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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43315

FusionGeneSummary for ZNF430_OR7E24

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF430_OR7E24
Fusion gene ID: 43315
HgeneTgene
Gene symbol

ZNF430

OR7E24

Gene ID

80264

26648

Gene namezinc finger protein 430olfactory receptor family 7 subfamily E member 24
Synonyms-HSHT2|OR19-8|OR7E24P|OR7E24Q
Cytomap

19p12

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 430olfactory receptor 7E24olfactory receptor OR19-14
Modification date2018051920180523
UniProtAcc

Q9H8G1

Q6IFN5

Ensembl transtripts involved in fusion geneENST00000261560, ENST00000599548, 
ENST00000595401, 
ENST00000456448, 
Fusion gene scores* DoF score5 X 2 X 4=401 X 1 X 1=1
# samples 51
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: ZNF430 [Title/Abstract] AND OR7E24 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCSTCGA-N8-A4PP-01AZNF430chr19

21216990

+OR7E24chr19

9361761

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000261560ENST00000456448ZNF430chr19

21216990

+OR7E24chr19

9361761

+
Frame-shiftENST00000599548ENST00000456448ZNF430chr19

21216990

+OR7E24chr19

9361761

+
In-frameENST00000595401ENST00000456448ZNF430chr19

21216990

+OR7E24chr19

9361761

+

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FusionProtFeatures for ZNF430_OR7E24


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF430

Q9H8G1

OR7E24

Q6IFN5

May be involved in transcriptional regulation. Odorant receptor. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF430_OR7E24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZNF430_ENST00000595401_chr19_21216990_+_OR7E24_ENST00000456448_chr19_9361761_+_1006aa
MENLKSGVYPLKEASGCPGADRNLLVYSFYEKGPLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLGIAVSKPDLITCLEQG
KEPWNMKRHAMVDQPPGRXEXTQQTTXMRGPKKKKANAXNVIXESVFQSKYFLGSLSFFFXFCPRIGSSSVLCFXIQGFFPLGDLPSSLL
SEPKSSSWHARLTIXLLFHCFGGHTNIYMILRNSMLNYFLFFFLSFFFFLRLSFMLVAQAKVQWHDLGSLQPLPPGFKQFSCLSLLSRWN
YRHLPPCPVNFLYFXXRQGFTMLGRLVSNSXPQVIHPPWPPKVLGLQVXATAPGQTIFLVLFLHHVXNVXXXWFLFHCFLLLLLTFLHTP
FCSYYYILEIXFEIIKHHVFLLCSFSSRLLWLFEVYCCFLXILELYFPLLXRKMPLKFXXGIYXIYRLLRXXDTLTIFIFSICRHAIFLN
LCLLXFLLLITYLSLXRFFTSLFSEIYHFNAILNCFLSLLKCMEQXLHTCVLILCFANLLSVLIQTNFNVVFMVFYIXNHMIHKQQLFTC
VQFQWLFKNVFDSLFCHILPVLCXNRSIDNGHNVVLHXCLXIXRSKQLLKLLXTGFSRXRSFSVMSPGSXNALWVCSGEGVXLGHKAAGS
ALGSTFSWLVTGAWVVVIPILFLDRLNILQHFDLXSRQXGRFLQSGSYIMVLISGCEXVWRLLSTGEDYCSYADKFFFNGISVLHSRFYE
XICHLLLLRSFISVFCXCRFLNIELLCFFVSLLYYNFRQFAIRFISYNXEINQPYVCHNXIYMCVCVYLXIXPQYWLWLILYIFFLSQFS
VVVLSHLSEXSWKYFHHLLFSPCVXXXCFSHLCVRETLLXFEGNFXKDLXICIFFSFSFRKINCCKNTXYLPSXIYLGVPFRARHGGGSH
LXSRIIXAQKFETNLGNIWRVPLYKMFFKNSQAXCCASVVQATCKTEVGGLLEPQSLRPKXAIIVPLHSSFLTEXDCVSKWQQNLTPRPA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZNF430_ENST00000595401_chr19_21216990_+_OR7E24_ENST00000456448_chr19_9361761_+_3018nt
ATGGAGAACCTGAAGTCTGGAGTGTATCCTCTCAAGGAAGCAAGTGGATGCCCTGGGGCTGACAGGAATCTTCTGGTGTACTCTTTTTAT
GAAAAGGGGCCATTGACATTTAGGGATGTGGCCATAGAATTTTCTCTGGAGGAGTGGCAATGCCTGGACACTGCTCAGCAGGATTTGTAT
AGAAAAGTGATGTTAGAGAACTACAGAAACCTGGTCTTCTTGGGTATTGCTGTTTCTAAGCCAGACCTGATCACCTGTCTAGAGCAAGGA
AAAGAGCCCTGGAATATGAAGAGACATGCGATGGTAGATCAACCCCCAGGTAGGTGAGAGTGAACACAACAGACGACATGAATGAGAGGT
CCAAAAAAGAAGAAAGCCAATGCTTAAAATGTTATTTGAGAATCTGTGTTCCAAAGCAAATATTTTCTGGGAAGCCTGAGTTTTTTTTTT
TAATTTTGCCCTCGCATAGGGTCATCTTCTGTCTTATGCTTTTAAATTCAAGGATTCTTTCCCCTTGGTGATCTCCCTTCAAGTTTGCTA
TCAGAACCAAAGTCCTCTTCATGGCATGCGAGACTCACAATCTGACTGCTTTTCCATTGTTTTGGGGGACACACAAATATCTACATGATT
TTGAGAAACTCTATGTTAAACTATTTTCTTTTCTTTTTTCTTTCTTTTTTTTTTTTTTTGAGACTGAGTTTCATGCTCGTTGCCCAGGCT
AAAGTGCAATGGCACGATCTAGGCTCACTGCAACCTCTGCCTCCTGGATTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGGTGGAAT
TACAGGCACCTGCCACCATGCCCAGTTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGGCAGGCTGGTCTCAAACTCC
TGACCTCAAGTGATCCACCCGCCTTGGCCTCCCAAAGTACTAGGATTACAGGTGTGAGCCACTGCACCTGGCCAAACTATTTTCTTAGTT
CTCTTTTTGCATCATGTCTGAAATGTGTAATAGTAGTGGTTTCTGTTCCACTGTTTTTTGTTGTTGTTGTTAACTTTTCTGCACACTCCA
TTCTGTTCTTATTACTATATTCTCGAAATATAGTTTGAAATTATAAAGCATCATGTCTTTCTACTTTGTTCTTTTTCCTCACGATTGCTT
TGGCTATTTGAAGTTTATTGTTGTTTCTTGTAAATTTTAGAATTGTATTTTCCATTACTGTGAAGAAAAATGCCACTGAAATTTTGATAG
GGAATTTATTGAATCTATAGATTACTTAGATAATAGGACACTTTAACAATATTTATTTTTTCAATCTGTAGACATGCAATATTTTTAAAT
TTGTGTCTTCTCTAATTTCTTTTATTAATAACATATCTTTCGTTGTAAAGATTTTTTACTTCCTTGTTCTCAGAAATTTATCATTTTAAT
GCTATTTTAAATTGTTTTCTTTCTCTGTTAAAGTGTATGGAACAATAACTTCATACTTGTGTGTTAATTTTATGTTTTGCTAATTTACTG
AGTGTATTAATTCAGACAAATTTCAATGTAGTGTTCATGGTTTTTTATATATAAAATCATATGATCCACAAACAGCAACTTTTTACTTGT
GTTCAATTTCAGTGGCTTTTTAAAAATGTTTTTGACTCATTATTCTGCCACATACTTCCAGTGCTATGTTAAAATAGAAGCATTGACAAT
GGGCACAATGTAGTTTTGCATTAGTGTCTGTGAATTTGAAGGAGCAAACAACTCCTCAAGCTTCTATAAACTGGTTTCAGTAGGTAAAGA
TCTTTTTCTGTCATGTCTCCAGGGTCATAGAATGCTCTCTGGGTTTGTAGTGGAGAGGGGGTGTAGCTTGGTCACAAGGCTGCTGGGTCT
GCACTAGGGTCCACCTTTAGTTGGCTTGTTACAGGGGCTTGGGTAGTGGTAATTCCCATTTTATTTTTGGACAGACTGAATATCCTTCAA
CACTTTGATCTGTAGAGCAGACAATAGGGCAGGTTTCTGCAGTCAGGTTCATATATAATGGTCCTTATATCAGGATGTGAATGAGTATGG
CGTTTATTGAGTACCGGAGAGGATTACTGTAGTTATGCAGACAAATTCTTTTTTAATGGTATATCAGTGTTGCACAGCAGATTTTATGAG
TAAATATGTCACTTACTATTACTGCGCAGTTTCATATCAGTGTTTTGTTAGTGTAGGTTTCTTAACATTGAGTTATTGTGTTTTTTTGTT
TCACTTTTGTATTATAATTTTAGACAGTTTGCAATTCGGTTTATCTCTTATAATTAAGAGATAAATCAGCCATATGTCTGTCACAATTAG
ATATATATGTGTGTGTGTGTTTATCTATAAATATGACCCCAATATTGGTTATGGCTTATCTTGTATATATTCTTTCTTAGCCAATTTTCA
GTGGTTGTTTTATCTCACCTAAGTGAGTAGTCATGGAAATATTTTCACCATCTCTTATTTTCACCATGTGTTTAATGATGATGTTTCTCT
CACCTTTGTGTGAGAGAAACACTTTTGTAATTTGAAGGTAATTTTTGAAAAGATTTATAAATCTGTATTTTTTTCAGTTTTTCCTTTAGA
AAAATTAATTGTTGTAAAAACACATAATATTTACCATCTTAAATCTATTTAGGTGTACCTTTTAGGGCCAGACATGGTGGTGGCTCACAT
CTGTAATCCAGGATTATTTGAGCTCAAAAGTTTGAGACCAACCTGGGAAACATATGGAGAGTCCCTCTCTACAAAATGTTTTTTAAAAAT
AGCCAGGCATAGTGTTGTGCATCTGTGGTTCAGGCTACTTGCAAGACTGAGGTGGGAGGGTTACTTGAGCCTCAGAGTTTGAGGCCGAAG
TGAGCCATAATTGTACCACTGCACTCCAGCTTTTTGACAGAGTGAGACTGTGTCTCCAAATGGCAGCAAAATTTAACACCTAGGCCTGCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNF430_ENST00000595401_chr19_21216990_+_OR7E24_ENST00000456448_chr19_9361761_+_4160nt
ATAAAGCCTGAGGCGGCGGCAGCGGCGGAGTTGGCGGCTTGGAGAGCTCGGGAGAGTTCCCTGGAACCAGAACTTGGACCTTCTCGCTTC
TGTCCTCCGTTTAGTCTCCTCCTCGGCGGGAGCCCTCGCGACGCGCCCGGCCCGGAGCCCCCAGCGCAGCGGCCGCGGAGAACCTGAAGT
CTGGAGTGTATCCTCTCAAGGAAGCAAGTGGATGCCCTGGGGCTGACAGGAATCTTCTGGTGTACTCTTTTTATGAAAAGGGGCCATTGA
CATTTAGGGATGTGGCCATAGAATTTTCTCTGGAGGAGTGGCAATGCCTGGACACTGCTCAGCAGGATTTGTATAGAAAAGTGATGTTAG
AGAACTACAGAAACCTGGTCTTCTTGGGTATTGCTGTTTCTAAGCCAGACCTGATCACCTGTCTAGAGCAAGGAAAAGAGCCCTGGAATA
TGAAGAGACATGCGATGGTAGATCAACCCCCAGGTAGGTGAGAGTGAACACAACAGACGACATGAATGAGAGGTCCAAAAAAGAAGAAAG
CCAATGCTTAAAATGTTATTTGAGAATCTGTGTTCCAAAGCAAATATTTTCTGGGAAGCCTGAGTTTTTTTTTTTAATTTTGCCCTCGCA
TAGGGTCATCTTCTGTCTTATGCTTTTAAATTCAAGGATTCTTTCCCCTTGGTGATCTCCCTTCAAGTTTGCTATCAGAACCAAAGTCCT
CTTCATGGCATGCGAGACTCACAATCTGACTGCTTTTCCATTGTTTTGGGGGACACACAAATATCTACATGATTTTGAGAAACTCTATGT
TAAACTATTTTCTTTTCTTTTTTCTTTCTTTTTTTTTTTTTTTGAGACTGAGTTTCATGCTCGTTGCCCAGGCTAAAGTGCAATGGCACG
ATCTAGGCTCACTGCAACCTCTGCCTCCTGGATTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGGTGGAATTACAGGCACCTGCCAC
CATGCCCAGTTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGGCAGGCTGGTCTCAAACTCCTGACCTCAAGTGATCC
ACCCGCCTTGGCCTCCCAAAGTACTAGGATTACAGGTGTGAGCCACTGCACCTGGCCAAACTATTTTCTTAGTTCTCTTTTTGCATCATG
TCTGAAATGTGTAATAGTAGTGGTTTCTGTTCCACTGTTTTTTGTTGTTGTTGTTAACTTTTCTGCACACTCCATTCTGTTCTTATTACT
ATATTCTCGAAATATAGTTTGAAATTATAAAGCATCATGTCTTTCTACTTTGTTCTTTTTCCTCACGATTGCTTTGGCTATTTGAAGTTT
ATTGTTGTTTCTTGTAAATTTTAGAATTGTATTTTCCATTACTGTGAAGAAAAATGCCACTGAAATTTTGATAGGGAATTTATTGAATCT
ATAGATTACTTAGATAATAGGACACTTTAACAATATTTATTTTTTCAATCTGTAGACATGCAATATTTTTAAATTTGTGTCTTCTCTAAT
TTCTTTTATTAATAACATATCTTTCGTTGTAAAGATTTTTTACTTCCTTGTTCTCAGAAATTTATCATTTTAATGCTATTTTAAATTGTT
TTCTTTCTCTGTTAAAGTGTATGGAACAATAACTTCATACTTGTGTGTTAATTTTATGTTTTGCTAATTTACTGAGTGTATTAATTCAGA
CAAATTTCAATGTAGTGTTCATGGTTTTTTATATATAAAATCATATGATCCACAAACAGCAACTTTTTACTTGTGTTCAATTTCAGTGGC
TTTTTAAAAATGTTTTTGACTCATTATTCTGCCACATACTTCCAGTGCTATGTTAAAATAGAAGCATTGACAATGGGCACAATGTAGTTT
TGCATTAGTGTCTGTGAATTTGAAGGAGCAAACAACTCCTCAAGCTTCTATAAACTGGTTTCAGTAGGTAAAGATCTTTTTCTGTCATGT
CTCCAGGGTCATAGAATGCTCTCTGGGTTTGTAGTGGAGAGGGGGTGTAGCTTGGTCACAAGGCTGCTGGGTCTGCACTAGGGTCCACCT
TTAGTTGGCTTGTTACAGGGGCTTGGGTAGTGGTAATTCCCATTTTATTTTTGGACAGACTGAATATCCTTCAACACTTTGATCTGTAGA
GCAGACAATAGGGCAGGTTTCTGCAGTCAGGTTCATATATAATGGTCCTTATATCAGGATGTGAATGAGTATGGCGTTTATTGAGTACCG
GAGAGGATTACTGTAGTTATGCAGACAAATTCTTTTTTAATGGTATATCAGTGTTGCACAGCAGATTTTATGAGTAAATATGTCACTTAC
TATTACTGCGCAGTTTCATATCAGTGTTTTGTTAGTGTAGGTTTCTTAACATTGAGTTATTGTGTTTTTTTGTTTCACTTTTGTATTATA
ATTTTAGACAGTTTGCAATTCGGTTTATCTCTTATAATTAAGAGATAAATCAGCCATATGTCTGTCACAATTAGATATATATGTGTGTGT
GTGTTTATCTATAAATATGACCCCAATATTGGTTATGGCTTATCTTGTATATATTCTTTCTTAGCCAATTTTCAGTGGTTGTTTTATCTC
ACCTAAGTGAGTAGTCATGGAAATATTTTCACCATCTCTTATTTTCACCATGTGTTTAATGATGATGTTTCTCTCACCTTTGTGTGAGAG
AAACACTTTTGTAATTTGAAGGTAATTTTTGAAAAGATTTATAAATCTGTATTTTTTTCAGTTTTTCCTTTAGAAAAATTAATTGTTGTA
AAAACACATAATATTTACCATCTTAAATCTATTTAGGTGTACCTTTTAGGGCCAGACATGGTGGTGGCTCACATCTGTAATCCAGGATTA
TTTGAGCTCAAAAGTTTGAGACCAACCTGGGAAACATATGGAGAGTCCCTCTCTACAAAATGTTTTTTAAAAATAGCCAGGCATAGTGTT
GTGCATCTGTGGTTCAGGCTACTTGCAAGACTGAGGTGGGAGGGTTACTTGAGCCTCAGAGTTTGAGGCCGAAGTGAGCCATAATTGTAC
CACTGCACTCCAGCTTTTTGACAGAGTGAGACTGTGTCTCCTGTCCGAGCTACACAGAGCCACAGAATCTCACAGGTGTCTCAGAATTCC
TCCTCCTGGGACTCTCAGAGGATCCAGAACTGCAGCCGGTCCTCGCTGGGCTGTTCCTGTCCATGTACCTGGTCACGGTGCTGGGGAACC
TGCTCATCATCCTGGCTGTCAGCTCTGACTCCCACCTCCACACCCCCATGTACTTCTTCCTCTCCAACCTGTCCTTGGCTGACATCGGTT
TCACCTCCACCACGGTCCCCAAGATGATTGTGGACATGCAAACTCACAGCAGAGTCATCTCCTATGAAGGCTGCCTGACTCAGATGTCTT
TTTTTGTCCTTTTTGCATGTATGGATGACATGCTCCTGAGTGTGATGGCCTATGACCGGTTTGTGGCCATCTGTCACCCCCTGCACTACC
GAATCATCATGAACCCACGCCTCTGTGGCTTCTTAATCTTGTTGTCTTTTTTTATTAGTCTTTTGGACTCCCAGTTGCACAATTTGATTA
TGTTACAGCTCACCTGCTTCAAGGATGTGGACATTTCTAATTTCTTCTGTGACCCTTCTCAACTCCTCCACCTTAGGTGTTCCGACACCT
TCATCAATGAAATGGTCATATATTTCATGGGTGCCATATTTGGCTGTCTCCCTATCTCAGGGATCCTTTTCTCTTACTATAAAATTGTTT
CCCCCATTCTGAGAGTTCCAACATCAGATGGGAAGTATAAAGCCTTCTCCACCTGTGGCTCTCACCTGGCAGTTGTTTGCTTATTTTATG
GAACAGGGCTTGTAGGGTACCTCAGTTCAGCTGTGTTACCATCCCCCAGGAAGAGTATGGTGGCTTCAGTGATGTACACTGTGGTCACCC
CCATGCTGAACCCCTTCATCTACAGCCTGAGGAACAAGGACATTCAAAGTGCCCTGTGCAGGCTGCATGGCAGAATCATCAAATCTCATC
ATCTCCATCCTTTTTGTTATATGGGATAGAAATGGCAGCAAAATTTAACACCTAGGCCTGCAAATTCTGCCTCCTTGGTCACATTATTTT


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FusionGenePPI for ZNF430_OR7E24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF430FBL, NEUROG3, CLEC3A, HRC, ZNF223, RPS14, VWCEOR7E24


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF430_OR7E24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF430_OR7E24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZNF430C0032460Polycystic Ovary Syndrome1CTD_human