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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43538

FusionGeneSummary for ZNF626_RERG

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF626_RERG
Fusion gene ID: 43538
HgeneTgene
Gene symbol

ZNF626

RERG

Gene ID

199777

85004

Gene namezinc finger protein 626RAS like estrogen regulated growth inhibitor
Synonyms--
Cytomap

19p12

12p12.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 626CTC-513N18.7ras-related and estrogen-regulated growth inhibitor
Modification date2018051920180519
UniProtAcc

Q68DY1

Q96A58

Ensembl transtripts involved in fusion geneENST00000601440, ENST00000291750, 
ENST00000256953, ENST00000538313, 
ENST00000536465, ENST00000546331, 
ENST00000537647, ENST00000437578, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 3 X 4=36
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF626 [Title/Abstract] AND RERG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRERG

GO:0008285

negative regulation of cell proliferation

11533059

TgeneRERG

GO:0009725

response to hormone

11533059

TgeneRERG

GO:0030308

negative regulation of cell growth

11533059


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-29-1703-01AZNF626chr19

20828490

-RERGchr12

15490404

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000601440ENST00000256953ZNF626chr19

20828490

-RERGchr12

15490404

-
5CDS-intronENST00000601440ENST00000538313ZNF626chr19

20828490

-RERGchr12

15490404

-
5CDS-intronENST00000601440ENST00000536465ZNF626chr19

20828490

-RERGchr12

15490404

-
5CDS-intronENST00000601440ENST00000546331ZNF626chr19

20828490

-RERGchr12

15490404

-
5CDS-intronENST00000601440ENST00000537647ZNF626chr19

20828490

-RERGchr12

15490404

-
5CDS-intronENST00000601440ENST00000437578ZNF626chr19

20828490

-RERGchr12

15490404

-
5CDS-intronENST00000291750ENST00000256953ZNF626chr19

20828490

-RERGchr12

15490404

-
5CDS-intronENST00000291750ENST00000538313ZNF626chr19

20828490

-RERGchr12

15490404

-
5CDS-intronENST00000291750ENST00000536465ZNF626chr19

20828490

-RERGchr12

15490404

-
5CDS-intronENST00000291750ENST00000546331ZNF626chr19

20828490

-RERGchr12

15490404

-
5CDS-intronENST00000291750ENST00000537647ZNF626chr19

20828490

-RERGchr12

15490404

-
5CDS-intronENST00000291750ENST00000437578ZNF626chr19

20828490

-RERGchr12

15490404

-

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FusionProtFeatures for ZNF626_RERG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF626

Q68DY1

RERG

Q96A58

May be involved in transcriptional regulation. Binds GDP/GTP and possesses intrinsic GTPase activity.Has higher affinity for GDP than for GTP. In cell linesoverexpression leads to a reduction in the rate of proliferation,colony formation and in tumorigenic potential.{ECO:0000269|PubMed:11533059}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF626_RERG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF626_RERG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF626FHL2, ID3RERGFBXW7, ARHGEF17


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF626_RERG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF626_RERG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource