|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 43305 |
FusionGeneSummary for ZNF423_TNFSF10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF423_TNFSF10 | Fusion gene ID: 43305 | Hgene | Tgene | Gene symbol | ZNF423 | TNFSF10 | Gene ID | 23090 | 8743 |
| Gene name | zinc finger protein 423 | TNF superfamily member 10 | |
| Synonyms | Ebfaz|JBTS19|NPHP14|OAZ|Roaz|ZFP423|Zfp104|hOAZ | APO2L|Apo-2L|CD253|TL2|TNLG6A|TRAIL | |
| Cytomap | 16q12.1 | 3q26.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 423OLF-1/EBF associated zinc fingerSmad- and Olf-interacting zinc finger proteinearly B-cell factor associated zinc finger proteinolf1/EBF-associated zinc finger protein | tumor necrosis factor ligand superfamily member 10Apo-2 ligandTNF-related apoptosis inducing ligand TRAILchemokine tumor necrosis factor ligand superfamily member 10tumor necrosis factor (ligand) family, member 10tumor necrosis factor (ligand) superf | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q2M1K9 | P50591 | |
| Ensembl transtripts involved in fusion gene | ENST00000561648, ENST00000563137, ENST00000562871, ENST00000262383, ENST00000535559, ENST00000567169, ENST00000562520, | ENST00000241261, ENST00000420541, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 5 X 4 X 4=80 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZNF423 [Title/Abstract] AND TNFSF10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZNF423 | GO:0045892 | negative regulation of transcription, DNA-templated | 10660046 |
| Hgene | ZNF423 | GO:0045893 | positive regulation of transcription, DNA-templated | 10660046 |
| Tgene | TNFSF10 | GO:0043065 | positive regulation of apoptotic process | 21525171 |
| Tgene | TNFSF10 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 21459798|21525171|22266862 |
| Tgene | TNFSF10 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria | 22266862 |
| Tgene | TNFSF10 | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway | 20097879|21525171|22266862 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCS | TCGA-NF-A5CP-01A | ZNF423 | chr16 | 49889646 | - | TNFSF10 | chr3 | 172232788 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000561648 | ENST00000241261 | ZNF423 | chr16 | 49889646 | - | TNFSF10 | chr3 | 172232788 | - |
| intron-3CDS | ENST00000561648 | ENST00000420541 | ZNF423 | chr16 | 49889646 | - | TNFSF10 | chr3 | 172232788 | - |
| 5UTR-3CDS | ENST00000563137 | ENST00000241261 | ZNF423 | chr16 | 49889646 | - | TNFSF10 | chr3 | 172232788 | - |
| 5UTR-3CDS | ENST00000563137 | ENST00000420541 | ZNF423 | chr16 | 49889646 | - | TNFSF10 | chr3 | 172232788 | - |
| intron-3CDS | ENST00000562871 | ENST00000241261 | ZNF423 | chr16 | 49889646 | - | TNFSF10 | chr3 | 172232788 | - |
| intron-3CDS | ENST00000562871 | ENST00000420541 | ZNF423 | chr16 | 49889646 | - | TNFSF10 | chr3 | 172232788 | - |
| intron-3CDS | ENST00000262383 | ENST00000241261 | ZNF423 | chr16 | 49889646 | - | TNFSF10 | chr3 | 172232788 | - |
| intron-3CDS | ENST00000262383 | ENST00000420541 | ZNF423 | chr16 | 49889646 | - | TNFSF10 | chr3 | 172232788 | - |
| intron-3CDS | ENST00000535559 | ENST00000241261 | ZNF423 | chr16 | 49889646 | - | TNFSF10 | chr3 | 172232788 | - |
| intron-3CDS | ENST00000535559 | ENST00000420541 | ZNF423 | chr16 | 49889646 | - | TNFSF10 | chr3 | 172232788 | - |
| intron-3CDS | ENST00000567169 | ENST00000241261 | ZNF423 | chr16 | 49889646 | - | TNFSF10 | chr3 | 172232788 | - |
| intron-3CDS | ENST00000567169 | ENST00000420541 | ZNF423 | chr16 | 49889646 | - | TNFSF10 | chr3 | 172232788 | - |
| intron-3CDS | ENST00000562520 | ENST00000241261 | ZNF423 | chr16 | 49889646 | - | TNFSF10 | chr3 | 172232788 | - |
| intron-3CDS | ENST00000562520 | ENST00000420541 | ZNF423 | chr16 | 49889646 | - | TNFSF10 | chr3 | 172232788 | - |
Top |
FusionProtFeatures for ZNF423_TNFSF10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF423 | TNFSF10 |
| Transcription factor that can both act as an activatoror a repressor depending on the context. Plays a central role inBMP signaling and olfactory neurogenesis. Associates with SMADs inresponse to BMP2 leading to activate transcription of BMP targetgenes. Acts as a transcriptional repressor via its interactionwith EBF1, a transcription factor involved in terminal olfactoryreceptor neurons differentiation; this interaction preventing EBF1to bind DNA and activate olfactory-specific genes. Involved inolfactory neurogenesis by participating in a developmental switchthat regulates the transition from differentiation to maturationin olfactory receptor neurons. Controls proliferation anddifferentiation of neural precursors in cerebellar vermisformation. {ECO:0000269|PubMed:10660046}. | Cytokine that binds to TNFRSF10A/TRAILR1,TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 andpossibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288).Induces apoptosis. Its activity may be modulated by binding to thedecoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 andTNFRSF11B/OPG that cannot induce apoptosis.{ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:26457518}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ZNF423_TNFSF10 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ZNF423_TNFSF10 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZNF423 | PARP1, SMAD4, SMAD1, EBF1, EBF2, EBF3, USP7, CEP290, LYN, BRCA1, MTA1, ZNF219, RBBP7, MBD3L1, ZG16B | TNFSF10 | ACP5, RBM48, TNFSF10, TNFRSF10D, TNFRSF10B, TNFRSF10A, CFLAR, CASP8, FADD, SOCS3, RIPK1, TNFAIP3, TRAF2, CASP3, ZDHHC17 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ZNF423_TNFSF10 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ZNF423_TNFSF10 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ZNF423 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| Hgene | ZNF423 | C3539071 | NEPHRONOPHTHISIS 14 | 1 | UNIPROT |
| Tgene | TNFSF10 | C0033578 | Prostatic Neoplasms | 4 | CTD_human |
| Tgene | TNFSF10 | C0017638 | Glioma | 2 | CTD_human |
| Tgene | TNFSF10 | C0027659 | Neoplasms, Experimental | 2 | CTD_human |
| Tgene | TNFSF10 | C0027686 | Pathologic Neovascularization | 2 | CTD_human |
| Tgene | TNFSF10 | C0000786 | Spontaneous abortion | 1 | CTD_human |
| Tgene | TNFSF10 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Tgene | TNFSF10 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Tgene | TNFSF10 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Tgene | TNFSF10 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Tgene | TNFSF10 | C0017636 | Glioblastoma | 1 | CTD_human |
| Tgene | TNFSF10 | C0021400 | Influenza | 1 | CTD_human |
| Tgene | TNFSF10 | C0022665 | Kidney Neoplasm | 1 | CTD_human |
| Tgene | TNFSF10 | C0023418 | leukemia | 1 | CTD_human |
| Tgene | TNFSF10 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Tgene | TNFSF10 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | TNFSF10 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | TNFSF10 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | TNFSF10 | C0027819 | Neuroblastoma | 1 | CTD_human |
| Tgene | TNFSF10 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
| Tgene | TNFSF10 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Tgene | TNFSF10 | C0919267 | ovarian neoplasm | 1 | CTD_human |
| Tgene | TNFSF10 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | TNFSF10 | C2239176 | Liver carcinoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|