FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 43308

FusionGeneSummary for ZNF429_C2CD3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF429_C2CD3
Fusion gene ID: 43308
HgeneTgene
Gene symbol

ZNF429

C2CD3

Gene ID

353088

26005

Gene namezinc finger protein 429C2 calcium dependent domain containing 3
Synonyms-OFD14
Cytomap

19p12

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 429C2 domain-containing protein 3
Modification date2018052220180519
UniProtAcc

Q86V71

Q4AC94

Ensembl transtripts involved in fusion geneENST00000594022, ENST00000358491, 
ENST00000597078, 		ENST00000334126, 
ENST00000313663, ENST00000542452, 
ENST00000539061, 
Fusion gene scores* DoF score3 X 3 X 3=2710 X 9 X 6=540
# samples 311
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/540*10)=-2.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF429 [Title/Abstract] AND C2CD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneC2CD3

GO:0061511

centriole elongation

24997988

TgeneC2CD3

GO:0071539

protein localization to centrosome

24997988


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-GN-A8LL-06AZNF429chr19

21688576

+C2CD3chr11

73809300

-
TCGALDSKCMTCGA-GN-A8LL-06AZNF429chr19

21688882

+C2CD3chr11

73809300

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000594022ENST00000334126ZNF429chr19

21688576

+C2CD3chr11

73809300

-
intron-3CDSENST00000594022ENST00000313663ZNF429chr19

21688576

+C2CD3chr11

73809300

-
intron-intronENST00000594022ENST00000542452ZNF429chr19

21688576

+C2CD3chr11

73809300

-
intron-intronENST00000594022ENST00000539061ZNF429chr19

21688576

+C2CD3chr11

73809300

-
Frame-shiftENST00000358491ENST00000334126ZNF429chr19

21688576

+C2CD3chr11

73809300

-
Frame-shiftENST00000358491ENST00000313663ZNF429chr19

21688576

+C2CD3chr11

73809300

-
5CDS-intronENST00000358491ENST00000542452ZNF429chr19

21688576

+C2CD3chr11

73809300

-
5CDS-intronENST00000358491ENST00000539061ZNF429chr19

21688576

+C2CD3chr11

73809300

-
Frame-shiftENST00000597078ENST00000334126ZNF429chr19

21688576

+C2CD3chr11

73809300

-
Frame-shiftENST00000597078ENST00000313663ZNF429chr19

21688576

+C2CD3chr11

73809300

-
5CDS-intronENST00000597078ENST00000542452ZNF429chr19

21688576

+C2CD3chr11

73809300

-
5CDS-intronENST00000597078ENST00000539061ZNF429chr19

21688576

+C2CD3chr11

73809300

-
intron-3CDSENST00000594022ENST00000334126ZNF429chr19

21688882

+C2CD3chr11

73809300

-
intron-3CDSENST00000594022ENST00000313663ZNF429chr19

21688882

+C2CD3chr11

73809300

-
intron-intronENST00000594022ENST00000542452ZNF429chr19

21688882

+C2CD3chr11

73809300

-
intron-intronENST00000594022ENST00000539061ZNF429chr19

21688882

+C2CD3chr11

73809300

-
intron-3CDSENST00000358491ENST00000334126ZNF429chr19

21688882

+C2CD3chr11

73809300

-
intron-3CDSENST00000358491ENST00000313663ZNF429chr19

21688882

+C2CD3chr11

73809300

-
intron-intronENST00000358491ENST00000542452ZNF429chr19

21688882

+C2CD3chr11

73809300

-
intron-intronENST00000358491ENST00000539061ZNF429chr19

21688882

+C2CD3chr11

73809300

-
intron-3CDSENST00000597078ENST00000334126ZNF429chr19

21688882

+C2CD3chr11

73809300

-
intron-3CDSENST00000597078ENST00000313663ZNF429chr19

21688882

+C2CD3chr11

73809300

-
intron-intronENST00000597078ENST00000542452ZNF429chr19

21688882

+C2CD3chr11

73809300

-
intron-intronENST00000597078ENST00000539061ZNF429chr19

21688882

+C2CD3chr11

73809300

-

Top

FusionProtFeatures for ZNF429_C2CD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF429

Q86V71

C2CD3

Q4AC94

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ZNF429_C2CD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ZNF429_C2CD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF429C2CD3CEP63, CENPJ, MED4, CEP162, PCM1, SPICE1, CEP128, CEP135, CEP89, CNTRL, OFD1, CDC14A, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZNF429_C2CD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ZNF429_C2CD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC2CD3C0029294Orofaciodigital Syndromes1CTD_human
TgeneC2CD3C4014780OROFACIODIGITAL SYNDROME XIV1ORPHANET;UNIPROT