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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43364

FusionGeneSummary for ZNF492_FCHO1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF492_FCHO1
Fusion gene ID: 43364
HgeneTgene
Gene symbol

ZNF492

FCHO1

Gene ID

57615

23149

Gene namezinc finger protein 492FCH domain only 1
SynonymsZNF115-
Cytomap

19p12

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 492zinc finger protein 115 (Y20)F-BAR domain only protein 1FCH domain only protein 1
Modification date2018040320180523
UniProtAcc

Q9P255

O14526

Ensembl transtripts involved in fusion geneENST00000456783, ENST00000594202, 
ENST00000389133, ENST00000252771, 
ENST00000600676, ENST00000599236, 
ENST00000596536, ENST00000595033, 
ENST00000539407, ENST00000596951, 
ENST00000597512, 
Fusion gene scores* DoF score2 X 2 X 1=42 X 2 X 2=8
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: ZNF492 [Title/Abstract] AND FCHO1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-B6-A0RL-01AZNF492chr19

22817223

+FCHO1chr19

17897383

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000456783ENST00000594202ZNF492chr19

22817223

+FCHO1chr19

17897383

+
5UTR-3CDSENST00000456783ENST00000389133ZNF492chr19

22817223

+FCHO1chr19

17897383

+
5UTR-3CDSENST00000456783ENST00000252771ZNF492chr19

22817223

+FCHO1chr19

17897383

+
5UTR-3CDSENST00000456783ENST00000600676ZNF492chr19

22817223

+FCHO1chr19

17897383

+
5UTR-intronENST00000456783ENST00000599236ZNF492chr19

22817223

+FCHO1chr19

17897383

+
5UTR-intronENST00000456783ENST00000596536ZNF492chr19

22817223

+FCHO1chr19

17897383

+
5UTR-intronENST00000456783ENST00000595033ZNF492chr19

22817223

+FCHO1chr19

17897383

+
5UTR-intronENST00000456783ENST00000539407ZNF492chr19

22817223

+FCHO1chr19

17897383

+
5UTR-intronENST00000456783ENST00000596951ZNF492chr19

22817223

+FCHO1chr19

17897383

+
5UTR-intronENST00000456783ENST00000597512ZNF492chr19

22817223

+FCHO1chr19

17897383

+

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FusionProtFeatures for ZNF492_FCHO1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF492

Q9P255

FCHO1

O14526

May be involved in transcriptional regulation. Functions in an early step of clathrin-mediatedendocytosis. Has both a membrane binding/bending activity and theability to recruit proteins essential to the formation offunctional clathrin-coated pits. May regulate Bmp signaling byregulating clathrin-mediated endocytosis of Bmp receptors.{ECO:0000269|PubMed:20448150}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF492_FCHO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF492_FCHO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF492FCHO1ZBTB16, CUL5, APP, PTK6, LGALS14, EXOSC5, FNBP1, SRPK2, EPS15, FCHO2, PCGF1, EPS15L1, AP2A1, AP2A2, SRR, AP1B1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF492_FCHO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF492_FCHO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource