![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 43467 |
FusionGeneSummary for ZNF585A_CCDC3 |
![]() |
Fusion gene information | Fusion gene name: ZNF585A_CCDC3 | Fusion gene ID: 43467 | Hgene | Tgene | Gene symbol | ZNF585A | CCDC3 | Gene ID | 199704 | 83643 |
Gene name | zinc finger protein 585A | coiled-coil domain containing 3 | |
Synonyms | - | - | |
Cytomap | 19q13.12 | 10p13 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 585A | coiled-coil domain-containing protein 3fat/vessel-derived secretory proteinfavine | |
Modification date | 20180519 | 20180329 | |
UniProtAcc | Q6P3V2 | Q9BQI4 | |
Ensembl transtripts involved in fusion gene | ENST00000588723, ENST00000356958, ENST00000292841, ENST00000392157, ENST00000355533, ENST00000588354, | ENST00000378825, ENST00000378839, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 3 X 3 X 3=27 |
# samples | 3 | 3 | |
** MAII score | log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZNF585A [Title/Abstract] AND CCDC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-V1-A9O5-06A | ZNF585A | chr19 | 37646767 | - | CCDC3 | chr10 | 13040512 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000588723 | ENST00000378825 | ZNF585A | chr19 | 37646767 | - | CCDC3 | chr10 | 13040512 | - |
5UTR-5UTR | ENST00000588723 | ENST00000378839 | ZNF585A | chr19 | 37646767 | - | CCDC3 | chr10 | 13040512 | - |
Frame-shift | ENST00000356958 | ENST00000378825 | ZNF585A | chr19 | 37646767 | - | CCDC3 | chr10 | 13040512 | - |
5CDS-5UTR | ENST00000356958 | ENST00000378839 | ZNF585A | chr19 | 37646767 | - | CCDC3 | chr10 | 13040512 | - |
In-frame | ENST00000292841 | ENST00000378825 | ZNF585A | chr19 | 37646767 | - | CCDC3 | chr10 | 13040512 | - |
5CDS-5UTR | ENST00000292841 | ENST00000378839 | ZNF585A | chr19 | 37646767 | - | CCDC3 | chr10 | 13040512 | - |
Frame-shift | ENST00000392157 | ENST00000378825 | ZNF585A | chr19 | 37646767 | - | CCDC3 | chr10 | 13040512 | - |
5CDS-5UTR | ENST00000392157 | ENST00000378839 | ZNF585A | chr19 | 37646767 | - | CCDC3 | chr10 | 13040512 | - |
In-frame | ENST00000355533 | ENST00000378825 | ZNF585A | chr19 | 37646767 | - | CCDC3 | chr10 | 13040512 | - |
5CDS-5UTR | ENST00000355533 | ENST00000378839 | ZNF585A | chr19 | 37646767 | - | CCDC3 | chr10 | 13040512 | - |
intron-3CDS | ENST00000588354 | ENST00000378825 | ZNF585A | chr19 | 37646767 | - | CCDC3 | chr10 | 13040512 | - |
intron-5UTR | ENST00000588354 | ENST00000378839 | ZNF585A | chr19 | 37646767 | - | CCDC3 | chr10 | 13040512 | - |
Top |
FusionProtFeatures for ZNF585A_CCDC3 |
![]() |
Hgene | Tgene |
ZNF585A | CCDC3 |
May be involved in transcriptional regulation. | Negatively regulates TNF-alpha-induced pro-inflammatoryresponse in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (PubMed:25193116). Positivelyregulates lipid accumulation in adipose cells (By similarity).{ECO:0000250|UniProtKB:Q9D6Y1, ECO:0000269|PubMed:25193116}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ZNF585A_CCDC3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_ZNF585A_ENST00000292841_chr19_37646767_-_CCDC3_ENST00000378825_chr10_13040512_-_146aa DGXKLXPLASRSQFPRCHLPRHSREQKDVFXPFPVFKLFARAAAGDFLQXLGNPGRQXAHVLLGAEGLVXGGGPRQETAAESGHPGEAQP >In-frame_ZNF585A_ENST00000355533_chr19_37646767_-_CCDC3_ENST00000378825_chr10_13040512_-_146aa DGXKLXPLASRSQFPRCHLPRHSREQKDVFXPFPVFKLFARAAAGDFLQXLGNPGRQXAHVLLGAEGLVXGGGPRQETAAESGHPGEAQP |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_ZNF585A_ENST00000292841_chr19_37646767_-_CCDC3_ENST00000378825_chr10_13040512_-_439nt GATGGATGAAAATTATAACCTCTTGCCTCACGGAGTCAATTTCCAAGATGCCATCTTCCCAGACACTCAAGAGAACAGAAGGATGTTTTC TAGCCTTTTCCAGTTTTCAAACTGTTCGCAAGGGCAGCAGCTGGCGACTTTCTCCAGTGACTGGGAAATCCAGGAAGACAGTAGGCTCAT GTGCTCCTCGGTGCAGAAGGCCTTGTTTGAGGAGGAGGACCACGTCAAGAAACTGCAGCAGAAAGTGGCCACCCTGGAGAAGCGCAACCG GCAGCTCCGGGAGCGAGTGAAGAAGGTCAAGAGGTCCTTGCGGCAGGCGCGTAAGAAGGGCCGCCACCTGGAGCTGGCGAACCAGAAACT >In-frame_ZNF585A_ENST00000355533_chr19_37646767_-_CCDC3_ENST00000378825_chr10_13040512_-_439nt GATGGATGAAAATTATAACCTCTTGCCTCACGGAGTCAATTTCCAAGATGCCATCTTCCCAGACACTCAAGAGAACAGAAGGATGTTTTC TAGCCTTTTCCAGTTTTCAAACTGTTCGCAAGGGCAGCAGCTGGCGACTTTCTCCAGTGACTGGGAAATCCAGGAAGACAGTAGGCTCAT GTGCTCCTCGGTGCAGAAGGCCTTGTTTGAGGAGGAGGACCACGTCAAGAAACTGCAGCAGAAAGTGGCCACCCTGGAGAAGCGCAACCG GCAGCTCCGGGAGCGAGTGAAGAAGGTCAAGAGGTCCTTGCGGCAGGCGCGTAAGAAGGGCCGCCACCTGGAGCTGGCGAACCAGAAACT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_ZNF585A_ENST00000292841_chr19_37646767_-_CCDC3_ENST00000378825_chr10_13040512_-_2853nt GGACCGGAAGTGGAAGTGGTCTTCCAAGGCTTTTTTGCCGCTGGTGTCAGGAGTATTTTCATATTCCAATACCGATAAATCTTTGAGGTT TCTGGGTGTCTCTGGGGAGCCCCTGGGCCAGATTTTCCTCTAGACTCCAGCCCATCTCTTCAGAGCAGCTCTGCTTGAGTTCACAGATGA CTGCCAAGCTTCAGACACCCTACAGAAAAAGGGTTGAGACCCAGTGTGGCCATGCCAGCTAATTGGACCTCACCTCAGAAATCCTCAGCC CTGGCTCCAGAGGATCATGGCAGCTCCTATGAGTGTTAACCTTGATGCCTGAAAGAACTGGAAATTATGAAGATAGATTCAGAAGTCAAA TATGTTAACTAACTGCATTGAAGAGTAGAAGAAAACAATAGCCTAGGATCAGTGTCCTTCAGGGATGTGGCTATCGATTTCAGCAGAGAG GAATGGCGGCACCTGGACCCTTCTCAGAGAAACCTGTACCGGGATGTGATGCTGGAGACCTACAGCCACCTGCTCTCAGTAGGATATCAA GTTCCTGAAGCAGAGGTGGTCATGTTGGAGCAAGGAAAGGAACCATGGGCACTGCAGGGTGAGAGGCCACGTCAGAGCTGCCCAGGATGG ATGAAAATTATAACCTCTTGCCTCACGGAGTCAATTTCCAAGATGCCATCTTCCCAGACACTCAAGAGAACAGAAGGATGTTTTCTAGCC TTTTCCAGTTTTCAAACTGTTCGCAAGGGCAGCAGCTGGCGACTTTCTCCAGTGACTGGGAAATCCAGGAAGACAGTAGGCTCATGTGCT CCTCGGTGCAGAAGGCCTTGTTTGAGGAGGAGGACCACGTCAAGAAACTGCAGCAGAAAGTGGCCACCCTGGAGAAGCGCAACCGGCAGC TCCGGGAGCGAGTGAAGAAGGTCAAGAGGTCCTTGCGGCAGGCGCGTAAGAAGGGCCGCCACCTGGAGCTGGCGAACCAGAAACTCAGTG AGAAGCTGGCGGCGGGCGCGCTGCCGCACATCAATGCCCGGGGGCCCGTGCGCCCCCCCTACCTGCGGGGGTAACGGGCCTGGGGGCTGC CAGGTGTGCAGGGCCAATCCTGACGGTAATTGAGAATGAGTGAGGTTTCGTACATGCAGCTATTTCAAGGGTTGTAAGAGTTTTTGTTTT TAATCACGCATTTGGTAGAGTCTAAATGGATAAAATGCAAGGCTTGCTTTCCCCTTGGGTGCTGGCCTCAATGTCAGACCCCACGCGCTG CCCCTTCCTGGCCTGACCCCAGACGCAGTGCCTGGCAGTCCAGAGGCAGTGGGATCCCTGAGTGCTGAATGCTCGCCTGCAGAGCAGCCC AGAAAGAGCCCTGACTGGGGAGAGAACATTTTAGAATCTCTAGTGTAAAAGACATCAACGTGCTTAGCCTTTATTTCAGAAAAAAATCAG GGTGGTTCCCAGCTCCCCAGTCCAGGACAACCATTAGTCCTGATGAGTGAGCTGACGCTGGTGCTGGAACCTGCTGGCACCTCACTGGCC ACATCTTTGGAAGGGGATGGTGGCCTTGCATCCAAGATGCCTGAAAATCAGCACGTGCAGGGCCTCCCTATCCAGCCAGCATTTTCCTTC CAGCTGAGGCAGGTGAAGACTTCATAAGCTCATCACAGGGGAGGGAATTAGGAGCAGGGCAGCAGGTAATTAAACAAGATAAATTATACC TGATTTCCAACACCAGCTACAAAGAGTTGAAGATGATACCTATGGGTCGCGTTAACACAGGGGGCAACTGCCTTGATCGGCCTGCCATGG GTCATCAGACTGCTTCCTAAATTGAGAGAAACTGAGCAATCTCTCAGCCACTGCTATAGTCTAACTTCTTGTTTGCTGAGTAATTGTTTC TAATGTCTCTGAACTCAAAGTGAGGTGCTCCAAGACGCTGTGAACTTCTGCAAAGACACCTCCTTACCTACTGGGATCACGTGACCTGAC CTCACTCCCAGCCAGGCTCCCAAAGGGCTCATTCCAGCCATTCCAATCTCTTCTTCTTTATGCAAACACTTTTCCCCCACAACAAGCCTT GTTTGTTCCGATAGGAATACGTGTACGTCAGTGCACTTGTCCTTACGTCAGTTCCTTACACCACCAAAGCACTTCACCTTTCTGGAAATA AAACTTTTAAGACACTACTATAAGTAAAAATGAGAGTATTCACTAGACTTATTGCTCAGGCACATTTGAGTGGGTCCCAGCTGTGTGATT AAGAAGTCAACTGGGTGGCCTTTTCTGGGTTATCTTCTGATCATGGCCTTTCAACCCAACAAGGGCCCTTCCCTGCTCTTCCACCAGTAA AGGCTCCTGGCCTCTCATCAGGATCTGCCCCCCAGAGACCCCCCCCAGACACTGCAGGGCCTGGTGATGCTGTCCTCTGTACCGGAAATG GCAGGCACTGTCAGATTTCCACTCTTCTGCCTTTAGGAAGGCTGGGTGCTTCTTGCTCTGACAGCCAGTCTGGGGAGATGACTCTTACGT TGCTTGAGTCTTGGTGGCAGGCTGCTGTCCACGGGGGAGAAGTCTCTGCTCTGGACTGGACAGAAGAGAGACTTTTACCCTGGGGCACTC ACACGGCCAAGCTTCTGCCACCACTTCATTAGCTGTATTCTCCATAGTATGGTGAAATAGCAGGTGCGTCTTCTAGTTTATTCCTCCTGG GGACATTTCCTCAAAGCAGTTTTGCGCCCCCGCAAGGGAATGGTCAGCCTAAGGGTAATGTACAGCCCGTGCTTGGAGAACCATGGAAGC >In-frame_ZNF585A_ENST00000355533_chr19_37646767_-_CCDC3_ENST00000378825_chr10_13040512_-_2853nt GGACCGGAAGTGGAAGTGGTCTTCCAAGGCTTTTTTGCCGCTGGTGTCAGGAGTATTTTCATATTCCAATACCGATAAATCTTTGAGGTT TCTGGGTGTCTCTGGGGAGCCCCTGGGCCAGATTTTCCTCTAGACTCCAGCCCATCTCTTCAGAGCAGCTCTGCTTGAGTTCACAGATGA CTGCCAAGCTTCAGACACCCTACAGAAAAAGGGTTGAGACCCAGTGTGGCCATGCCAGCTAATTGGACCTCACCTCAGAAATCCTCAGCC CTGGCTCCAGAGGATCATGGCAGCTCCTATGAGTGTTAACCTTGATGCCTGAAAGAACTGGAAATTATGAAGATAGATTCAGAAGTCAAA TATGTTAACTAACTGCATTGAAGAGTAGAAGAAAACAATAGCCTAGGATCAGTGTCCTTCAGGGATGTGGCTATCGATTTCAGCAGAGAG GAATGGCGGCACCTGGACCCTTCTCAGAGAAACCTGTACCGGGATGTGATGCTGGAGACCTACAGCCACCTGCTCTCAGTAGGATATCAA GTTCCTGAAGCAGAGGTGGTCATGTTGGAGCAAGGAAAGGAACCATGGGCACTGCAGGGTGAGAGGCCACGTCAGAGCTGCCCAGGATGG ATGAAAATTATAACCTCTTGCCTCACGGAGTCAATTTCCAAGATGCCATCTTCCCAGACACTCAAGAGAACAGAAGGATGTTTTCTAGCC TTTTCCAGTTTTCAAACTGTTCGCAAGGGCAGCAGCTGGCGACTTTCTCCAGTGACTGGGAAATCCAGGAAGACAGTAGGCTCATGTGCT CCTCGGTGCAGAAGGCCTTGTTTGAGGAGGAGGACCACGTCAAGAAACTGCAGCAGAAAGTGGCCACCCTGGAGAAGCGCAACCGGCAGC TCCGGGAGCGAGTGAAGAAGGTCAAGAGGTCCTTGCGGCAGGCGCGTAAGAAGGGCCGCCACCTGGAGCTGGCGAACCAGAAACTCAGTG AGAAGCTGGCGGCGGGCGCGCTGCCGCACATCAATGCCCGGGGGCCCGTGCGCCCCCCCTACCTGCGGGGGTAACGGGCCTGGGGGCTGC CAGGTGTGCAGGGCCAATCCTGACGGTAATTGAGAATGAGTGAGGTTTCGTACATGCAGCTATTTCAAGGGTTGTAAGAGTTTTTGTTTT TAATCACGCATTTGGTAGAGTCTAAATGGATAAAATGCAAGGCTTGCTTTCCCCTTGGGTGCTGGCCTCAATGTCAGACCCCACGCGCTG CCCCTTCCTGGCCTGACCCCAGACGCAGTGCCTGGCAGTCCAGAGGCAGTGGGATCCCTGAGTGCTGAATGCTCGCCTGCAGAGCAGCCC AGAAAGAGCCCTGACTGGGGAGAGAACATTTTAGAATCTCTAGTGTAAAAGACATCAACGTGCTTAGCCTTTATTTCAGAAAAAAATCAG GGTGGTTCCCAGCTCCCCAGTCCAGGACAACCATTAGTCCTGATGAGTGAGCTGACGCTGGTGCTGGAACCTGCTGGCACCTCACTGGCC ACATCTTTGGAAGGGGATGGTGGCCTTGCATCCAAGATGCCTGAAAATCAGCACGTGCAGGGCCTCCCTATCCAGCCAGCATTTTCCTTC CAGCTGAGGCAGGTGAAGACTTCATAAGCTCATCACAGGGGAGGGAATTAGGAGCAGGGCAGCAGGTAATTAAACAAGATAAATTATACC TGATTTCCAACACCAGCTACAAAGAGTTGAAGATGATACCTATGGGTCGCGTTAACACAGGGGGCAACTGCCTTGATCGGCCTGCCATGG GTCATCAGACTGCTTCCTAAATTGAGAGAAACTGAGCAATCTCTCAGCCACTGCTATAGTCTAACTTCTTGTTTGCTGAGTAATTGTTTC TAATGTCTCTGAACTCAAAGTGAGGTGCTCCAAGACGCTGTGAACTTCTGCAAAGACACCTCCTTACCTACTGGGATCACGTGACCTGAC CTCACTCCCAGCCAGGCTCCCAAAGGGCTCATTCCAGCCATTCCAATCTCTTCTTCTTTATGCAAACACTTTTCCCCCACAACAAGCCTT GTTTGTTCCGATAGGAATACGTGTACGTCAGTGCACTTGTCCTTACGTCAGTTCCTTACACCACCAAAGCACTTCACCTTTCTGGAAATA AAACTTTTAAGACACTACTATAAGTAAAAATGAGAGTATTCACTAGACTTATTGCTCAGGCACATTTGAGTGGGTCCCAGCTGTGTGATT AAGAAGTCAACTGGGTGGCCTTTTCTGGGTTATCTTCTGATCATGGCCTTTCAACCCAACAAGGGCCCTTCCCTGCTCTTCCACCAGTAA AGGCTCCTGGCCTCTCATCAGGATCTGCCCCCCAGAGACCCCCCCCAGACACTGCAGGGCCTGGTGATGCTGTCCTCTGTACCGGAAATG GCAGGCACTGTCAGATTTCCACTCTTCTGCCTTTAGGAAGGCTGGGTGCTTCTTGCTCTGACAGCCAGTCTGGGGAGATGACTCTTACGT TGCTTGAGTCTTGGTGGCAGGCTGCTGTCCACGGGGGAGAAGTCTCTGCTCTGGACTGGACAGAAGAGAGACTTTTACCCTGGGGCACTC ACACGGCCAAGCTTCTGCCACCACTTCATTAGCTGTATTCTCCATAGTATGGTGAAATAGCAGGTGCGTCTTCTAGTTTATTCCTCCTGG GGACATTTCCTCAAAGCAGTTTTGCGCCCCCGCAAGGGAATGGTCAGCCTAAGGGTAATGTACAGCCCGTGCTTGGAGAACCATGGAAGC |
Top |
FusionGenePPI for ZNF585A_CCDC3 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF585A | CBX5 | CCDC3 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ZNF585A_CCDC3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ZNF585A_CCDC3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |