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Fusion gene ID: 43364 |
FusionGeneSummary for ZNF492_FCHO1 |
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Fusion gene information | Fusion gene name: ZNF492_FCHO1 | Fusion gene ID: 43364 | Hgene | Tgene | Gene symbol | ZNF492 | FCHO1 | Gene ID | 57615 | 23149 |
Gene name | zinc finger protein 492 | FCH domain only 1 | |
Synonyms | ZNF115 | - | |
Cytomap | 19p12 | 19p13.11 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 492zinc finger protein 115 (Y20) | F-BAR domain only protein 1FCH domain only protein 1 | |
Modification date | 20180403 | 20180523 | |
UniProtAcc | Q9P255 | O14526 | |
Ensembl transtripts involved in fusion gene | ENST00000456783, | ENST00000594202, ENST00000389133, ENST00000252771, ENST00000600676, ENST00000599236, ENST00000596536, ENST00000595033, ENST00000539407, ENST00000596951, ENST00000597512, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 2 X 2=8 |
# samples | 2 | 2 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: ZNF492 [Title/Abstract] AND FCHO1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-B6-A0RL-01A | ZNF492 | chr19 | 22817223 | + | FCHO1 | chr19 | 17897383 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000456783 | ENST00000594202 | ZNF492 | chr19 | 22817223 | + | FCHO1 | chr19 | 17897383 | + |
5UTR-3CDS | ENST00000456783 | ENST00000389133 | ZNF492 | chr19 | 22817223 | + | FCHO1 | chr19 | 17897383 | + |
5UTR-3CDS | ENST00000456783 | ENST00000252771 | ZNF492 | chr19 | 22817223 | + | FCHO1 | chr19 | 17897383 | + |
5UTR-3CDS | ENST00000456783 | ENST00000600676 | ZNF492 | chr19 | 22817223 | + | FCHO1 | chr19 | 17897383 | + |
5UTR-intron | ENST00000456783 | ENST00000599236 | ZNF492 | chr19 | 22817223 | + | FCHO1 | chr19 | 17897383 | + |
5UTR-intron | ENST00000456783 | ENST00000596536 | ZNF492 | chr19 | 22817223 | + | FCHO1 | chr19 | 17897383 | + |
5UTR-intron | ENST00000456783 | ENST00000595033 | ZNF492 | chr19 | 22817223 | + | FCHO1 | chr19 | 17897383 | + |
5UTR-intron | ENST00000456783 | ENST00000539407 | ZNF492 | chr19 | 22817223 | + | FCHO1 | chr19 | 17897383 | + |
5UTR-intron | ENST00000456783 | ENST00000596951 | ZNF492 | chr19 | 22817223 | + | FCHO1 | chr19 | 17897383 | + |
5UTR-intron | ENST00000456783 | ENST00000597512 | ZNF492 | chr19 | 22817223 | + | FCHO1 | chr19 | 17897383 | + |
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FusionProtFeatures for ZNF492_FCHO1 |
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Hgene | Tgene |
ZNF492 | FCHO1 |
May be involved in transcriptional regulation. | Functions in an early step of clathrin-mediatedendocytosis. Has both a membrane binding/bending activity and theability to recruit proteins essential to the formation offunctional clathrin-coated pits. May regulate Bmp signaling byregulating clathrin-mediated endocytosis of Bmp receptors.{ECO:0000269|PubMed:20448150}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF492_FCHO1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF492_FCHO1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF492 | FCHO1 | ZBTB16, CUL5, APP, PTK6, LGALS14, EXOSC5, FNBP1, SRPK2, EPS15, FCHO2, PCGF1, EPS15L1, AP2A1, AP2A2, SRR, AP1B1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF492_FCHO1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF492_FCHO1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |