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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4356

FusionGeneSummary for BRAF_C7orf10

check button Fusion gene summary
Fusion gene informationFusion gene name: BRAF_C7orf10
Fusion gene ID: 4356
HgeneTgene
Gene symbol

BRAF

C7orf10

Gene ID

673

79783

Gene nameB-Raf proto-oncogene, serine/threonine kinasesuccinyl-CoA:glutarate-CoA transferase
SynonymsB-RAF1|B-raf|BRAF1|NS7|RAFB1C7orf10|DERP13|GA3|ORF19
Cytomap

7q34

7p14.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene succinate--hydroxymethylglutarate CoA-transferaseRussel-Silver syndrome candidatedermal papilla-derived protein 13succinylCoA:glutarate-CoA transferase
Modification date2018052720180522
UniProtAcc

P15056

Ensembl transtripts involved in fusion geneENST00000288602, ENST00000309930, 
ENST00000401647, ENST00000335693, 
ENST00000464028, ENST00000540834, 
Fusion gene scores* DoF score18 X 12 X 10=21608 X 4 X 8=256
# samples 228
** MAII scorelog2(22/2160*10)=-3.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRAF [Title/Abstract] AND C7orf10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRAF

GO:0006468

protein phosphorylation

17563371

HgeneBRAF

GO:0010828

positive regulation of glucose transmembrane transport

23010278

HgeneBRAF

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

HgeneBRAF

GO:0043066

negative regulation of apoptotic process

19667065

HgeneBRAF

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22065586

HgeneBRAF

GO:0071277

cellular response to calcium ion

18567582

HgeneBRAF

GO:0090150

establishment of protein localization to membrane

23010278


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTHCATCGA-FY-A40N-01ABRAFchr7

140624366

-C7orf10chr7

40789033

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000288602ENST00000309930BRAFchr7

140624366

-C7orf10chr7

40789033

+
In-frameENST00000288602ENST00000401647BRAFchr7

140624366

-C7orf10chr7

40789033

+
In-frameENST00000288602ENST00000335693BRAFchr7

140624366

-C7orf10chr7

40789033

+
5CDS-intronENST00000288602ENST00000464028BRAFchr7

140624366

-C7orf10chr7

40789033

+
5CDS-intronENST00000288602ENST00000540834BRAFchr7

140624366

-C7orf10chr7

40789033

+

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FusionProtFeatures for BRAF_C7orf10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRAF

P15056

C7orf10

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRAFchr7:140624366chr7:40789033ENST00000288602-1186_1146767Compositional biasNote=Poly-Gly

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRAFchr7:140624366chr7:40789033ENST00000288602-118122_12946767Compositional biasNote=Poly-Ser
HgeneBRAFchr7:140624366chr7:40789033ENST00000288602-118428_43246767Compositional biasNote=Poly-Ser
HgeneBRAFchr7:140624366chr7:40789033ENST00000288602-118155_22746767DomainRBD
HgeneBRAFchr7:140624366chr7:40789033ENST00000288602-118457_71746767DomainProtein kinase
HgeneBRAFchr7:140624366chr7:40789033ENST00000288602-118463_47146767Nucleotide bindingATP
HgeneBRAFchr7:140624366chr7:40789033ENST00000288602-118234_28046767Zinc fingerPhorbol-ester/DAG-type


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FusionGeneSequence for BRAF_C7orf10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000309930_chr7_40789033_+_122aa
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVLHNGLVMEMEHPTVGKISVPGPAVRYSKFKMSEARPPPLLGQH

>In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000401647_chr7_40789033_+_122aa
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVLHNGLVMEMEHPTVGKISVPGPAVRYSKFKMSEARPPPLLGQH

>In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000335693_chr7_40789033_+_122aa
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVLHNGLVMEMEHPTVGKISVPGPAVRYSKFKMSEARPPPLLGQH


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000309930_chr7_40789033_+_366nt
ATGGCGGCGCTGAGCGGTGGCGGTGGTGGCGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGC
GCCGGCGCCGCGGCCTCTTCGGCTGCGGACCCTGCCATTCCGGAGGAGGTATTACACAATGGCCTCGTTATGGAGATGGAGCATCCAACT
GTGGGGAAGATTTCCGTCCCAGGCCCAGCTGTGAGATACAGTAAGTTCAAGATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCAC
ACAACGCACATCCTGAAGGAGGTCCTGAGATACGATGACAGGGCCATCGGGGAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACT

>In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000401647_chr7_40789033_+_366nt
ATGGCGGCGCTGAGCGGTGGCGGTGGTGGCGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGC
GCCGGCGCCGCGGCCTCTTCGGCTGCGGACCCTGCCATTCCGGAGGAGGTATTACACAATGGCCTCGTTATGGAGATGGAGCATCCAACT
GTGGGGAAGATTTCCGTCCCAGGCCCAGCTGTGAGATACAGTAAGTTCAAGATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCAC
ACAACGCACATCCTGAAGGAGGTCCTGAGATACGATGACAGGGCCATCGGGGAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACT

>In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000335693_chr7_40789033_+_366nt
ATGGCGGCGCTGAGCGGTGGCGGTGGTGGCGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGC
GCCGGCGCCGCGGCCTCTTCGGCTGCGGACCCTGCCATTCCGGAGGAGGTATTACACAATGGCCTCGTTATGGAGATGGAGCATCCAACT
GTGGGGAAGATTTCCGTCCCAGGCCCAGCTGTGAGATACAGTAAGTTCAAGATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCAC
ACAACGCACATCCTGAAGGAGGTCCTGAGATACGATGACAGGGCCATCGGGGAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACT


* Fusion transcript sequences (Full-length transcript).
>In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000309930_chr7_40789033_+_706nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTATTACACAATGGCCTCGTTATGGAGATGGAGCATCCAACTGTGGGGAAGATTTCCGTCCCAGGCCCAGC
TGTGAGATACAGTAAGTTCAAGATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCACACAACGCACATCCTGAAGGAGGTCCTGAG
ATACGATGACAGGGCCATCGGGGAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACTCACTGACAAAGGAAAAGGGCTCTTCCTCA
TAACCTCGATCCGAATACACTGGCAAAGGCAACACTTTGCTTGGACCCTTCTCCCCAGTTCTGATACCACTAAAAAGAAGATTTAGAGTA
ACTCCAGATTTCTTACATGGCATCTCCAGAATGGCTCTGGTATTAATGAATCTAGTGCCTTTTAAATGTATCCCACGTTTTGTTCCCTAC

>In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000401647_chr7_40789033_+_579nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTATTACACAATGGCCTCGTTATGGAGATGGAGCATCCAACTGTGGGGAAGATTTCCGTCCCAGGCCCAGC
TGTGAGATACAGTAAGTTCAAGATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCACACAACGCACATCCTGAAGGAGGTCCTGAG
ATACGATGACAGGGCCATCGGGGAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACTCACTGACAAAGGAAAAGGGCTCTTCCTCA
TAACCTCGATCCGAATACACTGGCAAAGGCAACACTTTGCTTGGACCCTTCTCCCCAGTTCTGATACCACTAAAAAGAAGATTTAGAGTA

>In-frame_BRAF_ENST00000288602_chr7_140624366_-_C7orf10_ENST00000335693_chr7_40789033_+_711nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTATTACACAATGGCCTCGTTATGGAGATGGAGCATCCAACTGTGGGGAAGATTTCCGTCCCAGGCCCAGC
TGTGAGATACAGTAAGTTCAAGATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCACACAACGCACATCCTGAAGGAGGTCCTGAG
ATACGATGACAGGGCCATCGGGGAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACTCACTGACAAAGGAAAAGGGCTCTTCCTCA
TAACCTCGATCCGAATACACTGGCAAAGGCAACACTTTGCTTGGACCCTTCTCCCCAGTTCTGATACCACTAAAAAGAAGATTTAGAGTA
ACTCCAGATTTCTTACATGGCATCTCCAGAATGGCTCTGGTATTAATGAATCTAGTGCCTTTTAAATGTATCCCACGTTTTGTTCCCTAC


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FusionGenePPI for BRAF_C7orf10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BRAFYWHAB, YWHAG, YWHAQ, YWHAZ, SFN, HRAS, AKT1, MAPK3, RAP1GAP, RAF1, MRAS, RAP1A, PAK2, TERF1, CCDC88A, NEDD4L, MAP2K1, RNF149, KSR1, BRAP, PRKCE, RPS6KB2, HSP90AA1, BRAF, YWHAE, HSPA5, MAP2K2, HSPA1A, HSPA8, YWHAH, HSPA9, ARAF, CDC37, HSP90AB1, PHKB, LIMK1, IQGAP1, MAPK1, BAD, LIPF, MUS81, FBXW7, FGFR2, BRCA2, VHL, FNTA, HDAC2, PIK3CA, EGFR, PTEN, FNIP1, FNIP2, RAB3GAP1, KRAS, KIAA0141, FKBPL, ARMCX3, KCNC4, RPTOR, CYLD, NRASC7orf10


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BRAF_C7orf10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneBRAFP15056DB08881VemurafenibSerine/threonine-protein kinase B-rafsmall moleculeapproved
HgeneBRAFP15056DB08896RegorafenibSerine/threonine-protein kinase B-rafsmall moleculeapproved
HgeneBRAFP15056DB00398SorafenibSerine/threonine-protein kinase B-rafsmall moleculeapproved|investigational
HgeneBRAFP15056DB08912DabrafenibSerine/threonine-protein kinase B-rafsmall moleculeapproved|investigational

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RelatedDiseases for BRAF_C7orf10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRAFC0025202melanoma21CTD_human
HgeneBRAFC1527249Colorectal Cancer8UNIPROT
HgeneBRAFC1275081Cardio-facio-cutaneous syndrome6CTD_human;ORPHANET;UNIPROT
HgeneBRAFC0009404Colorectal Neoplasms4CTD_human
HgeneBRAFC0040136Thyroid Neoplasm4CTD_human
HgeneBRAFC0024305Lymphoma, Non-Hodgkin3UNIPROT
HgeneBRAFC0684249Carcinoma of lung3UNIPROT
HgeneBRAFC3150970NOONAN SYNDROME 73CTD_human;UNIPROT
HgeneBRAFC0152013Adenocarcinoma of lung (disorder)2CTD_human
HgeneBRAFC0002448Ameloblastoma1CTD_human
HgeneBRAFC0004114Astrocytoma1CTD_human
HgeneBRAFC0010276Craniopharyngioma1CTD_human;ORPHANET
HgeneBRAFC0017638Glioma1CTD_human
HgeneBRAFC0022665Kidney Neoplasm1CTD_human
HgeneBRAFC0023903Liver neoplasms1CTD_human
HgeneBRAFC0024694Mandibular Neoplasms1CTD_human
HgeneBRAFC0028326Noonan Syndrome1CTD_human;ORPHANET
HgeneBRAFC0033578Prostatic Neoplasms1CTD_human
HgeneBRAFC0036920Sezary Syndrome1CTD_human
HgeneBRAFC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
HgeneBRAFC0206686Adrenocortical carcinoma1CTD_human
HgeneBRAFC0206754Neuroendocrine Tumors1CTD_human
HgeneBRAFC0238463Papillary thyroid carcinoma1CTD_human;ORPHANET
HgeneBRAFC0587248Costello syndrome (disorder)1CTD_human
HgeneBRAFC0596263Carcinogenesis1CTD_human
HgeneBRAFC0920269Microsatellite Instability1CTD_human
HgeneBRAFC2239176Liver carcinoma1CTD_human