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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43510

FusionGeneSummary for ZNF608_SLC9A9

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF608_SLC9A9
Fusion gene ID: 43510
HgeneTgene
Gene symbol

ZNF608

SLC9A9

Gene ID

57507

285195

Gene namezinc finger protein 608solute carrier family 9 member A9
SynonymsNY-REN-36AUTS16|NHE9
Cytomap

5q23.2

3q24

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 608renal carcinoma antigen NY-REN-36sodium/hydrogen exchanger 9Na(+)/H(+) exchanger 9putative protein product of Nbla00118sodium/proton exchanger NHE9solute carrier family 9 (sodium/hydrogen exchanger)solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9
Modification date2018051920180523
UniProtAcc

Q9ULD9

Q8IVB4

Ensembl transtripts involved in fusion geneENST00000504926, ENST00000306315, 
ENST00000513985, 
ENST00000316549, 
ENST00000498717, 
Fusion gene scores* DoF score4 X 4 X 1=167 X 7 X 5=245
# samples 47
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF608 [Title/Abstract] AND SLC9A9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG999752ZNF608chr5

124035130

+SLC9A9chr3

143437054

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000504926ENST00000316549ZNF608chr5

124035130

+SLC9A9chr3

143437054

+
intron-intronENST00000504926ENST00000498717ZNF608chr5

124035130

+SLC9A9chr3

143437054

+
intron-intronENST00000306315ENST00000316549ZNF608chr5

124035130

+SLC9A9chr3

143437054

+
intron-intronENST00000306315ENST00000498717ZNF608chr5

124035130

+SLC9A9chr3

143437054

+
intron-intronENST00000513985ENST00000316549ZNF608chr5

124035130

+SLC9A9chr3

143437054

+
intron-intronENST00000513985ENST00000498717ZNF608chr5

124035130

+SLC9A9chr3

143437054

+

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FusionProtFeatures for ZNF608_SLC9A9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF608

Q9ULD9

SLC9A9

Q8IVB4

Transcription factor, which represses ZNF609transcription. {ECO:0000250|UniProtKB:Q56A10}. May act in electroneutral exchange of protons for Na(+)across membranes. Involved in the effusion of Golgi luminal H(+)in exchange for cytosolic cations. Involved in organelle ionhomeostasis by contributing to the maintenance of the uniqueacidic pH values of the Golgi and post-Golgi compartments in thecell. {ECO:0000269|PubMed:15522866}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF608_SLC9A9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF608_SLC9A9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF608_SLC9A9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF608_SLC9A9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSLC9A9C0004352Autistic Disorder1CTD_human