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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 43366

FusionGeneSummary for ZNF493_RPL13A

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF493_RPL13A
Fusion gene ID: 43366
HgeneTgene
Gene symbol

ZNF493

RPL13A

Gene ID

284443

23521

Gene namezinc finger protein 493ribosomal protein L13a
Synonyms-L13A|TSTA1
Cytomap

19p12

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 49360S ribosomal protein L13a23 kDa highly basic proteinlarge ribosomal subunit protein uL13tissue specific transplantation antigen 1
Modification date2018040320180523
UniProtAcc

Q6ZR52

P40429

Ensembl transtripts involved in fusion geneENST00000596302, ENST00000392288, 
ENST00000594390, ENST00000355504, 
ENST00000339914, ENST00000599461, 
ENST00000391857, ENST00000477613, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 5 X 4=100
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF493 [Title/Abstract] AND RPL13A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPL13A

GO:0017148

negative regulation of translation

14567916|23071094

TgeneRPL13A

GO:0071346

cellular response to interferon-gamma

15479637

TgeneRPL13A

GO:1901194

negative regulation of formation of translation preinitiation complex

17218275


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPAADTCGA-US-A776-01AZNF493chr19

21580069

+RPL13Achr19

49993107

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000596302ENST00000391857ZNF493chr19

21580069

+RPL13Achr19

49993107

+
5CDS-3UTRENST00000596302ENST00000477613ZNF493chr19

21580069

+RPL13Achr19

49993107

+
In-frameENST00000392288ENST00000391857ZNF493chr19

21580069

+RPL13Achr19

49993107

+
5CDS-3UTRENST00000392288ENST00000477613ZNF493chr19

21580069

+RPL13Achr19

49993107

+
In-frameENST00000594390ENST00000391857ZNF493chr19

21580069

+RPL13Achr19

49993107

+
5CDS-3UTRENST00000594390ENST00000477613ZNF493chr19

21580069

+RPL13Achr19

49993107

+
5UTR-3CDSENST00000355504ENST00000391857ZNF493chr19

21580069

+RPL13Achr19

49993107

+
5UTR-3UTRENST00000355504ENST00000477613ZNF493chr19

21580069

+RPL13Achr19

49993107

+
In-frameENST00000339914ENST00000391857ZNF493chr19

21580069

+RPL13Achr19

49993107

+
5CDS-3UTRENST00000339914ENST00000477613ZNF493chr19

21580069

+RPL13Achr19

49993107

+
Frame-shiftENST00000599461ENST00000391857ZNF493chr19

21580069

+RPL13Achr19

49993107

+
5CDS-3UTRENST00000599461ENST00000477613ZNF493chr19

21580069

+RPL13Achr19

49993107

+

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FusionProtFeatures for ZNF493_RPL13A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF493

Q6ZR52

RPL13A

P40429

May be involved in transcriptional regulation. Associated with ribosomes but is not required forcanonical ribosome function and has extra-ribosomal functions.Component of the GAIT (gamma interferon-activated inhibitor oftranslation) complex which mediates interferon-gamma-inducedtranscript-selective translation inhibition in inflammationprocesses. Upon interferon-gamma activation and subsequentphosphorylation dissociates from the ribosome and assembles intothe GAIT complex which binds to stem loop-containing GAIT elementsin the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin)and suppresses their translation. In the GAIT complex interactswith m7G cap-bound eIF4G at or near the eIF3-binding site andblocks the recruitment of the 43S ribosomal complex. Involved inmethylation of rRNA. {ECO:0000269|PubMed:14567916,ECO:0000269|PubMed:17218275, ECO:0000269|PubMed:17921318,ECO:0000269|PubMed:23071094}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14109_13110104Zinc fingerC2H2-type 4%3B degenerate
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14137_15910104Zinc fingerC2H2-type 5
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14165_18710104Zinc fingerC2H2-type 6%3B degenerate
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14193_21510104Zinc fingerC2H2-type 7%3B degenerate
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14221_24310104Zinc fingerC2H2-type 8%3B degenerate
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14249_27110104Zinc fingerC2H2-type 9
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+1426_4810104Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14277_29910104Zinc fingerC2H2-type 10
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14305_32710104Zinc fingerC2H2-type 11
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14333_35510104Zinc fingerC2H2-type 12
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14361_38310104Zinc fingerC2H2-type 13
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14389_41110104Zinc fingerC2H2-type 14
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14417_43910104Zinc fingerC2H2-type 15
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14445_46710104Zinc fingerC2H2-type 16
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14473_49510104Zinc fingerC2H2-type 17
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14501_52310104Zinc fingerC2H2-type 18
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14529_55110104Zinc fingerC2H2-type 19
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+1454_7610104Zinc fingerC2H2-type 2
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14557_57910104Zinc fingerC2H2-type 20
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14585_60710104Zinc fingerC2H2-type 21
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+14613_63510104Zinc fingerC2H2-type 22
HgeneZNF493chr19:21580069chr19:49993107ENST00000339914+1482_10410104Zinc fingerC2H2-type 3
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12109_131-44647Zinc fingerC2H2-type 4%3B degenerate
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12137_159-44647Zinc fingerC2H2-type 5
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12165_187-44647Zinc fingerC2H2-type 6%3B degenerate
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12193_215-44647Zinc fingerC2H2-type 7%3B degenerate
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12221_243-44647Zinc fingerC2H2-type 8%3B degenerate
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12249_271-44647Zinc fingerC2H2-type 9
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+1226_48-44647Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12277_299-44647Zinc fingerC2H2-type 10
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12305_327-44647Zinc fingerC2H2-type 11
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12333_355-44647Zinc fingerC2H2-type 12
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12361_383-44647Zinc fingerC2H2-type 13
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12389_411-44647Zinc fingerC2H2-type 14
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12417_439-44647Zinc fingerC2H2-type 15
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12445_467-44647Zinc fingerC2H2-type 16
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12473_495-44647Zinc fingerC2H2-type 17
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12501_523-44647Zinc fingerC2H2-type 18
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12529_551-44647Zinc fingerC2H2-type 19
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+1254_76-44647Zinc fingerC2H2-type 2
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12557_579-44647Zinc fingerC2H2-type 20
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12585_607-44647Zinc fingerC2H2-type 21
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+12613_635-44647Zinc fingerC2H2-type 22
HgeneZNF493chr19:21580069chr19:49993107ENST00000355504+1282_104-44647Zinc fingerC2H2-type 3
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14109_13110775Zinc fingerC2H2-type 4%3B degenerate
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14137_15910775Zinc fingerC2H2-type 5
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14165_18710775Zinc fingerC2H2-type 6%3B degenerate
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14193_21510775Zinc fingerC2H2-type 7%3B degenerate
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14221_24310775Zinc fingerC2H2-type 8%3B degenerate
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14249_27110775Zinc fingerC2H2-type 9
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+1426_4810775Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14277_29910775Zinc fingerC2H2-type 10
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14305_32710775Zinc fingerC2H2-type 11
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14333_35510775Zinc fingerC2H2-type 12
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14361_38310775Zinc fingerC2H2-type 13
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14389_41110775Zinc fingerC2H2-type 14
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14417_43910775Zinc fingerC2H2-type 15
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14445_46710775Zinc fingerC2H2-type 16
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14473_49510775Zinc fingerC2H2-type 17
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14501_52310775Zinc fingerC2H2-type 18
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14529_55110775Zinc fingerC2H2-type 19
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+1454_7610775Zinc fingerC2H2-type 2
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14557_57910775Zinc fingerC2H2-type 20
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14585_60710775Zinc fingerC2H2-type 21
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+14613_63510775Zinc fingerC2H2-type 22
HgeneZNF493chr19:21580069chr19:49993107ENST00000392288+1482_10410775Zinc fingerC2H2-type 3


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FusionGeneSequence for ZNF493_RPL13A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZNF493_ENST00000596302_chr19_21580069_+_RPL13A_ENST00000391857_chr19_49993107_+_209aa
MPGPPESLDMVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTNPSRGPYHFRAPSRIFWRTVR
GMLPHKTKRGQAALDRLKVFDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKIHYRKKKQLM

>In-frame_ZNF493_ENST00000392288_chr19_21580069_+_RPL13A_ENST00000391857_chr19_49993107_+_209aa
MPGPPESLDMVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTNPSRGPYHFRAPSRIFWRTVR
GMLPHKTKRGQAALDRLKVFDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKIHYRKKKQLM

>In-frame_ZNF493_ENST00000594390_chr19_21580069_+_RPL13A_ENST00000391857_chr19_49993107_+_209aa
MPGPPESLDMVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTNPSRGPYHFRAPSRIFWRTVR
GMLPHKTKRGQAALDRLKVFDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKIHYRKKKQLM

>In-frame_ZNF493_ENST00000339914_chr19_21580069_+_RPL13A_ENST00000391857_chr19_49993107_+_209aa
MPGPPESLDMVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTNPSRGPYHFRAPSRIFWRTVR
GMLPHKTKRGQAALDRLKVFDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKIHYRKKKQLM


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZNF493_ENST00000596302_chr19_21580069_+_RPL13A_ENST00000391857_chr19_49993107_+_627nt
ATGCCAGGACCCCCTGAAAGCCTAGACATGGTCCTGGTGCTTGATGGTCGAGGCCATCTCCTGGGCCGCCTGGCGGCCATCGTGGCTAAA
CAGGTACTGCTGGGCCGGAAGGTGGTGGTCGTACGCTGTGAAGGCATCAACATTTCTGGCAATTTCTACAGAAACAAGTTGAAGTACCTG
GCTTTCCTCCGCAAGCGGATGAACACCAACCCTTCCCGAGGCCCCTACCACTTCCGGGCCCCCAGCCGCATCTTCTGGCGGACCGTGCGA
GGTATGCTGCCCCACAAAACCAAGCGAGGCCAGGCCGCTCTGGACCGTCTCAAGGTGTTTGACGGCATCCCACCGCCCTACGACAAGAAA
AAGCGGATGGTGGTTCCTGCTGCCCTCAAGGTCGTGCGTCTGAAGCCTACAAGAAAGTTTGCCTATCTGGGGCGCCTGGCTCACGAGGTT
GGCTGGAAGTACCAGGCAGTGACAGCCACCCTGGAGGAGAAGAGGAAAGAGAAAGCCAAGATCCACTACCGGAAGAAGAAACAGCTCATG

>In-frame_ZNF493_ENST00000392288_chr19_21580069_+_RPL13A_ENST00000391857_chr19_49993107_+_627nt
ATGCCAGGACCCCCTGAAAGCCTAGACATGGTCCTGGTGCTTGATGGTCGAGGCCATCTCCTGGGCCGCCTGGCGGCCATCGTGGCTAAA
CAGGTACTGCTGGGCCGGAAGGTGGTGGTCGTACGCTGTGAAGGCATCAACATTTCTGGCAATTTCTACAGAAACAAGTTGAAGTACCTG
GCTTTCCTCCGCAAGCGGATGAACACCAACCCTTCCCGAGGCCCCTACCACTTCCGGGCCCCCAGCCGCATCTTCTGGCGGACCGTGCGA
GGTATGCTGCCCCACAAAACCAAGCGAGGCCAGGCCGCTCTGGACCGTCTCAAGGTGTTTGACGGCATCCCACCGCCCTACGACAAGAAA
AAGCGGATGGTGGTTCCTGCTGCCCTCAAGGTCGTGCGTCTGAAGCCTACAAGAAAGTTTGCCTATCTGGGGCGCCTGGCTCACGAGGTT
GGCTGGAAGTACCAGGCAGTGACAGCCACCCTGGAGGAGAAGAGGAAAGAGAAAGCCAAGATCCACTACCGGAAGAAGAAACAGCTCATG

>In-frame_ZNF493_ENST00000594390_chr19_21580069_+_RPL13A_ENST00000391857_chr19_49993107_+_627nt
ATGCCAGGACCCCCTGAAAGCCTAGACATGGTCCTGGTGCTTGATGGTCGAGGCCATCTCCTGGGCCGCCTGGCGGCCATCGTGGCTAAA
CAGGTACTGCTGGGCCGGAAGGTGGTGGTCGTACGCTGTGAAGGCATCAACATTTCTGGCAATTTCTACAGAAACAAGTTGAAGTACCTG
GCTTTCCTCCGCAAGCGGATGAACACCAACCCTTCCCGAGGCCCCTACCACTTCCGGGCCCCCAGCCGCATCTTCTGGCGGACCGTGCGA
GGTATGCTGCCCCACAAAACCAAGCGAGGCCAGGCCGCTCTGGACCGTCTCAAGGTGTTTGACGGCATCCCACCGCCCTACGACAAGAAA
AAGCGGATGGTGGTTCCTGCTGCCCTCAAGGTCGTGCGTCTGAAGCCTACAAGAAAGTTTGCCTATCTGGGGCGCCTGGCTCACGAGGTT
GGCTGGAAGTACCAGGCAGTGACAGCCACCCTGGAGGAGAAGAGGAAAGAGAAAGCCAAGATCCACTACCGGAAGAAGAAACAGCTCATG

>In-frame_ZNF493_ENST00000339914_chr19_21580069_+_RPL13A_ENST00000391857_chr19_49993107_+_627nt
ATGCCAGGACCCCCTGAAAGCCTAGACATGGTCCTGGTGCTTGATGGTCGAGGCCATCTCCTGGGCCGCCTGGCGGCCATCGTGGCTAAA
CAGGTACTGCTGGGCCGGAAGGTGGTGGTCGTACGCTGTGAAGGCATCAACATTTCTGGCAATTTCTACAGAAACAAGTTGAAGTACCTG
GCTTTCCTCCGCAAGCGGATGAACACCAACCCTTCCCGAGGCCCCTACCACTTCCGGGCCCCCAGCCGCATCTTCTGGCGGACCGTGCGA
GGTATGCTGCCCCACAAAACCAAGCGAGGCCAGGCCGCTCTGGACCGTCTCAAGGTGTTTGACGGCATCCCACCGCCCTACGACAAGAAA
AAGCGGATGGTGGTTCCTGCTGCCCTCAAGGTCGTGCGTCTGAAGCCTACAAGAAAGTTTGCCTATCTGGGGCGCCTGGCTCACGAGGTT
GGCTGGAAGTACCAGGCAGTGACAGCCACCCTGGAGGAGAAGAGGAAAGAGAAAGCCAAGATCCACTACCGGAAGAAGAAACAGCTCATG


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNF493_ENST00000596302_chr19_21580069_+_RPL13A_ENST00000391857_chr19_49993107_+_1239nt
GATGTGGCTGGGCCATTGTTTCTCTCTGCTGCCGGAGCTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGAC
CTGAAGATACTGGGAAATCCATAGCTAAGATGCCAGGACCCCCTGAAAGCCTAGACATGGTCCTGGTGCTTGATGGTCGAGGCCATCTCC
TGGGCCGCCTGGCGGCCATCGTGGCTAAACAGGTACTGCTGGGCCGGAAGGTGGTGGTCGTACGCTGTGAAGGCATCAACATTTCTGGCA
ATTTCTACAGAAACAAGTTGAAGTACCTGGCTTTCCTCCGCAAGCGGATGAACACCAACCCTTCCCGAGGCCCCTACCACTTCCGGGCCC
CCAGCCGCATCTTCTGGCGGACCGTGCGAGGTATGCTGCCCCACAAAACCAAGCGAGGCCAGGCCGCTCTGGACCGTCTCAAGGTGTTTG
ACGGCATCCCACCGCCCTACGACAAGAAAAAGCGGATGGTGGTTCCTGCTGCCCTCAAGGTCGTGCGTCTGAAGCCTACAAGAAAGTTTG
CCTATCTGGGGCGCCTGGCTCACGAGGTTGGCTGGAAGTACCAGGCAGTGACAGCCACCCTGGAGGAGAAGAGGAAAGAGAAAGCCAAGA
TCCACTACCGGAAGAAGAAACAGCTCATGAGGCTACGGAAACAGGCCGAGAAGAACGTGGAGAAGAAAATTGACAAATACACAGAGGTCC
TCAAGACCCACGGACTCCTGGTCTGAGCCCAATAAAGACTGTTAATTCCTCATGCGTTGCCTGCCCTTCCTCCATTGTTGCCCTGGAATG
TACGGGACCCAGGGGCAGCAGCAGTCCAGGTGCCACAGGCAGCCCTGGGACATAGGAAGCTGGGAGCAAGGAAAGGGTCTTAGTCACTGC
CTCCCGAAGTTGCTTGAAAGCACTCGGAGAATTGTGCAGGTGTCATTTATCTATGACCAATAGGAAGAGCAACCAGTTACTATGAGTGAA
AGGGAGCCAGAAGACTGATTGGAGGGCCCTATCTTGTGAGTGGGGCATCTGTTGGACTTTCCACCTGGTCATATACTCTGCAGCTGTTAG
AATGTGCAAGCACTTGGGGACAGCATGAGCTTGCTGTTGTACACAGGGTATTTCTAGAAGCAGAAATAGACTGGGAAGATGCACAACCAA

>In-frame_ZNF493_ENST00000392288_chr19_21580069_+_RPL13A_ENST00000391857_chr19_49993107_+_1229nt
GGCCATTGTTTCTCTCTGCTGCCGGAGCTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGACCTGAAGATAC
TGGGAAATCCATAGCTAAGATGCCAGGACCCCCTGAAAGCCTAGACATGGTCCTGGTGCTTGATGGTCGAGGCCATCTCCTGGGCCGCCT
GGCGGCCATCGTGGCTAAACAGGTACTGCTGGGCCGGAAGGTGGTGGTCGTACGCTGTGAAGGCATCAACATTTCTGGCAATTTCTACAG
AAACAAGTTGAAGTACCTGGCTTTCCTCCGCAAGCGGATGAACACCAACCCTTCCCGAGGCCCCTACCACTTCCGGGCCCCCAGCCGCAT
CTTCTGGCGGACCGTGCGAGGTATGCTGCCCCACAAAACCAAGCGAGGCCAGGCCGCTCTGGACCGTCTCAAGGTGTTTGACGGCATCCC
ACCGCCCTACGACAAGAAAAAGCGGATGGTGGTTCCTGCTGCCCTCAAGGTCGTGCGTCTGAAGCCTACAAGAAAGTTTGCCTATCTGGG
GCGCCTGGCTCACGAGGTTGGCTGGAAGTACCAGGCAGTGACAGCCACCCTGGAGGAGAAGAGGAAAGAGAAAGCCAAGATCCACTACCG
GAAGAAGAAACAGCTCATGAGGCTACGGAAACAGGCCGAGAAGAACGTGGAGAAGAAAATTGACAAATACACAGAGGTCCTCAAGACCCA
CGGACTCCTGGTCTGAGCCCAATAAAGACTGTTAATTCCTCATGCGTTGCCTGCCCTTCCTCCATTGTTGCCCTGGAATGTACGGGACCC
AGGGGCAGCAGCAGTCCAGGTGCCACAGGCAGCCCTGGGACATAGGAAGCTGGGAGCAAGGAAAGGGTCTTAGTCACTGCCTCCCGAAGT
TGCTTGAAAGCACTCGGAGAATTGTGCAGGTGTCATTTATCTATGACCAATAGGAAGAGCAACCAGTTACTATGAGTGAAAGGGAGCCAG
AAGACTGATTGGAGGGCCCTATCTTGTGAGTGGGGCATCTGTTGGACTTTCCACCTGGTCATATACTCTGCAGCTGTTAGAATGTGCAAG
CACTTGGGGACAGCATGAGCTTGCTGTTGTACACAGGGTATTTCTAGAAGCAGAAATAGACTGGGAAGATGCACAACCAAGGGGTTACAG

>In-frame_ZNF493_ENST00000594390_chr19_21580069_+_RPL13A_ENST00000391857_chr19_49993107_+_1225nt
ATTGTTTCTCTCTGCTGCCGGAGCTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGACCTGAAGATACTGGG
AAATCCATAGCTAAGATGCCAGGACCCCCTGAAAGCCTAGACATGGTCCTGGTGCTTGATGGTCGAGGCCATCTCCTGGGCCGCCTGGCG
GCCATCGTGGCTAAACAGGTACTGCTGGGCCGGAAGGTGGTGGTCGTACGCTGTGAAGGCATCAACATTTCTGGCAATTTCTACAGAAAC
AAGTTGAAGTACCTGGCTTTCCTCCGCAAGCGGATGAACACCAACCCTTCCCGAGGCCCCTACCACTTCCGGGCCCCCAGCCGCATCTTC
TGGCGGACCGTGCGAGGTATGCTGCCCCACAAAACCAAGCGAGGCCAGGCCGCTCTGGACCGTCTCAAGGTGTTTGACGGCATCCCACCG
CCCTACGACAAGAAAAAGCGGATGGTGGTTCCTGCTGCCCTCAAGGTCGTGCGTCTGAAGCCTACAAGAAAGTTTGCCTATCTGGGGCGC
CTGGCTCACGAGGTTGGCTGGAAGTACCAGGCAGTGACAGCCACCCTGGAGGAGAAGAGGAAAGAGAAAGCCAAGATCCACTACCGGAAG
AAGAAACAGCTCATGAGGCTACGGAAACAGGCCGAGAAGAACGTGGAGAAGAAAATTGACAAATACACAGAGGTCCTCAAGACCCACGGA
CTCCTGGTCTGAGCCCAATAAAGACTGTTAATTCCTCATGCGTTGCCTGCCCTTCCTCCATTGTTGCCCTGGAATGTACGGGACCCAGGG
GCAGCAGCAGTCCAGGTGCCACAGGCAGCCCTGGGACATAGGAAGCTGGGAGCAAGGAAAGGGTCTTAGTCACTGCCTCCCGAAGTTGCT
TGAAAGCACTCGGAGAATTGTGCAGGTGTCATTTATCTATGACCAATAGGAAGAGCAACCAGTTACTATGAGTGAAAGGGAGCCAGAAGA
CTGATTGGAGGGCCCTATCTTGTGAGTGGGGCATCTGTTGGACTTTCCACCTGGTCATATACTCTGCAGCTGTTAGAATGTGCAAGCACT
TGGGGACAGCATGAGCTTGCTGTTGTACACAGGGTATTTCTAGAAGCAGAAATAGACTGGGAAGATGCACAACCAAGGGGTTACAGGCAT

>In-frame_ZNF493_ENST00000339914_chr19_21580069_+_RPL13A_ENST00000391857_chr19_49993107_+_1202nt
CTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGACCTGAAGATACTGGGAAATCCATAGCTAAGATGCCAGG
ACCCCCTGAAAGCCTAGACATGGTCCTGGTGCTTGATGGTCGAGGCCATCTCCTGGGCCGCCTGGCGGCCATCGTGGCTAAACAGGTACT
GCTGGGCCGGAAGGTGGTGGTCGTACGCTGTGAAGGCATCAACATTTCTGGCAATTTCTACAGAAACAAGTTGAAGTACCTGGCTTTCCT
CCGCAAGCGGATGAACACCAACCCTTCCCGAGGCCCCTACCACTTCCGGGCCCCCAGCCGCATCTTCTGGCGGACCGTGCGAGGTATGCT
GCCCCACAAAACCAAGCGAGGCCAGGCCGCTCTGGACCGTCTCAAGGTGTTTGACGGCATCCCACCGCCCTACGACAAGAAAAAGCGGAT
GGTGGTTCCTGCTGCCCTCAAGGTCGTGCGTCTGAAGCCTACAAGAAAGTTTGCCTATCTGGGGCGCCTGGCTCACGAGGTTGGCTGGAA
GTACCAGGCAGTGACAGCCACCCTGGAGGAGAAGAGGAAAGAGAAAGCCAAGATCCACTACCGGAAGAAGAAACAGCTCATGAGGCTACG
GAAACAGGCCGAGAAGAACGTGGAGAAGAAAATTGACAAATACACAGAGGTCCTCAAGACCCACGGACTCCTGGTCTGAGCCCAATAAAG
ACTGTTAATTCCTCATGCGTTGCCTGCCCTTCCTCCATTGTTGCCCTGGAATGTACGGGACCCAGGGGCAGCAGCAGTCCAGGTGCCACA
GGCAGCCCTGGGACATAGGAAGCTGGGAGCAAGGAAAGGGTCTTAGTCACTGCCTCCCGAAGTTGCTTGAAAGCACTCGGAGAATTGTGC
AGGTGTCATTTATCTATGACCAATAGGAAGAGCAACCAGTTACTATGAGTGAAAGGGAGCCAGAAGACTGATTGGAGGGCCCTATCTTGT
GAGTGGGGCATCTGTTGGACTTTCCACCTGGTCATATACTCTGCAGCTGTTAGAATGTGCAAGCACTTGGGGACAGCATGAGCTTGCTGT
TGTACACAGGGTATTTCTAGAAGCAGAAATAGACTGGGAAGATGCACAACCAAGGGGTTACAGGCATCGCCCATGCTCCTCACCTGTATT


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FusionGenePPI for ZNF493_RPL13A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF493RPL13AGOLM1, NOP56, CALM1, NFX1, CUL3, CUL5, CUL1, CAND1, ESR1, MAGOH, EIF4A3, FN1, VCAM1, TP63, UBL4A, ITGA4, PAN2, IGSF8, ICAM1, CRP, ALG12, STOM, ALDH2, CYP2E1, FNTA, ND1, RPL30, VTN, ETS1, TARDBP, RPA3, RPA2, RPA1, ZBTB1, CEP250, TUBG1, HUWE1, CCDC8, EED, RNF2, RPL14, RPL8, NIFK, THAP7, ZC3H3, PRR11, NTRK1, EIF6, FBL, PABPC1, PABPC4, POLR1C, RPL10, RPL10A, RPL11, RPL12, HSPA8, RPL13, RPL18, RPL18A, RPL19, RPL21, RPL22, RPL23, RPL23A, RPL24, RPL27, RPL3, RPL31, RPL34, RPL35, RPL36, RPL38, RPL7, RPLP0, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS19, RPS2, RPS20, RPS23, RPS25, RPS3, RPS3A, RPS5, RPS8, RPS9, RPSA, SEC61A1, RPL15, RPL17, RPL27A, RPL32, RPL35A, RPL37A, RPL4, RPL5, RPL6, RPL7A, RPL9, RPLP2, RPS14, RPS18, LOC101929876, RPS26, RPS27, RPS4X, RPS6, RPS7, PTEN, HNRNPU, NPM1, MCM2, NF2, ZNF746, RRS1, CNBP, SART3, RBM34, KIAA0020, NCL, CYLD, PDHA1, FOXA1, TRIM25, YAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF493_RPL13A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF493_RPL13A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource