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Fusion gene ID: 43538 |
FusionGeneSummary for ZNF626_RERG |
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Fusion gene information | Fusion gene name: ZNF626_RERG | Fusion gene ID: 43538 | Hgene | Tgene | Gene symbol | ZNF626 | RERG | Gene ID | 199777 | 85004 |
Gene name | zinc finger protein 626 | RAS like estrogen regulated growth inhibitor | |
Synonyms | - | - | |
Cytomap | 19p12 | 12p12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 626CTC-513N18.7 | ras-related and estrogen-regulated growth inhibitor | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q68DY1 | Q96A58 | |
Ensembl transtripts involved in fusion gene | ENST00000601440, ENST00000291750, | ENST00000256953, ENST00000538313, ENST00000536465, ENST00000546331, ENST00000537647, ENST00000437578, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 3 X 3 X 4=36 |
# samples | 3 | 4 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZNF626 [Title/Abstract] AND RERG [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RERG | GO:0008285 | negative regulation of cell proliferation | 11533059 |
Tgene | RERG | GO:0009725 | response to hormone | 11533059 |
Tgene | RERG | GO:0030308 | negative regulation of cell growth | 11533059 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-29-1703-01A | ZNF626 | chr19 | 20828490 | - | RERG | chr12 | 15490404 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000601440 | ENST00000256953 | ZNF626 | chr19 | 20828490 | - | RERG | chr12 | 15490404 | - |
5CDS-intron | ENST00000601440 | ENST00000538313 | ZNF626 | chr19 | 20828490 | - | RERG | chr12 | 15490404 | - |
5CDS-intron | ENST00000601440 | ENST00000536465 | ZNF626 | chr19 | 20828490 | - | RERG | chr12 | 15490404 | - |
5CDS-intron | ENST00000601440 | ENST00000546331 | ZNF626 | chr19 | 20828490 | - | RERG | chr12 | 15490404 | - |
5CDS-intron | ENST00000601440 | ENST00000537647 | ZNF626 | chr19 | 20828490 | - | RERG | chr12 | 15490404 | - |
5CDS-intron | ENST00000601440 | ENST00000437578 | ZNF626 | chr19 | 20828490 | - | RERG | chr12 | 15490404 | - |
5CDS-intron | ENST00000291750 | ENST00000256953 | ZNF626 | chr19 | 20828490 | - | RERG | chr12 | 15490404 | - |
5CDS-intron | ENST00000291750 | ENST00000538313 | ZNF626 | chr19 | 20828490 | - | RERG | chr12 | 15490404 | - |
5CDS-intron | ENST00000291750 | ENST00000536465 | ZNF626 | chr19 | 20828490 | - | RERG | chr12 | 15490404 | - |
5CDS-intron | ENST00000291750 | ENST00000546331 | ZNF626 | chr19 | 20828490 | - | RERG | chr12 | 15490404 | - |
5CDS-intron | ENST00000291750 | ENST00000537647 | ZNF626 | chr19 | 20828490 | - | RERG | chr12 | 15490404 | - |
5CDS-intron | ENST00000291750 | ENST00000437578 | ZNF626 | chr19 | 20828490 | - | RERG | chr12 | 15490404 | - |
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FusionProtFeatures for ZNF626_RERG |
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Hgene | Tgene |
ZNF626 | RERG |
May be involved in transcriptional regulation. | Binds GDP/GTP and possesses intrinsic GTPase activity.Has higher affinity for GDP than for GTP. In cell linesoverexpression leads to a reduction in the rate of proliferation,colony formation and in tumorigenic potential.{ECO:0000269|PubMed:11533059}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF626_RERG |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF626_RERG |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF626 | FHL2, ID3 | RERG | FBXW7, ARHGEF17 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF626_RERG |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF626_RERG |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |