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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43344

FusionGeneSummary for ZNF461_MATN2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF461_MATN2
Fusion gene ID: 43344
HgeneTgene
Gene symbol

ZNF461

MATN2

Gene ID

92283

4147

Gene namezinc finger protein 461matrilin 2
SynonymsGIOT-1|GIOT1|HZF28-
Cytomap

19q13.12

8q22.1-q22.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 461gonadotropin-inducible ovary transcription repressor 1zinc finger protein 28matrilin-2testis tissue sperm-binding protein Li 94mP
Modification date2018052220180523
UniProtAcc

Q8TAF7

O00339

Ensembl transtripts involved in fusion geneENST00000588268, ENST00000360357, 
ENST00000540605, 		ENST00000521689, 
ENST00000254898, ENST00000524308, 
ENST00000522025, ENST00000520016, 
ENST00000518238, 
Fusion gene scores* DoF score3 X 2 X 3=189 X 8 X 8=576
# samples 310
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/576*10)=-2.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF461 [Title/Abstract] AND MATN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AC-A5XU-01AZNF461chr19

37155600

-MATN2chr8

98900303

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000588268ENST00000521689ZNF461chr19

37155600

-MATN2chr8

98900303

+
5CDS-5UTRENST00000588268ENST00000254898ZNF461chr19

37155600

-MATN2chr8

98900303

+
5CDS-5UTRENST00000588268ENST00000524308ZNF461chr19

37155600

-MATN2chr8

98900303

+
5CDS-intronENST00000588268ENST00000522025ZNF461chr19

37155600

-MATN2chr8

98900303

+
5CDS-5UTRENST00000588268ENST00000520016ZNF461chr19

37155600

-MATN2chr8

98900303

+
5CDS-intronENST00000588268ENST00000518238ZNF461chr19

37155600

-MATN2chr8

98900303

+
5CDS-5UTRENST00000360357ENST00000521689ZNF461chr19

37155600

-MATN2chr8

98900303

+
5CDS-5UTRENST00000360357ENST00000254898ZNF461chr19

37155600

-MATN2chr8

98900303

+
5CDS-5UTRENST00000360357ENST00000524308ZNF461chr19

37155600

-MATN2chr8

98900303

+
5CDS-intronENST00000360357ENST00000522025ZNF461chr19

37155600

-MATN2chr8

98900303

+
5CDS-5UTRENST00000360357ENST00000520016ZNF461chr19

37155600

-MATN2chr8

98900303

+
5CDS-intronENST00000360357ENST00000518238ZNF461chr19

37155600

-MATN2chr8

98900303

+
intron-5UTRENST00000540605ENST00000521689ZNF461chr19

37155600

-MATN2chr8

98900303

+
intron-5UTRENST00000540605ENST00000254898ZNF461chr19

37155600

-MATN2chr8

98900303

+
intron-5UTRENST00000540605ENST00000524308ZNF461chr19

37155600

-MATN2chr8

98900303

+
intron-intronENST00000540605ENST00000522025ZNF461chr19

37155600

-MATN2chr8

98900303

+
intron-5UTRENST00000540605ENST00000520016ZNF461chr19

37155600

-MATN2chr8

98900303

+
intron-intronENST00000540605ENST00000518238ZNF461chr19

37155600

-MATN2chr8

98900303

+

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FusionProtFeatures for ZNF461_MATN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF461

Q8TAF7

MATN2

O00339

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF461_MATN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF461_MATN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF461SF1, HDAC2, KRTAP10-3MATN2MATN2, FBN2, COL1A1, MATN1, MATN4, ATXN7, CACNA1A, ATXN1, ATXN1L, CBFA2T3, DVL3, KRAS, NELL2, NELL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF461_MATN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF461_MATN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource