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Fusion gene ID: 4347 |
FusionGeneSummary for BPTF_RAD17 |
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Fusion gene information | Fusion gene name: BPTF_RAD17 | Fusion gene ID: 4347 | Hgene | Tgene | Gene symbol | BPTF | RAD17 | Gene ID | 2186 | 5884 |
Gene name | bromodomain PHD finger transcription factor | RAD17 checkpoint clamp loader component | |
Synonyms | FAC1|FALZ|NEDDFL|NURF301 | CCYC|HRAD17|R24L|RAD17SP|RAD24 | |
Cytomap | 17q24.2 | 5q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | nucleosome-remodeling factor subunit BPTFbromodomain and PHD domain transcription factorbromodomain and PHD finger-containing transcription factorfetal Alz-50 clone 1 proteinfetal Alz-50 reactive clone 1fetal Alzheimer antigennucleosome remodeling f | cell cycle checkpoint protein RAD17RAD1 homologRAD17 homologRF-C activator 1 homologRad17-like proteincell cycle checkpoint protein (RAD17) | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q12830 | O75943 | |
Ensembl transtripts involved in fusion gene | ENST00000335221, ENST00000321892, ENST00000306378, ENST00000424123, ENST00000577770, | ENST00000361732, ENST00000509734, ENST00000354868, ENST00000521422, ENST00000504177, ENST00000354312, ENST00000345306, ENST00000305138, ENST00000282891, ENST00000358030, ENST00000380774, | |
Fusion gene scores | * DoF score | 20 X 16 X 10=3200 | 5 X 5 X 4=100 |
# samples | 25 | 5 | |
** MAII score | log2(25/3200*10)=-3.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: BPTF [Title/Abstract] AND RAD17 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BPTF | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10727212 |
Hgene | BPTF | GO:0006338 | chromatin remodeling | 14609955 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCEC | TCGA-D1-A3JP-01A | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000335221 | ENST00000361732 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
Frame-shift | ENST00000335221 | ENST00000509734 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
Frame-shift | ENST00000335221 | ENST00000354868 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
Frame-shift | ENST00000335221 | ENST00000521422 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000335221 | ENST00000504177 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000335221 | ENST00000354312 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000335221 | ENST00000345306 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000335221 | ENST00000305138 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000335221 | ENST00000282891 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000335221 | ENST00000358030 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000335221 | ENST00000380774 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
Frame-shift | ENST00000321892 | ENST00000361732 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
Frame-shift | ENST00000321892 | ENST00000509734 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
Frame-shift | ENST00000321892 | ENST00000354868 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
Frame-shift | ENST00000321892 | ENST00000521422 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000321892 | ENST00000504177 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000321892 | ENST00000354312 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000321892 | ENST00000345306 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000321892 | ENST00000305138 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000321892 | ENST00000282891 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000321892 | ENST00000358030 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000321892 | ENST00000380774 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-3CDS | ENST00000306378 | ENST00000361732 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-3CDS | ENST00000306378 | ENST00000509734 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-3CDS | ENST00000306378 | ENST00000354868 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-3CDS | ENST00000306378 | ENST00000521422 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-intron | ENST00000306378 | ENST00000504177 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-intron | ENST00000306378 | ENST00000354312 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-intron | ENST00000306378 | ENST00000345306 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-intron | ENST00000306378 | ENST00000305138 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-intron | ENST00000306378 | ENST00000282891 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-intron | ENST00000306378 | ENST00000358030 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-intron | ENST00000306378 | ENST00000380774 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
Frame-shift | ENST00000424123 | ENST00000361732 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
Frame-shift | ENST00000424123 | ENST00000509734 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
Frame-shift | ENST00000424123 | ENST00000354868 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
Frame-shift | ENST00000424123 | ENST00000521422 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000424123 | ENST00000504177 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000424123 | ENST00000354312 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000424123 | ENST00000345306 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000424123 | ENST00000305138 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000424123 | ENST00000282891 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000424123 | ENST00000358030 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
5CDS-intron | ENST00000424123 | ENST00000380774 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-3CDS | ENST00000577770 | ENST00000361732 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-3CDS | ENST00000577770 | ENST00000509734 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-3CDS | ENST00000577770 | ENST00000354868 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-3CDS | ENST00000577770 | ENST00000521422 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-intron | ENST00000577770 | ENST00000504177 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-intron | ENST00000577770 | ENST00000354312 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-intron | ENST00000577770 | ENST00000345306 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-intron | ENST00000577770 | ENST00000305138 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-intron | ENST00000577770 | ENST00000282891 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-intron | ENST00000577770 | ENST00000358030 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
intron-intron | ENST00000577770 | ENST00000380774 | BPTF | chr17 | 65871860 | + | RAD17 | chr5 | 68692224 | + |
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FusionProtFeatures for BPTF_RAD17 |
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Hgene | Tgene |
BPTF | RAD17 |
Histone-binding component of NURF (nucleosome-remodelingfactor), a complex which catalyzes ATP-dependent nucleosomesliding and facilitates transcription of chromatin. Specificallyrecognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which marktranscription start sites of virtually all active genes. May alsoregulate transcription through direct binding to DNA ortranscription factors. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BPTF_RAD17 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BPTF_RAD17 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
BPTF | MAZ, SMAD2, SMAD3, HIST1H3A, SMARCA1, RBBP4, RBBP7, USF1, SQSTM1, H3F3A, SIRT7, HIST1H4I, PGR, KEAP1, HMGXB4, NCOR1, SMARCD2, HIST3H3, CBX6, NFE2L2, C17orf49, CUL7, EED, BUB1, DEK, KIAA1429, SNRNP200, TFAP4, LLGL2, SMC1A, TIMM13, FOXK2, POU5F1, WHSC1L1, EGFR, RFXANK, HSPB7, NCAPH2, DLST, BRCA1 | RAD17 | ATM, ATR, PRKDC, RAD9B, RAD9A, RFC2, RFC3, RFC4, RFC5, POLE, POLE2, POLE3, POLE4, HUS1, RAD1, NHP2L1, RFC1, USP20, ALK, CLSPN, FOXO3, H2AFX, CDH1, CBX6, CBX7, PRMT6, COPS7A, CHEK2, CHEK1, TOP1, TOP2A, TOP3A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BPTF_RAD17 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BPTF_RAD17 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BPTF | C0005695 | Bladder Neoplasm | 1 | CTD_human |