	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 43418

FusionGeneSummary for ZNF544_SENP6

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF544_SENP6
	Fusion gene ID: 43418
		Hgene	Tgene
	Gene symbol	ZNF544	SENP6
	Gene ID	27300	26054
	Gene name	zinc finger protein 544	SUMO specific peptidase 6
	Synonyms	-	SSP1\|SUSP1
	Cytomap	19q13.43	6q14.1
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 544	sentrin-specific protease 62810017C20RikSUMO-1-specific protease 1SUMO1/sentrin specific peptidase 6SUMO1/sentrin specific protease 6sentrin/SUMO-specific protease SENP6
	Modification date	20180519	20180523
	UniProtAcc	Q6NX49	Q9GZR1
	Ensembl transtripts involved in fusion gene	ENST00000599227, ENST00000269829, ENST00000594384, ENST00000596597, ENST00000596825, ENST00000333581, ENST00000599953, ENST00000596652, ENST00000600044, ENST00000600220, ENST00000596929, ENST00000595981, ENST00000415203,	ENST00000370010, ENST00000370014, ENST00000447266, ENST00000541192, ENST00000327284, ENST00000436928,
Fusion gene scores	* DoF score	6 X 3 X 5=90	8 X 12 X 6=576
	# samples	6	14
	** MAII score	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/576*10)=-2.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZNF544 [Title/Abstract] AND SENP6 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SENP6	GO:0070646	protein modification by small protein removal	20212317

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-A8-A094-01A	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000599227	ENST00000370010	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000599227	ENST00000370014	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000599227	ENST00000447266	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000599227	ENST00000541192	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000599227	ENST00000327284	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-intron	ENST00000599227	ENST00000436928	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000269829	ENST00000370010	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000269829	ENST00000370014	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000269829	ENST00000447266	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000269829	ENST00000541192	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000269829	ENST00000327284	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-intron	ENST00000269829	ENST00000436928	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000594384	ENST00000370010	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000594384	ENST00000370014	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000594384	ENST00000447266	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000594384	ENST00000541192	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000594384	ENST00000327284	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-intron	ENST00000594384	ENST00000436928	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
3UTR-3CDS	ENST00000596597	ENST00000370010	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
3UTR-3CDS	ENST00000596597	ENST00000370014	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
3UTR-3CDS	ENST00000596597	ENST00000447266	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
3UTR-3CDS	ENST00000596597	ENST00000541192	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
3UTR-3CDS	ENST00000596597	ENST00000327284	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
3UTR-intron	ENST00000596597	ENST00000436928	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000596825	ENST00000370010	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000596825	ENST00000370014	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000596825	ENST00000447266	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000596825	ENST00000541192	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000596825	ENST00000327284	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-intron	ENST00000596825	ENST00000436928	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000333581	ENST00000370010	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000333581	ENST00000370014	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000333581	ENST00000447266	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000333581	ENST00000541192	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000333581	ENST00000327284	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-intron	ENST00000333581	ENST00000436928	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
intron-3CDS	ENST00000599953	ENST00000370010	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
intron-3CDS	ENST00000599953	ENST00000370014	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
intron-3CDS	ENST00000599953	ENST00000447266	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
intron-3CDS	ENST00000599953	ENST00000541192	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
intron-3CDS	ENST00000599953	ENST00000327284	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
intron-intron	ENST00000599953	ENST00000436928	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000596652	ENST00000370010	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000596652	ENST00000370014	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000596652	ENST00000447266	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000596652	ENST00000541192	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000596652	ENST00000327284	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-intron	ENST00000596652	ENST00000436928	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000600044	ENST00000370010	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000600044	ENST00000370014	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000600044	ENST00000447266	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000600044	ENST00000541192	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000600044	ENST00000327284	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-intron	ENST00000600044	ENST00000436928	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000600220	ENST00000370010	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000600220	ENST00000370014	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000600220	ENST00000447266	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000600220	ENST00000541192	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000600220	ENST00000327284	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-intron	ENST00000600220	ENST00000436928	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000596929	ENST00000370010	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000596929	ENST00000370014	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000596929	ENST00000447266	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000596929	ENST00000541192	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000596929	ENST00000327284	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-intron	ENST00000596929	ENST00000436928	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000595981	ENST00000370010	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000595981	ENST00000370014	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000595981	ENST00000447266	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000595981	ENST00000541192	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-3CDS	ENST00000595981	ENST00000327284	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
5UTR-intron	ENST00000595981	ENST00000436928	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
intron-3CDS	ENST00000415203	ENST00000370010	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
intron-3CDS	ENST00000415203	ENST00000370014	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
intron-3CDS	ENST00000415203	ENST00000447266	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
intron-3CDS	ENST00000415203	ENST00000541192	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
intron-3CDS	ENST00000415203	ENST00000327284	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+
intron-intron	ENST00000415203	ENST00000436928	ZNF544	chr19	58741828	+	SENP6	chr6	76385576	+

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FusionProtFeatures for ZNF544_SENP6

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZNF544 Q6NX49	SENP6 Q9GZR1
May be involved in transcriptional regulation.	Protease that deconjugates SUMO1, SUMO2 and SUMO3 fromtargeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 andSUMO3 precursors. Deconjugates SUMO1 from RXRA, leading totranscriptional activation. Involved in chromosome alignment andspindle assembly, by regulating the kinetochore CENPH-CENPI-CENPKcomplex. Desumoylates PML and CENPI, protecting them fromdegradation by the ubiquitin ligase RNF4, which targetspolysumoylated proteins for proteasomal degradation. Desumoylatesalso RPA1, thus preventing recruitment of RAD51 to the DNA damagefoci to initiate DNA repair through homologous recombination.{ECO:0000269\|PubMed:16912044, ECO:0000269\|PubMed:17000875,ECO:0000269\|PubMed:18799455, ECO:0000269\|PubMed:20212317,ECO:0000269\|PubMed:20705237, ECO:0000269\|PubMed:21148299}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for ZNF544_SENP6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF544_SENP6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
ZNF544	TRAF2, GLRX3, TSGA10, NDEL1, SHMT2, MOV10, NXF1, RABIF, ZAK, GNPAT, CENPB	SENP6	RUVBL2, KAT5, SUMO2, COPS5, LMNA, SP1, SUMO1, PLA2G2A, FHL3, EXO1, PRPF19, ZDBF2

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for ZNF544_SENP6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ZNF544_SENP6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 43418

FusionGeneSummary for ZNF544_SENP6

FusionProtFeatures for ZNF544_SENP6

FusionGeneSequence for ZNF544_SENP6

FusionGenePPI for ZNF544_SENP6

RelatedDrugs for ZNF544_SENP6

RelatedDiseases for ZNF544_SENP6