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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43385

FusionGeneSummary for ZNF516_MBP

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF516_MBP
Fusion gene ID: 43385
HgeneTgene
Gene symbol

ZNF516

MBP

Gene ID

9658

5553

Gene namezinc finger protein 516proteoglycan 2, pro eosinophil major basic protein
SynonymsHsT287BMPG|MBP|MBP1|proMBP
Cytomap

18q23

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 516bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Modification date2018052320180519
UniProtAcc

Q92618

P02686

Ensembl transtripts involved in fusion geneENST00000443185, ENST00000524431, 
ENST00000382582, ENST00000355994, 
ENST00000397875, ENST00000397866, 
ENST00000397865, ENST00000527041, 
ENST00000359645, ENST00000528160, 
ENST00000397869, ENST00000354542, 
ENST00000526111, ENST00000580402, 
ENST00000579129, ENST00000578193, 
ENST00000397863, ENST00000397860, 
ENST00000487778, 
Fusion gene scores* DoF score1 X 1 X 1=126 X 20 X 3=1560
# samples 127
** MAII scorelog2(1/1*10)=3.32192809488736log2(27/1560*10)=-2.53051471669878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF516 [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-AX-A3FX-01AZNF516chr18

74202637

-MBPchr18

74702016

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000443185ENST00000382582ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-3CDSENST00000443185ENST00000355994ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-3CDSENST00000443185ENST00000397875ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-3CDSENST00000443185ENST00000397866ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-3CDSENST00000443185ENST00000397865ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-3CDSENST00000443185ENST00000527041ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-3CDSENST00000443185ENST00000359645ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000443185ENST00000528160ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000443185ENST00000397869ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000443185ENST00000354542ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000443185ENST00000526111ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000443185ENST00000580402ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000443185ENST00000579129ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000443185ENST00000578193ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000443185ENST00000397863ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000443185ENST00000397860ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000443185ENST00000487778ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-3CDSENST00000524431ENST00000382582ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-3CDSENST00000524431ENST00000355994ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-3CDSENST00000524431ENST00000397875ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-3CDSENST00000524431ENST00000397866ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-3CDSENST00000524431ENST00000397865ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-3CDSENST00000524431ENST00000527041ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-3CDSENST00000524431ENST00000359645ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000524431ENST00000528160ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000524431ENST00000397869ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000524431ENST00000354542ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000524431ENST00000526111ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000524431ENST00000580402ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000524431ENST00000579129ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000524431ENST00000578193ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000524431ENST00000397863ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000524431ENST00000397860ZNF516chr18

74202637

-MBPchr18

74702016

-
intron-intronENST00000524431ENST00000487778ZNF516chr18

74202637

-MBPchr18

74702016

-

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FusionProtFeatures for ZNF516_MBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF516

Q92618

MBP

P02686

Transcriptional regulator that binds to the promoter andactivates the transcription of genes promoting brown adiposetissue (BAT) differentiation. Among brown adipose tissue-specificgenes, binds the proximal region of the promoter of the UCP1 geneto activate its transcription and thereby regulate thermogenesis(By similarity). May also play a role in the cellular response toreplication stress (PubMed:23446422).{ECO:0000250|UniProtKB:Q7TSH3, ECO:0000269|PubMed:23446422}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF516_MBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF516_MBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF516KDM1A, HIST3H3, ZBP1, HDAC1, DYRK1B, CTBP1, MED23, HYPK, EGFR, LCOR, ZBTB42MBPTRPM7, PRMT5, STK39, HLA-DRA, PLP1, TSSK6, IRAK4, PRKCA, PRKCI, PRKCZ, PPP2R5C, LIMK1, LIMK2, TBK1, IKBKE, STK3, APTX, ATN1, ATXN1, MAPK14, LRRK2, PRKDC, MAPK12, MAPK11, MAPK13, MAPK3, MAPK1, CDK1, CDK5, MAP3K5, TLK1, RPS6KA6, DDX58, MELK, CDK7, CDK8, CDK9, HIPK2, SQSTM1, PKN1, ULK1, PRKCB, MAP3K3, CTDSP1, ABL1, MUS81, RPS6KA5, MYH6, MAP3K1, MAPK8, CTDSPL, NLN, IDE, PTPRA, PRKCD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF516_MBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF516_MBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMBPC0036341Schizophrenia4PSYGENET
TgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
TgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneMBPC0011303Demyelinating Diseases1CTD_human
TgeneMBPC0027873Neuromyelitis Optica1CTD_human