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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43328

FusionGeneSummary for ZNF43_EFHB

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF43_EFHB
Fusion gene ID: 43328
HgeneTgene
Gene symbol

ZNF43

EFHB

Gene ID

7594

151651

Gene namezinc finger protein 43EF-hand domain family member B
SynonymsHTF6|KOX27|ZNF39L1CFAP21
Cytomap

19p12

3p24.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 43zinc finger protein 39-like 1 (KOX 27)zinc finger protein HTF6zinc finger protein KOX27EF-hand domain-containing family member Bcilia and flagella associated protein 21
Modification date2018040320180403
UniProtAcc

P17038

Q8N7U6

Ensembl transtripts involved in fusion geneENST00000594012, ENST00000595461, 
ENST00000598381, ENST00000598288, 
ENST00000354959, ENST00000599414, 
ENST00000295824, ENST00000344838, 
ENST00000498089, 
Fusion gene scores* DoF score2 X 3 X 2=121 X 2 X 1=2
# samples 21
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/2*10)=2.32192809488736
Context

PubMed: ZNF43 [Title/Abstract] AND EFHB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-5508-01AZNF43chr19

22018838

-EFHBchr3

19977826

-
TCGALDPRADTCGA-EJ-5508-01AZNF43chr19

22033740

-EFHBchr3

19962059

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000594012ENST00000295824ZNF43chr19

22018838

-EFHBchr3

19977826

-
intron-5UTRENST00000594012ENST00000344838ZNF43chr19

22018838

-EFHBchr3

19977826

-
intron-intronENST00000594012ENST00000498089ZNF43chr19

22018838

-EFHBchr3

19977826

-
intron-intronENST00000595461ENST00000295824ZNF43chr19

22018838

-EFHBchr3

19977826

-
intron-5UTRENST00000595461ENST00000344838ZNF43chr19

22018838

-EFHBchr3

19977826

-
intron-intronENST00000595461ENST00000498089ZNF43chr19

22018838

-EFHBchr3

19977826

-
intron-intronENST00000598381ENST00000295824ZNF43chr19

22018838

-EFHBchr3

19977826

-
intron-5UTRENST00000598381ENST00000344838ZNF43chr19

22018838

-EFHBchr3

19977826

-
intron-intronENST00000598381ENST00000498089ZNF43chr19

22018838

-EFHBchr3

19977826

-
intron-intronENST00000598288ENST00000295824ZNF43chr19

22018838

-EFHBchr3

19977826

-
intron-5UTRENST00000598288ENST00000344838ZNF43chr19

22018838

-EFHBchr3

19977826

-
intron-intronENST00000598288ENST00000498089ZNF43chr19

22018838

-EFHBchr3

19977826

-
5CDS-intronENST00000354959ENST00000295824ZNF43chr19

22018838

-EFHBchr3

19977826

-
5CDS-5UTRENST00000354959ENST00000344838ZNF43chr19

22018838

-EFHBchr3

19977826

-
5CDS-intronENST00000354959ENST00000498089ZNF43chr19

22018838

-EFHBchr3

19977826

-
intron-intronENST00000599414ENST00000295824ZNF43chr19

22018838

-EFHBchr3

19977826

-
intron-5UTRENST00000599414ENST00000344838ZNF43chr19

22018838

-EFHBchr3

19977826

-
intron-intronENST00000599414ENST00000498089ZNF43chr19

22018838

-EFHBchr3

19977826

-
5UTR-3CDSENST00000594012ENST00000295824ZNF43chr19

22033740

-EFHBchr3

19962059

-
5UTR-3CDSENST00000594012ENST00000344838ZNF43chr19

22033740

-EFHBchr3

19962059

-
5UTR-5UTRENST00000594012ENST00000498089ZNF43chr19

22033740

-EFHBchr3

19962059

-
5UTR-3CDSENST00000595461ENST00000295824ZNF43chr19

22033740

-EFHBchr3

19962059

-
5UTR-3CDSENST00000595461ENST00000344838ZNF43chr19

22033740

-EFHBchr3

19962059

-
5UTR-5UTRENST00000595461ENST00000498089ZNF43chr19

22033740

-EFHBchr3

19962059

-
intron-3CDSENST00000598381ENST00000295824ZNF43chr19

22033740

-EFHBchr3

19962059

-
intron-3CDSENST00000598381ENST00000344838ZNF43chr19

22033740

-EFHBchr3

19962059

-
intron-5UTRENST00000598381ENST00000498089ZNF43chr19

22033740

-EFHBchr3

19962059

-
intron-3CDSENST00000598288ENST00000295824ZNF43chr19

22033740

-EFHBchr3

19962059

-
intron-3CDSENST00000598288ENST00000344838ZNF43chr19

22033740

-EFHBchr3

19962059

-
intron-5UTRENST00000598288ENST00000498089ZNF43chr19

22033740

-EFHBchr3

19962059

-
intron-3CDSENST00000354959ENST00000295824ZNF43chr19

22033740

-EFHBchr3

19962059

-
intron-3CDSENST00000354959ENST00000344838ZNF43chr19

22033740

-EFHBchr3

19962059

-
intron-5UTRENST00000354959ENST00000498089ZNF43chr19

22033740

-EFHBchr3

19962059

-
intron-3CDSENST00000599414ENST00000295824ZNF43chr19

22033740

-EFHBchr3

19962059

-
intron-3CDSENST00000599414ENST00000344838ZNF43chr19

22033740

-EFHBchr3

19962059

-
intron-5UTRENST00000599414ENST00000498089ZNF43chr19

22033740

-EFHBchr3

19962059

-

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FusionProtFeatures for ZNF43_EFHB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF43

P17038

EFHB

Q8N7U6

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF43_EFHB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF43_EFHB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF43EFHB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF43_EFHB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF43_EFHB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource