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Fusion gene ID: 43335 |
FusionGeneSummary for ZNF451_NADSYN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF451_NADSYN1 | Fusion gene ID: 43335 | Hgene | Tgene | Gene symbol | ZNF451 | NADSYN1 | Gene ID | 26036 | 55191 |
| Gene name | zinc finger protein 451 | NAD synthetase 1 | |
| Synonyms | COASTER|dJ417I1.1 | - | |
| Cytomap | 6p12.1 | 11q13.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 SUMO-protein ligase ZNF451E3 SUMO-protein transferase ZNF451coactivator for steroid receptors | glutamine-dependent NAD(+) synthetaseNAD(+) synthaseNAD(+) synthetaseglutamine-dependent NAD synthetase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y4E5 | Q6IA69 | |
| Ensembl transtripts involved in fusion gene | ENST00000370706, ENST00000357489, ENST00000491832, ENST00000370708, ENST00000370702, ENST00000370710, ENST00000510989, | ENST00000319023, ENST00000539574, ENST00000530055, ENST00000526039, | |
| Fusion gene scores | * DoF score | 3 X 4 X 2=24 | 9 X 9 X 5=405 |
| # samples | 3 | 11 | |
| ** MAII score | log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/405*10)=-1.88041838424733 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZNF451 [Title/Abstract] AND NADSYN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZNF451 | GO:0016925 | protein sumoylation | 26524494 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A0A4-01A | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| TCGA | LD | BRCA | TCGA-A8-A0A4-01A | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000370706 | ENST00000319023 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000370706 | ENST00000539574 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000370706 | ENST00000530055 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000370706 | ENST00000526039 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| Frame-shift | ENST00000357489 | ENST00000319023 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000357489 | ENST00000539574 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000357489 | ENST00000530055 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000357489 | ENST00000526039 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| Frame-shift | ENST00000491832 | ENST00000319023 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000491832 | ENST00000539574 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000491832 | ENST00000530055 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000491832 | ENST00000526039 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-3CDS | ENST00000370708 | ENST00000319023 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370708 | ENST00000539574 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370708 | ENST00000530055 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370708 | ENST00000526039 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-3CDS | ENST00000370702 | ENST00000319023 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370702 | ENST00000539574 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370702 | ENST00000530055 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370702 | ENST00000526039 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-3CDS | ENST00000370710 | ENST00000319023 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370710 | ENST00000539574 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370710 | ENST00000530055 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370710 | ENST00000526039 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-3CDS | ENST00000510989 | ENST00000319023 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000510989 | ENST00000539574 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000510989 | ENST00000530055 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000510989 | ENST00000526039 | ZNF451 | chr6 | 56999668 | + | NADSYN1 | chr11 | 71174478 | + |
| Frame-shift | ENST00000370706 | ENST00000319023 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000370706 | ENST00000539574 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000370706 | ENST00000530055 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000370706 | ENST00000526039 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| Frame-shift | ENST00000357489 | ENST00000319023 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000357489 | ENST00000539574 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000357489 | ENST00000530055 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000357489 | ENST00000526039 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| Frame-shift | ENST00000491832 | ENST00000319023 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000491832 | ENST00000539574 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000491832 | ENST00000530055 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| 5CDS-intron | ENST00000491832 | ENST00000526039 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-3CDS | ENST00000370708 | ENST00000319023 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370708 | ENST00000539574 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370708 | ENST00000530055 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370708 | ENST00000526039 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-3CDS | ENST00000370702 | ENST00000319023 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370702 | ENST00000539574 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370702 | ENST00000530055 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370702 | ENST00000526039 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-3CDS | ENST00000370710 | ENST00000319023 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370710 | ENST00000539574 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370710 | ENST00000530055 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000370710 | ENST00000526039 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-3CDS | ENST00000510989 | ENST00000319023 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000510989 | ENST00000539574 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000510989 | ENST00000530055 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
| intron-intron | ENST00000510989 | ENST00000526039 | ZNF451 | chr6 | 56993638 | + | NADSYN1 | chr11 | 71174478 | + |
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FusionProtFeatures for ZNF451_NADSYN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF451 | NADSYN1 |
| E3 SUMO-protein ligase; has a preference for SUMO2 andSUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of targetproteins (PubMed:26524493, PubMed:26524494). Plays a role inprotein SUMO2 modification in response to stress caused by DNAdamage and by proteasome inhibitors (in vitro). Required for MCM4sumoylation (By similarity). Has no activity with SUMO1(PubMed:26524493). Preferentially transfers an additional SUMO2chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493).Negatively regulates transcriptional activation mediated by theSMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267).Plays a role in regulating the transcription of AR targets(PubMed:18656483). {ECO:0000250|UniProtKB:Q8C0P7,ECO:0000269|PubMed:18656483, ECO:0000269|PubMed:24324267,ECO:0000269|PubMed:26524493, ECO:0000269|PubMed:26524494}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF451_NADSYN1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF451_NADSYN1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZNF451 | CALCOCO2, RAP1GDS1, FXR2, UBE2I, RNF40, CREB1, PCBD1, LZTR1, CDC5L, AR, HTT, PRPF40A, MPP5, CPTP, KDM1A, JMJD6, PRMT1, PRMT8, SUV39H1, ZNF451, UBC, SUMO1, PIAS1, PIAS2, SUMO2, PIK3R3, FAM118A, CDCA4, BATF3 | NADSYN1 | CUTC, MYO15B, UPF1, AIP, STUB1, EGFR, FKBPL, CSGALNACT2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF451_NADSYN1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | NADSYN1 | Q6IA69 | DB00142 | Glutamic Acid | Glutamine-dependent NAD(+) synthetase | small molecule | approved|nutraceutical |
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RelatedDiseases for ZNF451_NADSYN1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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