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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43318

FusionGeneSummary for ZNF431_WIZ

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF431_WIZ
Fusion gene ID: 43318
HgeneTgene
Gene symbol

ZNF431

WIZ

Gene ID

170959

58525

Gene namezinc finger protein 431widely interspaced zinc finger motifs
Synonyms-ZNF803
Cytomap

19p12

19p13.12

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 431protein WizWIZ zinc fingerwidely-interspaced zinc finger-containing proteinzinc finger protein 803
Modification date2018051920180519
UniProtAcc

Q8TF32

O95785

Ensembl transtripts involved in fusion geneENST00000600692, ENST00000599296, 
ENST00000594425, ENST00000311048, 
ENST00000594821, 
ENST00000389282, 
ENST00000599910, ENST00000263381, 
ENST00000599686, ENST00000545156, 
Fusion gene scores* DoF score3 X 1 X 2=64 X 4 X 3=48
# samples 34
** MAII scorelog2(3/6*10)=2.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF431 [Title/Abstract] AND WIZ [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWIZ

GO:0070208

protein heterotrimerization

16702210


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A24S-01AZNF431chr19

21326446

+WIZchr19

15540900

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000600692ENST00000389282ZNF431chr19

21326446

+WIZchr19

15540900

-
Frame-shiftENST00000600692ENST00000599910ZNF431chr19

21326446

+WIZchr19

15540900

-
5CDS-intronENST00000600692ENST00000263381ZNF431chr19

21326446

+WIZchr19

15540900

-
5CDS-intronENST00000600692ENST00000599686ZNF431chr19

21326446

+WIZchr19

15540900

-
5CDS-intronENST00000600692ENST00000545156ZNF431chr19

21326446

+WIZchr19

15540900

-
Frame-shiftENST00000599296ENST00000389282ZNF431chr19

21326446

+WIZchr19

15540900

-
Frame-shiftENST00000599296ENST00000599910ZNF431chr19

21326446

+WIZchr19

15540900

-
5CDS-intronENST00000599296ENST00000263381ZNF431chr19

21326446

+WIZchr19

15540900

-
5CDS-intronENST00000599296ENST00000599686ZNF431chr19

21326446

+WIZchr19

15540900

-
5CDS-intronENST00000599296ENST00000545156ZNF431chr19

21326446

+WIZchr19

15540900

-
Frame-shiftENST00000594425ENST00000389282ZNF431chr19

21326446

+WIZchr19

15540900

-
Frame-shiftENST00000594425ENST00000599910ZNF431chr19

21326446

+WIZchr19

15540900

-
5CDS-intronENST00000594425ENST00000263381ZNF431chr19

21326446

+WIZchr19

15540900

-
5CDS-intronENST00000594425ENST00000599686ZNF431chr19

21326446

+WIZchr19

15540900

-
5CDS-intronENST00000594425ENST00000545156ZNF431chr19

21326446

+WIZchr19

15540900

-
Frame-shiftENST00000311048ENST00000389282ZNF431chr19

21326446

+WIZchr19

15540900

-
Frame-shiftENST00000311048ENST00000599910ZNF431chr19

21326446

+WIZchr19

15540900

-
5CDS-intronENST00000311048ENST00000263381ZNF431chr19

21326446

+WIZchr19

15540900

-
5CDS-intronENST00000311048ENST00000599686ZNF431chr19

21326446

+WIZchr19

15540900

-
5CDS-intronENST00000311048ENST00000545156ZNF431chr19

21326446

+WIZchr19

15540900

-
intron-3CDSENST00000594821ENST00000389282ZNF431chr19

21326446

+WIZchr19

15540900

-
intron-3CDSENST00000594821ENST00000599910ZNF431chr19

21326446

+WIZchr19

15540900

-
intron-intronENST00000594821ENST00000263381ZNF431chr19

21326446

+WIZchr19

15540900

-
intron-intronENST00000594821ENST00000599686ZNF431chr19

21326446

+WIZchr19

15540900

-
intron-intronENST00000594821ENST00000545156ZNF431chr19

21326446

+WIZchr19

15540900

-

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FusionProtFeatures for ZNF431_WIZ


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF431

Q8TF32

WIZ

O95785

Sequence-specific DNA binding transcriptional repressor.Represses target gene transcription by recruiting HDAC1 and HDAC2histone deacetylases. Acts as a specific transcriptional repressorfor PTCH1 during embryonic development. Required for osteoblastdifferentiation and sonic hedgehog/SHH signaling response. Bindsto the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF431_WIZ


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF431_WIZ


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF431TK1, CDKN1A, SMN1, ANXA7, TYRP1, APP, ICAM3, CDX1, ZNF512WIZEHMT2, CTBP1, CTBP2, CDYL, OSGEP, RPS10, RPP14, TK1, CDKN1A, SMN1, RCC1, PIN1, TSC22D1, C8orf33, SMARCAD1, TFAP4, ZC3H4, CBX5, NOTCH1, HDAC2, HECW2, SUV39H1, SUV39H2, ZBTB1, BRCA1, EED, RNF2, CTSG, TRIM10, BIRC7, MIER2, ZBTB46, FBXW11, EHMT1, DOK5, EWSR1, PRPF31, UACA, MIER1, APC, TUBG1, CBX4, ZNF644, POLR1E, WDR77, USP45, CDYL2, C17orf49, MIER3, MAX, FOXE1, FOXG1, SNW1, RC3H1, CDC14B, XAGE2, XAGE3, ZNF462, L3MBTL1, IKZF5, SIRT6, HDAC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF431_WIZ


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF431_WIZ


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource