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Fusion gene ID: 43311 |
FusionGeneSummary for ZNF430_BRD4 |
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Fusion gene information | Fusion gene name: ZNF430_BRD4 | Fusion gene ID: 43311 | Hgene | Tgene | Gene symbol | ZNF430 | BRD4 | Gene ID | 80264 | 23476 |
Gene name | zinc finger protein 430 | bromodomain containing 4 | |
Synonyms | - | CAP|HUNK1|HUNKI|MCAP | |
Cytomap | 19p12 | 19p13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 430 | bromodomain-containing protein 4chromosome-associated protein | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q9H8G1 | O60885 | |
Ensembl transtripts involved in fusion gene | ENST00000261560, ENST00000599548, ENST00000595401, | ENST00000263377, ENST00000371835, ENST00000360016, ENST00000602230, | |
Fusion gene scores | * DoF score | 5 X 2 X 4=40 | 8 X 10 X 6=480 |
# samples | 5 | 12 | |
** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/480*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF430 [Title/Abstract] AND BRD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | BRD4 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter | 19103749|23086925 |
Tgene | BRD4 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 19103749 |
Tgene | BRD4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23086925|23317504 |
Tgene | BRD4 | GO:0050727 | regulation of inflammatory response | 19103749 |
Tgene | BRD4 | GO:1901407 | regulation of phosphorylation of RNA polymerase II C-terminal domain | 23086925 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-EB-A44O-01A | ZNF430 | chr19 | 21216990 | + | BRD4 | chr19 | 15383944 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000261560 | ENST00000263377 | ZNF430 | chr19 | 21216990 | + | BRD4 | chr19 | 15383944 | - |
5CDS-5UTR | ENST00000261560 | ENST00000371835 | ZNF430 | chr19 | 21216990 | + | BRD4 | chr19 | 15383944 | - |
5CDS-5UTR | ENST00000261560 | ENST00000360016 | ZNF430 | chr19 | 21216990 | + | BRD4 | chr19 | 15383944 | - |
5CDS-intron | ENST00000261560 | ENST00000602230 | ZNF430 | chr19 | 21216990 | + | BRD4 | chr19 | 15383944 | - |
5CDS-5UTR | ENST00000599548 | ENST00000263377 | ZNF430 | chr19 | 21216990 | + | BRD4 | chr19 | 15383944 | - |
5CDS-5UTR | ENST00000599548 | ENST00000371835 | ZNF430 | chr19 | 21216990 | + | BRD4 | chr19 | 15383944 | - |
5CDS-5UTR | ENST00000599548 | ENST00000360016 | ZNF430 | chr19 | 21216990 | + | BRD4 | chr19 | 15383944 | - |
5CDS-intron | ENST00000599548 | ENST00000602230 | ZNF430 | chr19 | 21216990 | + | BRD4 | chr19 | 15383944 | - |
5CDS-5UTR | ENST00000595401 | ENST00000263377 | ZNF430 | chr19 | 21216990 | + | BRD4 | chr19 | 15383944 | - |
5CDS-5UTR | ENST00000595401 | ENST00000371835 | ZNF430 | chr19 | 21216990 | + | BRD4 | chr19 | 15383944 | - |
5CDS-5UTR | ENST00000595401 | ENST00000360016 | ZNF430 | chr19 | 21216990 | + | BRD4 | chr19 | 15383944 | - |
5CDS-intron | ENST00000595401 | ENST00000602230 | ZNF430 | chr19 | 21216990 | + | BRD4 | chr19 | 15383944 | - |
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FusionProtFeatures for ZNF430_BRD4 |
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Hgene | Tgene |
ZNF430 | BRD4 |
May be involved in transcriptional regulation. | Chromatin reader protein that recognizes and bindsacetylated histones and plays a key role in transmission ofepigenetic memory across cell divisions and transcriptionregulation. Remains associated with acetylated chromatinthroughout the entire cell cycle and provides epigenetic memoryfor postmitotic G1 gene transcription by preserving acetylatedchromatin status and maintaining high-order chromatin structure.During interphase, plays a key role in regulating thetranscription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters: BRD4 is required toform the transcriptionally active P-TEFb complex by displacingnegative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can thenphosphorylate the C-terminal domain (CTD) of RNA polymerase II.Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD)of RNA polymerase II. According to a report, directly acts as anatypical protein kinase and mediates phosphorylation of 'Ser-2' ofthe C-terminal domain (CTD) of RNA polymerase II; these datahowever need additional evidences in vivo (PubMed:22509028). Inaddition to acetylated histones, also recognizes and bindsacetylated RELA, leading to further recruitment of the P-TEFbcomplex and subsequent activation of NF-kappa-B. Also acts as aregulator of p53/TP53-mediated transcription: followingphosphorylation by CK2, recruited to p53/TP53 specific targetpromoters. {ECO:0000269|PubMed:22509028}. Isoform B: Acts as a chromatin insulator in the DNAdamage response pathway. Inhibits DNA damage response signaling byrecruiting the condensin-2 complex to acetylated histones, leadingto chromatin structure remodeling, insulating the region from DNAdamage response by limiting spreading of histone H2AFX/H2A.xphosphorylation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF430_BRD4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF430_BRD4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF430 | FBL, NEUROG3, CLEC3A, HRC, ZNF223, RPS14, VWCE | BRD4 | RFC1, RFC2, RFC3, RFC4, RFC5, HIST4H4, SIPA1, MED12, MED14, MED24, MED17, CCNT1, CDK9, CCNT2, HEXIM1, HIST2H3C, HIST2H4A, KDM5B, EP300, AFF1, MESDC2, C8orf33, HIST1H3A, HIST1H4A, KAT8, YWHAZ, YWHAE, MED1, CHD4, JMJD6, BAIAP2, BAIAP2L1, RBM25, BRD3, BRD2, WHSC1, GLTSCR1, ATAD5, SMARCA4, ZNF592, BRD9, WHSC1L1, SIRT1, SIRT5, AK1, PGAM2, LDHC, CKM, ELAVL1, MYC, MLLT1, RPL6, PRPF40A, RN7SK, TCERG1, STAT3, GPSM1, FAM90A1, CYP1A1, AP3M1, NUMA1, DMAP1, RTF1, ZC3H18, MMGT1, SMC1A, CDC5L, CHD8, PTAR1, BRCA1, PTEN, FGFR3, KDM5C, DHFR, RB1, MAP2K1, PIP4K2A, CAMKV, CHEK2, CHEK1, WEE1, CDC7, INO80B, TRIM25, CUL1, CUL3, SPOP, AR, ERG |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF430_BRD4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF430_BRD4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZNF430 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Tgene | BRD4 | C0017636 | Glioblastoma | 2 | CTD_human |
Tgene | BRD4 | C0002170 | Alopecia | 1 | CTD_human |
Tgene | BRD4 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Tgene | BRD4 | C0020507 | Hyperplasia | 1 | CTD_human |
Tgene | BRD4 | C0020542 | Pulmonary Hypertension | 1 | CTD_human |
Tgene | BRD4 | C0025149 | Medulloblastoma | 1 | CTD_human |
Tgene | BRD4 | C0029463 | Osteosarcoma | 1 | CTD_human |
Tgene | BRD4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | BRD4 | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
Tgene | BRD4 | C0085413 | Polycystic Kidney, Autosomal Dominant | 1 | CTD_human |