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Fusion gene ID: 43329 |
FusionGeneSummary for ZNF440_ECSIT |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF440_ECSIT | Fusion gene ID: 43329 | Hgene | Tgene | Gene symbol | ZNF440 | ECSIT | Gene ID | 126070 | 51295 |
| Gene name | zinc finger protein 440 | ECSIT signalling integrator | |
| Synonyms | - | SITPEC | |
| Cytomap | 19p13.2 | 19p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 440 | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrialECSIT homologlikely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8IYI8 | Q9BQ95 | |
| Ensembl transtripts involved in fusion gene | ENST00000304060, | ENST00000270517, ENST00000588998, ENST00000252440, ENST00000417981, ENST00000591104, ENST00000592312, ENST00000591352, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 3 X 3=36 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZNF440 [Title/Abstract] AND ECSIT [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ECSIT | GO:0051341 | regulation of oxidoreductase activity | 17344420 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UVM | TCGA-VD-AA8M-01A | ZNF440 | chr19 | 11925265 | + | ECSIT | chr19 | 11618863 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000304060 | ENST00000270517 | ZNF440 | chr19 | 11925265 | + | ECSIT | chr19 | 11618863 | - |
| In-frame | ENST00000304060 | ENST00000588998 | ZNF440 | chr19 | 11925265 | + | ECSIT | chr19 | 11618863 | - |
| In-frame | ENST00000304060 | ENST00000252440 | ZNF440 | chr19 | 11925265 | + | ECSIT | chr19 | 11618863 | - |
| In-frame | ENST00000304060 | ENST00000417981 | ZNF440 | chr19 | 11925265 | + | ECSIT | chr19 | 11618863 | - |
| In-frame | ENST00000304060 | ENST00000591104 | ZNF440 | chr19 | 11925265 | + | ECSIT | chr19 | 11618863 | - |
| In-frame | ENST00000304060 | ENST00000592312 | ZNF440 | chr19 | 11925265 | + | ECSIT | chr19 | 11618863 | - |
| 5CDS-5UTR | ENST00000304060 | ENST00000591352 | ZNF440 | chr19 | 11925265 | + | ECSIT | chr19 | 11618863 | - |
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FusionProtFeatures for ZNF440_ECSIT |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF440 | ECSIT |
| May be involved in transcriptional regulation. | Adapter protein of the Toll-like and IL-1 receptorsignaling pathway that is involved in the activation of NF-kappa-Bvia MAP3K1. Promotes proteolytic activation of MAP3K1. Involved inthe BMP signaling pathway. Required for normal embryonicdevelopment (By similarity). {ECO:0000250}. Required for efficient assembly of mitochondrialNADH:ubiquinone oxidoreductase. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ZNF440 | chr19:11925265 | chr19:11618863 | ENST00000304060 | + | 1 | 4 | 4_86 | 1 | 596 | Domain | KRAB |
| Hgene | >ZNF440 | chr19:11925265 | chr19:11618863 | ENST00000304060 | + | 1 | 4 | 144_166 | 1 | 596 | Zinc finger | C2H2-type 1%3B degenerate |
| Hgene | >ZNF440 | chr19:11925265 | chr19:11618863 | ENST00000304060 | + | 1 | 4 | 172_194 | 1 | 596 | Zinc finger | C2H2-type 2 |
| Hgene | >ZNF440 | chr19:11925265 | chr19:11618863 | ENST00000304060 | + | 1 | 4 | 200_222 | 1 | 596 | Zinc finger | C2H2-type 3 |
| Hgene | >ZNF440 | chr19:11925265 | chr19:11618863 | ENST00000304060 | + | 1 | 4 | 228_250 | 1 | 596 | Zinc finger | C2H2-type 4 |
| Hgene | >ZNF440 | chr19:11925265 | chr19:11618863 | ENST00000304060 | + | 1 | 4 | 256_278 | 1 | 596 | Zinc finger | C2H2-type 5%3B degenerate |
| Hgene | >ZNF440 | chr19:11925265 | chr19:11618863 | ENST00000304060 | + | 1 | 4 | 284_306 | 1 | 596 | Zinc finger | C2H2-type 6 |
| Hgene | >ZNF440 | chr19:11925265 | chr19:11618863 | ENST00000304060 | + | 1 | 4 | 312_334 | 1 | 596 | Zinc finger | C2H2-type 7 |
| Hgene | >ZNF440 | chr19:11925265 | chr19:11618863 | ENST00000304060 | + | 1 | 4 | 340_362 | 1 | 596 | Zinc finger | C2H2-type 8 |
| Hgene | >ZNF440 | chr19:11925265 | chr19:11618863 | ENST00000304060 | + | 1 | 4 | 368_390 | 1 | 596 | Zinc finger | C2H2-type 9 |
| Hgene | >ZNF440 | chr19:11925265 | chr19:11618863 | ENST00000304060 | + | 1 | 4 | 396_418 | 1 | 596 | Zinc finger | C2H2-type 10 |
| Hgene | >ZNF440 | chr19:11925265 | chr19:11618863 | ENST00000304060 | + | 1 | 4 | 424_448 | 1 | 596 | Zinc finger | C2H2-type 11 |
| Hgene | >ZNF440 | chr19:11925265 | chr19:11618863 | ENST00000304060 | + | 1 | 4 | 458_480 | 1 | 596 | Zinc finger | C2H2-type 12 |
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FusionGeneSequence for ZNF440_ECSIT |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000270517_chr19_11618863_-_187aa MVPLPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCVYYHILRADLLPPEEREVEETPEEWNLYYPMQLDLE YVRSGWDNYEFDINEVEEGPVFAMCMAGAHDQATMAKWIQGLQETNPTLAQIPVVFRLAGSTRELQTSSAGLEEPPLPEDHQEEDDNLQR >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000588998_chr19_11618863_-_52aa >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000252440_chr19_11618863_-_52aa >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000417981_chr19_11618863_-_187aa MVPLPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCVYYHILRADLLPPEEREVEETPEEWNLYYPMQLDLE YVRSGWDNYEFDINEVEEGPVFAMCMAGAHDQATMAKWIQGLQETNPTLAQIPVVFRLAGSTRELQTSSAGLEEPPLPEDHQEEDDNLQR >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000591104_chr19_11618863_-_52aa >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000592312_chr19_11618863_-_139aa MVPLPKDSTGAADPPQPHIVGKSESMGAAKSLTLPRPCQVLAGPRLGSLGLWAESLAGHRACMSPHQESRVPISRPPWPATIQPGLSLLR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000270517_chr19_11618863_-_561nt ATGGTTCCTTTGCCCAAAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGGAATCCAGAGTCCCGATCAGCAGGCCGCC CTGGCCCGCCACAATCCAGCCCGGCCTGTCTTTGTTGAGGGCCCCTTCTCCCTGTGGCTCCGCAACAAGTGTGTGTATTACCACATCCTC AGAGCTGACTTGCTGCCCCCGGAGGAGAGGGAAGTGGAAGAGACGCCGGAGGAGTGGAACCTCTACTACCCGATGCAGCTGGACCTGGAG TATGTGAGGAGTGGCTGGGACAACTACGAGTTTGACATCAATGAAGTGGAGGAAGGCCCTGTCTTCGCCATGTGCATGGCGGGTGCTCAT GACCAGGCGACGATGGCTAAGTGGATCCAGGGCCTGCAGGAGACCAACCCAACCCTGGCCCAGATCCCCGTGGTCTTCCGCCTCGCCGGG TCCACCCGGGAGCTCCAGACATCCTCTGCAGGGCTGGAGGAGCCGCCCCTGCCCGAGGACCACCAGGAAGAAGACGACAACCTGCAGCGA >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000588998_chr19_11618863_-_156nt ATGGTTCCTTTGCCCAAAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGGAAGTGGAAGAGACGCCGGAGGAGTGGAA >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000252440_chr19_11618863_-_156nt ATGGTTCCTTTGCCCAAAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGGAAGTGGAAGAGACGCCGGAGGAGTGGAA >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000417981_chr19_11618863_-_561nt ATGGTTCCTTTGCCCAAAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGGAATCCAGAGTCCCGATCAGCAGGCCGCC CTGGCCCGCCACAATCCAGCCCGGCCTGTCTTTGTTGAGGGCCCCTTCTCCCTGTGGCTCCGCAACAAGTGTGTGTATTACCACATCCTC AGAGCTGACTTGCTGCCCCCGGAGGAGAGGGAAGTGGAAGAGACGCCGGAGGAGTGGAACCTCTACTACCCGATGCAGCTGGACCTGGAG TATGTGAGGAGTGGCTGGGACAACTACGAGTTTGACATCAATGAAGTGGAGGAAGGCCCTGTCTTCGCCATGTGCATGGCGGGTGCTCAT GACCAGGCGACGATGGCTAAGTGGATCCAGGGCCTGCAGGAGACCAACCCAACCCTGGCCCAGATCCCCGTGGTCTTCCGCCTCGCCGGG TCCACCCGGGAGCTCCAGACATCCTCTGCAGGGCTGGAGGAGCCGCCCCTGCCCGAGGACCACCAGGAAGAAGACGACAACCTGCAGCGA >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000591104_chr19_11618863_-_156nt ATGGTTCCTTTGCCCAAAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGAGCTGACTTGCTGCCCCCGGAGGAGAGGG >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000592312_chr19_11618863_-_417nt ATGGTTCCTTTGCCCAAAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGGTAAGTCCGAGAGCATGGGGGCAGCCAAG TCTCTAACCTTACCCAGGCCCTGCCAGGTTCTCGCTGGGCCTAGGCTGGGCTCCCTGGGCCTCTGGGCCGAGTCCCTTGCAGGGCACAGG GCATGTATGTCTCCACACCAGGAATCCAGAGTCCCGATCAGCAGGCCGCCCTGGCCCGCCACAATCCAGCCCGGCCTGTCTTTGTTGAGG GCCCCTTCTCCCTGTGGCTCCGCAACAAGTGTGTGTATTACCACATCCTCAGAGCTGACTTGCTGCCCCCGGAGGAGAGGGAAGTGGAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000270517_chr19_11618863_-_993nt ATTCCTTTAGTGCTGCGCCGACAGCGGTCAGGATCTCGGCTTTCTTGCTTCGAGAGGGACTAGGTGCCTCCACCAGAGCTTCTGTCGCTC TGTAACCTGCACTGTGACCTACACTAGTCGCGGGAGCCACGCAGAGGACGCCGGAACACCCTGGAAGCCGAGAAATGGTTCCTTTGCCCA AAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGGAATCCAGAGTCCCGATCAGCAGGCCGCCCTGGCCCGCCACAATC CAGCCCGGCCTGTCTTTGTTGAGGGCCCCTTCTCCCTGTGGCTCCGCAACAAGTGTGTGTATTACCACATCCTCAGAGCTGACTTGCTGC CCCCGGAGGAGAGGGAAGTGGAAGAGACGCCGGAGGAGTGGAACCTCTACTACCCGATGCAGCTGGACCTGGAGTATGTGAGGAGTGGCT GGGACAACTACGAGTTTGACATCAATGAAGTGGAGGAAGGCCCTGTCTTCGCCATGTGCATGGCGGGTGCTCATGACCAGGCGACGATGG CTAAGTGGATCCAGGGCCTGCAGGAGACCAACCCAACCCTGGCCCAGATCCCCGTGGTCTTCCGCCTCGCCGGGTCCACCCGGGAGCTCC AGACATCCTCTGCAGGGCTGGAGGAGCCGCCCCTGCCCGAGGACCACCAGGAAGAAGACGACAACCTGCAGCGACAGCAGCAGGGCCAGA GCTAGTCTGAGCCGGCGCGAGGGCACGGGCTGTGGCCCGAGGAGGCGGTGGACTGAAGGCATGAGATGCCCTTTGAGTGTACAGCAAATC AATGTTTTCCTGCTTGGGGCTCTCTTCCCTCATCTCTAGCAGTATGGCATCCCCTCCCCAGGATCTCGGGCTGCCAGCGATGGGCAGGCG AGACCCCTCCAGAATCTGCAGGCGCCTCTGGTTCTCCGAATTCAAATAAAAAGGGGCGGGAGCGCTGTTGGTTGTGCGCATGCGCAGTTT >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000588998_chr19_11618863_-_831nt ATTCCTTTAGTGCTGCGCCGACAGCGGTCAGGATCTCGGCTTTCTTGCTTCGAGAGGGACTAGGTGCCTCCACCAGAGCTTCTGTCGCTC TGTAACCTGCACTGTGACCTACACTAGTCGCGGGAGCCACGCAGAGGACGCCGGAACACCCTGGAAGCCGAGAAATGGTTCCTTTGCCCA AAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGGAAGTGGAAGAGACGCCGGAGGAGTGGAACCTCTACTACCCGATG CAGCTGGACCTGGAGTATGTGAGGAGTGGCTGGGACAACTACGAGTTTGACATCAATGAAGTGGAGGAAGGCCCTGTCTTCGCCATGTGC ATGGCGGGTGCTCATGACCAGGCGACGATGGCTAAGTGGATCCAGGGCCTGCAGGAGACCAACCCAACCCTGGCCCAGATCCCCGTGGTC TTCCGCCTCGCCGGGTCCACCCGGGAGCTCCAGACATCCTCTGCAGGGCTGGAGGAGCCGCCCCTGCCCGAGGACCACCAGGAAGAAGAC GACAACCTGCAGCGACAGCAGCAGGGCCAGAGCTAGTCTGAGCCGGCGCGAGGGCACGGGCTGTGGCCCGAGGAGGCGGTGGACTGAAGG CATGAGATGCCCTTTGAGTGTACAGCAAATCAATGTTTTCCTGCTTGGGGCTCTCTTCCCTCATCTCTAGCAGTATGGCATCCCCTCCCC AGGATCTCGGGCTGCCAGCGATGGGCAGGCGAGACCCCTCCAGAATCTGCAGGCGCCTCTGGTTCTCCGAATTCAAATAAAAAGGGGCGG >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000252440_chr19_11618863_-_831nt ATTCCTTTAGTGCTGCGCCGACAGCGGTCAGGATCTCGGCTTTCTTGCTTCGAGAGGGACTAGGTGCCTCCACCAGAGCTTCTGTCGCTC TGTAACCTGCACTGTGACCTACACTAGTCGCGGGAGCCACGCAGAGGACGCCGGAACACCCTGGAAGCCGAGAAATGGTTCCTTTGCCCA AAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGGAAGTGGAAGAGACGCCGGAGGAGTGGAACCTCTACTACCCGATG CAGCTGGACCTGGAGTATGTGAGGAGTGGCTGGGACAACTACGAGTTTGACATCAATGAAGTGGAGGAAGGCCCTGTCTTCGCCATGTGC ATGGCGGGTGCTCATGACCAGGCGACGATGGCTAAGTGGATCCAGGGCCTGCAGGAGACCAACCCAACCCTGGCCCAGATCCCCGTGGTC TTCCGCCTCGCCGGGTCCACCCGGGAGCTCCAGACATCCTCTGCAGGGCTGGAGGAGCCGCCCCTGCCCGAGGACCACCAGGAAGAAGAC GACAACCTGCAGCGACAGCAGCAGGGCCAGAGCTAGTCTGAGCCGGCGCGAGGGCACGGGCTGTGGCCCGAGGAGGCGGTGGACTGAAGG CATGAGATGCCCTTTGAGTGTACAGCAAATCAATGTTTTCCTGCTTGGGGCTCTCTTCCCTCATCTCTAGCAGTATGGCATCCCCTCCCC AGGATCTCGGGCTGCCAGCGATGGGCAGGCGAGACCCCTCCAGAATCTGCAGGCGCCTCTGGTTCTCCGAATTCAAATAAAAAGGGGCGG >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000417981_chr19_11618863_-_907nt ATTCCTTTAGTGCTGCGCCGACAGCGGTCAGGATCTCGGCTTTCTTGCTTCGAGAGGGACTAGGTGCCTCCACCAGAGCTTCTGTCGCTC TGTAACCTGCACTGTGACCTACACTAGTCGCGGGAGCCACGCAGAGGACGCCGGAACACCCTGGAAGCCGAGAAATGGTTCCTTTGCCCA AAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGGAATCCAGAGTCCCGATCAGCAGGCCGCCCTGGCCCGCCACAATC CAGCCCGGCCTGTCTTTGTTGAGGGCCCCTTCTCCCTGTGGCTCCGCAACAAGTGTGTGTATTACCACATCCTCAGAGCTGACTTGCTGC CCCCGGAGGAGAGGGAAGTGGAAGAGACGCCGGAGGAGTGGAACCTCTACTACCCGATGCAGCTGGACCTGGAGTATGTGAGGAGTGGCT GGGACAACTACGAGTTTGACATCAATGAAGTGGAGGAAGGCCCTGTCTTCGCCATGTGCATGGCGGGTGCTCATGACCAGGCGACGATGG CTAAGTGGATCCAGGGCCTGCAGGAGACCAACCCAACCCTGGCCCAGATCCCCGTGGTCTTCCGCCTCGCCGGGTCCACCCGGGAGCTCC AGACATCCTCTGCAGGGCTGGAGGAGCCGCCCCTGCCCGAGGACCACCAGGAAGAAGACGACAACCTGCAGCGACAGCAGCAGGGCCAGA GCTAGTCTGAGCCGGCGCGAGGGCACGGGCTGTGGCCCGAGGAGGCGGTGGACTGAAGGCATGAGATGCCCTTTGAGTGTACAGCAAATC AATGTTTTCCTGCTTGGGGCTCTCTTCCCTCATCTCTAGCAGTATGGCATCCCCTCCCCAGGATCTCGGGCTGCCAGCGATGGGCAGGCG >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000591104_chr19_11618863_-_604nt ATTCCTTTAGTGCTGCGCCGACAGCGGTCAGGATCTCGGCTTTCTTGCTTCGAGAGGGACTAGGTGCCTCCACCAGAGCTTCTGTCGCTC TGTAACCTGCACTGTGACCTACACTAGTCGCGGGAGCCACGCAGAGGACGCCGGAACACCCTGGAAGCCGAGAAATGGTTCCTTTGCCCA AAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGAGCTGACTTGCTGCCCCCGGAGGAGAGGGAAGTGGAAGAGACGCC GGAGGAGTGGAACCTCTACTACCCGATGCAGCTGGACCTGGAGTATGTGAGGAGTGGCTGGGACAACTACGAGTTTGACATCAATGAAGT GGAGGAAGGCCCTGTCTTCGCCATGTGCATGGCGGGTGCTCATGACCAGGCGACGATGGCTAAGTGGATCCAGGGCCTGCAGGAGACCAA CCCAACCCTGGCCCAGATCCCCGTGGTCTTCCGCCTCGCCGGGTCCACCCGGGAGCTCCAGACATCCTCTGCAGGGCTGGAGGAGCCGCC >In-frame_ZNF440_ENST00000304060_chr19_11925265_+_ECSIT_ENST00000592312_chr19_11618863_-_748nt ATTCCTTTAGTGCTGCGCCGACAGCGGTCAGGATCTCGGCTTTCTTGCTTCGAGAGGGACTAGGTGCCTCCACCAGAGCTTCTGTCGCTC TGTAACCTGCACTGTGACCTACACTAGTCGCGGGAGCCACGCAGAGGACGCCGGAACACCCTGGAAGCCGAGAAATGGTTCCTTTGCCCA AAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGGTAAGTCCGAGAGCATGGGGGCAGCCAAGTCTCTAACCTTACCCA GGCCCTGCCAGGTTCTCGCTGGGCCTAGGCTGGGCTCCCTGGGCCTCTGGGCCGAGTCCCTTGCAGGGCACAGGGCATGTATGTCTCCAC ACCAGGAATCCAGAGTCCCGATCAGCAGGCCGCCCTGGCCCGCCACAATCCAGCCCGGCCTGTCTTTGTTGAGGGCCCCTTCTCCCTGTG GCTCCGCAACAAGTGTGTGTATTACCACATCCTCAGAGCTGACTTGCTGCCCCCGGAGGAGAGGGAAGTGGAAGAGACGCCGGAGGAGTG GAACCTCTACTACCCGATGCAGCTGGACCTGGAGTATGTGAGGAGTGGCTGGGACAACTACGAGTTTGACATCAATGAAGTGGAGGAAGG CCCTGTCTTCGCCATGTGCATGGCGGGTGCTCATGACCAGGCGACGATGGCTAAGTGGATCCAGGGCCTGCAGGAGACCAACCCAACCCT |
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FusionGenePPI for ZNF440_ECSIT |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZNF440 | MDFI, KRTAP4-12, MAP4K5, PAX9, XBP1, TRAF1, MID2, MTUS2, KRTAP10-9, KRTAP10-1, NOTCH2NL, CCNDBP1, LMNA | ECSIT | STRN4, IMMT, SETDB1, TLR4, TRIM59, MAVS, A2M, CDC37, PAXIP1, BLMH, PSEN2, PSEN1, APOE, AP1M2, CYP2C18, DNAJB1, ELAVL3, EXOC6, EXOSC1, FARSA, GCDH, IFIT5, LONP1, LOXL4, PRDX2, RAD23A, RHEB, ECSIT, FBXW4, CEP55, STAMBPL1, MAST1, RNF32, APP, CYP2C8, CYP2C9, FBXL12, IFIT3, PI4K2A, RAB3A, DHX15, ABCB10, NDUFAF1, MYC, RELA, NFKB1, MAP3K7, NDUFS3, TIMMDC1, PARP16, FAS, P2RY12, NDUFB1, MTIF2, ND4, GFM1, NDUFS2, ACADVL, DECR1, NDUFA3, PPP2R2D, NDUFAF4, ACAD9, NDUFB8, CLPP, MGME1, ND1, TRMT61B, NDUFA8, COA1, TMEM126B, NDUFC2, NDUFS8, NDUFB5, NNT, ABCC10, LPAR1, FAF2, CLEC5A, ACTN1, ACTN4, TMEM186, TMEM70, CYP24A1, MRPS17, ITGB1, NDUFAF3, MCCC2, ATAD3B, IARS2, GCAT, NDUFS1, NDUFB11, NDUFS5, NDUFA13, LLGL2, PPP2R2A, ATP6V1C2, SMURF1, IPPK, ASPH, FAM136A, NDUFS7, C3AR1, MARVELD2, VIPR2, CD93, KIAA0430, HELZ, SOWAHA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF440_ECSIT |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF440_ECSIT |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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