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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43336

FusionGeneSummary for ZNF451_ZNF451

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF451_ZNF451
Fusion gene ID: 43336
HgeneTgene
Gene symbol

ZNF451

ZNF451

Gene ID

26036

26036

Gene namezinc finger protein 451zinc finger protein 451
SynonymsCOASTER|dJ417I1.1COASTER|dJ417I1.1
Cytomap

6p12.1

6p12.1

Type of geneprotein-codingprotein-coding
DescriptionE3 SUMO-protein ligase ZNF451E3 SUMO-protein transferase ZNF451coactivator for steroid receptorsE3 SUMO-protein ligase ZNF451E3 SUMO-protein transferase ZNF451coactivator for steroid receptors
Modification date2018052320180523
UniProtAcc

Q9Y4E5

Q9Y4E5

Ensembl transtripts involved in fusion geneENST00000370706, ENST00000357489, 
ENST00000491832, ENST00000370708, 
ENST00000370702, ENST00000370710, 
ENST00000510989, 		ENST00000370706, 
ENST00000357489, ENST00000491832, 
ENST00000370708, ENST00000370702, 
ENST00000370710, ENST00000510989, 
Fusion gene scores* DoF score3 X 4 X 2=245 X 5 X 4=100
# samples 35
** MAII scorelog2(3/24*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF451 [Title/Abstract] AND ZNF451 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF451

GO:0016925

protein sumoylation

26524494

TgeneZNF451

GO:0016925

protein sumoylation

26524494


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA489269ZNF451chr6

56972998

-ZNF451chr6

56973019

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000370706ENST00000370706ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000370706ENST00000357489ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000370706ENST00000491832ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-3UTRENST00000370706ENST00000370708ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000370706ENST00000370702ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000370706ENST00000370710ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000370706ENST00000510989ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000357489ENST00000370706ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000357489ENST00000357489ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000357489ENST00000491832ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-3UTRENST00000357489ENST00000370708ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000357489ENST00000370702ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000357489ENST00000370710ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000357489ENST00000510989ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000491832ENST00000370706ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000491832ENST00000357489ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000491832ENST00000491832ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-3UTRENST00000491832ENST00000370708ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000491832ENST00000370702ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000491832ENST00000370710ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000491832ENST00000510989ZNF451chr6

56972998

-ZNF451chr6

56973019

+
3UTR-intronENST00000370708ENST00000370706ZNF451chr6

56972998

-ZNF451chr6

56973019

+
3UTR-intronENST00000370708ENST00000357489ZNF451chr6

56972998

-ZNF451chr6

56973019

+
3UTR-intronENST00000370708ENST00000491832ZNF451chr6

56972998

-ZNF451chr6

56973019

+
3UTR-3UTRENST00000370708ENST00000370708ZNF451chr6

56972998

-ZNF451chr6

56973019

+
3UTR-intronENST00000370708ENST00000370702ZNF451chr6

56972998

-ZNF451chr6

56973019

+
3UTR-intronENST00000370708ENST00000370710ZNF451chr6

56972998

-ZNF451chr6

56973019

+
3UTR-intronENST00000370708ENST00000510989ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000370702ENST00000370706ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000370702ENST00000357489ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000370702ENST00000491832ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-3UTRENST00000370702ENST00000370708ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000370702ENST00000370702ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000370702ENST00000370710ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000370702ENST00000510989ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000370710ENST00000370706ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000370710ENST00000357489ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000370710ENST00000491832ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-3UTRENST00000370710ENST00000370708ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000370710ENST00000370702ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000370710ENST00000370710ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000370710ENST00000510989ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000510989ENST00000370706ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000510989ENST00000357489ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000510989ENST00000491832ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-3UTRENST00000510989ENST00000370708ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000510989ENST00000370702ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000510989ENST00000370710ZNF451chr6

56972998

-ZNF451chr6

56973019

+
intron-intronENST00000510989ENST00000510989ZNF451chr6

56972998

-ZNF451chr6

56973019

+

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FusionProtFeatures for ZNF451_ZNF451


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF451

Q9Y4E5

ZNF451

Q9Y4E5

E3 SUMO-protein ligase; has a preference for SUMO2 andSUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of targetproteins (PubMed:26524493, PubMed:26524494). Plays a role inprotein SUMO2 modification in response to stress caused by DNAdamage and by proteasome inhibitors (in vitro). Required for MCM4sumoylation (By similarity). Has no activity with SUMO1(PubMed:26524493). Preferentially transfers an additional SUMO2chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493).Negatively regulates transcriptional activation mediated by theSMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267).Plays a role in regulating the transcription of AR targets(PubMed:18656483). {ECO:0000250|UniProtKB:Q8C0P7,ECO:0000269|PubMed:18656483, ECO:0000269|PubMed:24324267,ECO:0000269|PubMed:26524493, ECO:0000269|PubMed:26524494}. E3 SUMO-protein ligase; has a preference for SUMO2 andSUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of targetproteins (PubMed:26524493, PubMed:26524494). Plays a role inprotein SUMO2 modification in response to stress caused by DNAdamage and by proteasome inhibitors (in vitro). Required for MCM4sumoylation (By similarity). Has no activity with SUMO1(PubMed:26524493). Preferentially transfers an additional SUMO2chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493).Negatively regulates transcriptional activation mediated by theSMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267).Plays a role in regulating the transcription of AR targets(PubMed:18656483). {ECO:0000250|UniProtKB:Q8C0P7,ECO:0000269|PubMed:18656483, ECO:0000269|PubMed:24324267,ECO:0000269|PubMed:26524493, ECO:0000269|PubMed:26524494}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF451_ZNF451


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF451_ZNF451


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF451_ZNF451


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF451_ZNF451


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource