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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43312

FusionGeneSummary for ZNF430_CD19

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF430_CD19
Fusion gene ID: 43312
HgeneTgene
Gene symbol

ZNF430

CD19

Gene ID

80264

930

Gene namezinc finger protein 430CD19 molecule
Synonyms-B4|CVID3
Cytomap

19p12

16p11.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 430B-lymphocyte antigen CD19B-lymphocyte surface antigen B4T-cell surface antigen Leu-12differentiation antigen CD19
Modification date2018051920180523
UniProtAcc

Q9H8G1

P15391

Ensembl transtripts involved in fusion geneENST00000261560, ENST00000599548, 
ENST00000595401, 
ENST00000538922, 
ENST00000324662, ENST00000567541, 
Fusion gene scores* DoF score5 X 2 X 4=401 X 1 X 1=1
# samples 51
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: ZNF430 [Title/Abstract] AND CD19 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-GV-A3JW-01AZNF430chr19

21205687

+CD19chr16

28944232

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000261560ENST00000538922ZNF430chr19

21205687

+CD19chr16

28944232

+
Frame-shiftENST00000261560ENST00000324662ZNF430chr19

21205687

+CD19chr16

28944232

+
Frame-shiftENST00000261560ENST00000567541ZNF430chr19

21205687

+CD19chr16

28944232

+
Frame-shiftENST00000599548ENST00000538922ZNF430chr19

21205687

+CD19chr16

28944232

+
Frame-shiftENST00000599548ENST00000324662ZNF430chr19

21205687

+CD19chr16

28944232

+
Frame-shiftENST00000599548ENST00000567541ZNF430chr19

21205687

+CD19chr16

28944232

+
Frame-shiftENST00000595401ENST00000538922ZNF430chr19

21205687

+CD19chr16

28944232

+
Frame-shiftENST00000595401ENST00000324662ZNF430chr19

21205687

+CD19chr16

28944232

+
Frame-shiftENST00000595401ENST00000567541ZNF430chr19

21205687

+CD19chr16

28944232

+

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FusionProtFeatures for ZNF430_CD19


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF430

Q9H8G1

CD19

P15391

May be involved in transcriptional regulation. Assembles with the antigen receptor of B-lymphocytes inorder to decrease the threshold for antigen receptor-dependentstimulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF430_CD19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF430_CD19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF430FBL, NEUROG3, CLEC3A, HRC, ZNF223, RPS14, VWCECD19CD81, IFITM1, CR2, CD82, VAV1, VAV2, CD22, SYK, CD79A, CD79B, CD9, ECT2, POLR2M, FAM188A, B3GNT3, IGSF8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF430_CD19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCD19P15391DB09052BlinatumomabB-lymphocyte antigen CD19biotechapproved|investigational

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RelatedDiseases for ZNF430_CD19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZNF430C0032460Polycystic Ovary Syndrome1CTD_human
TgeneCD19C0001768Agammaglobulinemia1CTD_human
TgeneCD19C0001969Alcoholic Intoxication1PSYGENET
TgeneCD19C0009447Common Variable Immunodeficiency1CTD_human;ORPHANET