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Fusion gene ID: 43312 |
FusionGeneSummary for ZNF430_CD19 |
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Fusion gene information | Fusion gene name: ZNF430_CD19 | Fusion gene ID: 43312 | Hgene | Tgene | Gene symbol | ZNF430 | CD19 | Gene ID | 80264 | 930 |
Gene name | zinc finger protein 430 | CD19 molecule | |
Synonyms | - | B4|CVID3 | |
Cytomap | 19p12 | 16p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 430 | B-lymphocyte antigen CD19B-lymphocyte surface antigen B4T-cell surface antigen Leu-12differentiation antigen CD19 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9H8G1 | P15391 | |
Ensembl transtripts involved in fusion gene | ENST00000261560, ENST00000599548, ENST00000595401, | ENST00000538922, ENST00000324662, ENST00000567541, | |
Fusion gene scores | * DoF score | 5 X 2 X 4=40 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ZNF430 [Title/Abstract] AND CD19 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-GV-A3JW-01A | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000261560 | ENST00000538922 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
Frame-shift | ENST00000261560 | ENST00000324662 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
Frame-shift | ENST00000261560 | ENST00000567541 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
Frame-shift | ENST00000599548 | ENST00000538922 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
Frame-shift | ENST00000599548 | ENST00000324662 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
Frame-shift | ENST00000599548 | ENST00000567541 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
Frame-shift | ENST00000595401 | ENST00000538922 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
Frame-shift | ENST00000595401 | ENST00000324662 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
Frame-shift | ENST00000595401 | ENST00000567541 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
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FusionProtFeatures for ZNF430_CD19 |
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Hgene | Tgene |
ZNF430 | CD19 |
May be involved in transcriptional regulation. | Assembles with the antigen receptor of B-lymphocytes inorder to decrease the threshold for antigen receptor-dependentstimulation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF430_CD19 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF430_CD19 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF430 | FBL, NEUROG3, CLEC3A, HRC, ZNF223, RPS14, VWCE | CD19 | CD81, IFITM1, CR2, CD82, VAV1, VAV2, CD22, SYK, CD79A, CD79B, CD9, ECT2, POLR2M, FAM188A, B3GNT3, IGSF8 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF430_CD19 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | CD19 | P15391 | DB09052 | Blinatumomab | B-lymphocyte antigen CD19 | biotech | approved|investigational |
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RelatedDiseases for ZNF430_CD19 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZNF430 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Tgene | CD19 | C0001768 | Agammaglobulinemia | 1 | CTD_human |
Tgene | CD19 | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
Tgene | CD19 | C0009447 | Common Variable Immunodeficiency | 1 | CTD_human;ORPHANET |