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Fusion gene ID: 43436 |
FusionGeneSummary for ZNF561_MED16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF561_MED16 | Fusion gene ID: 43436 | Hgene | Tgene | Gene symbol | ZNF561 | MED16 | Gene ID | 93134 | 10025 |
| Gene name | zinc finger protein 561 | mediator complex subunit 16 | |
| Synonyms | - | DRIP92|THRAP5|TRAP95 | |
| Cytomap | 19p13.2 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 561 | mediator of RNA polymerase II transcription subunit 16thyroid hormone receptor-associated protein 5thyroid hormone receptor-associated protein complex 95 kDa componentthyroid hormone receptor-associated protein, 95-kD subunitvitamin D3 receptor-intera | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8N587 | Q9Y2X0 | |
| Ensembl transtripts involved in fusion gene | ENST00000424629, ENST00000302851, ENST00000326044, ENST00000354661, ENST00000495503, | ENST00000395808, ENST00000589119, ENST00000312090, ENST00000269814, ENST00000325464, ENST00000606828, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 5 X 3=75 |
| # samples | 1 | 5 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZNF561 [Title/Abstract] AND MED16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MED16 | GO:0006367 | transcription initiation from RNA polymerase II promoter | 12218053 |
| Tgene | MED16 | GO:0030518 | intracellular steroid hormone receptor signaling pathway | 11867769 |
| Tgene | MED16 | GO:0030521 | androgen receptor signaling pathway | 12218053 |
| Tgene | MED16 | GO:0045893 | positive regulation of transcription, DNA-templated | 10198638 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-13-1409-01A | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000424629 | ENST00000395808 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| Frame-shift | ENST00000424629 | ENST00000589119 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| Frame-shift | ENST00000424629 | ENST00000312090 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| Frame-shift | ENST00000424629 | ENST00000269814 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| Frame-shift | ENST00000424629 | ENST00000325464 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| 5CDS-intron | ENST00000424629 | ENST00000606828 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| Frame-shift | ENST00000302851 | ENST00000395808 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| Frame-shift | ENST00000302851 | ENST00000589119 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| Frame-shift | ENST00000302851 | ENST00000312090 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| In-frame | ENST00000302851 | ENST00000269814 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| Frame-shift | ENST00000302851 | ENST00000325464 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| 5CDS-intron | ENST00000302851 | ENST00000606828 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| Frame-shift | ENST00000326044 | ENST00000395808 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| Frame-shift | ENST00000326044 | ENST00000589119 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| Frame-shift | ENST00000326044 | ENST00000312090 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| In-frame | ENST00000326044 | ENST00000269814 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| Frame-shift | ENST00000326044 | ENST00000325464 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| 5CDS-intron | ENST00000326044 | ENST00000606828 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| 5UTR-3CDS | ENST00000354661 | ENST00000395808 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| 5UTR-3CDS | ENST00000354661 | ENST00000589119 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| 5UTR-3CDS | ENST00000354661 | ENST00000312090 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| 5UTR-3CDS | ENST00000354661 | ENST00000269814 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| 5UTR-3CDS | ENST00000354661 | ENST00000325464 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| 5UTR-intron | ENST00000354661 | ENST00000606828 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| 5UTR-3CDS | ENST00000495503 | ENST00000395808 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| 5UTR-3CDS | ENST00000495503 | ENST00000589119 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| 5UTR-3CDS | ENST00000495503 | ENST00000312090 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| 5UTR-3CDS | ENST00000495503 | ENST00000269814 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| 5UTR-3CDS | ENST00000495503 | ENST00000325464 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
| 5UTR-intron | ENST00000495503 | ENST00000606828 | ZNF561 | chr19 | 9727721 | - | MED16 | chr19 | 871253 | - |
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FusionProtFeatures for ZNF561_MED16 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF561 | MED16 |
| May be involved in transcriptional regulation. | Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. {ECO:0000269|PubMed:10198638,ECO:0000269|PubMed:10235266}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF561_MED16 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZNF561_ENST00000302851_chr19_9727721_-_MED16_ENST00000269814_chr19_871253_-_197aa MAAIYLSRGFFSREPICPFEEKTKVERMVEDYLASGYQDSVTFDDVAVDFTPEEWALLDTTEKYLYRDVMLENYMNLASVGRDEGPASEP DEALVDECCLLPSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKIDHLRRLHLGACPTEECKACT >In-frame_ZNF561_ENST00000326044_chr19_9727721_-_MED16_ENST00000269814_chr19_871253_-_117aa VAMRAQRASRTRRWWMNAACCPASCLSPAWTGCQPATAWLAACSPSSPFVCSLAGRPRCLAVLPPCSSTASPGPQASPRSTTCGGCTLAL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZNF561_ENST00000302851_chr19_9727721_-_MED16_ENST00000269814_chr19_871253_-_592nt ATGGCAGCCATTTATTTGTCCCGTGGGTTTTTTTCCAGGGAACCAATCTGCCCTTTTGAAGAAAAGACAAAGGTAGAAAGGATGGTGGAG GACTACCTGGCAAGTGGTTATCAGGATTCAGTGACGTTTGATGATGTGGCTGTGGACTTCACCCCAGAGGAGTGGGCTTTACTGGACACA ACTGAGAAATACCTCTACAGAGATGTGATGCTGGAGAACTACATGAACCTGGCCTCTGTGGGTCGCGATGAGGGCCCAGCGAGCGAGCCG GACGAGGCGCTGGTGGATGAATGCTGCCTGCTGCCCAGCCAGCTGCTTATCCCCAGCCTGGACTGGCTGCCAGCCAGCGACGGCCTGGTT AGCCGCCTGCAGCCCAAGCAGCCCCTTCGTCTGCAGTTTGGCCGGGCGCCCACGCTGCCTGGCAGTGCTGCCACCCTGCAGCTCGACGGC CTCGCCAGGGCCCCAGGCCAGCCCAAGATCGACCACCTGCGGAGGCTGCACCTTGGCGCTTGCCCCACGGAGGAATGCAAGGCCTGCACC >In-frame_ZNF561_ENST00000326044_chr19_9727721_-_MED16_ENST00000269814_chr19_871253_-_351nt GTCGCGATGAGGGCCCAGCGAGCGAGCCGGACGAGGCGCTGGTGGATGAATGCTGCCTGCTGCCCAGCCAGCTGCTTATCCCCAGCCTGG ACTGGCTGCCAGCCAGCGACGGCCTGGTTAGCCGCCTGCAGCCCAAGCAGCCCCTTCGTCTGCAGTTTGGCCGGGCGCCCACGCTGCCTG GCAGTGCTGCCACCCTGCAGCTCGACGGCCTCGCCAGGGCCCCAGGCCAGCCCAAGATCGACCACCTGCGGAGGCTGCACCTTGGCGCTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZNF561_ENST00000302851_chr19_9727721_-_MED16_ENST00000269814_chr19_871253_-_1442nt GTTCTGCATCCCCCTCCCTGAGCCAACCCCAGGCCCTTTCTGCACCCACCCGAGAGGAAACTAGAATTTCTGTGTTCTACCCGGTCCTAC GTGGCTGAAACTGGAGCCCACGAGCCTCGCCCGGCCAGAGTGTTGAAGCGGAAGTGACGTCAGCGCACCACCGCCATCTTTTCCGGCGCT GGCTCCTCTCCGTCAGTGCGGTTTCGCCTTTATGGTGGTGGAGTCTGCCCAGGCTGTGGACCGCAAATAACCCTGTACAAAGAGGAATGG AGATTGCCTCTATCCACCTAGATTCATAAGCTGGCCTGAGGTGATCTTGGCATCAAGGAAGGGATGCACATCATCACACCATCAGCTTCA GAGAATGGCAGCCATTTATTTGTCCCGTGGGTTTTTTTCCAGGGAACCAATCTGCCCTTTTGAAGAAAAGACAAAGGTAGAAAGGATGGT GGAGGACTACCTGGCAAGTGGTTATCAGGATTCAGTGACGTTTGATGATGTGGCTGTGGACTTCACCCCAGAGGAGTGGGCTTTACTGGA CACAACTGAGAAATACCTCTACAGAGATGTGATGCTGGAGAACTACATGAACCTGGCCTCTGTGGGTCGCGATGAGGGCCCAGCGAGCGA GCCGGACGAGGCGCTGGTGGATGAATGCTGCCTGCTGCCCAGCCAGCTGCTTATCCCCAGCCTGGACTGGCTGCCAGCCAGCGACGGCCT GGTTAGCCGCCTGCAGCCCAAGCAGCCCCTTCGTCTGCAGTTTGGCCGGGCGCCCACGCTGCCTGGCAGTGCTGCCACCCTGCAGCTCGA CGGCCTCGCCAGGGCCCCAGGCCAGCCCAAGATCGACCACCTGCGGAGGCTGCACCTTGGCGCTTGCCCCACGGAGGAATGCAAGGCCTG CACCAGGTGCGGCTGTGTCACCATGCTCAAGTCGCCCAACAGAACCACGGCGGTGAAGCAGTGGGAGCAGCGCTGGATCAAGAACTGCCT GTGCGGTGGGCTCTGGTGGCGGGTGCCCCTCAGCTACCCCTGAGCCCAGCTGCCCCTCAGCTACTCCTCAGCTACCCCTCAGCTGCCCCT GAGCCCGGCTGCTGCAAGAGCCACCGCTCGCCCTGGACTCTCCTCGGCGCGGTTAACCTCAGCCCGCCCTGCAGGGCTGTTGAAGGCCGT GGGCCGGACGCCTGCGTGACCAGCAGAGCTTCTGAGGAAGCCCCTGCCTTTGTCCAGCTGGGCCCGCAGTCCACACACCACTCTCCCAGG ACCCCCAGATCCCTGGACCATCTGCATCCAGAGGACCGTCCGTGACGGCCGGGGGTCCAGGCGGACCTTGTGGTGACCCGGCTCGGGCGT CTCCTCGGTTTCCTTGCCTCACCCGCGGAGAGCGCTGAACCTGGACAAGCAGCGGCTGGGAAGGACAGGTCCAATAAACGCCCTCTGCGC >In-frame_ZNF561_ENST00000326044_chr19_9727721_-_MED16_ENST00000269814_chr19_871253_-_1273nt TTTCCGGCGCTGGCTCCTCTCCGTCAGTGCGGTTTCGCCTTTATGGTGGTGGAGTCTGCCCAGGCTGTGGACCGCAAATAACCCTGTACA AAGAGGAATGGAGATTGCCTCTATCCACCTAGATTCATAAGCTGGCCTGAGGTGATCTTGGCATCAAGGAAGGGATGCACATCATCACAC CATCAGCTTCAGAGAATGGCAGCCATTTATTTGTCCCGTGGGTTTTTTTCCAGGGAACCAATCTGCCCTTTTGAAGAAAAGACAAAGGTA GAAAGGATGGTGGAGGACTACCTGGCAAGTGGTTATCAGGATTCAGTGACGTTTGATGATGTGGCTGTGGACTTCACCCCAGAGGAGTGG GCTTTACTGGACACAACTGAGAAATACCTCTACAGAGATGTGATGCTGGAGAACTACATGAACCTGGCCTCTGTGGGTCGCGATGAGGGC CCAGCGAGCGAGCCGGACGAGGCGCTGGTGGATGAATGCTGCCTGCTGCCCAGCCAGCTGCTTATCCCCAGCCTGGACTGGCTGCCAGCC AGCGACGGCCTGGTTAGCCGCCTGCAGCCCAAGCAGCCCCTTCGTCTGCAGTTTGGCCGGGCGCCCACGCTGCCTGGCAGTGCTGCCACC CTGCAGCTCGACGGCCTCGCCAGGGCCCCAGGCCAGCCCAAGATCGACCACCTGCGGAGGCTGCACCTTGGCGCTTGCCCCACGGAGGAA TGCAAGGCCTGCACCAGGTGCGGCTGTGTCACCATGCTCAAGTCGCCCAACAGAACCACGGCGGTGAAGCAGTGGGAGCAGCGCTGGATC AAGAACTGCCTGTGCGGTGGGCTCTGGTGGCGGGTGCCCCTCAGCTACCCCTGAGCCCAGCTGCCCCTCAGCTACTCCTCAGCTACCCCT CAGCTGCCCCTGAGCCCGGCTGCTGCAAGAGCCACCGCTCGCCCTGGACTCTCCTCGGCGCGGTTAACCTCAGCCCGCCCTGCAGGGCTG TTGAAGGCCGTGGGCCGGACGCCTGCGTGACCAGCAGAGCTTCTGAGGAAGCCCCTGCCTTTGTCCAGCTGGGCCCGCAGTCCACACACC ACTCTCCCAGGACCCCCAGATCCCTGGACCATCTGCATCCAGAGGACCGTCCGTGACGGCCGGGGGTCCAGGCGGACCTTGTGGTGACCC GGCTCGGGCGTCTCCTCGGTTTCCTTGCCTCACCCGCGGAGAGCGCTGAACCTGGACAAGCAGCGGCTGGGAAGGACAGGTCCAATAAAC |
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FusionGenePPI for ZNF561_MED16 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZNF561 | ELAVL1, MOV10, ZNF562, PSMC1 | MED16 | MED10, MED9, MED29, MED19, MED28, MED26, PPARGC1A, CDK8, THRA, VDR, HNF4A, ESR1, ESR2, MED1, MED30, CEBPE, LZTR1, TRRAP, KAT2A, SUPT7L, SUPT3H, MYC, MED12, MED18, ZC3H13, OBFC1, QKI, TADA2A, MED25, MED15, TRA, HIST1H3A, CTDP1, MED8, MED14, MED4, MED24, MED13, MED21, MED11, CDK19, RALY, FBXW7, EPAS1, HECW2, MED7, EFNB2, CCNC, ACVR1, TCL1B, MED13L, MED17, MED27, MED6, WBP11, NTRK1, MED23, MED20, FOSL2, MYO1C, POLR2G, AURKA, XRCC3, EMC2, DNAJC7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF561_MED16 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF561_MED16 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MED16 | C0014175 | Endometriosis | 1 | CTD_human |
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