTCTAACACCATCTTC
TGTGTCCTAAAGCCAGTATATATATAATATTTTTAAAACTCTGCAAAGATTGGAACAAGAAGTGGTGGGATACATTTTTTGGCATAAACT
GGGCTATGTGTGCCCGGTATTTTTTCTTTCCCCCCTATTTCTTTGGAGGGTTTTGTTCAGAAACAATGTGCTATAGCCAGAGAGAGTCGA
TCTTACAAAGTCCCTGCATTTACTTTCACAGCAAGAACTGCTACCTTGATTAGACAGGAAGGAGAACAACTACTACAACAAAGAGAATAA


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FusionGenePPI for ZNF66_MLLT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF66MLLT3APPBP2, MCM6, BCOR, RBM48, EEF1A1, PTN, LRIF1, DOT1L, SGK1, AFF4, AFF1, CDK9, AFF3, ACACA, SIRT1, CCNT1, NIPBL, EAF1, ELL3, PCGF1, MLLT1, EEF2, ELL, MLLT10, CCNT2, RNF2, KMT2A, CHD4, ELL2, PAF1, APP, CDK6, MED26, HSP90B1, EXOSC3, FAM9A, EDA, DENND2D, EPB41L3, XPO1, H3F3A, PIP4K2A, EPB41L2, CAMKV, MLLT6, SNX24, BPIFB1, MDK, PES1, EPB41L5, ARRB2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF66_MLLT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF66_MLLT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMLLT3C0005586Bipolar Disorder1PSYGENET