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Fusion gene ID: 43318 |
FusionGeneSummary for ZNF431_WIZ |
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Fusion gene information | Fusion gene name: ZNF431_WIZ | Fusion gene ID: 43318 | Hgene | Tgene | Gene symbol | ZNF431 | WIZ | Gene ID | 170959 | 58525 |
Gene name | zinc finger protein 431 | widely interspaced zinc finger motifs | |
Synonyms | - | ZNF803 | |
Cytomap | 19p12 | 19p13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 431 | protein WizWIZ zinc fingerwidely-interspaced zinc finger-containing proteinzinc finger protein 803 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8TF32 | O95785 | |
Ensembl transtripts involved in fusion gene | ENST00000600692, ENST00000599296, ENST00000594425, ENST00000311048, ENST00000594821, | ENST00000389282, ENST00000599910, ENST00000263381, ENST00000599686, ENST00000545156, | |
Fusion gene scores | * DoF score | 3 X 1 X 2=6 | 4 X 4 X 3=48 |
# samples | 3 | 4 | |
** MAII score | log2(3/6*10)=2.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF431 [Title/Abstract] AND WIZ [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | WIZ | GO:0070208 | protein heterotrimerization | 16702210 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AR-A24S-01A | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000600692 | ENST00000389282 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
Frame-shift | ENST00000600692 | ENST00000599910 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
5CDS-intron | ENST00000600692 | ENST00000263381 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
5CDS-intron | ENST00000600692 | ENST00000599686 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
5CDS-intron | ENST00000600692 | ENST00000545156 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
Frame-shift | ENST00000599296 | ENST00000389282 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
Frame-shift | ENST00000599296 | ENST00000599910 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
5CDS-intron | ENST00000599296 | ENST00000263381 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
5CDS-intron | ENST00000599296 | ENST00000599686 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
5CDS-intron | ENST00000599296 | ENST00000545156 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
Frame-shift | ENST00000594425 | ENST00000389282 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
Frame-shift | ENST00000594425 | ENST00000599910 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
5CDS-intron | ENST00000594425 | ENST00000263381 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
5CDS-intron | ENST00000594425 | ENST00000599686 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
5CDS-intron | ENST00000594425 | ENST00000545156 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
Frame-shift | ENST00000311048 | ENST00000389282 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
Frame-shift | ENST00000311048 | ENST00000599910 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
5CDS-intron | ENST00000311048 | ENST00000263381 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
5CDS-intron | ENST00000311048 | ENST00000599686 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
5CDS-intron | ENST00000311048 | ENST00000545156 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
intron-3CDS | ENST00000594821 | ENST00000389282 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
intron-3CDS | ENST00000594821 | ENST00000599910 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
intron-intron | ENST00000594821 | ENST00000263381 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
intron-intron | ENST00000594821 | ENST00000599686 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
intron-intron | ENST00000594821 | ENST00000545156 | ZNF431 | chr19 | 21326446 | + | WIZ | chr19 | 15540900 | - |
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FusionProtFeatures for ZNF431_WIZ |
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Hgene | Tgene |
ZNF431 | WIZ |
Sequence-specific DNA binding transcriptional repressor.Represses target gene transcription by recruiting HDAC1 and HDAC2histone deacetylases. Acts as a specific transcriptional repressorfor PTCH1 during embryonic development. Required for osteoblastdifferentiation and sonic hedgehog/SHH signaling response. Bindsto the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF431_WIZ |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF431_WIZ |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF431 | TK1, CDKN1A, SMN1, ANXA7, TYRP1, APP, ICAM3, CDX1, ZNF512 | WIZ | EHMT2, CTBP1, CTBP2, CDYL, OSGEP, RPS10, RPP14, TK1, CDKN1A, SMN1, RCC1, PIN1, TSC22D1, C8orf33, SMARCAD1, TFAP4, ZC3H4, CBX5, NOTCH1, HDAC2, HECW2, SUV39H1, SUV39H2, ZBTB1, BRCA1, EED, RNF2, CTSG, TRIM10, BIRC7, MIER2, ZBTB46, FBXW11, EHMT1, DOK5, EWSR1, PRPF31, UACA, MIER1, APC, TUBG1, CBX4, ZNF644, POLR1E, WDR77, USP45, CDYL2, C17orf49, MIER3, MAX, FOXE1, FOXG1, SNW1, RC3H1, CDC14B, XAGE2, XAGE3, ZNF462, L3MBTL1, IKZF5, SIRT6, HDAC1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF431_WIZ |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF431_WIZ |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |