![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 43496 |
FusionGeneSummary for ZNF595_RAB28 |
![]() |
Fusion gene information | Fusion gene name: ZNF595_RAB28 | Fusion gene ID: 43496 | Hgene | Tgene | Gene symbol | ZNF595 | RAB28 | Gene ID | 152687 | 9364 |
Gene name | zinc finger protein 595 | RAB28, member RAS oncogene family | |
Synonyms | - | CORD18 | |
Cytomap | 4p16.3 | 4p15.33 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 595 | ras-related protein Rab-28 | |
Modification date | 20180522 | 20180526 | |
UniProtAcc | P51157 | ||
Ensembl transtripts involved in fusion gene | ENST00000339368, ENST00000509152, ENST00000526473, | ENST00000330852, ENST00000288723, ENST00000338176, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 2 X 3=18 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZNF595 [Title/Abstract] AND RAB28 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-X6-A8C2-01A | ZNF595 | chr4 | 53385 | + | RAB28 | chr4 | 13383218 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000339368 | ENST00000330852 | ZNF595 | chr4 | 53385 | + | RAB28 | chr4 | 13383218 | - |
3UTR-3CDS | ENST00000339368 | ENST00000288723 | ZNF595 | chr4 | 53385 | + | RAB28 | chr4 | 13383218 | - |
3UTR-3CDS | ENST00000339368 | ENST00000338176 | ZNF595 | chr4 | 53385 | + | RAB28 | chr4 | 13383218 | - |
Frame-shift | ENST00000509152 | ENST00000330852 | ZNF595 | chr4 | 53385 | + | RAB28 | chr4 | 13383218 | - |
Frame-shift | ENST00000509152 | ENST00000288723 | ZNF595 | chr4 | 53385 | + | RAB28 | chr4 | 13383218 | - |
Frame-shift | ENST00000509152 | ENST00000338176 | ZNF595 | chr4 | 53385 | + | RAB28 | chr4 | 13383218 | - |
Frame-shift | ENST00000526473 | ENST00000330852 | ZNF595 | chr4 | 53385 | + | RAB28 | chr4 | 13383218 | - |
Frame-shift | ENST00000526473 | ENST00000288723 | ZNF595 | chr4 | 53385 | + | RAB28 | chr4 | 13383218 | - |
Frame-shift | ENST00000526473 | ENST00000338176 | ZNF595 | chr4 | 53385 | + | RAB28 | chr4 | 13383218 | - |
Top |
FusionProtFeatures for ZNF595_RAB28 |
![]() |
Hgene | Tgene |
ZNF595 | RAB28 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ZNF595_RAB28 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ZNF595_RAB28 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF595 | JUNB, TRIM28 | RAB28 | APP, DUSP12, DUSP23, FBXO42, PDE6D, NCOA3, CTSV, CCDC144A, HMMR, KIF7, HSF1, MNS1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ZNF595_RAB28 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ZNF595_RAB28 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |