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Fusion gene ID: 43510 |
FusionGeneSummary for ZNF608_SLC9A9 |
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Fusion gene information | Fusion gene name: ZNF608_SLC9A9 | Fusion gene ID: 43510 | Hgene | Tgene | Gene symbol | ZNF608 | SLC9A9 | Gene ID | 57507 | 285195 |
Gene name | zinc finger protein 608 | solute carrier family 9 member A9 | |
Synonyms | NY-REN-36 | AUTS16|NHE9 | |
Cytomap | 5q23.2 | 3q24 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 608renal carcinoma antigen NY-REN-36 | sodium/hydrogen exchanger 9Na(+)/H(+) exchanger 9putative protein product of Nbla00118sodium/proton exchanger NHE9solute carrier family 9 (sodium/hydrogen exchanger)solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9ULD9 | Q8IVB4 | |
Ensembl transtripts involved in fusion gene | ENST00000504926, ENST00000306315, ENST00000513985, | ENST00000316549, ENST00000498717, | |
Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 7 X 7 X 5=245 |
# samples | 4 | 7 | |
** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF608 [Title/Abstract] AND SLC9A9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG999752 | ZNF608 | chr5 | 124035130 | + | SLC9A9 | chr3 | 143437054 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000504926 | ENST00000316549 | ZNF608 | chr5 | 124035130 | + | SLC9A9 | chr3 | 143437054 | + |
intron-intron | ENST00000504926 | ENST00000498717 | ZNF608 | chr5 | 124035130 | + | SLC9A9 | chr3 | 143437054 | + |
intron-intron | ENST00000306315 | ENST00000316549 | ZNF608 | chr5 | 124035130 | + | SLC9A9 | chr3 | 143437054 | + |
intron-intron | ENST00000306315 | ENST00000498717 | ZNF608 | chr5 | 124035130 | + | SLC9A9 | chr3 | 143437054 | + |
intron-intron | ENST00000513985 | ENST00000316549 | ZNF608 | chr5 | 124035130 | + | SLC9A9 | chr3 | 143437054 | + |
intron-intron | ENST00000513985 | ENST00000498717 | ZNF608 | chr5 | 124035130 | + | SLC9A9 | chr3 | 143437054 | + |
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FusionProtFeatures for ZNF608_SLC9A9 |
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Hgene | Tgene |
ZNF608 | SLC9A9 |
Transcription factor, which represses ZNF609transcription. {ECO:0000250|UniProtKB:Q56A10}. | May act in electroneutral exchange of protons for Na(+)across membranes. Involved in the effusion of Golgi luminal H(+)in exchange for cytosolic cations. Involved in organelle ionhomeostasis by contributing to the maintenance of the uniqueacidic pH values of the Golgi and post-Golgi compartments in thecell. {ECO:0000269|PubMed:15522866}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF608_SLC9A9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF608_SLC9A9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF608_SLC9A9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF608_SLC9A9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SLC9A9 | C0004352 | Autistic Disorder | 1 | CTD_human |