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Fusion gene ID: 43315 |
FusionGeneSummary for ZNF430_OR7E24 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF430_OR7E24 | Fusion gene ID: 43315 | Hgene | Tgene | Gene symbol | ZNF430 | OR7E24 | Gene ID | 80264 | 26648 |
| Gene name | zinc finger protein 430 | olfactory receptor family 7 subfamily E member 24 | |
| Synonyms | - | HSHT2|OR19-8|OR7E24P|OR7E24Q | |
| Cytomap | 19p12 | 19p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 430 | olfactory receptor 7E24olfactory receptor OR19-14 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9H8G1 | Q6IFN5 | |
| Ensembl transtripts involved in fusion gene | ENST00000261560, ENST00000599548, ENST00000595401, | ENST00000456448, | |
| Fusion gene scores | * DoF score | 5 X 2 X 4=40 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ZNF430 [Title/Abstract] AND OR7E24 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCS | TCGA-N8-A4PP-01A | ZNF430 | chr19 | 21216990 | + | OR7E24 | chr19 | 9361761 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000261560 | ENST00000456448 | ZNF430 | chr19 | 21216990 | + | OR7E24 | chr19 | 9361761 | + |
| Frame-shift | ENST00000599548 | ENST00000456448 | ZNF430 | chr19 | 21216990 | + | OR7E24 | chr19 | 9361761 | + |
| In-frame | ENST00000595401 | ENST00000456448 | ZNF430 | chr19 | 21216990 | + | OR7E24 | chr19 | 9361761 | + |
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FusionProtFeatures for ZNF430_OR7E24 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF430 | OR7E24 |
| May be involved in transcriptional regulation. | Odorant receptor. {ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF430_OR7E24 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZNF430_ENST00000595401_chr19_21216990_+_OR7E24_ENST00000456448_chr19_9361761_+_1006aa MENLKSGVYPLKEASGCPGADRNLLVYSFYEKGPLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLGIAVSKPDLITCLEQG KEPWNMKRHAMVDQPPGRXEXTQQTTXMRGPKKKKANAXNVIXESVFQSKYFLGSLSFFFXFCPRIGSSSVLCFXIQGFFPLGDLPSSLL SEPKSSSWHARLTIXLLFHCFGGHTNIYMILRNSMLNYFLFFFLSFFFFLRLSFMLVAQAKVQWHDLGSLQPLPPGFKQFSCLSLLSRWN YRHLPPCPVNFLYFXXRQGFTMLGRLVSNSXPQVIHPPWPPKVLGLQVXATAPGQTIFLVLFLHHVXNVXXXWFLFHCFLLLLLTFLHTP FCSYYYILEIXFEIIKHHVFLLCSFSSRLLWLFEVYCCFLXILELYFPLLXRKMPLKFXXGIYXIYRLLRXXDTLTIFIFSICRHAIFLN LCLLXFLLLITYLSLXRFFTSLFSEIYHFNAILNCFLSLLKCMEQXLHTCVLILCFANLLSVLIQTNFNVVFMVFYIXNHMIHKQQLFTC VQFQWLFKNVFDSLFCHILPVLCXNRSIDNGHNVVLHXCLXIXRSKQLLKLLXTGFSRXRSFSVMSPGSXNALWVCSGEGVXLGHKAAGS ALGSTFSWLVTGAWVVVIPILFLDRLNILQHFDLXSRQXGRFLQSGSYIMVLISGCEXVWRLLSTGEDYCSYADKFFFNGISVLHSRFYE XICHLLLLRSFISVFCXCRFLNIELLCFFVSLLYYNFRQFAIRFISYNXEINQPYVCHNXIYMCVCVYLXIXPQYWLWLILYIFFLSQFS VVVLSHLSEXSWKYFHHLLFSPCVXXXCFSHLCVRETLLXFEGNFXKDLXICIFFSFSFRKINCCKNTXYLPSXIYLGVPFRARHGGGSH LXSRIIXAQKFETNLGNIWRVPLYKMFFKNSQAXCCASVVQATCKTEVGGLLEPQSLRPKXAIIVPLHSSFLTEXDCVSKWQQNLTPRPA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZNF430_ENST00000595401_chr19_21216990_+_OR7E24_ENST00000456448_chr19_9361761_+_3018nt ATGGAGAACCTGAAGTCTGGAGTGTATCCTCTCAAGGAAGCAAGTGGATGCCCTGGGGCTGACAGGAATCTTCTGGTGTACTCTTTTTAT GAAAAGGGGCCATTGACATTTAGGGATGTGGCCATAGAATTTTCTCTGGAGGAGTGGCAATGCCTGGACACTGCTCAGCAGGATTTGTAT AGAAAAGTGATGTTAGAGAACTACAGAAACCTGGTCTTCTTGGGTATTGCTGTTTCTAAGCCAGACCTGATCACCTGTCTAGAGCAAGGA AAAGAGCCCTGGAATATGAAGAGACATGCGATGGTAGATCAACCCCCAGGTAGGTGAGAGTGAACACAACAGACGACATGAATGAGAGGT CCAAAAAAGAAGAAAGCCAATGCTTAAAATGTTATTTGAGAATCTGTGTTCCAAAGCAAATATTTTCTGGGAAGCCTGAGTTTTTTTTTT TAATTTTGCCCTCGCATAGGGTCATCTTCTGTCTTATGCTTTTAAATTCAAGGATTCTTTCCCCTTGGTGATCTCCCTTCAAGTTTGCTA TCAGAACCAAAGTCCTCTTCATGGCATGCGAGACTCACAATCTGACTGCTTTTCCATTGTTTTGGGGGACACACAAATATCTACATGATT TTGAGAAACTCTATGTTAAACTATTTTCTTTTCTTTTTTCTTTCTTTTTTTTTTTTTTTGAGACTGAGTTTCATGCTCGTTGCCCAGGCT AAAGTGCAATGGCACGATCTAGGCTCACTGCAACCTCTGCCTCCTGGATTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGGTGGAAT TACAGGCACCTGCCACCATGCCCAGTTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGGCAGGCTGGTCTCAAACTCC TGACCTCAAGTGATCCACCCGCCTTGGCCTCCCAAAGTACTAGGATTACAGGTGTGAGCCACTGCACCTGGCCAAACTATTTTCTTAGTT CTCTTTTTGCATCATGTCTGAAATGTGTAATAGTAGTGGTTTCTGTTCCACTGTTTTTTGTTGTTGTTGTTAACTTTTCTGCACACTCCA TTCTGTTCTTATTACTATATTCTCGAAATATAGTTTGAAATTATAAAGCATCATGTCTTTCTACTTTGTTCTTTTTCCTCACGATTGCTT TGGCTATTTGAAGTTTATTGTTGTTTCTTGTAAATTTTAGAATTGTATTTTCCATTACTGTGAAGAAAAATGCCACTGAAATTTTGATAG GGAATTTATTGAATCTATAGATTACTTAGATAATAGGACACTTTAACAATATTTATTTTTTCAATCTGTAGACATGCAATATTTTTAAAT TTGTGTCTTCTCTAATTTCTTTTATTAATAACATATCTTTCGTTGTAAAGATTTTTTACTTCCTTGTTCTCAGAAATTTATCATTTTAAT GCTATTTTAAATTGTTTTCTTTCTCTGTTAAAGTGTATGGAACAATAACTTCATACTTGTGTGTTAATTTTATGTTTTGCTAATTTACTG AGTGTATTAATTCAGACAAATTTCAATGTAGTGTTCATGGTTTTTTATATATAAAATCATATGATCCACAAACAGCAACTTTTTACTTGT GTTCAATTTCAGTGGCTTTTTAAAAATGTTTTTGACTCATTATTCTGCCACATACTTCCAGTGCTATGTTAAAATAGAAGCATTGACAAT GGGCACAATGTAGTTTTGCATTAGTGTCTGTGAATTTGAAGGAGCAAACAACTCCTCAAGCTTCTATAAACTGGTTTCAGTAGGTAAAGA TCTTTTTCTGTCATGTCTCCAGGGTCATAGAATGCTCTCTGGGTTTGTAGTGGAGAGGGGGTGTAGCTTGGTCACAAGGCTGCTGGGTCT GCACTAGGGTCCACCTTTAGTTGGCTTGTTACAGGGGCTTGGGTAGTGGTAATTCCCATTTTATTTTTGGACAGACTGAATATCCTTCAA CACTTTGATCTGTAGAGCAGACAATAGGGCAGGTTTCTGCAGTCAGGTTCATATATAATGGTCCTTATATCAGGATGTGAATGAGTATGG CGTTTATTGAGTACCGGAGAGGATTACTGTAGTTATGCAGACAAATTCTTTTTTAATGGTATATCAGTGTTGCACAGCAGATTTTATGAG TAAATATGTCACTTACTATTACTGCGCAGTTTCATATCAGTGTTTTGTTAGTGTAGGTTTCTTAACATTGAGTTATTGTGTTTTTTTGTT TCACTTTTGTATTATAATTTTAGACAGTTTGCAATTCGGTTTATCTCTTATAATTAAGAGATAAATCAGCCATATGTCTGTCACAATTAG ATATATATGTGTGTGTGTGTTTATCTATAAATATGACCCCAATATTGGTTATGGCTTATCTTGTATATATTCTTTCTTAGCCAATTTTCA GTGGTTGTTTTATCTCACCTAAGTGAGTAGTCATGGAAATATTTTCACCATCTCTTATTTTCACCATGTGTTTAATGATGATGTTTCTCT CACCTTTGTGTGAGAGAAACACTTTTGTAATTTGAAGGTAATTTTTGAAAAGATTTATAAATCTGTATTTTTTTCAGTTTTTCCTTTAGA AAAATTAATTGTTGTAAAAACACATAATATTTACCATCTTAAATCTATTTAGGTGTACCTTTTAGGGCCAGACATGGTGGTGGCTCACAT CTGTAATCCAGGATTATTTGAGCTCAAAAGTTTGAGACCAACCTGGGAAACATATGGAGAGTCCCTCTCTACAAAATGTTTTTTAAAAAT AGCCAGGCATAGTGTTGTGCATCTGTGGTTCAGGCTACTTGCAAGACTGAGGTGGGAGGGTTACTTGAGCCTCAGAGTTTGAGGCCGAAG TGAGCCATAATTGTACCACTGCACTCCAGCTTTTTGACAGAGTGAGACTGTGTCTCCAAATGGCAGCAAAATTTAACACCTAGGCCTGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZNF430_ENST00000595401_chr19_21216990_+_OR7E24_ENST00000456448_chr19_9361761_+_4160nt ATAAAGCCTGAGGCGGCGGCAGCGGCGGAGTTGGCGGCTTGGAGAGCTCGGGAGAGTTCCCTGGAACCAGAACTTGGACCTTCTCGCTTC TGTCCTCCGTTTAGTCTCCTCCTCGGCGGGAGCCCTCGCGACGCGCCCGGCCCGGAGCCCCCAGCGCAGCGGCCGCGGAGAACCTGAAGT CTGGAGTGTATCCTCTCAAGGAAGCAAGTGGATGCCCTGGGGCTGACAGGAATCTTCTGGTGTACTCTTTTTATGAAAAGGGGCCATTGA CATTTAGGGATGTGGCCATAGAATTTTCTCTGGAGGAGTGGCAATGCCTGGACACTGCTCAGCAGGATTTGTATAGAAAAGTGATGTTAG AGAACTACAGAAACCTGGTCTTCTTGGGTATTGCTGTTTCTAAGCCAGACCTGATCACCTGTCTAGAGCAAGGAAAAGAGCCCTGGAATA TGAAGAGACATGCGATGGTAGATCAACCCCCAGGTAGGTGAGAGTGAACACAACAGACGACATGAATGAGAGGTCCAAAAAAGAAGAAAG CCAATGCTTAAAATGTTATTTGAGAATCTGTGTTCCAAAGCAAATATTTTCTGGGAAGCCTGAGTTTTTTTTTTTAATTTTGCCCTCGCA TAGGGTCATCTTCTGTCTTATGCTTTTAAATTCAAGGATTCTTTCCCCTTGGTGATCTCCCTTCAAGTTTGCTATCAGAACCAAAGTCCT CTTCATGGCATGCGAGACTCACAATCTGACTGCTTTTCCATTGTTTTGGGGGACACACAAATATCTACATGATTTTGAGAAACTCTATGT TAAACTATTTTCTTTTCTTTTTTCTTTCTTTTTTTTTTTTTTTGAGACTGAGTTTCATGCTCGTTGCCCAGGCTAAAGTGCAATGGCACG ATCTAGGCTCACTGCAACCTCTGCCTCCTGGATTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGGTGGAATTACAGGCACCTGCCAC CATGCCCAGTTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGGCAGGCTGGTCTCAAACTCCTGACCTCAAGTGATCC ACCCGCCTTGGCCTCCCAAAGTACTAGGATTACAGGTGTGAGCCACTGCACCTGGCCAAACTATTTTCTTAGTTCTCTTTTTGCATCATG TCTGAAATGTGTAATAGTAGTGGTTTCTGTTCCACTGTTTTTTGTTGTTGTTGTTAACTTTTCTGCACACTCCATTCTGTTCTTATTACT ATATTCTCGAAATATAGTTTGAAATTATAAAGCATCATGTCTTTCTACTTTGTTCTTTTTCCTCACGATTGCTTTGGCTATTTGAAGTTT ATTGTTGTTTCTTGTAAATTTTAGAATTGTATTTTCCATTACTGTGAAGAAAAATGCCACTGAAATTTTGATAGGGAATTTATTGAATCT ATAGATTACTTAGATAATAGGACACTTTAACAATATTTATTTTTTCAATCTGTAGACATGCAATATTTTTAAATTTGTGTCTTCTCTAAT TTCTTTTATTAATAACATATCTTTCGTTGTAAAGATTTTTTACTTCCTTGTTCTCAGAAATTTATCATTTTAATGCTATTTTAAATTGTT TTCTTTCTCTGTTAAAGTGTATGGAACAATAACTTCATACTTGTGTGTTAATTTTATGTTTTGCTAATTTACTGAGTGTATTAATTCAGA CAAATTTCAATGTAGTGTTCATGGTTTTTTATATATAAAATCATATGATCCACAAACAGCAACTTTTTACTTGTGTTCAATTTCAGTGGC TTTTTAAAAATGTTTTTGACTCATTATTCTGCCACATACTTCCAGTGCTATGTTAAAATAGAAGCATTGACAATGGGCACAATGTAGTTT TGCATTAGTGTCTGTGAATTTGAAGGAGCAAACAACTCCTCAAGCTTCTATAAACTGGTTTCAGTAGGTAAAGATCTTTTTCTGTCATGT CTCCAGGGTCATAGAATGCTCTCTGGGTTTGTAGTGGAGAGGGGGTGTAGCTTGGTCACAAGGCTGCTGGGTCTGCACTAGGGTCCACCT TTAGTTGGCTTGTTACAGGGGCTTGGGTAGTGGTAATTCCCATTTTATTTTTGGACAGACTGAATATCCTTCAACACTTTGATCTGTAGA GCAGACAATAGGGCAGGTTTCTGCAGTCAGGTTCATATATAATGGTCCTTATATCAGGATGTGAATGAGTATGGCGTTTATTGAGTACCG GAGAGGATTACTGTAGTTATGCAGACAAATTCTTTTTTAATGGTATATCAGTGTTGCACAGCAGATTTTATGAGTAAATATGTCACTTAC TATTACTGCGCAGTTTCATATCAGTGTTTTGTTAGTGTAGGTTTCTTAACATTGAGTTATTGTGTTTTTTTGTTTCACTTTTGTATTATA ATTTTAGACAGTTTGCAATTCGGTTTATCTCTTATAATTAAGAGATAAATCAGCCATATGTCTGTCACAATTAGATATATATGTGTGTGT GTGTTTATCTATAAATATGACCCCAATATTGGTTATGGCTTATCTTGTATATATTCTTTCTTAGCCAATTTTCAGTGGTTGTTTTATCTC ACCTAAGTGAGTAGTCATGGAAATATTTTCACCATCTCTTATTTTCACCATGTGTTTAATGATGATGTTTCTCTCACCTTTGTGTGAGAG AAACACTTTTGTAATTTGAAGGTAATTTTTGAAAAGATTTATAAATCTGTATTTTTTTCAGTTTTTCCTTTAGAAAAATTAATTGTTGTA AAAACACATAATATTTACCATCTTAAATCTATTTAGGTGTACCTTTTAGGGCCAGACATGGTGGTGGCTCACATCTGTAATCCAGGATTA TTTGAGCTCAAAAGTTTGAGACCAACCTGGGAAACATATGGAGAGTCCCTCTCTACAAAATGTTTTTTAAAAATAGCCAGGCATAGTGTT GTGCATCTGTGGTTCAGGCTACTTGCAAGACTGAGGTGGGAGGGTTACTTGAGCCTCAGAGTTTGAGGCCGAAGTGAGCCATAATTGTAC CACTGCACTCCAGCTTTTTGACAGAGTGAGACTGTGTCTCCTGTCCGAGCTACACAGAGCCACAGAATCTCACAGGTGTCTCAGAATTCC TCCTCCTGGGACTCTCAGAGGATCCAGAACTGCAGCCGGTCCTCGCTGGGCTGTTCCTGTCCATGTACCTGGTCACGGTGCTGGGGAACC TGCTCATCATCCTGGCTGTCAGCTCTGACTCCCACCTCCACACCCCCATGTACTTCTTCCTCTCCAACCTGTCCTTGGCTGACATCGGTT TCACCTCCACCACGGTCCCCAAGATGATTGTGGACATGCAAACTCACAGCAGAGTCATCTCCTATGAAGGCTGCCTGACTCAGATGTCTT TTTTTGTCCTTTTTGCATGTATGGATGACATGCTCCTGAGTGTGATGGCCTATGACCGGTTTGTGGCCATCTGTCACCCCCTGCACTACC GAATCATCATGAACCCACGCCTCTGTGGCTTCTTAATCTTGTTGTCTTTTTTTATTAGTCTTTTGGACTCCCAGTTGCACAATTTGATTA TGTTACAGCTCACCTGCTTCAAGGATGTGGACATTTCTAATTTCTTCTGTGACCCTTCTCAACTCCTCCACCTTAGGTGTTCCGACACCT TCATCAATGAAATGGTCATATATTTCATGGGTGCCATATTTGGCTGTCTCCCTATCTCAGGGATCCTTTTCTCTTACTATAAAATTGTTT CCCCCATTCTGAGAGTTCCAACATCAGATGGGAAGTATAAAGCCTTCTCCACCTGTGGCTCTCACCTGGCAGTTGTTTGCTTATTTTATG GAACAGGGCTTGTAGGGTACCTCAGTTCAGCTGTGTTACCATCCCCCAGGAAGAGTATGGTGGCTTCAGTGATGTACACTGTGGTCACCC CCATGCTGAACCCCTTCATCTACAGCCTGAGGAACAAGGACATTCAAAGTGCCCTGTGCAGGCTGCATGGCAGAATCATCAAATCTCATC ATCTCCATCCTTTTTGTTATATGGGATAGAAATGGCAGCAAAATTTAACACCTAGGCCTGCAAATTCTGCCTCCTTGGTCACATTATTTT |
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FusionGenePPI for ZNF430_OR7E24 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZNF430 | FBL, NEUROG3, CLEC3A, HRC, ZNF223, RPS14, VWCE | OR7E24 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF430_OR7E24 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF430_OR7E24 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ZNF430 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
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