![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 43385 |
FusionGeneSummary for ZNF516_MBP |
![]() |
Fusion gene information | Fusion gene name: ZNF516_MBP | Fusion gene ID: 43385 | Hgene | Tgene | Gene symbol | ZNF516 | MBP | Gene ID | 9658 | 5553 |
Gene name | zinc finger protein 516 | proteoglycan 2, pro eosinophil major basic protein | |
Synonyms | HsT287 | BMPG|MBP|MBP1|proMBP | |
Cytomap | 18q23 | 11q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 516 | bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q92618 | P02686 | |
Ensembl transtripts involved in fusion gene | ENST00000443185, ENST00000524431, | ENST00000382582, ENST00000355994, ENST00000397875, ENST00000397866, ENST00000397865, ENST00000527041, ENST00000359645, ENST00000528160, ENST00000397869, ENST00000354542, ENST00000526111, ENST00000580402, ENST00000579129, ENST00000578193, ENST00000397863, ENST00000397860, ENST00000487778, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 26 X 20 X 3=1560 |
# samples | 1 | 27 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(27/1560*10)=-2.53051471669878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF516 [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCEC | TCGA-AX-A3FX-01A | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000443185 | ENST00000382582 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-3CDS | ENST00000443185 | ENST00000355994 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-3CDS | ENST00000443185 | ENST00000397875 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-3CDS | ENST00000443185 | ENST00000397866 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-3CDS | ENST00000443185 | ENST00000397865 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-3CDS | ENST00000443185 | ENST00000527041 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-3CDS | ENST00000443185 | ENST00000359645 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000443185 | ENST00000528160 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000443185 | ENST00000397869 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000443185 | ENST00000354542 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000443185 | ENST00000526111 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000443185 | ENST00000580402 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000443185 | ENST00000579129 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000443185 | ENST00000578193 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000443185 | ENST00000397863 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000443185 | ENST00000397860 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000443185 | ENST00000487778 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-3CDS | ENST00000524431 | ENST00000382582 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-3CDS | ENST00000524431 | ENST00000355994 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-3CDS | ENST00000524431 | ENST00000397875 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-3CDS | ENST00000524431 | ENST00000397866 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-3CDS | ENST00000524431 | ENST00000397865 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-3CDS | ENST00000524431 | ENST00000527041 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-3CDS | ENST00000524431 | ENST00000359645 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000524431 | ENST00000528160 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000524431 | ENST00000397869 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000524431 | ENST00000354542 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000524431 | ENST00000526111 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000524431 | ENST00000580402 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000524431 | ENST00000579129 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000524431 | ENST00000578193 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000524431 | ENST00000397863 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000524431 | ENST00000397860 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
intron-intron | ENST00000524431 | ENST00000487778 | ZNF516 | chr18 | 74202637 | - | MBP | chr18 | 74702016 | - |
Top |
FusionProtFeatures for ZNF516_MBP |
![]() |
Hgene | Tgene |
ZNF516 | MBP |
Transcriptional regulator that binds to the promoter andactivates the transcription of genes promoting brown adiposetissue (BAT) differentiation. Among brown adipose tissue-specificgenes, binds the proximal region of the promoter of the UCP1 geneto activate its transcription and thereby regulate thermogenesis(By similarity). May also play a role in the cellular response toreplication stress (PubMed:23446422).{ECO:0000250|UniProtKB:Q7TSH3, ECO:0000269|PubMed:23446422}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ZNF516_MBP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ZNF516_MBP |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF516 | KDM1A, HIST3H3, ZBP1, HDAC1, DYRK1B, CTBP1, MED23, HYPK, EGFR, LCOR, ZBTB42 | MBP | TRPM7, PRMT5, STK39, HLA-DRA, PLP1, TSSK6, IRAK4, PRKCA, PRKCI, PRKCZ, PPP2R5C, LIMK1, LIMK2, TBK1, IKBKE, STK3, APTX, ATN1, ATXN1, MAPK14, LRRK2, PRKDC, MAPK12, MAPK11, MAPK13, MAPK3, MAPK1, CDK1, CDK5, MAP3K5, TLK1, RPS6KA6, DDX58, MELK, CDK7, CDK8, CDK9, HIPK2, SQSTM1, PKN1, ULK1, PRKCB, MAP3K3, CTDSP1, ABL1, MUS81, RPS6KA5, MYH6, MAP3K1, MAPK8, CTDSPL, NLN, IDE, PTPRA, PRKCD |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ZNF516_MBP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ZNF516_MBP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MBP | C0036341 | Schizophrenia | 4 | PSYGENET |
Tgene | MBP | C0014072 | Experimental Autoimmune Encephalomyelitis | 3 | CTD_human |
Tgene | MBP | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Tgene | MBP | C0011303 | Demyelinating Diseases | 1 | CTD_human |
Tgene | MBP | C0027873 | Neuromyelitis Optica | 1 | CTD_human |