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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 43367

FusionGeneSummary for ZNF493_TMBIM4

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF493_TMBIM4
Fusion gene ID: 43367
HgeneTgene
Gene symbol

ZNF493

TMBIM4

Gene ID

284443

51643

Gene namezinc finger protein 493transmembrane BAX inhibitor motif containing 4
Synonyms-CGI-119|GAAP|LFG4|S1R|ZPRO
Cytomap

19p12

12q14.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 493protein lifeguard 4Golgi anti-apoptotic proteinZ-proteintransmembrane BAX inhibitor motif-containing protein 4
Modification date2018040320180519
UniProtAcc

Q6ZR52

Q9HC24

Ensembl transtripts involved in fusion geneENST00000596302, ENST00000392288, 
ENST00000594390, ENST00000355504, 
ENST00000339914, ENST00000599461, 
ENST00000539652, ENST00000556010, 
ENST00000358230, ENST00000544599, 
ENST00000286424, ENST00000398033, 
ENST00000542724, ENST00000535812, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 2 X 2=16
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF493 [Title/Abstract] AND TMBIM4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTMBIM4

GO:0050848

regulation of calcium-mediated signaling

19553469


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A48N-01AZNF493chr19

21580069

+TMBIM4chr12

66547228

-
TCGALDSARCTCGA-DX-A48N-01AZNF493chr19

21596451

+TMBIM4chr12

66547228

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000596302ENST00000539652ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
In-frameENST00000596302ENST00000556010ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
Frame-shiftENST00000596302ENST00000358230ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-5UTRENST00000596302ENST00000544599ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-5UTRENST00000596302ENST00000286424ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-5UTRENST00000596302ENST00000398033ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-intronENST00000596302ENST00000542724ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-intronENST00000596302ENST00000535812ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
In-frameENST00000392288ENST00000539652ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
In-frameENST00000392288ENST00000556010ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
Frame-shiftENST00000392288ENST00000358230ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-5UTRENST00000392288ENST00000544599ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-5UTRENST00000392288ENST00000286424ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-5UTRENST00000392288ENST00000398033ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-intronENST00000392288ENST00000542724ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-intronENST00000392288ENST00000535812ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
In-frameENST00000594390ENST00000539652ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
In-frameENST00000594390ENST00000556010ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
Frame-shiftENST00000594390ENST00000358230ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-5UTRENST00000594390ENST00000544599ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-5UTRENST00000594390ENST00000286424ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-5UTRENST00000594390ENST00000398033ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-intronENST00000594390ENST00000542724ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-intronENST00000594390ENST00000535812ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5UTR-3CDSENST00000355504ENST00000539652ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5UTR-3CDSENST00000355504ENST00000556010ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5UTR-3CDSENST00000355504ENST00000358230ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5UTR-5UTRENST00000355504ENST00000544599ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5UTR-5UTRENST00000355504ENST00000286424ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5UTR-5UTRENST00000355504ENST00000398033ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5UTR-intronENST00000355504ENST00000542724ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5UTR-intronENST00000355504ENST00000535812ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
In-frameENST00000339914ENST00000539652ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
In-frameENST00000339914ENST00000556010ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
Frame-shiftENST00000339914ENST00000358230ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-5UTRENST00000339914ENST00000544599ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-5UTRENST00000339914ENST00000286424ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-5UTRENST00000339914ENST00000398033ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-intronENST00000339914ENST00000542724ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-intronENST00000339914ENST00000535812ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
Frame-shiftENST00000599461ENST00000539652ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
Frame-shiftENST00000599461ENST00000556010ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
Frame-shiftENST00000599461ENST00000358230ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-5UTRENST00000599461ENST00000544599ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-5UTRENST00000599461ENST00000286424ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-5UTRENST00000599461ENST00000398033ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-intronENST00000599461ENST00000542724ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
5CDS-intronENST00000599461ENST00000535812ZNF493chr19

21580069

+TMBIM4chr12

66547228

-
intron-3CDSENST00000596302ENST00000539652ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000596302ENST00000556010ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000596302ENST00000358230ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000596302ENST00000544599ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000596302ENST00000286424ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000596302ENST00000398033ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000596302ENST00000542724ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000596302ENST00000535812ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000392288ENST00000539652ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000392288ENST00000556010ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000392288ENST00000358230ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000392288ENST00000544599ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000392288ENST00000286424ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000392288ENST00000398033ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000392288ENST00000542724ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000392288ENST00000535812ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
3UTR-3CDSENST00000594390ENST00000539652ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
3UTR-3CDSENST00000594390ENST00000556010ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
3UTR-3CDSENST00000594390ENST00000358230ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
3UTR-5UTRENST00000594390ENST00000544599ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
3UTR-5UTRENST00000594390ENST00000286424ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
3UTR-5UTRENST00000594390ENST00000398033ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
3UTR-intronENST00000594390ENST00000542724ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
3UTR-intronENST00000594390ENST00000535812ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000355504ENST00000539652ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000355504ENST00000556010ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000355504ENST00000358230ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000355504ENST00000544599ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000355504ENST00000286424ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000355504ENST00000398033ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000355504ENST00000542724ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000355504ENST00000535812ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000339914ENST00000539652ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000339914ENST00000556010ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000339914ENST00000358230ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000339914ENST00000544599ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000339914ENST00000286424ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000339914ENST00000398033ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000339914ENST00000542724ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000339914ENST00000535812ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000599461ENST00000539652ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000599461ENST00000556010ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000599461ENST00000358230ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000599461ENST00000544599ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000599461ENST00000286424ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000599461ENST00000398033ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000599461ENST00000542724ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000599461ENST00000535812ZNF493chr19

21596451

+TMBIM4chr12

66547228

-

Top

FusionProtFeatures for ZNF493_TMBIM4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF493

Q6ZR52

TMBIM4

Q9HC24

May be involved in transcriptional regulation. Anti-apoptotic protein which can inhibit apoptosisinduced by intrinsic and extrinsic apoptotic stimuli. Can modulateboth capacitative Ca2+ entry and inositol 1,4,5-trisphosphate(IP3)-mediated Ca2+ release. {ECO:0000269|PubMed:17319741,ECO:0000269|PubMed:19553469}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMBIM4chr19:21580069chr12:66547228ENST00000358230-07209_22932239IntramembraneHelical
TgeneTMBIM4chr19:21580069chr12:66547228ENST00000358230-07119_12032239Topological domainLumenal
TgeneTMBIM4chr19:21580069chr12:66547228ENST00000358230-07142_15132239Topological domainCytoplasmic
TgeneTMBIM4chr19:21580069chr12:66547228ENST00000358230-07173_17532239Topological domainLumenal
TgeneTMBIM4chr19:21580069chr12:66547228ENST00000358230-07197_20832239Topological domainCytoplasmic
TgeneTMBIM4chr19:21580069chr12:66547228ENST00000358230-07230_23832239Topological domainCytoplasmic
TgeneTMBIM4chr19:21580069chr12:66547228ENST00000358230-0760_6832239Topological domainLumenal
TgeneTMBIM4chr19:21580069chr12:66547228ENST00000358230-0790_9732239Topological domainCytoplasmic
TgeneTMBIM4chr19:21580069chr12:66547228ENST00000358230-07121_14132239TransmembraneHelical
TgeneTMBIM4chr19:21580069chr12:66547228ENST00000358230-07152_17232239TransmembraneHelical
TgeneTMBIM4chr19:21580069chr12:66547228ENST00000358230-07176_19632239TransmembraneHelical
TgeneTMBIM4chr19:21580069chr12:66547228ENST00000358230-0739_5932239TransmembraneHelical
TgeneTMBIM4chr19:21580069chr12:66547228ENST00000358230-0769_8932239TransmembraneHelical
TgeneTMBIM4chr19:21580069chr12:66547228ENST00000358230-0798_11832239TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14109_13110104Zinc fingerC2H2-type 4%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14137_15910104Zinc fingerC2H2-type 5
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14165_18710104Zinc fingerC2H2-type 6%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14193_21510104Zinc fingerC2H2-type 7%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14221_24310104Zinc fingerC2H2-type 8%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14249_27110104Zinc fingerC2H2-type 9
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+1426_4810104Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14277_29910104Zinc fingerC2H2-type 10
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14305_32710104Zinc fingerC2H2-type 11
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14333_35510104Zinc fingerC2H2-type 12
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14361_38310104Zinc fingerC2H2-type 13
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14389_41110104Zinc fingerC2H2-type 14
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14417_43910104Zinc fingerC2H2-type 15
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14445_46710104Zinc fingerC2H2-type 16
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14473_49510104Zinc fingerC2H2-type 17
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14501_52310104Zinc fingerC2H2-type 18
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14529_55110104Zinc fingerC2H2-type 19
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+1454_7610104Zinc fingerC2H2-type 2
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14557_57910104Zinc fingerC2H2-type 20
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14585_60710104Zinc fingerC2H2-type 21
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+14613_63510104Zinc fingerC2H2-type 22
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914+1482_10410104Zinc fingerC2H2-type 3
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12109_131-44647Zinc fingerC2H2-type 4%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12137_159-44647Zinc fingerC2H2-type 5
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12165_187-44647Zinc fingerC2H2-type 6%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12193_215-44647Zinc fingerC2H2-type 7%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12221_243-44647Zinc fingerC2H2-type 8%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12249_271-44647Zinc fingerC2H2-type 9
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+1226_48-44647Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12277_299-44647Zinc fingerC2H2-type 10
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12305_327-44647Zinc fingerC2H2-type 11
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12333_355-44647Zinc fingerC2H2-type 12
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12361_383-44647Zinc fingerC2H2-type 13
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12389_411-44647Zinc fingerC2H2-type 14
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12417_439-44647Zinc fingerC2H2-type 15
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12445_467-44647Zinc fingerC2H2-type 16
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12473_495-44647Zinc fingerC2H2-type 17
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12501_523-44647Zinc fingerC2H2-type 18
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12529_551-44647Zinc fingerC2H2-type 19
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+1254_76-44647Zinc fingerC2H2-type 2
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12557_579-44647Zinc fingerC2H2-type 20
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12585_607-44647Zinc fingerC2H2-type 21
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+12613_635-44647Zinc fingerC2H2-type 22
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504+1282_104-44647Zinc fingerC2H2-type 3
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14109_13110775Zinc fingerC2H2-type 4%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14137_15910775Zinc fingerC2H2-type 5
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14165_18710775Zinc fingerC2H2-type 6%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14193_21510775Zinc fingerC2H2-type 7%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14221_24310775Zinc fingerC2H2-type 8%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14249_27110775Zinc fingerC2H2-type 9
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+1426_4810775Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14277_29910775Zinc fingerC2H2-type 10
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14305_32710775Zinc fingerC2H2-type 11
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14333_35510775Zinc fingerC2H2-type 12
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14361_38310775Zinc fingerC2H2-type 13
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14389_41110775Zinc fingerC2H2-type 14
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14417_43910775Zinc fingerC2H2-type 15
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14445_46710775Zinc fingerC2H2-type 16
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14473_49510775Zinc fingerC2H2-type 17
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14501_52310775Zinc fingerC2H2-type 18
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14529_55110775Zinc fingerC2H2-type 19
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+1454_7610775Zinc fingerC2H2-type 2
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14557_57910775Zinc fingerC2H2-type 20
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14585_60710775Zinc fingerC2H2-type 21
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+14613_63510775Zinc fingerC2H2-type 22
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288+1482_10410775Zinc fingerC2H2-type 3
TgeneTMBIM4chr19:21580069chr12:66547228ENST00000358230-071_3832239Topological domainCytoplasmic


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FusionGeneSequence for ZNF493_TMBIM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZNF493_ENST00000596302_chr19_21580069_+_TMBIM4_ENST00000539652_chr12_66547228_-_10aa

>In-frame_ZNF493_ENST00000596302_chr19_21580069_+_TMBIM4_ENST00000556010_chr12_66547228_-_10aa

>In-frame_ZNF493_ENST00000392288_chr19_21580069_+_TMBIM4_ENST00000539652_chr12_66547228_-_10aa

>In-frame_ZNF493_ENST00000392288_chr19_21580069_+_TMBIM4_ENST00000556010_chr12_66547228_-_10aa

>In-frame_ZNF493_ENST00000594390_chr19_21580069_+_TMBIM4_ENST00000539652_chr12_66547228_-_10aa

>In-frame_ZNF493_ENST00000594390_chr19_21580069_+_TMBIM4_ENST00000556010_chr12_66547228_-_10aa

>In-frame_ZNF493_ENST00000339914_chr19_21580069_+_TMBIM4_ENST00000539652_chr12_66547228_-_10aa

>In-frame_ZNF493_ENST00000339914_chr19_21580069_+_TMBIM4_ENST00000556010_chr12_66547228_-_10aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZNF493_ENST00000596302_chr19_21580069_+_TMBIM4_ENST00000539652_chr12_66547228_-_30nt

>In-frame_ZNF493_ENST00000596302_chr19_21580069_+_TMBIM4_ENST00000556010_chr12_66547228_-_30nt

>In-frame_ZNF493_ENST00000392288_chr19_21580069_+_TMBIM4_ENST00000539652_chr12_66547228_-_30nt

>In-frame_ZNF493_ENST00000392288_chr19_21580069_+_TMBIM4_ENST00000556010_chr12_66547228_-_30nt

>In-frame_ZNF493_ENST00000594390_chr19_21580069_+_TMBIM4_ENST00000539652_chr12_66547228_-_30nt

>In-frame_ZNF493_ENST00000594390_chr19_21580069_+_TMBIM4_ENST00000556010_chr12_66547228_-_30nt

>In-frame_ZNF493_ENST00000339914_chr19_21580069_+_TMBIM4_ENST00000539652_chr12_66547228_-_30nt

>In-frame_ZNF493_ENST00000339914_chr19_21580069_+_TMBIM4_ENST00000556010_chr12_66547228_-_30nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNF493_ENST00000596302_chr19_21580069_+_TMBIM4_ENST00000539652_chr12_66547228_-_1002nt
GATGTGGCTGGGCCATTGTTTCTCTCTGCTGCCGGAGCTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGAC
CTGAAGATACTGGGAAATCCATAGCTAAGATGCCAGGACCCCCTGAAAGCCTAGACATGCCTTTCTGAGAAAAGTCTACAGCATTCTTTC
TCTGCAGGTTCTCTTAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAAT
TTTGCTGTTTGCCCTCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGG
ATTTACGCTGTTGGAAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTAC
AGTATTTTTTGGTTTGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGCCGCTGCAGGAGCCCTTCTTTTCT
GTGGATTCATCATCTATGACACACACTCACTGATGCATAAACTGTCACCTGAAGAGTACGTATTAGCTGCCATCAGCCTCTACTTGGATA
TCATCAATCTATTCCTGCACCTGTTACGGTTTCTGGAAGCAGTTAATAAAAAGTAAAACATGGCTAAAAGCTTACGGAGTAAGTGGAAAA
GAAAGATGCGTGCTGAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACGGTGATGTTTTAA
TGAAAGATGTTCAAGAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAAAAGATGAAAAAG
ATGACATGAAAATGGAGACTGATATTAAGAGAAACAAAAAGACTCTTCTAGACCAGCATGGACAGTACCCAATATGGATGAACCAAAGGC

>In-frame_ZNF493_ENST00000596302_chr19_21580069_+_TMBIM4_ENST00000556010_chr12_66547228_-_990nt
GATGTGGCTGGGCCATTGTTTCTCTCTGCTGCCGGAGCTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGAC
CTGAAGATACTGGGAAATCCATAGCTAAGATGCCAGGACCCCCTGAAAGCCTAGACATGCCTTTCTGAGAAAAGTCTACAGCATTCTTTC
TCTGCAGGTTCTCTTAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAAT
TTTGCTGTTTGCCCTCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGG
ATTTACGCTGTTGGAAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTAC
AGTATTTTTTGGTTTGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGCCGCTGCAGGAGCCCTTCTTTTCT
GTGGATTCATCATCTATGACACACACTCACTGATGCATAAACTGTCACCTGAAGAGTACGTATTAGCTGCCATCAGCCTCTACTTGGATA
TCATCAATCTATTCCTGCACCTGTTACGGTTTCTGGAAGCAGTTAATAAAAAGTAAAACATGGCTAAAAGCTTACGGAGTAAGTGGAAAA
GAAAGATGCGTGCTGAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACGGTGATGTTTTAA
TGAAAGATGTTCAAGAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAAAAGATGAAAAAG
ATGACATGAAAATGGAGACTGATATTAAGAGAAACAAAAAGACTCTTCTAGACCAGCATGGACAGTACCCAATATGGATGAACCAAAGGC

>In-frame_ZNF493_ENST00000392288_chr19_21580069_+_TMBIM4_ENST00000539652_chr12_66547228_-_992nt
GGCCATTGTTTCTCTCTGCTGCCGGAGCTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGACCTGAAGATAC
TGGGAAATCCATAGCTAAGATGCCAGGACCCCCTGAAAGCCTAGACATGCCTTTCTGAGAAAAGTCTACAGCATTCTTTCTCTGCAGGTT
CTCTTAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGCTGTTT
GCCCTCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTACGCTG
TTGGAAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTATTTTTT
GGTTTGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGCCGCTGCAGGAGCCCTTCTTTTCTGTGGATTCAT
CATCTATGACACACACTCACTGATGCATAAACTGTCACCTGAAGAGTACGTATTAGCTGCCATCAGCCTCTACTTGGATATCATCAATCT
ATTCCTGCACCTGTTACGGTTTCTGGAAGCAGTTAATAAAAAGTAAAACATGGCTAAAAGCTTACGGAGTAAGTGGAAAAGAAAGATGCG
TGCTGAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACGGTGATGTTTTAATGAAAGATGT
TCAAGAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAAAAGATGAAAAAGATGACATGAA
AATGGAGACTGATATTAAGAGAAACAAAAAGACTCTTCTAGACCAGCATGGACAGTACCCAATATGGATGAACCAAAGGCAAAGAAAAAG

>In-frame_ZNF493_ENST00000392288_chr19_21580069_+_TMBIM4_ENST00000556010_chr12_66547228_-_980nt
GGCCATTGTTTCTCTCTGCTGCCGGAGCTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGACCTGAAGATAC
TGGGAAATCCATAGCTAAGATGCCAGGACCCCCTGAAAGCCTAGACATGCCTTTCTGAGAAAAGTCTACAGCATTCTTTCTCTGCAGGTT
CTCTTAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGCTGTTT
GCCCTCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTACGCTG
TTGGAAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTATTTTTT
GGTTTGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGCCGCTGCAGGAGCCCTTCTTTTCTGTGGATTCAT
CATCTATGACACACACTCACTGATGCATAAACTGTCACCTGAAGAGTACGTATTAGCTGCCATCAGCCTCTACTTGGATATCATCAATCT
ATTCCTGCACCTGTTACGGTTTCTGGAAGCAGTTAATAAAAAGTAAAACATGGCTAAAAGCTTACGGAGTAAGTGGAAAAGAAAGATGCG
TGCTGAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACGGTGATGTTTTAATGAAAGATGT
TCAAGAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAAAAGATGAAAAAGATGACATGAA

>In-frame_ZNF493_ENST00000594390_chr19_21580069_+_TMBIM4_ENST00000539652_chr12_66547228_-_988nt
ATTGTTTCTCTCTGCTGCCGGAGCTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGACCTGAAGATACTGGG
AAATCCATAGCTAAGATGCCAGGACCCCCTGAAAGCCTAGACATGCCTTTCTGAGAAAAGTCTACAGCATTCTTTCTCTGCAGGTTCTCT
TAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGCTGTTTGCCC
TCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTACGCTGTTGG
AAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTATTTTTTGGTT
TGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGCCGCTGCAGGAGCCCTTCTTTTCTGTGGATTCATCATC
TATGACACACACTCACTGATGCATAAACTGTCACCTGAAGAGTACGTATTAGCTGCCATCAGCCTCTACTTGGATATCATCAATCTATTC
CTGCACCTGTTACGGTTTCTGGAAGCAGTTAATAAAAAGTAAAACATGGCTAAAAGCTTACGGAGTAAGTGGAAAAGAAAGATGCGTGCT
GAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACGGTGATGTTTTAATGAAAGATGTTCAA
GAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAAAAGATGAAAAAGATGACATGAAAATG

>In-frame_ZNF493_ENST00000594390_chr19_21580069_+_TMBIM4_ENST00000556010_chr12_66547228_-_976nt
ATTGTTTCTCTCTGCTGCCGGAGCTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGACCTGAAGATACTGGG
AAATCCATAGCTAAGATGCCAGGACCCCCTGAAAGCCTAGACATGCCTTTCTGAGAAAAGTCTACAGCATTCTTTCTCTGCAGGTTCTCT
TAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGCTGTTTGCCC
TCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTACGCTGTTGG
AAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTATTTTTTGGTT
TGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGCCGCTGCAGGAGCCCTTCTTTTCTGTGGATTCATCATC
TATGACACACACTCACTGATGCATAAACTGTCACCTGAAGAGTACGTATTAGCTGCCATCAGCCTCTACTTGGATATCATCAATCTATTC
CTGCACCTGTTACGGTTTCTGGAAGCAGTTAATAAAAAGTAAAACATGGCTAAAAGCTTACGGAGTAAGTGGAAAAGAAAGATGCGTGCT
GAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACGGTGATGTTTTAATGAAAGATGTTCAA
GAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAAAAGATGAAAAAGATGACATGAAAATG

>In-frame_ZNF493_ENST00000339914_chr19_21580069_+_TMBIM4_ENST00000539652_chr12_66547228_-_965nt
CTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGACCTGAAGATACTGGGAAATCCATAGCTAAGATGCCAGG
ACCCCCTGAAAGCCTAGACATGCCTTTCTGAGAAAAGTCTACAGCATTCTTTCTCTGCAGGTTCTCTTAACTACAGTGACTTCAACAGTT
TTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGCTGTTTGCCCTCGGATCTCTGGGTTTGATTTTT
GCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTACGCTGTTGGAAGCTCTGACTGTGGCAGTTGTT
GTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTATTTTTTGGTTTGACTGTGTATACTCTACAATCT
AAGAAGGATTTCAGCAAATTTGGAGCAGGCCGCTGCAGGAGCCCTTCTTTTCTGTGGATTCATCATCTATGACACACACTCACTGATGCA
TAAACTGTCACCTGAAGAGTACGTATTAGCTGCCATCAGCCTCTACTTGGATATCATCAATCTATTCCTGCACCTGTTACGGTTTCTGGA
AGCAGTTAATAAAAAGTAAAACATGGCTAAAAGCTTACGGAGTAAGTGGAAAAGAAAGATGCGTGCTGAAAAGAGAAAAAAGAATGCCCC
AAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACGGTGATGTTTTAATGAAAGATGTTCAAGAGATAGCAACTGTGGTGGTACC
CAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAAAAGATGAAAAAGATGACATGAAAATGGAGACTGATATTAAGAGAAACAA

>In-frame_ZNF493_ENST00000339914_chr19_21580069_+_TMBIM4_ENST00000556010_chr12_66547228_-_953nt
CTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGACCTGAAGATACTGGGAAATCCATAGCTAAGATGCCAGG
ACCCCCTGAAAGCCTAGACATGCCTTTCTGAGAAAAGTCTACAGCATTCTTTCTCTGCAGGTTCTCTTAACTACAGTGACTTCAACAGTT
TTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGCTGTTTGCCCTCGGATCTCTGGGTTTGATTTTT
GCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTACGCTGTTGGAAGCTCTGACTGTGGCAGTTGTT
GTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTATTTTTTGGTTTGACTGTGTATACTCTACAATCT
AAGAAGGATTTCAGCAAATTTGGAGCAGGCCGCTGCAGGAGCCCTTCTTTTCTGTGGATTCATCATCTATGACACACACTCACTGATGCA
TAAACTGTCACCTGAAGAGTACGTATTAGCTGCCATCAGCCTCTACTTGGATATCATCAATCTATTCCTGCACCTGTTACGGTTTCTGGA
AGCAGTTAATAAAAAGTAAAACATGGCTAAAAGCTTACGGAGTAAGTGGAAAAGAAAGATGCGTGCTGAAAAGAGAAAAAAGAATGCCCC
AAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACGGTGATGTTTTAATGAAAGATGTTCAAGAGATAGCAACTGTGGTGGTACC
CAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAAAAGATGAAAAAGATGACATGAAAATGGAGACTGATATTAAGAGAAACAA


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FusionGenePPI for ZNF493_TMBIM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF493TMBIM4SLC27A4, RPN2, CCDC47, DDOST, PPIB, MTX1, PRPSAP1, DFFA, COX4I1, VKORC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF493_TMBIM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF493_TMBIM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTMBIM4C0029927Ovarian Cysts1CTD_human