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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43496

FusionGeneSummary for ZNF595_RAB28

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF595_RAB28
Fusion gene ID: 43496
HgeneTgene
Gene symbol

ZNF595

RAB28

Gene ID

152687

9364

Gene namezinc finger protein 595RAB28, member RAS oncogene family
Synonyms-CORD18
Cytomap

4p16.3

4p15.33

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 595ras-related protein Rab-28
Modification date2018052220180526
UniProtAcc

P51157

Ensembl transtripts involved in fusion geneENST00000339368, ENST00000509152, 
ENST00000526473, 
ENST00000330852, 
ENST00000288723, ENST00000338176, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 3=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF595 [Title/Abstract] AND RAB28 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-X6-A8C2-01AZNF595chr4

53385

+RAB28chr4

13383218

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000339368ENST00000330852ZNF595chr4

53385

+RAB28chr4

13383218

-
3UTR-3CDSENST00000339368ENST00000288723ZNF595chr4

53385

+RAB28chr4

13383218

-
3UTR-3CDSENST00000339368ENST00000338176ZNF595chr4

53385

+RAB28chr4

13383218

-
Frame-shiftENST00000509152ENST00000330852ZNF595chr4

53385

+RAB28chr4

13383218

-
Frame-shiftENST00000509152ENST00000288723ZNF595chr4

53385

+RAB28chr4

13383218

-
Frame-shiftENST00000509152ENST00000338176ZNF595chr4

53385

+RAB28chr4

13383218

-
Frame-shiftENST00000526473ENST00000330852ZNF595chr4

53385

+RAB28chr4

13383218

-
Frame-shiftENST00000526473ENST00000288723ZNF595chr4

53385

+RAB28chr4

13383218

-
Frame-shiftENST00000526473ENST00000338176ZNF595chr4

53385

+RAB28chr4

13383218

-

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FusionProtFeatures for ZNF595_RAB28


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF595

RAB28

P51157

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF595_RAB28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF595_RAB28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF595JUNB, TRIM28RAB28APP, DUSP12, DUSP23, FBXO42, PDE6D, NCOA3, CTSV, CCDC144A, HMMR, KIF7, HSF1, MNS1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF595_RAB28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF595_RAB28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource