![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 43420 |
FusionGeneSummary for ZNF546_HNRNPD |
![]() |
Fusion gene information | Fusion gene name: ZNF546_HNRNPD | Fusion gene ID: 43420 | Hgene | Tgene | Gene symbol | ZNF546 | HNRNPD | Gene ID | 339327 | 3184 |
Gene name | zinc finger protein 546 | heterogeneous nuclear ribonucleoprotein D | |
Synonyms | ZNF49 | AUF1|AUF1A|HNRPD|P37|hnRNPD0 | |
Cytomap | 19q13.2 | 4q21.22 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 546CTC-471F3.6zinc finger protein 49 | heterogeneous nuclear ribonucleoprotein D0ARE-binding protein AUFI, type AAU-rich element RNA binding protein 1, 37kDahnRNP D0 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q86UE3 | Q14103 | |
Ensembl transtripts involved in fusion gene | ENST00000597363, ENST00000596894, ENST00000600094, ENST00000347077, | ENST00000313899, ENST00000353341, ENST00000543098, ENST00000352301, ENST00000508119, ENST00000541060, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 10 X 10 X 3=300 |
# samples | 1 | 12 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(12/300*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF546 [Title/Abstract] AND HNRNPD [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCS | TCGA-N8-A4PP-01A | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000597363 | ENST00000313899 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
intron-3CDS | ENST00000597363 | ENST00000353341 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
intron-3CDS | ENST00000597363 | ENST00000543098 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
intron-3CDS | ENST00000597363 | ENST00000352301 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
intron-intron | ENST00000597363 | ENST00000508119 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
intron-intron | ENST00000597363 | ENST00000541060 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
intron-3CDS | ENST00000596894 | ENST00000313899 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
intron-3CDS | ENST00000596894 | ENST00000353341 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
intron-3CDS | ENST00000596894 | ENST00000543098 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
intron-3CDS | ENST00000596894 | ENST00000352301 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
intron-intron | ENST00000596894 | ENST00000508119 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
intron-intron | ENST00000596894 | ENST00000541060 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
Frame-shift | ENST00000600094 | ENST00000313899 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
Frame-shift | ENST00000600094 | ENST00000353341 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
Frame-shift | ENST00000600094 | ENST00000543098 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
Frame-shift | ENST00000600094 | ENST00000352301 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
5CDS-intron | ENST00000600094 | ENST00000508119 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
5CDS-intron | ENST00000600094 | ENST00000541060 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
Frame-shift | ENST00000347077 | ENST00000313899 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
Frame-shift | ENST00000347077 | ENST00000353341 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
Frame-shift | ENST00000347077 | ENST00000543098 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
Frame-shift | ENST00000347077 | ENST00000352301 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
5CDS-intron | ENST00000347077 | ENST00000508119 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
5CDS-intron | ENST00000347077 | ENST00000541060 | ZNF546 | chr19 | 40514472 | + | HNRNPD | chr4 | 83280792 | - |
Top |
FusionProtFeatures for ZNF546_HNRNPD |
![]() |
Hgene | Tgene |
ZNF546 | HNRNPD |
May be involved in transcriptional regulation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ZNF546_HNRNPD |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ZNF546_HNRNPD |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF546 | HNRNPD | LSM5, SAFB, TRN-GTT2-1, HSPB1, HSPA4, HSPA8, EIF4G1, HNRNPD, HNRNPH1, CDK9, MEPCE, KHDRBS2, GPN1, BANF1, MTA2, HDAC1, PABPC1, H2AFX, CD4, HDAC5, HSPB2, MAPK6, PCBP1, PCBP2, VHL, SMARCAD1, SREK1, ARRB2, HNRNPA1, PAIP1, BCL2, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, SYNCRIP, YBX1, IGF2BP2, UBE2I, MEOX2, GRB2, VEGFA, TNF, HNRNPR, PTBP1, RBMX, HNRNPF, HNRNPL, HNRNPA2B1, HNRNPA0, HNRNPA3, MRPL12, RPS28, RALY, HNRNPDL, AHNAK, RMDN3, SEPT9, SLC30A5, DDX1, MSH2, SMURF1, SFN, FN1, VCAM1, SNRPC, SF3B4, U2AF2, HNRNPC, HNRNPU, HNRNPK, HNRNPH3, PTBP2, IFIT2, IFIT3, IL7R, BRCA1, ITGA4, PAN2, CD81, IGSF8, ICAM1, HMGA1, C1QBP, RPSA, ACTB, GTF3C3, CD97, EXOSC4, EEF2, SNAPC4, ABCC10, BET1L, TSEN34, CINP, SHISA5, MPP1, TMEM261, GUK1, P4HB, FLNA, ARF4, SLC3A2, MAP2K1, HIRA, DGCR2, CAPN1, HBZ, PDLIM7, IMMT, PYCR1, SLC27A5, NTMT1, DHX30, CUTA, GTSE1, FBXL15, COL18A1, IMMP2L, COG7, PPOX, CTSB, PEX10, UQCRC1, PRDX3, SDF2, B3GAT3, PARK2, EIF3K, DENR, IPO11, ERI1, PAFAH1B3, KHSRP, RPS12, WNK1, RPA1, RPA2, RPA3, ERG, ASB2, HSPA5, IVNS1ABP, STAU1, NCL, KAT2B, FUS, ING4, MYC, ENO1, MOV10, NXF1, MDM2, CUL7, OBSL1, EED, ESR1, BTRC, FBXW11, PTGS2, CHEK1, DNAJC7, HNRNPAB, AURKA, C2orf49, HSPA9, NAA50, PICALM, PKM, SFPQ, TARS, TOMM34, UBE2G2, PGK1, NTRK1, SCARNA22, EWSR1, BLMH, SLC25A20, CETN2, DKC1, DNM2, ETFA, FANCD2, ACSL4, MTOR, GOLGA4, HEXA, DYNC1H1, HNRNPH2, MYEF2, HSD17B4, HSPA6, ITGB4, EIF6, MAP3K4, MYH1, NHS, PDCL, PLXNB1, PPM1A, RBM4, RET, SRSF6, UAP1, TARBP1, GCFC2, TLN1, TNFRSF1A, BAG6, USP11, DYSF, NRP1, TAX1BP1, FUBP3, GTF2IRD1, ESPL1, ARHGAP32, C2CD5, OSBPL2, RBM8A, PRMT3, SAP18, ABCA7, TUBB3, PPIH, SRSF10, COG2, FNDC3A, MORC2, FAM120A, USP24, KIAA0368, DICER1, SIRT5, KLHDC2, INTS7, PKN3, PNPLA8, CHMP5, UHRF1BP1, RASIP1, PINX1, HEATR3, SMEK2, ZNF286A, GPBP1, PDRG1, SBF2, TLN2, KLF16, OBSCN, WDR24, GPRIN1, MRPL55, PTGR2, PPP1R18, DDX51, HNRNPCL1, MCM2, SNW1, CYLD, TRIM25, UBE2A, HEY1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ZNF546_HNRNPD |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | HNRNPD | Q14103 | DB11638 | Artenimol | Heterogeneous nuclear ribonucleoprotein D0 | small molecule | approved|investigational |
Top |
RelatedDiseases for ZNF546_HNRNPD |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |