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Fusion gene ID: 43380 |
FusionGeneSummary for ZNF512_ANXA4 |
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Fusion gene information | Fusion gene name: ZNF512_ANXA4 | Fusion gene ID: 43380 | Hgene | Tgene | Gene symbol | ZNF512 | ANXA4 | Gene ID | 84450 | 307 |
Gene name | zinc finger protein 512 | annexin A4 | |
Synonyms | - | ANX4|HEL-S-274|P32.5|PAP-II|PIG28|PP4-X|ZAP36 | |
Cytomap | 2p23.3 | 2p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 512 | annexin A435-beta calcimedinannexin IV (placental anticoagulant protein II)annexin-4carbohydrate-binding protein p33/p41chromobindin-4endonexin Iepididymis secretory protein Li 274lipocortin IVplacental anticoagulant protein IIproliferation-indu | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q96ME7 | P09525 | |
Ensembl transtripts involved in fusion gene | ENST00000379717, ENST00000355467, ENST00000494548, ENST00000556601, ENST00000416005, ENST00000413371, | ENST00000418066, ENST00000409920, ENST00000394295, ENST00000536030, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 8 X 3 X 7=168 |
# samples | 3 | 10 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/168*10)=-0.748461233004036 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF512 [Title/Abstract] AND ANXA4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ANXA4 | GO:0006357 | regulation of transcription by RNA polymerase II | 20237821 |
Tgene | ANXA4 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 20237821 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCEC | TCGA-A5-A2K4-01A | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000379717 | ENST00000418066 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000379717 | ENST00000409920 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000379717 | ENST00000394295 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000379717 | ENST00000536030 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5CDS-3UTR | ENST00000355467 | ENST00000418066 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000355467 | ENST00000409920 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000355467 | ENST00000394295 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000355467 | ENST00000536030 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
3UTR-3UTR | ENST00000494548 | ENST00000418066 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
3UTR-5UTR | ENST00000494548 | ENST00000409920 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
3UTR-5UTR | ENST00000494548 | ENST00000394295 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
3UTR-5UTR | ENST00000494548 | ENST00000536030 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5UTR-3UTR | ENST00000556601 | ENST00000418066 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5UTR-5UTR | ENST00000556601 | ENST00000409920 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5UTR-5UTR | ENST00000556601 | ENST00000394295 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5UTR-5UTR | ENST00000556601 | ENST00000536030 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5CDS-3UTR | ENST00000416005 | ENST00000418066 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000416005 | ENST00000409920 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000416005 | ENST00000394295 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000416005 | ENST00000536030 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5UTR-3UTR | ENST00000413371 | ENST00000418066 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5UTR-5UTR | ENST00000413371 | ENST00000409920 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5UTR-5UTR | ENST00000413371 | ENST00000394295 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
5UTR-5UTR | ENST00000413371 | ENST00000536030 | ZNF512 | chr2 | 27806009 | + | ANXA4 | chr2 | 70008652 | + |
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FusionProtFeatures for ZNF512_ANXA4 |
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Hgene | Tgene |
ZNF512 | ANXA4 |
May be involved in transcriptional regulation. | Calcium/phospholipid-binding protein which promotesmembrane fusion and is involved in exocytosis. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF512_ANXA4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF512_ANXA4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF512 | SIRT7, RNF2, NOL12, RPL14, NPM1, THAP7, PRR11, IFI16, HIST1H2BG, HIST1H3A, CDC14B, ZNF273, ZNF724P, RPL26L1, WDR3, ZNF346, BLM, DDX31, RPL30, C3orf17, NAT10, ZCCHC17, NOL8, BUD13, RPL5, NGDN, STAU1, LENG8, NOL6, URB2, NVL, PDCD11, RPL32, RPF1, GLTSCR2, KNOP1, BBX, URB1, RPL18, CEBPZ, TAF1A, CENPU, RPL37A, CNBP, ZNF121, GTPBP4, RSBN1, DDX51, YTHDC2, PPAN-P2RY11, RRP8, REXO4, DDX24, NOC2L, GNL2, GPATCH4, RPL8, ZCCHC6, RNMTL1, RRP7A, DDX54, FXR1, WDR46, ZBTB24, RPS3A, ZNF593, ZNF431, NMNAT1, RPL4, SDAD1, DDX21, HIST2H2AB, RBM34, RPL13, RBMX2, ZNF668, FTSJ3, RRS1, NOP2, ZNF771, NR3C1, DLST | ANXA4 | NFKB1, H2AFX, UCHL5, SMPD1, NMT2, TINF2, POT1, DNAJB11, ANXA7, MPST, ANXA3, ANXA1, PADI4, EZH2, RAB8A, RHOU, CDH1, SF3A3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF512_ANXA4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF512_ANXA4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ANXA4 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | ANXA4 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Tgene | ANXA4 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | ANXA4 | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | ANXA4 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | ANXA4 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | ANXA4 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | ANXA4 | C0032927 | Precancerous Conditions | 1 | CTD_human |
Tgene | ANXA4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | ANXA4 | C2239176 | Liver carcinoma | 1 | CTD_human |