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Fusion gene ID: 4356 |
FusionGeneSummary for BRAF_C7orf10 |
Fusion gene summary |
Fusion gene information | Fusion gene name: BRAF_C7orf10 | Fusion gene ID: 4356 | Hgene | Tgene | Gene symbol | BRAF | C7orf10 | Gene ID | 673 | 79783 |
Gene name | B-Raf proto-oncogene, serine/threonine kinase | succinyl-CoA:glutarate-CoA transferase | |
Synonyms | B-RAF1|B-raf|BRAF1|NS7|RAFB1 | C7orf10|DERP13|GA3|ORF19 | |
Cytomap | 7q34 | 7p14.1 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene | succinate--hydroxymethylglutarate CoA-transferaseRussel-Silver syndrome candidatedermal papilla-derived protein 13succinylCoA:glutarate-CoA transferase | |
Modification date | 20180527 | 20180522 | |
UniProtAcc | P15056 | ||
Ensembl transtripts involved in fusion gene | ENST00000288602, | ENST00000309930, ENST00000401647, ENST00000335693, ENST00000464028, ENST00000540834, | |
Fusion gene scores | * DoF score | 18 X 12 X 10=2160 | 8 X 4 X 8=256 |
# samples | 22 | 8 | |
** MAII score | log2(22/2160*10)=-3.29545588352617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/256*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: BRAF [Title/Abstract] AND C7orf10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BRAF | GO:0006468 | protein phosphorylation | 17563371 |
Hgene | BRAF | GO:0010828 | positive regulation of glucose transmembrane transport | 23010278 |
Hgene | BRAF | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19667065 |
Hgene | BRAF | GO:0043066 | negative regulation of apoptotic process | 19667065 |
Hgene | BRAF | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22065586 |
Hgene | BRAF | GO:0071277 | cellular response to calcium ion | 18567582 |
Hgene | BRAF | GO:0090150 | establishment of protein localization to membrane | 23010278 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | THCA | TCGA-FY-A40N-01A | BRAF | chr7 | 140624366 | - | C7orf10 | chr7 | 40789033 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000288602 | ENST00000309930 | BRAF | chr7 | 140624366 | - | C7orf10 | chr7 | 40789033 | + |
In-frame | ENST00000288602 | ENST00000401647 | BRAF | chr7 | 140624366 | - | C7orf10 | chr7 | 40789033 | + |
In-frame | ENST00000288602 | ENST00000335693 | BRAF | chr7 | 140624366 | - | C7orf10 | chr7 | 40789033 | + |
5CDS-intron | ENST00000288602 | ENST00000464028 | BRAF | chr7 | 140624366 | - | C7orf10 | chr7 | 40789033 | + |
5CDS-intron | ENST00000288602 | ENST00000540834 | BRAF | chr7 | 140624366 | - | C7orf10 | chr7 | 40789033 | + |
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FusionProtFeatures for BRAF_C7orf10 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
BRAF | C7orf10 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | BRAF | chr7:140624366 | chr7:40789033 | ENST00000288602 | - | 1 | 18 | 6_11 | 46 | 767 | Compositional bias | Note=Poly-Gly |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >BRAF | chr7:140624366 | chr7:40789033 | ENST00000288602 | - | 1 | 18 | 122_129 | 46 | 767 | Compositional bias | Note=Poly-Ser |
Hgene | >BRAF | chr7:140624366 | chr7:40789033 | ENST00000288602 | - | 1 | 18 | 428_432 | 46 | 767 | Compositional bias | Note=Poly-Ser |
Hgene | >BRAF | chr7:140624366 | chr7:40789033 | ENST00000288602 | - | 1 | 18 | 155_227 | 46 | 767 | Domain | RBD |
Hgene | >BRAF | chr7:140624366 | chr7:40789033 | ENST00000288602 | - | 1 | 18 | 457_717 | 46 | 767 | Domain | Protein kinase |
Hgene | >BRAF | chr7:140624366 | chr7:40789033 | ENST00000288602 | - | 1 | 18 | 463_471 | 46 | 767 | Nucleotide binding | ATP |
Hgene | >BRAF | chr7:140624366 | chr7:40789033 | ENST00000288602 | - | 1 | 18 | 234_280 | 46 | 767 | Zinc finger | Phorbol-ester/DAG-type |
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FusionGeneSequence for BRAF_C7orf10 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000309930_chr7_40789033_+_122aa MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVLHNGLVMEMEHPTVGKISVPGPAVRYSKFKMSEARPPPLLGQH >In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000401647_chr7_40789033_+_122aa MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVLHNGLVMEMEHPTVGKISVPGPAVRYSKFKMSEARPPPLLGQH >In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000335693_chr7_40789033_+_122aa MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVLHNGLVMEMEHPTVGKISVPGPAVRYSKFKMSEARPPPLLGQH |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000309930_chr7_40789033_+_366nt ATGGCGGCGCTGAGCGGTGGCGGTGGTGGCGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGC GCCGGCGCCGCGGCCTCTTCGGCTGCGGACCCTGCCATTCCGGAGGAGGTATTACACAATGGCCTCGTTATGGAGATGGAGCATCCAACT GTGGGGAAGATTTCCGTCCCAGGCCCAGCTGTGAGATACAGTAAGTTCAAGATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCAC ACAACGCACATCCTGAAGGAGGTCCTGAGATACGATGACAGGGCCATCGGGGAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACT >In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000401647_chr7_40789033_+_366nt ATGGCGGCGCTGAGCGGTGGCGGTGGTGGCGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGC GCCGGCGCCGCGGCCTCTTCGGCTGCGGACCCTGCCATTCCGGAGGAGGTATTACACAATGGCCTCGTTATGGAGATGGAGCATCCAACT GTGGGGAAGATTTCCGTCCCAGGCCCAGCTGTGAGATACAGTAAGTTCAAGATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCAC ACAACGCACATCCTGAAGGAGGTCCTGAGATACGATGACAGGGCCATCGGGGAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACT >In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000335693_chr7_40789033_+_366nt ATGGCGGCGCTGAGCGGTGGCGGTGGTGGCGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGC GCCGGCGCCGCGGCCTCTTCGGCTGCGGACCCTGCCATTCCGGAGGAGGTATTACACAATGGCCTCGTTATGGAGATGGAGCATCCAACT GTGGGGAAGATTTCCGTCCCAGGCCCAGCTGTGAGATACAGTAAGTTCAAGATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCAC ACAACGCACATCCTGAAGGAGGTCCTGAGATACGATGACAGGGCCATCGGGGAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000309930_chr7_40789033_+_706nt CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA CCCTGCCATTCCGGAGGAGGTATTACACAATGGCCTCGTTATGGAGATGGAGCATCCAACTGTGGGGAAGATTTCCGTCCCAGGCCCAGC TGTGAGATACAGTAAGTTCAAGATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCACACAACGCACATCCTGAAGGAGGTCCTGAG ATACGATGACAGGGCCATCGGGGAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACTCACTGACAAAGGAAAAGGGCTCTTCCTCA TAACCTCGATCCGAATACACTGGCAAAGGCAACACTTTGCTTGGACCCTTCTCCCCAGTTCTGATACCACTAAAAAGAAGATTTAGAGTA ACTCCAGATTTCTTACATGGCATCTCCAGAATGGCTCTGGTATTAATGAATCTAGTGCCTTTTAAATGTATCCCACGTTTTGTTCCCTAC >In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000401647_chr7_40789033_+_579nt CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA CCCTGCCATTCCGGAGGAGGTATTACACAATGGCCTCGTTATGGAGATGGAGCATCCAACTGTGGGGAAGATTTCCGTCCCAGGCCCAGC TGTGAGATACAGTAAGTTCAAGATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCACACAACGCACATCCTGAAGGAGGTCCTGAG ATACGATGACAGGGCCATCGGGGAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACTCACTGACAAAGGAAAAGGGCTCTTCCTCA TAACCTCGATCCGAATACACTGGCAAAGGCAACACTTTGCTTGGACCCTTCTCCCCAGTTCTGATACCACTAAAAAGAAGATTTAGAGTA >In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000335693_chr7_40789033_+_711nt CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA CCCTGCCATTCCGGAGGAGGTATTACACAATGGCCTCGTTATGGAGATGGAGCATCCAACTGTGGGGAAGATTTCCGTCCCAGGCCCAGC TGTGAGATACAGTAAGTTCAAGATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCACACAACGCACATCCTGAAGGAGGTCCTGAG ATACGATGACAGGGCCATCGGGGAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACTCACTGACAAAGGAAAAGGGCTCTTCCTCA TAACCTCGATCCGAATACACTGGCAAAGGCAACACTTTGCTTGGACCCTTCTCCCCAGTTCTGATACCACTAAAAAGAAGATTTAGAGTA ACTCCAGATTTCTTACATGGCATCTCCAGAATGGCTCTGGTATTAATGAATCTAGTGCCTTTTAAATGTATCCCACGTTTTGTTCCCTAC |
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FusionGenePPI for BRAF_C7orf10 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
BRAF | YWHAB, YWHAG, YWHAQ, YWHAZ, SFN, HRAS, AKT1, MAPK3, RAP1GAP, RAF1, MRAS, RAP1A, PAK2, TERF1, CCDC88A, NEDD4L, MAP2K1, RNF149, KSR1, BRAP, PRKCE, RPS6KB2, HSP90AA1, BRAF, YWHAE, HSPA5, MAP2K2, HSPA1A, HSPA8, YWHAH, HSPA9, ARAF, CDC37, HSP90AB1, PHKB, LIMK1, IQGAP1, MAPK1, BAD, LIPF, MUS81, FBXW7, FGFR2, BRCA2, VHL, FNTA, HDAC2, PIK3CA, EGFR, PTEN, FNIP1, FNIP2, RAB3GAP1, KRAS, KIAA0141, FKBPL, ARMCX3, KCNC4, RPTOR, CYLD, NRAS | C7orf10 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BRAF_C7orf10 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | BRAF | P15056 | DB08881 | Vemurafenib | Serine/threonine-protein kinase B-raf | small molecule | approved |
Hgene | BRAF | P15056 | DB08896 | Regorafenib | Serine/threonine-protein kinase B-raf | small molecule | approved |
Hgene | BRAF | P15056 | DB00398 | Sorafenib | Serine/threonine-protein kinase B-raf | small molecule | approved|investigational |
Hgene | BRAF | P15056 | DB08912 | Dabrafenib | Serine/threonine-protein kinase B-raf | small molecule | approved|investigational |
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RelatedDiseases for BRAF_C7orf10 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BRAF | C0025202 | melanoma | 21 | CTD_human |
Hgene | BRAF | C1527249 | Colorectal Cancer | 8 | UNIPROT |
Hgene | BRAF | C1275081 | Cardio-facio-cutaneous syndrome | 6 | CTD_human;ORPHANET;UNIPROT |
Hgene | BRAF | C0009404 | Colorectal Neoplasms | 4 | CTD_human |
Hgene | BRAF | C0040136 | Thyroid Neoplasm | 4 | CTD_human |
Hgene | BRAF | C0024305 | Lymphoma, Non-Hodgkin | 3 | UNIPROT |
Hgene | BRAF | C0684249 | Carcinoma of lung | 3 | UNIPROT |
Hgene | BRAF | C3150970 | NOONAN SYNDROME 7 | 3 | CTD_human;UNIPROT |
Hgene | BRAF | C0152013 | Adenocarcinoma of lung (disorder) | 2 | CTD_human |
Hgene | BRAF | C0002448 | Ameloblastoma | 1 | CTD_human |
Hgene | BRAF | C0004114 | Astrocytoma | 1 | CTD_human |
Hgene | BRAF | C0010276 | Craniopharyngioma | 1 | CTD_human;ORPHANET |
Hgene | BRAF | C0017638 | Glioma | 1 | CTD_human |
Hgene | BRAF | C0022665 | Kidney Neoplasm | 1 | CTD_human |
Hgene | BRAF | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | BRAF | C0024694 | Mandibular Neoplasms | 1 | CTD_human |
Hgene | BRAF | C0028326 | Noonan Syndrome | 1 | CTD_human;ORPHANET |
Hgene | BRAF | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | BRAF | C0036920 | Sezary Syndrome | 1 | CTD_human |
Hgene | BRAF | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
Hgene | BRAF | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
Hgene | BRAF | C0206754 | Neuroendocrine Tumors | 1 | CTD_human |
Hgene | BRAF | C0238463 | Papillary thyroid carcinoma | 1 | CTD_human;ORPHANET |
Hgene | BRAF | C0587248 | Costello syndrome (disorder) | 1 | CTD_human |
Hgene | BRAF | C0596263 | Carcinogenesis | 1 | CTD_human |
Hgene | BRAF | C0920269 | Microsatellite Instability | 1 | CTD_human |
Hgene | BRAF | C2239176 | Liver carcinoma | 1 | CTD_human |